Tight control of RNA processing and degradation is a crucial step of post-transcriptional gene regulation. The RNA exosome is a big multisubunit complex, that regulates nearly every category of transcripts, synthesized in the cell. While the recruitment of the exosome to its substrates and structural basis for it are well described, the contribution of individual subunits to the exosome function and assembly remains elusive. The advertised project utilizes various protein perturbation techniques (inducible KO, AID-system) combined with flow-cytometry, microscopy and classical biochemistry to gain in-depth insights into RNA exosome biology. The project offers the opportunity to acquire a broad range of technical skills and to learn to independently conduct a research project.
Candidates are expected to be fluent in English, have excellent communication and inter-personal skills and to be highly motivated to become part of an international and multi-disciplinary research group. Candidates should hold a BSc. degree in Molecular Biology, Bio-chemistry, Cell Biology or a related field and have basic laboratory experience.
Applications with a motivation letter and CV highlighting relevant theoretical and practical background should be sent to firstname.lastname@example.org.