Despite modern sequencing methods, determining the precise sequence of the genetic code for ribosomal RNA (rRNA) has been technically challenging due to its repetitive nature. The Lab of Peter Schlögelhofer has now, for the first time for any organism, sequenced and assembled large parts of the rDNA-encoding nucleolus organizing region of the model plant Arabidopsis thaliana. In their study, published in Nature Communications, the scientists also identified several tissue-specific rRNA variants, which may have functional roles in specialized ribosomes.
Changes in daylength are a well-established annual timing cue for animal behavior and physiology. An international collaboration of scientists led by Kristin Tessmar-Raible at the Max Perutz Labs now shows that, in addition to daylength, marine bristle worms sense seasonal intensity changes of UVA/deep violet light to adjust the levels of important neurohormones and their behavior. The study is published in Nature Ecology and Evolution.
The Austrian Science Fund (FWF) has granted a second four-year funding period for the Doctoral Program “Signaling Mechanisms in Cellular Homeostasis” (SMICH), allocating a total of more than 2 million Euros. The program will recruit students through the Vienna BioCenter PhD selection and will provide structured training and a scientific framework for students interested in cellular homeostasis.
Borja Mateos (Konrat Lab) and Anete Romanauska (Köhler Lab) are among this year’s exceptional young scientists awarded the Vienna BioCenter PhD award. To this day, 19 Max Perutz Labs students have received the prize for their PhD work. The prize was initiated in 2005 by former Perutz group leader Renée Schroeder and acknowledges the best PhD theses across the four research institutes at the Vienna BioCenter. Among previous awardees are current Perutz group leaders Martin Leeb and Stefan Ameres, and former principal investigator Claudine Kraft.
Group leader Joao Matos, who was recently recruited to the Perutz, has been awarded a prestigious ERC Consolidator Grant. The funding, a total of 2 million over 5 years, will help Joao and his team’s efforts to decipher the molecular controls that ensure a balanced exchange of genetic material during meiosis.
Viruses depend on their hosts to copy themselves and spread. Upon infection, a virus will hijack the host machinery to replicate its genome, manufacture its proteins and assemble new viral particles. The host in defence deploys its own weapons against the virus in an attempt to combat the infection. This host defence depends on an intricate signaling chain that activates the host’s immune system. One tactic employed by viruses to enhance their replication and thwart the immune reaction is to interfere with this signaling mechanism. New research from the lab of Tim Skern and their collaborators from the University of Queensland (Australia) now shows how the vaccinia virus protein A46 disrupts immune signaling by jamming the cellular transmission chain. The paper is now online in the journal “Structure”.
The Max Perutz Labs are embedded in the Vienna Biocenter, providing access to outstanding core facilities shared by all members of the campus in addition to facilities unique to our institute.
With a strong molecular focus and a diversity of model organisms, we aim to bridge basic research with biomedicine.
To honour an extraordinary teacher and scientist, the Max Perutz Labs were named after Max Ferdinand Perutz, who, together with John C. Kendrew, was awarded the 1962 Nobel Prize in Chemistry for his studies on the structure of globular proteins ...
The Max Perutz Labs seek to educate students to think critically and analytically, challenge them to set ambitious goals, and instill in them both broad horizons and deep understanding. In doing so, we aspire to furnish them with the necessary knowledge and skills to push forward the frontiers of 21st century biomedical science.