The candidate shall support ongoing research projects of the group but may also pursue an individual (sub)project. Therefore, a high level of independence and good organizational skills are required.
The work will involve diverse methods including cultivation of bacteria, genetic engineering, protein purification, techniques for detection of RNA and protein (e.g. Northern/Western blotting), methods addressing interaction of biomolecules (pull-down, two-hybrid system) and others. Experience in working with bacteria and prior knowledge in Microbiology are highly appreciated but not a prerequisite to fill the position. As we are located at an international institute, good English skills are required.
Infection diseases caused by viruses and bacteria represent major threats for human health, livestock and agriculture. Gram-negative bacteria of the family Enterobacteriaceae including pathogenic E. coli strains are of particular concern as resistances against currently used antibiotics are rapidly emerging, demanding for novel therapies. These bacteria are protected by a cell wall sandwiched between an inner and an outer membrane, which forms an effective barrier limiting the efficacy of several antibiotics.
The cell envelope is crucial in sensing the external environment, activating intracellular signaling pathways through which the bacteria adapt to changing conditions. When they are exposed to antibiotics or other stresses that target the envelope, they activate multiple stress response systems to protect themselves. In our projects, we want to understand how these regulatory networks respond to envelope perturbation and achieve protection and repair.
Our laboratory is located at the Max Perutz labs – a joint venture Institute for Molecular Biology of the University of Vienna and the Medical University of Vienna on the Vienna BioCenter Campus. The laboratory is fully equipped and the campus offers access to multiple research facilities. Additional information on the Görke lab.
A technician position in an excellent research institute that is highly dynamic and international. The work will be non-routine and allows to develop creativity and independent thinking. Working times can be organized in a flexible manner depending on the organisational skills and independence of the candidate.
The employment contract (40 h/week) will be according to the standard salary for CTA positions funded by the FWF (https://www.fwf.ac.at/en/research-funding/personnel-costs/). The position is first limited to 3 years.
Depending on the interests and achievements of the candidate, the position may develop into a PhD project provided that the criteria for joining the doctoral school are met (for more information, please see: https://www.viennabiocenter.org/education/).
Please send your application documents to boris.goerke@univie.ac.at. Suitable candidates will be invited for interview. The position can be filled immediately. Applications will be considered until the position is filled.
Chromatin as a gatekeeper of chromosome replication
Mind matters. VBC mental health awareness
The multiple facets of Hop1 during meiotic prophase
Chromosomes as Mechanical Objects: from E.coli to Meiosis to Mammalian cells
Convergent evolution of CO2-fixing liquid-liquid phase separation
Viral envelope engineering for cell type specific delivery
New ways of leading: inclusive leadership and revising academic hierarchies
How an opportunistic human pathogen colonizes surfaces - From pathogen behavior to new drugs
Title to be announced
Decoding Molecular Plasticity in the Dark Proteome of the Nuclear Pore Complex
Probing the 3D genome architectural basis of neurodevelopment and aging in vivo
How to tango with four - the evolution of meiotic chromosome segregation after genome duplication
Multidimensional approach to decoding the mysteries of animal development
Connecting mitotic chromosomes to dynamic microtubules - insight from biochemical reconstitution
Membrane remodeling proteins at the junction between prokaryotes and eukaryotes
Neurodiversity in academia: strengths and challenges of neurodivergence
Gene expression dynamics during the awakening of the zygotic genome
When all is lost? Measuring historical signals
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Bacterial cell envelope homeostasis at the (post)transcriptional level
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced