A specific interest of the lab is to understand the lipid composition of the inner nuclear membrane (INM), a unique territory of the endoplasmic reticulum that intimately surrounds the genome. We recently discovered metabolic turnover of lipids at the INM and found that the INM can form nuclear lipid droplets that are used for lipid storage and gene regulation (Romanauska & Köhler, Cell 2018). Intriguingly, the INM is highly sensitive to specific fatty acids and executes a detoxification mechanism that is achieved by shunting “bad” fatty acids into cytosolic, as opposed to nuclear, lipid droplets (Romanauska & Köhler, Dev Cell 2021). This rewiring of lipid storage metabolism raises interesting questions about the role of specific lipids in INM function, how the biogenesis of distinct lipid droplet populations is controlled and how the INM communicates with chromatin (Gallego et al., Nature 2020). We expect these insights to be highly relevant for understanding a variety of human diseases.
We connect various methodological approaches, including sophisticated biochemical reconstitution, as well as single cell and real-time microscopy with new approaches of acute chemical and genetic perturbations.
Applicants should have a keen interest in fundamental aspects of cell biology and a proven background in molecular biology, biochemistry and/or quantitative microscopy. You should have obtained your PhD recently or expect to complete your PhD soon. A demonstrated scientific excellence with at least one strong published or upcoming first author paper is required.
The Köhler lab provides a stimulating environment for successful scientific work. The Max Perutz Labs are located at the Vienna BioCenter Campus, a leading biomedical research location in central Europe.
You will benefit from a range of excellent core facilities. The institute is home to scientists from over 40 different nations with English as the working language. Vienna was named as city with highest quality of life in the world for many times (Mercer survey). Childcare facilities are available on campus.
The position is endowed with a competitive salary and is available initially for 3 years. It can be turned into a permanent position depending on performance. Lab funding includes an ERC Consolidator Grant.
Please submit your CV, a statement of research accomplishments and future goals and arrange to have three letters of recommendation sent as well. Shortlisted candidates will be contacted via e-mail. The positions are open immediately.
Send correspondence to: Prof. Alwin Koehler – Scientific Director
More information can be found at: https://www.maxperutzlabs.ac.at/research/research-groups/koehler