Infections by human fungal pathogens cause about 1.5 million deaths each year – interfering with iron utilization in the fungus promises new therapeutic approaches. Candida species, the most prevalent opportunistic human fungal pathogens, affect severely immunocompromised individuals, and can cause severe invasive infections. The steep increase in infections by multidrug-resistant Candida glabrata pathogens has been posing serious therapeutic challenges. The prime risk factor for Candida infections is a severe immunosuppression, as often seen in the ageing population, microbial super-infections, organ transplantation patients, HIV cohorts as well as neonates.
Bacteria are masters of survival that manage to thrive under often hostile environments. One trick to their survival is their safeguarding envelope. Gram-negative bacteria are protected by a three-layer cell envelope composed of a cell wall sandwiched between two membranes. This structure protects the bacteria from harmful compounds including many antibiotics, which cannot cross this barrier. Boris Görke’s lab has now found out that in Escherichia coli an RNA binding protein senses and regulates synthesis of an important precursor of the bacterial cell envelope.
Researchers employ a variety of methods and tools in their day to day work. They rely on that these tools work as they are supposed to. Two new papers from the lab of Egon Ogris now show that several antibodies recognizing the enzyme PP2A, and an antibody widely used in a technique called Myc tagging lack the precision for their intended tasks. Their findings published in “Science Signaling” show that this and other Myc tag antibodies yield inconsistent results depending on the molecular surrounding of the tag, and that antibodies recognizing PP2A often prove to be unsuitable for measuring the activity of this enzyme.
Max Perutz Labs group leader Shotaro Otsuka was awarded a “Life Science” grant by the Vienna Science and Technology Fund (WWTF). This project is a collaboration, led by Daniel Gerlich from the Institute of Molecular Biotechnology (IMBA), which seeks to unravel the mechanistic basis for how chromatin is condensed into chromosomes during mitosis. The grant is endowed with 700.000 Euros.
All organisms need to adjust their energy consumption in response to internal and external signals, thereby allocating energy to growth, reproduction or rest. Florian Raible’s team at the Max Perutz Labs has shed light on how the marine bristle worm Platynereis dumerilii makes key metabolic decisions in response to developmental and environmental cues. Their study is published in the “Proceedings of the National Academy of Sciences of the United States of America (PNAS)”.
Max Perutz Labs group leaders Kristin Tessmar-Raible, Florian Raible and Arndt von Haeseler are part of a special research programme (SFB) grant, awarded by the Austrian Science Fund. The research network will work on stem cell modulation in neural development and regeneration. Congratulations also to Javier Martinez who is part of the “RNA-DECO” special research programme. These grants are the second and third SFBs awarded to scientists from the Max Perutz Labs and the Vienna BioCenter this December.
The Max Perutz Labs are embedded in the Vienna Biocenter, providing access to outstanding core facilities shared by all members of the campus in addition to facilities unique to our institute.
With a strong molecular focus and a diversity of model organisms, we aim to bridge basic research with biomedicine.
Cells communicate at every level and molecular misunderstandings must be avoided.
Cracking the genetic code and understanding how it can be corrupted.
Making sense of big data to drive hypothesis-based research.
Visualising the biochemistry of macromolecules in health and disease.
To honour an extraordinary teacher and scientist, the Max Perutz Labs were named after Max Ferdinand Perutz, who, together with John C. Kendrew, was awarded the 1962 Nobel Prize in Chemistry for his studies on the structure of globular proteins ...
The Max Perutz Labs seek to educate students to think critically and analytically, challenge them to set ambitious goals, and instill in them both broad horizons and deep understanding. In doing so, we aspire to furnish them with the necessary knowledge and skills to push forward the frontiers of 21st century biomedical science.