During the production of gametes, cells introduce DNA double strand breaks to facilitate the exchange of genetic material between maternal and paternal chromosomes, a process called crossing over. The number of breaks exceeds the final number of crossovers, with the remainder repaired as non-crossovers. TOP-3 is part of the BTR complex that can decatenate joint DNA molecules and reverse invading DNA strands, thereby mediating the non-crossover outcome and safeguarding chromosome integrity. “The function and mechanism of BTR has been studied in a variety of model organisms. However, biochemical reconstitution assays using mammalian proteins have so far omitted the ZnF domains”, says Verena Jantsch. “Consequently, the biological functions of these domains have been poorly characterized”.
Nina Vojtassakova, a diploma student and Rosaria Dello Stritto, a PhD student, engineered a mutant C. elegans lacking the TOP-3 ZnF domain. In contrast to the null mutant, viability was not affected. However, the authors observed an increased number of crossovers and a delay in the processing of recombination intermediates, hinting that the ZnF domain might be involved in reverting DNA strand invasions and/or resolution of catenated DNA strands by the BTR complex. The team could explain the milder phenotype by showing that the ZnF domain cooperates with another BTR protein, RMH-2, to localize the complex to early recombination intermediates and thus facilitate their processing. In doing so, TOP-3 also prevents recombination between heterologous DNA sequences, which can lead to dangerous chromosomal translocations.
The authors’ findings raise interesting questions about the role of the TOP3 ZnF domain during mitotic cell division, in which dysregulation of the BTR complex can lead to Bloom syndrome in humans, a disease characterized by genomic instability and increased susceptibility to cancer. “Using C. elegans, in which TOP-3 contains only one ZnF domain, we can now provide a better understanding of the importance of this highly conserved, but understudied domain in TOP3”, says Verena Jantsch. “Vertebrates, however, contain up to five of these domains. Our study thus may also provide incentives to study their function in more complex organisms, including humans”.
Publication:
Maria Rosaria Dello Stritto, Nina Vojtassakova, Maria Velkova, Patricia Hamminger, Patricia Ulm, Verena Jantsch: The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline. Nucleic Acids Research 2022
Dissection of the Function and Deposition of the histone variant H2A.W in Arabidopsis thaliana
Speaker: Anna SchmückerInstitute: GMI - Berger Lab
Monday Seminar (Internal)
Speaker: LOUBIERE Vincent (Stark), STANKUNAS Edvinas (Köhler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
How cohesin organizes the genome
Speaker: Jan-Michael PetersInstitute: IMP
Virus-host strategies to gain the upper hand during infections
Speaker: Gus VersteegInstitute: Max Perutz Labs
Leveraging the patient as the model to dissect and target metastasis
Speaker: Karuna GaneshInstitute: Sloan Kettering InstituteHost: Anna Obenauf
Mechanism of MCM helicase loading and regulation by CDK revealed by cryo-EM
Speaker: Tom MillerInstitute: University of CopenhagenHost: Clemens Plaschka
Life at Nature Genetics: what we do, how scientific publishing works, and how I got here
Speaker: Michael FletcherInstitute: Editor at Nature GeneticsHost: Alex Stark
Long-term single-cell quantification: New tools for old questions
Speaker: Timm SchroederInstitute: ETH ZurichHost: Manuela Baccarini
Cell competition: a paradigm to understand growth control and heterogeneity in complex tissues
Speaker: Stephanie EllisInstitute: Max Perutz Labs
Title to be announced
Speaker: Noelia UrbanInstitute: IMBA
Monday Seminar (Internal)
Speaker: LEYVA GONZALEZ Marco (Tanaka), MILJKOVIC Frane (Köhler), PINTER Theresa (Busslinger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Illuminating protein degradation by the 26S proteasome and its regulation by ubiquitin
Speaker: Andreas MartinInstitute: University of California, BerkeleyHost: David Haselbach
Cryo-EM reveals a structural diversity of bioenergetic complexes
Speaker: Alexey AmuntsInstitute: Science for Life Laboratory, Stockholm UniversityHost: Silvia Ramundo
Monday Seminar (Internal)
Speaker: SCHOLZ Julia (Otsuka), BAUER Bernd (Martens)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Global Views of Mammalian Development
Speaker: Jay ShendureInstitute: University of WashingtonHost: Alex Stark
Monday Seminar (Internal)
Speaker: ALMEIDA Bernardo (Stark), MILIVOJEV Nadja (Raible), HOLCIK Laurenz (Von Haeseler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: IGOLKINA Anna (Nordborg), KRAMMER Teresa (Tanaka), AMANN Sascha Josef (Haselbach)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
European Worm Meeting 2022
We cordially invite you to the 2022 European Worm Meeting (EWM) taking place in Vienna, July 27-30. The meeting is hosted by the University of Vienna.
