Martinez lab

Master’s Thesis: "Two functions - two sites: Revealing secrets of RNA ligation"

We love the meticulous processing – cleavage, ligation and modifications – that RNA molecules experience in mammalian cells. We have discovered enzymes and co-factors that splice pre-tRNAs, the champion being the tRNA ligase complex (tRNA-LC). Following discovery, we dissect their regulation, physiology, and in vivo functions in health and disease.

Open since Feb 16, 2026

About the research project

We have several projects in mind: 1) We found that the tRNA-LC exists in three isoforms. What do they do and where? 2) Why did Ashwin, the subunit that localizes the tRNA-LC into the nucleus (new!), only emerge in vertebrates? 3) Is the tRNA-LC involved in the export of intron-containing tRNAs post-splicing? Besides projects, we offer a vibrant and friendly atmosphere as well as collaborations within the VBC.

 

Candidates

Successful candidates should be already enrolled in a Master Program, for instance the Master in Molecular Biology, have experience at the bench, and a very good background in biochemistry and molecular and cellular biology. We are looking for a student that enjoys adventuring into the unknown, and think, read and work hard towards a goal. We are going to mentor her/him in this direction!

 

Application

If you are interested in this “RNAdventure”, please contact us with a CV, a short statement and, if possible, a letter of recommendation from a teacher or a supervisor until the end of February 2026.

 

Contact

Moritz Leitner, PhD student at the RNA@core Doctoral School. moritz.leitner@meduniwien.ac.at.

Javier Martinez, Group Leader. +43 01 427761803 javier.martinez@meduniwien.ac.at

 

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