The Vienna Covid-19 Diagnostics Initiative (VCDI) is a collaborative effort involving 20 scientific institutions across Vienna. The initiative has repurposed existing infrastructure, resources, and manpower to build a new diagnostics pipeline for the SARS-CoV-2 coronavirus. The initiative freely disseminates its know-how, operating procedures and latest developments. The VCDI is funded by the COVID-19 Rapid Response Call of the Vienna Science and Technology Fund (WWTF).
A marvel of complexity, the nucleus is the command center of the cell – harboring information, codes and controlled access. But different from man-made command centers, the nuclear interior looks chaotic to the eye of a scientist. Chromosomes, the carriers of genetic information, float amidst a sea of water, proteins, nucleic acids and other molecules, all engaged in a myriad of simultaneous reactions. These reactions have one major goal: to turn genes on and off at the right time and place. This process is called gene regulation and makes a brain cell look and act different from a muscle cell or a liver cell.
Infections by human fungal pathogens cause about 1.5 million deaths each year – interfering with iron utilization in the fungus promises new therapeutic approaches.
Multidrug resistance (MDR) is a fundamentally important medical phenomenon that undermines anticancer and anti-infective therapy of cancer or infectious diseases. Researchers of the Max Perutz Labs, a joint venture by the Medical University of Vienna and the University of Vienna, have delineated the molecular mechanism, whereby the human ABCG2 drug transporter drives MDR. The results suggest new therapeutic strategies to prevent MDR by inhibiting the ABCG2 transporter.
Mitosis is the process by which the genetic information encoded on chromosomes is equally distributed to two daughter cells, a fundamental feature of all life on earth. Scientists led by Alexander Dammermann at the Max Perutz Labs, a joint venture of the University of Vienna and the Medical University of Vienna, now examine how centrioles contribute to this process. The findings, published in “Developmental Cell”, help to elucidate the function of these tiny cellular structures in mitosis.