Centrosomes play a pivotal role in animal cell division by nucleating and organizing the microtubules of the mitotic spindle. They are composed of a centriole core and a surrounding pericentriolar material (PCM) matrix. Centrosomes act as mechanical elements that respond to pulling forces exerted by molecular motors on microtubules anchored within the PCM.
The aim of this project is to determine and characterize the molecular elements responsible for conferring mechanical strength to the PCM during cell division in C. elegans embryos.
A Master’s thesis position on an exciting, state-of-the art project in an interactive and international lab environment. The student will be supervised and trained throughout the project but will be expected to work independently. Master students will receive a stipend (similar to the FWF “Forschungsbeihilfe”) of about 470 euro/month.
• Dr. Alexander Dammermann (alex.dammermann@univie.ac.at)
• Júlia Garcia Baucells (julia.garcia.baucells@univie.ac.at)
Feel free to apply directly by sending a CV and motivation letter (max. 500 words) to one the email addresses.
For more details see our lab website, Twitter (@DammermannLab) and recent publications.
Chromatin as a gatekeeper of chromosome replication
Mind matters. VBC mental health awareness
The multiple facets of Hop1 during meiotic prophase
Chromosomes as Mechanical Objects: from E.coli to Meiosis to Mammalian cells
Convergent evolution of CO2-fixing liquid-liquid phase separation
Viral envelope engineering for cell type specific delivery
New ways of leading: inclusive leadership and revising academic hierarchies
How an opportunistic human pathogen colonizes surfaces - From pathogen behavior to new drugs
Title to be announced
Decoding Molecular Plasticity in the Dark Proteome of the Nuclear Pore Complex
Probing the 3D genome architectural basis of neurodevelopment and aging in vivo
How to tango with four - the evolution of meiotic chromosome segregation after genome duplication
Multidimensional approach to decoding the mysteries of animal development
Connecting mitotic chromosomes to dynamic microtubules - insight from biochemical reconstitution
Membrane remodeling proteins at the junction between prokaryotes and eukaryotes
Neurodiversity in academia: strengths and challenges of neurodivergence
Gene expression dynamics during the awakening of the zygotic genome
When all is lost? Measuring historical signals
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Bacterial cell envelope homeostasis at the (post)transcriptional level
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced