Our group is studying the biogenesis of small RNAs and their impact on the regulation of gene expression. sRNAs function as riboregulators of diverse cellular processes in eukaryotes as they target a multitude of different RNA substrates, ranging from transposons, aberrant transcripts, non-coding RNAs produced from repetitive loci up to bona fide mRNAs. To unravel the molecular mechanisms how sRNAs are produced, amplified and how they elicit their function we apply a multidisciplinary structural biology approach, combining X-ray crystallography and Electron microscopy with quantitative biochemistry.
For further information please visit our homepage or contact Sebastian by email.
Requirements: Finished study (B. Sc.) in Molecular Biology, Biochemistry or related, 45 ECTS accomplished in the Master module
Duration: ca. 12 months
Payment: acc. to FWF rates
Max Perutz Labs
Dept. of Structural and Computational Biology, Univ. Wien
Rm. 1622, Campus Vienna Biocenter 5, A-1030 Wien
Lingaraju, M., Johnsen, D., Schlundt, A., Langer, L.M., Basquin, J., Sattler, M., Jensen, T.H., Falk, S.* and Conti, E.* (2019). The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. Nature Communications 10, 3393
Schuller, J.M.*, Falk, S.*, Fromm, L., Hurt, E. and Conti, E. (2018). Structure of the nuclear exosome captured on a maturing pre-ribosome. Science Apr 13; 360, 219-222
Falk, S., Ebert, J., Kögel, A, Bonneau, F. and Conti, E. (2017). Mpp6 incorporation into the nuclear exosome contributes to RNA channeling through the Mtr4 helicase. Cell Reports 20, 2279–2286.
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