Schlögelhofer Lab

Master’s Thesis in Plant Molecular Biology

We study mechanisms of meiotic DNA double strand break (DSB) formation, DNA repair and recombination in the model plant Arabidopsis thaliana. We aim at gaining a holistic understanding ranging from the organism to the molecular details. To this end, we generate (hypo- and hyper-morphic) mutant plant lines and investigate the spatial and temporal distribution of key factors by regular and super-resolution microscopy.

Open since May 15, 2025

To understand mechanistic details, we employ a wide range of techniques including in vitro reconstitution of protein complexes, classical biochemistry and single molecule assays. In collaboration with the excellent on-site facilities and colleagues we perform next generation sequencing, mass spectrometry and structural analyses.

 

About the research project

Meiosis is a specialised cell division prior to the formation of generative cells, creating new allelic combinations of maternal and paternal genetic material. Genetic recombination depends on the introduction of meiotic DSBs but their regulation during meiotic progression is not fully understood. We are interested how meiosis specific chromatin factors affect DSB formation in plants.

 

Candidates

Successful candidates should

 

 

Application

Please include the following in your application:

Please send your application via email until 15.6.2025.

 

 

 

Contact

Univ.-Prof. Dr. Mag. Peter Schlögelhofer
peter.schloegelhofer@univie.ac.at

 

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