PHLPP2 (PH domain leucine-rich repeat-containing protein phosphatase) is a metal-dependent protein phosphatase that has been implicated in the attenuation of Akt signaling in cells. Akt is a pro-growth and survival kinase that is critical to insulin and growth factor signaling, and is hyperactivated in the majority of human cancers. As such, PHLPP2 is regarded as a tumor suppressor gene.
The Leonard lab investigates the mechanisms by which signals are transduced in the cell into appropriate downstream effects. The post-translational modification of proteins with a single phosphate group, a process called phosphorylation, is a ubiquitous signaling mechanism that governs the flow of this information. We are interested in the mechanisms that govern the addition of phosphate groups by KINASES, their removal by PHOSPHATASES, and the structural and functional consequences of these modifications. We use a wide variety of biochemical, biophysical and structural biology tools, complemented with cell biology, to explore how cells regulate the transmission of information at the molecular level. More information can be found on the Leonard lab group page.
Hold a Bachelor’s degree in biochemistry, chemistry or molecular biology
Have practical experience in molecular biology
Have a solid background in and affinity for computational work (data processing)
who is excited by science
who is fascinated by molecular mechanisms
who is creative, critical, and communicative
can work independently in a supportive team
Apply now by sending your CV and motivation letter to Thomas Leonard (firstname.lastname@example.org).