Monday Seminar (Internal)
Speaker: SCHMIDT Clara (Mendjan), GOGOVA Rebeca (Clausen), SAAD RODRIGUES Carolina (Schlögelhofer)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: YU Changwei (Brennecke), HAENDELER Simon (Von Haeseler), PASSERA Alessandro (Balzarotti)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SEONG Jinwoo (Rivron), NAVA GARCIA Marintia Mayola (Dagdas), DENEKE Victoria (Pauli)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Xin ChenInstitute: Johns Hopkins UniversityHost: Fred Berger
Monday Seminar (Internal)
Speaker: KELLNER Max Josef (Penninger), LEITNER Marie-Christin (Mendjan), TERIYAPIROM Isaree (Koo)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Mark DawsonInstitute: Peter MacCallum Cancer CentreHost: Johannes Zuber
Monday Seminar (Internal)
Speaker: HOLZMANN Viktoria (Rivron), LEV Itamar (Zimmer), HODAKOVA Zuzana (Haselbach)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Dominique BergmannInstitute: Stanford UniversityHost: Liam Dolan
Monday Seminar (Internal)
Speaker: BABADEI Olga (Decker), OTSUKI Leo (Tanaka), AYALA MUNOZ Farja (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Yves BarralInstitute: ETH ZurichHost: Shotaro Otsuka
Monday Seminar (Internal)
Speaker: TAKACS Zsuzsanna (Gerlich), DE LA CONCEPCION Juan Carlos (Dagdas), FEDL Anna (Busslinger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Sophie PetropoulosInstitute: Karolinska InstitutetHost: Nicolas Rivron
Title to be announced
Speaker: Benoit BruneauInstitute: Gladstone InstitutesHost: Sasha Mendjan
Monday Seminar (Internal)
Speaker: GALLI Lucrezia (Tanaka), HORN Sabrina (Peters), JACOBS Jelle (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Richard FlavellInstitute: Yale University School of MedicineHost: Meinrad Busslinger
Title to be announced
Speaker: Bernd BukauInstitute: ZMBHHost: Elif Karagäz
Monday Seminar (Internal)
Speaker: POPOVA Mariia (Peters), RITSCHKA Birgit (Tanaka), DOMBEY Rodolphe (Mari-Ordonez)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: INCARBONE Marco (Mittelsten Scheid), GRUNDMANN Lorenz (Haselbach), NEMCKO Filip (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: TELONI Federico (Gerlich), WALLNER Eva-Sophie (Dolan), PUSHPA BOSE Greeshma (Urban)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LIU Haijun (Nordborg), NAVALAYE Tsimafei (Ameres), NAAS Julia (Von Haeseler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: CHUGUNOVA Anastasia (Pauli), RÖTZER Johannes (Dolan), JONSSON Gustav (Penninger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KLAUS Loni (Stark), BENEDUM Johannes (Slade), LITTLEBOY Jamie (Knoblich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Daniel MucidaInstitute: Rockefeller UniversityHost: Meinrad Busslinger
Monday Seminar (Internal)
Speaker: ANTONIOLI Sumire (Leonard), LI Chong (Knoblich), PABST Gabriel (Zuber)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Lacra BintuInstitute: Stanford UniversityHost: Alex Stark
Monday Seminar (Internal)
Speaker: DIEZMA Laura (Nordborg/Mari-Ordonez), GHOSH Dipannita (Grade), PATEL Rajvi (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be annouced
Speaker: Adele MarstonInstitute: Wellcome Centre Cell Biology, University of EdinburghHost: Daniel Gerlich, Joao Matos
Monday Seminar (Internal)
