Luckily, evolution has helped the sensitive tRNA-LC to survive in the aerobic world by providing a tight companion, an oxidoreductase named PYROXD1, that protects it against oxidation employing a biochemically novel mechanism.
Can we say that PYROXD1 is an “unfaithful enzyme”? Yes, because while protecting the tRNA-LC, PYROXD1 also supports the function of other enzymes, specifically those that host a metal ion. Rather than blaming evolution, we will investigate those affairs, and you will become a “Molecular Detective”! In fact, we think that PYROXD1 could have a secret role in the metabolism of some metal ions! In our Lab, you will learn biochemistry, molecular biology and different “omics” – metallomics, metabolomics – in collaboration with the facilities at the Vienna BioCenter. You will be trained to think, write and present like a scientist in a vibrant, creative and curious lab atmosphere!
Successful candidates should have experience at the bench and must have finished their Bachelor. We encourage students that are fond of chemical mechanisms involving metal ions to apply. We are looking for hard-working students, with passion for science and ready to go the extra-mile.
Please contact us until March 15th if you are interested in joining forces to tackle the affairs of PYROXD1! In your email, please enclose a CV and a short letter of motivation. We will then conduct a short interview via zoom or in person.