Junior Imaging Scientist
We are seeking to expand our team with a Junior Imaging Scientist with a background in Biological Sciences, who is enthusiastic about applying cutting-edge light microscopy for imaging-based research.
Postdoctoral Researcher
The Hallacli Lab is looking for a full-time postdoctoral position who will lead an ambitious projected in RNA metabolism in Parkinson’s Disease.
Master Thesis Opportunity
Neurodegenerative diseases like Parkinson’s Disease (PD) pose a major challenge to our aging society. At the Hallacli Lab, we study how toxic protein aggregates, especially alpha-synuclein (α-syn), contribute to disease progression. Our recent work has uncovered a novel connection between α-syn and Processing bodies (P-bodies) - RNA granules that play key roles in RNA metabolism (Hallacli et.al, Cell, 2022). Our goal is to understand how these ancient structures contribute to α-syn-induced toxicity in neurons and how a-syn modulates RNA metabolism in the cell.
Master’s Thesis: "Two functions - two sites: Revealing secrets of RNA ligation"
We love the meticulous processing – cleavage, ligation and modifications – that RNA molecules experience in mammalian cells. We have discovered enzymes and co-factors that splice pre-tRNAs, the champion being the tRNA ligase complex (tRNA-LC). Following discovery, we dissect their regulation, physiology, and in vivo functions in health and disease.
office@maxperutzlabs.ac.at
+43 1 4277 240 01
Vienna BioCenter Dr.-Bohr-Gasse 9, 1030 Vienna
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