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Sascha Martens secures ERC Synergy Grant for autophagy research
Nov 06, 2025
How do harmful protein aggregates accumulate in our cells – and why can’t the cell’s natural garbage disposal system always remove them? ‘DegrAbility’, the new ERC Synergy Grant awarded to Perutz group leader Sascha Martens, in collaboration with former Perutz group leader Claudine Kraft (now University of Freiburg) and James Hurley (UC Berkeley), aims to answer this fundamental question. Over the next six years, the team will receive a total of €10 million to uncover how the cellular recycling system, known as autophagy, can be strengthened to prevent the accumulation of toxic protein aggregates that contribute to neurodegenerative diseases such as Alzheimer’s. This prestigious and highly competitive grant represents a major investment in fundamental cell biology research and unites three experts in autophagy and protein quality control.