Speaker: KORDIC Darja (Clausen), DEIBER Sebastian (Dolan), GEHRE Maja (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ZMAJKOVIC Jakub (Zuber), MAURER Eric (Peters), NOGALES MORAL Adrian (Köhler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HUETTER Christiane (Menche), BASSAT Elad (Tanaka), PETRZILEK Jan (Ameres)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KALIS Robert (Zuber), NAJM Ramsey (Knoblich), GEROCZ Emoke (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: AUGUSTO Pedro (Zimmer), POLISSENI Claudio (Tanaka), ELEWAUT Anais (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: GUO Pin (Dolan), DAO Pauline (Tessmar), JAVALI Alok(Rivron)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: STUART Hannah (Tanaka), KORESHOVA Alevtina (Burga), ZHAN Ni (Dagdas)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: CRONIN Shona (Obenauf), KANNO Tatsuo (Berger), PACHINGER Claudia (Dammermann)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SHUKLA Vikas (Berger), RODRIGUEZ TERRONES Diego (Tanaka), WIDEN Sonya (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: VOICHEK Yoav (Norborg), SESTINI Giovanni (Rivron), PETROULAKI Vasiliki (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BRUNNER Hanna (Haselbach), FRIDRICH Arie (Berger), AKULOVA Vasilina (Swarts)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: DE SANTIS Martina (Rivron), BUENDIA Daniel (Mari-Ordonez), VISANPATTANASIN Supapat (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: VOJTEK Matus (Stark), LEHMANN Christian (Knoblich), LEE Du-Hwa (Belkhadir)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SPICER Maximilian (Gerlich), ESTIVILL I CAPAAROS Guillem (Obenauf), MURPHY Paul (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: JÄGER Christina (Van der Veeken), PRADHAN Saurabh (Rivron), RAFANEL Baptiste (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BELACIC Katarina (Haselbach), HARVEY Zachary (Berger), MILOJKOVIC Lidija (Urban)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: GOMEZ SEGALAS Alba (Balzarotti), KOLESNIKOVA Sofia (Gerlich), HANDLER Dominik (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BAUCELLS Julia (Dammermann), PANAROTTO-PERICLES Melanie (Peters), VOICHEK Maya Shinan (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: DMITRIEV Vladimir (Goloborodko), HISANAGA Tetsuya (Berger), KHALDIEH Nina (Ameres)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SOMMER Theresa (Rivron), SHIRZADIAN YAZD Mehrta (Balzarotti), VERTESY Abel (Knoblich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: POLIKARPOVA Anastasia (Tanaka), CHAKRABORTY Oisorjo (Grade), CORSI Flavia (Goloborodko)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: FESSELET Jeanne (Kovarik), KHAURATOVIC Uladzislava (Matos/Golobordko), SHEN Jingyi (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: PERNEBRINK Mattias (Tanaka), HOHMANN Ulrich (Brennecke/Plaschka), MANOLOVA Toni (Falk)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: WU Shuangyang (Dolan), SCARAMUZZA Federico (Tessmar), KROGULL Daniel (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HEIDARI KHOEI Heidar (Rivron), BELL Caelan (Gerlich), GALUSKA Philipp (Djinovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ABDRAKHMANOV Alibek (Dagdas), WILLIAMS Thomas (Clausen), GEISMANN Maximilian (Balzarotti)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: JELENIC Stela (Saha), PACHECO FIALLOS Franics Belen (Plaschka), FONTES OLIVEIRA Tiago Manuel (Penninger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: NAGUMO WONG Sakurako (Knoblich), LORENZO ORTS Laura (Pauli), ROSS James (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RAFFL Gerald (Ameres), SAJTOS Bettina (Zuber), ISHIHARA Keisuke (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: STEINACKER Thomas (Gerlich), EDER Stephanie (Zimmer), TIKANOVA Polina (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SCHELLHAAS Ulla (Plaschka/Ameres), RUSCH Emma (Goloborodko), CLAVEL Marion (Dagdas)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RADHAKRISHNA PILLAI Balashankar (Saha), ADELMANN Leonie (Raible), BLAHA Andreas (Pauli)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: VULIN Milica (Obenauf), MEREITER Stefan (Penninger), BINDL Michael (Leeb)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LORBEER Franziska (Stark), MULVEY Hugh (Dolan), PÜHRINGER Florian (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HOLZER Elisabeth (Martens), COLOZZA Gabriele (Koo), FALCON CHAVEZ Francisco (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RÖHSNER Josef (Pauli), OKUN Anastasia (Karagöz), JUNG Pauline (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LICHT-MAYER Simon (Penninger), CAYGILL Samuel (Dolan), MIGOTTI Mario (Konrat)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SHUNMUGAM Dhanlakshmi (Baccarini), CECI GINISTRELLI Lavinia (Mendjan), VORLÄNDER Matthias (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KOK Jian Yi (Berger), HUMER Theresa (Pauli), SODERHOLM Adrian (Versteeg)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: STRAVS Ana (Knoblich), SANCHEZ DE MEDINA HERNANDEZ Victor (Dagdas), KRUMWIEDE Luisa (Gaidt)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: TAVERINI Katherina (Urban), SHETTY Kavya Krishna (Stark), CORIC Aida (Tessmar)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: GRABARCZYK Daniel (Clausen), PROTELL I DE MONTSERRAT Julia (Brennecke/Plaschka), MANCHENO JUNCOSA Estela (Mendjan)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ATTRILL Sarah (Dolan), UIJTTEWAAL Esther (Elling), SCIBISZ Grzegorz (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: DOLESCHALL Balint (Knoblich), FENG Sonjie (Bücker), BOURGUET Pierre (Berger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HORENKAMP Simone (Tanaka), CASEY Chloe (Dolan), KAPRAL Thomas (Zagrovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KOBAKHIDZE George (Dong), ANGELOPOULOU Eleni (Ellis), PACHANO Tomas (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RAMIREZ America (Köhler), VÖLKL Isabella (Bücker), HOANG Oi Pui (Technau)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LEITNER Moritz (Martinez), VOGEL Alexander (Yudushkin), KETTEL Paulina (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: TSAREV Aleksandr (Ameres), FIESELER Charlie (Zimmer), ABESAMIS Kim Ivan (Dong)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: STREUBEL Susanna (Dolan), KLEIFELD Justus (Urban), ORLIC Lucija (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SHULKINA Alexandra (Versteeg), GEETHA Sowmya (Jantsch), MADHUSUDHANAN Jalaja (Zimmer)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KOLLER Manuela (Campbell), GUPTA Ankit (Goloborodko), SCHMÖLLERL Johannes (Zuber)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: MARCHIORI Elisa (Van der Veeken), ACHLEITNER Anja (Martens), FAAS Victoria (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SALEWSKIJ Kirill (Penninger), KIRCHGATTERER Paul (Gaidt), REN Kaike (Otsuka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: MIHAILOVIC Milica (Karagöz), BELL Lillie (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
+43 1 4277 240 01
Today: 9am - 5pm
Vienna Biocenter (VBC)
Dr.-Bohr-Gasse 9, 1030 Vienna