Autophagy plays a key role in protecting cells against starvation, organelle damage, intracellular pathogens and protein aggregation. The latter process is associated to neurodegenerative diseases, the most common being Alzheimer's and Parkinson's. You will dissect how autophagy receptors recognise proteins known to accumulate in the aging human brain. Protein aggregation patterns correlate well with dementia progression: despite its highly therapeutic relevance, very few studies attempted to understand autophagy-aggregates interplay at a mechanistic level.
The project will focus on in vitro reconstitution of the autophagy machinery on aggregation-prone proteins, with a strong emphasis on understanding what molecular cues route them toward autophagic degradation. We are looking for a student with a genuine interest in advanced protein biochemistry methods.
We offer extensive training in molecular biology, biochemistry, microscopy and cell biology, a highly collaborative research environment and the possibility to conduct cutting edge research.