During germ cell development faulty meiocytes are eliminated via apoptosis, a programmed cell death to ensure that only healthy gametes are produced. The lab of Verena Jantsch has now discovered a previously undescribed role for topoisomerase 3 (TOP-3) in oocyte quality control of the model organism C. elegans. In the absence of TOP-3, cells accumulate aberrant recombination intermediates in the pre-meiotic and meiotic compartments of the gonad that are less capable of triggering apoptosis. DNA repair is directed to less accurate pathways, resulting in a pool of oocytes with low quality. The study is published in the Journal of Cell Biology.
The Medical University of Vienna in cooperation with the University of Vienna has launched a new Master´s Program in Molecular Precision Medicine dedicated to an understanding of human pathogenesis and the treatment of disease at a molecular and mechanistic level. The course brings basic, translational, and clinical scientists together with doctors to educate students in the opportunities, challenges, and future perspectives of precision medicine.
Centrioles are surrounded by a dense meshwork of proteins called the pericentriolar material (PCM), which together form centrosomes, the main microtubule-organizing centers of the cell. Alexander Dammermann’s group has discovered that centrosomes persist without centrioles in post-mitotic neurons of C. elegans. Key components of the PCM are expressed and incorporated into these centrosomes independent of centrioles and known mitotic regulators. The study, published in Current Biology, suggests that the assembly and maintenance of mitotic and non-mitotic centrosomes may be different.
The Austrian Science Fund has granted a doc.fund to a group of researchers from the Max Perutz Labs, the Faculty of Physics of the University of Vienna, the IMP and the IMBA. The grant is endowed with 1,6 Million Euros and will fund eight PhD positions over four years. Students will be recruited via the Vienna BioCenter PhD Program, and will receive multidisciplinary training to tackle fundamental questions in the field of liquid-liquid phase separation in biology. The doc.fund expects to start recruiting in fall 2021, and is coordinated by Bojan Zagrovic, a computational biologist at the Max Perutz Labs.
Lamins are structural proteins found at the nuclear periphery, where they regulate the mechanical properties of the nucleus and the organization of genetic material within the nucleus. However, they also play a poorly understood role in the nucleoplasm. New work from the lab of Roland Foisner and their collaborators from the Bar Ilan University (Israel) now shows that binding of A-type lamins in the nuclear interior to a protein called LAP2α regulates their mobility and that of surrounding chromatin. The study is published in e-life.
Pluripotent stem cells can give rise to all the different types of specialized cells in the adult organism. Scientists led by Martin Leeb have identified hundreds of genes involved in the exit from naïve pluripotency and show that their activity is largely confined to five key signaling pathways. Their study, published in the EMBO Journal, provides a comprehensive map of the genetic circuits that gate this fundamental cell state transition.
The Max Perutz Labs are embedded in the Vienna BioCenter, providing access to outstanding core facilities shared by all members of the campus in addition to facilities unique to our institute.
With a strong molecular focus and a diversity of model organisms, we aim to bridge basic research with biomedicine.
To honour an extraordinary teacher and scientist, the Max Perutz Labs were named after Max Ferdinand Perutz, who, together with John C. Kendrew, was awarded the 1962 Nobel Prize in Chemistry for his studies on the structure of globular proteins ...
The Max Perutz Labs seek to educate students to think critically and analytically, challenge them to set ambitious goals, and instill in them both broad horizons and deep understanding. In doing so, we aspire to furnish them with the necessary knowledge and skills to push forward the frontiers of 21st century biomedical science.