In this project, we aim to mechanistically dissect how accumulation of the misfolded proteins in the ER affects translation of the proteins on the ER membranes. You will work in a team with PhD student Aleksandra Anisimova, who has expertise in state-of–the-art next generation sequencing methods and established fundamental steps towards the project.
The Karagöz Lab combines cell biology with systems-level approaches and in vitro reconstitution to dissect cellular protein-quality control pathways. Currently, our team consists of a group of talented PhD, master’s students and research technicians working on diverse topics to reveal how cells respond to proteotoxic stress.
Successful candidates will:
Isolate ribosomes for mass spectrometry analyses and subsequent characterization by western blot analyses
Perform biochemical assays coupled with immunoprecipitation
Be involved in preparing next generation sequencing libraries
We are looking for a highly motivated candidate with:
Basic knowledge in biochemistry, molecular and cell biology
Motivation to learn and establish assays and methods
Fluency in English and good communication skills
Please send your CV and motivation letter by e-mail to firstname.lastname@example.org
Initial deadline for the application is September 29th, 2021. If not filled, the review of applications will continue thereafter until the position is filled.
The position is open from October 1st, 2021 on. An initial contract will be for nine months or a year with a possibility of extension if required.
For further details, please do not hesitate to contact Elif Karagöz