The instructions that make us who we are translate into a diverse array of complex and highly regulated processes that occur precisely and on time in every single cell. Mistakes in these processes can lead to disease. Scientists at the Max Perutz Labs study fundamental cellular and developmental processes at a mechanistic level.
Genetic information is encoded in genes, embedded in chromatin, and organized in chromosomes. Its implementation is dynamically regulated at different levels from DNA to RNA. At the Max Perutz Labs, scientists focus on fundamental processes of inheritance, nuclear architecture, genome organization, and RNA biology from bacteria to humans.
Malfunctions in our defense systems account for more than 85% of all human deaths. Max Perutz Labs scientists dissect the molecular mechanisms underlying the regulation of immune tolerance, signaling pathways in sterile and pathogenic inflammation, including cancer, as well as the principal mechanisms of immune surveillance in healthy, autoimmune, and infectious disease settings.
Biological processes are driven by the coordinated interaction of molecules within cells and tissues. The Max Perutz Labs studies how structure is related to function, the dynamics and energetics of the macromolecules that are at the heart of these processes, and the networks in which they operate. We aim to elucidate the mechanisms that shape our normal physiology and rationalize the role of aberrant macromolecules in disease.
Starting in April 2024
Erinc Hallacli
Deciphering molecular phenotypes in neurodegenerative diseases
How to do proteomics better, faster, smarter - recent developments and opportunities in mass spectrometry
Biomechanics of Muscle Morphogenesis
Control of cell fate and morphogenesis in the developing brain
Activation and regulation of plant immunity by secreted signaling peptides
Transcription start site selection is environmentally controlled to diversify the proteome in eukaryotes
How evolutionary interplay between sexes can help us define phenotypes and develop drugs
Mining for protein-protein interactions with AlphaFold: Lessons from Genome Maintenance
Probing life at the nanoscale - one molecule at a time
The Underworld of Deep-Sea Hydrothermal Vents
Epigenetic regulation of germline development
Sister chromatid cohesion is mediated by individual cohesin complexes
Capturing conformational transitions in the ubiquitin conjugation cascade
18th Microsymposium on RNA Biology
The „Microsymposium on RNA Biology“ is an international conference that brings together young scientists, junior and senior group leaders, and company representatives from all over the world to present and discuss their latest findings in the exciting field of small RNAs and beyond. The Microsymposium was founded in 2005 and has established itself as the major small RNA meeting in Europe. It is organized by the four research institutions IMBA, IMP, GMI and the Max Perutz Labs as well as by the RNA community of the Vienna BioCenter.
Parthenogenesis, cryptobiosis, and the survival in extreme environmental conditions
Ubiquitin & Friends Symposium 2024
The Ubiquitin & Friends Symposium is an annual international meeting taking place in the beautiful capital of Austria, aiming to bring together scholars from various fields studying ubiquitin/Ubl biology and protein degradation in a personal, family-like atmosphere, as suggested by the name.
The evolution and development of mollusc shells
Unraveling the Complexity of Crossover Regulation in C. elegans
Dynamics of 3D Genome Structure and Function
How superworms can help to solve our plastic waste crisis
Shaping morphogen gradients: from molecules to tissues and back
Studying stressed cells by in situ structural biology
Exploring Microbial Resilience: Unravelling Escherichia coliand#x27;s Stress Response at the Level of Protein Synthesis
Deep homology and deep diversity: Evolving genetic toolkits for making and sensing light
The evolution of cell type identity and tissue microecology at the fetal-maternal interface
Origin and diversification of gut-derived organs in chordates
Job's Dilemma for the Genome: Why Bad Things Happen to Good Chromosomes
Understanding how the DNA-loop-extruding protein complex Condensin folds a chromatinized genome into mitotic chromosomes
Striking physiology and cell biology of (marine) environmental microorganisms
Mechanisms controlling maintenance of cohesin dependent loops
Title to be announced