Laura is interested in epigenetics, specifically, on how the modification of chromatin with the small protein ubiquitin regulates transcription. This is a fundamental process both in healthy cells and in deranged form in human cancers. Over the past years, the Köhler lab has made important contributions to the field of chromatin ubiquitination, most recently by showing how the ubiquitin system can recognize chromatin with high specificity – the publication Laura is awarded for. Laura has already won the L’Oreal Austria Fellowship this year, and was previously awarded a DOC fellowship of the Austrian Academy of Sciences.
More info about the Researcher of the Month can be found here.
Publication:
Gallego L.D., Ghodgaonkar Steger M, Polyansky A, Schubert T, Zagrovic B, Zheng N, Clausen T, Herzog F, and Köhler A; Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6-Bre1. PNAS (2016) 113(38):10553-10558
Dissecting the turgor sensing mechanisms in the blast fungus Magnaporthe oryzae
Pikobodies: What does it take to bioengineer NLR immune receptor-nanobody fusions
scRNA and phylogenetics
Gene regulatory mechanisms governing human development, evolution and variation
Regulation of Cerebral Cortex Morphogenesis by Migrating Cells
Phage therapy for treating bacterial infections: a double-edged sword
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
SLiMs and SHelMs: Decoding how short linear and helical motifs direct PPP specificity to direct signaling
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Engineered nanocarriers for imaging of small proteins by CryoEM
Bacterial cell envelope homeostasis at the (post)transcriptional level
Title to be announced
Hydrologic extremes alter mechanisms and pathways of carbon export from mountainous floodplain soils
Dissecting post-transcriptional gene expression regulation in humans and viruses
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
Title to be announced
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced