Transient upregulation of IRF1 during exit from naive pluripotency confers viral protection.
Romeike, Merrit; Spach, Stephanie; Huber, Marie; Feng, Songjie; Vainorius, Gintautas; Elling, Ulrich; Versteeg, Gjis A; Buecker, Christa
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.
Huth, Michelle; Santini, Laura; Galimberti, Elena; Ramesmayer, Julia; Titz-Teixeira, Fabian; Sehlke, Robert; Oberhuemer, Michael; Stummer, Sarah; Herzog, Veronika; Garmhausen, Marius; Romeike, Merrit; Chugunova, Anastasia; Leesch, Friederike; Holcik, Laurenz; Weipoltshammer, Klara; Lackner, Andreas; Schoefer, Christian; von Haeseler, Arndt; Buecker, Christa; Pauli, Andrea; Ameres, Stefan L; Smith, Austin; Beyer, Andreas; Leeb, Martin
Science shines in a new virtual SY-Stem.
Buecker, Christa; Merkle, Florian T
Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency.
Lackner, Andreas; Sehlke, Robert; Garmhausen, Marius; Giuseppe Stirparo, Giuliano; Huth, Michelle; Titz-Teixeira, Fabian; van der Lelij, Petra; Ramesmayer, Julia; Thomas, Henry F; Ralser, Meryem; Santini, Laura; Galimberti, Elena; Sarov, Mihail; Stewart, A Francis; Smith, Austin; Beyer, Andreas; Leeb, Martin
Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
Thomas, Henry F; Kotova, Elena; Jayaram, Swathi; Pilz, Axel; Romeike, Merrit; Lackner, Andreas; Penz, Thomas; Bock, Christoph; Leeb, Martin; Halbritter, Florian; Wysocka, Joanna; Buecker, Christa
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos.
Shahbazi, Marta N; Scialdone, Antonio; Skorupska, Natalia; Weberling, Antonia; Recher, Gaelle; Zhu, Meng; Jedrusik, Agnieszka; Devito, Liani G; Noli, Laila; Macaulay, Iain C; Buecker, Christa; Khalaf, Yakoub; Ilic, Dusko; Voet, Thierry; Marioni, John C; Zernicka-Goetz, Magdalena
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis.
Hainzl, Eva; Stockinger, Silvia; Rauch, Isabella; Heider, Susanne; Berry, David; Lassnig, Caroline; Schwab, Clarissa; Rosebrock, Felix; Milinovich, Gabriel; Schlederer, Michaela; Wagner, Michael; Schleper, Christa; Loy, Alexander; Urich, Tim; Kenner, Lukas; Han, Xiaonan; Decker, Thomas; Strobl, Birgit; Müller, Mathias
Noncanonical effects of IRF9 in intestinal inflammation: more than type I and type III interferons.
Rauch, Isabella; Rosebrock, Felix; Hainzl, Eva; Heider, Susanne; Majoros, Andrea; Wienerroither, Sebastian; Strobl, Birgit; Stockinger, Silvia; Kenner, Lukas; Müller, Mathias; Decker, Thomas
Reorganization of enhancer patterns in transition from naive to primed pluripotency.
Buecker, Christa; Srinivasan, Rajini; Wu, Zhixiang; Calo, Eliezer; Acampora, Dario; Faial, Tiago; Simeone, Antonio; Tan, Minjia; Swigut, Tomasz; Wysocka, Joanna
DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells.
Chen, Hsu-Hsin; Welling, Maaike; Bloch, Donald B; Muñoz, Javier; Mientjes, Edwin; Chen, Xinjie; Tramp, Cody; Wu, Jie; Yabuuchi, Akiko; Chou, Yu-Fen; Buecker, Christa; Krainer, Adrian; Willemsen, Rob; Heck, Albert J; Geijsen, Niels
Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.
Samuel, Rekha; Daheron, Laurence; Liao, Shan; Vardam, Trupti; Kamoun, Walid S; Batista, Ana; Buecker, Christa; Schäfer, Richard; Han, Xiaoxing; Au, Patrick; Scadden, David T; Duda, Dan G; Fukumura, Dai; Jain, Rakesh K
Enhancers as information integration hubs in development: lessons from genomics.
Buecker, Christa; Wysocka, Joanna
A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells.
Buecker, Christa; Chen, Hsu-Hsin; Polo, Jose Maria; Daheron, Laurence; Bu, Lei; Barakat, Tahsin Stefan; Okwieka, Patricia; Porter, Andrew; Gribnau, Joost; Hochedlinger, Konrad; Geijsen, Niels
Different flavors of pluripotency, molecular mechanisms, and practical implications.
Buecker, Christa; Geijsen, Niels
An ES-like pluripotent state in FGF-dependent murine iPS cells.
Di Stefano, Bruno; Buecker, Christa; Ungaro, Federica; Prigione, Alessandro; Chen, Hsu-Hsin; Welling, Maaike; Eijpe, Maureen; Mostoslavsky, Gustavo; Tesar, Paul; Adjaye, James; Geijsen, Niels; Broccoli, Vania
Nutrient-regulated control of lysosome function by signaling lipid conversion
Shedding Light on the Dark Side of Terrestrial Ecosystems: Assessing Biogeochemical Processes in Soils
Protein homeostasis and lifelong cell maintenance
Dissecting the turgor sensing mechanisms in the blast fungus Magnaporthe oryzae
Pikobodies: What does it take to bioengineer NLR immune receptor-nanobody fusions
When all is lost? Measuring historical signals
Gene regulatory mechanisms governing human development, evolution and variation
Regulation of Cerebral Cortex Morphogenesis by Migrating Cells
Phage therapy for treating bacterial infections: a double-edged sword
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
SLiMs and SHelMs: Decoding how short linear and helical motifs direct PPP specificity to direct signaling
Title to be announced
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Engineered nanocarriers for imaging of small proteins by CryoEM
Bacterial cell envelope homeostasis at the (post)transcriptional level
Title to be announced
Hydrologic extremes alter mechanisms and pathways of carbon export from mountainous floodplain soils
Dissecting post-transcriptional gene expression regulation in humans and viruses
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
Title to be announced
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced