Master’s Thesis: "Two functions - two sites: Revealing secrets of RNA ligation"
We love the meticulous processing – cleavage, ligation and modifications – that RNA molecules experience in mammalian cells. We have discovered enzymes and co-factors that splice pre-tRNAs, the champion being the tRNA ligase complex (tRNA-LC). Following discovery, we dissect their regulation, physiology, and in vivo functions in health and disease.
Coordinator
Do you have excellent organizational skills, enjoy working independently, and stay on top of tasks even during busy periods? Then an exciting position awaits you in an international, supportive, and growth-oriented team at the Vienna BioCenter.
Lab Manager/Technician
We are looking for a lab manager/technician (full or part-time) with a passion for science to join the Hallacli group at the Max Perutz Labs. The position is available immediately.
Master Thesis Opportunity
Neurodegenerative diseases like Parkinson’s Disease (PD) pose a major challenge to our aging society. At the Hallacli Lab, we study how toxic protein aggregates, especially alpha-synuclein (α-syn), contribute to disease progression. Our recent work has uncovered a novel connection between α-syn and Processing bodies (P-bodies) - RNA granules that play key roles in RNA metabolism (Hallacli et.al, Cell, 2022). Our goal is to understand how these ancient structures contribute to α-syn-induced toxicity in neurons and how a-syn modulates RNA metabolism in the cell.
office@maxperutzlabs.ac.at
+43 1 4277 240 01
Vienna BioCenter Dr.-Bohr-Gasse 9, 1030 Vienna
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