CEA response is associated with tumor response and survival in patients with KRAS exon 2 wild-type and extended RAS wild-type metastatic colorectal cancer receiving first-line FOLFIRI plus cetuximab or bevacizumab (FIRE-3 trial).
Michl M, Stintzing S, Fischer von Weikersthal L, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran S-E, Heintges T, Lerchenmueller C, Kahl C, Seipelt G, Kullmann F, Stauch M, Scheithauer W, Hielscher J, Scholz M, Mueller S, Lerch M M, Modest D P, Kirchner T, Jung A, Heinemann V
The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.
Tortola Luigi, Nitsch Roberto, Bertrand Mathieu J M, Kogler Melanie, Redouane Younes, Kozieradzki Ivona, Uribesalgo Iris, Fennell Lilian M, Daugaard Mads, Klug Helene, Wirnsberger Gerald, Wimmer Reiner, Perlot Thomas, Sarao Renu, Rao Shuan, Hanada Toshikatsu, Takahashi Nozomi, Kernbauer Elisabeth, Demiröz Duygu, Lang Michaela, Superti-Furga Giulio, Decker Thomas, Pichler Andrea, Ikeda Fumiyo, Kroemer Guido, Vandenabeele Peter, Sorensen Poul H, Penninger Josef M
Emancipation from transcriptional latency: unphosphorylated STAT5 as guardian of hematopoietic differentiation.
Decker Thomas
Response to interferons and antibacterial innate immunity in the absence of tyrosine-phosphorylated STAT1.
Majoros Andrea, Platanitis Ekaterini, Szappanos Daniel, Cheon HyeonJoo, Vogl Claus, Shukla Priyank, Stark George R, Sexl Veronika, Schreiber Robert, Schindler Christian, Müller Mathias, Decker Thomas
Intestinal Microbiota Signatures Associated with Inflammation History in Mice Experiencing Recurring Colitis.
Berry David, Kuzyk Orest, Rauch Isabella, Heider Susanne, Schwab Clarissa, Hainzl Eva, Decker Thomas, Müller Mathias, Strobl Birgit, Schleper Christa, Urich Tim, Wagner Michael, Kenner Lukas, Loy Alexander
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis.
Hainzl Eva, Stockinger Silvia, Rauch Isabella, Heider Susanne, Berry David, Lassnig Caroline, Schwab Clarissa, Rosebrock Felix, Milinovich Gabriel, Schlederer Michaela, Wagner Michael, Schleper Christa, Loy Alexander, Urich Tim, Kenner Lukas, Han Xiaonan, Decker Thomas, Strobl Birgit, Müller Mathias
Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex.
Wienerroither Sebastian, Shukla Priyank, Farlik Matthias, Majoros Andrea, Stych Bernadette, Vogl Claus, Cheon HyeonJoo, Stark George R, Strobl Birgit, Müller Mathias, Decker Thomas
Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs.
Abdul-Sater Ali A, Majoros Andrea, Plumlee Courtney R, Perry Stuart, Gu Ai Di, Lee Carolyn, Shresta Sujan, Decker Thomas, Schindler Christian
Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons.
Rauch Isabella, Rosebrock Felix, Hainzl Eva, Heider Susanne, Majoros Andrea, Wienerroither Sebastian, Strobl Birgit, Stockinger Silvia, Kenner Lukas, Müller Mathias, Decker Thomas
Tracking heavy water (D2O) incorporation for identifying and sorting active microbial cells.
Berry David, Mader Esther, Lee Tae Kwon, Woebken Dagmar, Wang Yun, Zhu Di, Palatinszky Marton, Schintlmeister Arno, Schmid Markus C, Hanson Buck T, Shterzer Naama, Mizrahi Itzhak, Rauch Isabella, Decker Thomas, Bocklitz Thomas, Popp Jürgen, Gibson Christopher M, Fowler Patrick W, Huang Wei E, Wagner Michael
FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial.
Heinemann Volker, von Weikersthal Ludwig Fischer, Decker Thomas, Kiani Alexander, Vehling-Kaiser Ursula, Al-Batran Salah-Eddin, Heintges Tobias, Lerchenmüller Christian, Kahl Christoph, Seipelt Gernot, Kullmann Frank, Stauch Martina, Scheithauer Werner, Hielscher Jörg, Scholz Michael, Müller Sebastian, Link Hartmut, Niederle Norbert, Rost Andreas, Höffkes Heinz-Gert, Moehler Markus, Lindig Reinhard U, Modest Dominik P, Rossius Lisa, Kirchner Thomas, Jung Andreas, Stintzing Sebastian
STAT1 plays a role in TLR signal transduction and inflammatory responses.
Luu Kevin, Greenhill Claire J, Majoros Andrea, Decker Thomas, Jenkins Brendan J, Mansell Ashley
Type I interferons have opposing effects during the emergence and recovery phases of colitis.
Rauch Isabella, Hainzl Eva, Rosebrock Felix, Heider Susanne, Schwab Clarissa, Berry David, Stoiber Dagmar, Wagner Michael, Schleper Christa, Loy Alexander, Urich Tim, Müller Mathias, Strobl Birgit, Kenner Lukas, Decker Thomas
Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway.
Hansen Kathrine, Prabakaran Thaneas, Laustsen Anders, Jørgensen Sofie E, Rahbæk Stine H, Jensen Søren B, Nielsen Rikke, Leber Jess H, Decker Thomas, Horan Kristy A, Jakobsen Martin R, Paludan Søren R
STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.
Semper Christian, Leitner Nicole R, Lassnig Caroline, Parrini Matthias, Mahlakõiv Tanel, Rammerstorfer Michael, Lorenz Karin, Rigler Doris, Müller Simone, Kolbe Thomas, Vogl Claus, Rülicke Thomas, Staeheli Peter, Decker Thomas, Müller Mathias, Strobl Birgit
Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery.
Schwab Clarissa, Berry David, Rauch Isabella, Rennisch Ina, Ramesmayer Julia, Hainzl Eva, Heider Susanne, Decker Thomas, Kenner Lukas, Müller Mathias, Strobl Birgit, Wagner Michael, Schleper Christa, Loy Alexander, Urich Tim
Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins.
Wienerroither Sebastian, Rauch Isabella, Rosebrock Felix, Jamieson Amanda M, Bradner James, Muhar Matthias, Zuber Johannes, Müller Mathias, Decker Thomas
The regulation of inflammation by interferons and their STATs.
Rauch Isabella, Müller Mathias, Decker Thomas
Route of Infection Determines the Impact of Type I Interferons on Innate Immunity to Listeria monocytogenes.
Kernbauer Elisabeth, Maier Verena, Rauch Isabella, Müller Mathias, Decker Thomas
Role of tissue protection in lethal respiratory viral-bacterial coinfection.
Jamieson Amanda M, Pasman Lesley, Yu Shuang, Gamradt Pia, Homer Robert J, Decker Thomas, Medzhitov Ruslan