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From Weak Interactions to High Stability: Deciphering the Streptavidin-Biotin Interaction through NMR and Computational Analysis.

2025 The journal of physical chemistry. B
PMID:  40356290

Ptaszek Aleksandra L, Kratzwald Sarah, Sagan Filip, Migotti Mario, Sánchez-Murcia Pedro A, Konrat Robert, Platzer Gerald

Hepcidin and fungal infections: The liver fights back.

2025 Cell reports;44(5):115653.
PMID:  40319475

Kuchler Karl

Filamin C dimerisation is regulated by HSPB7.

2025 Nature communications;16(1):4090.
PMID:  40312381

Wang Zihao, Cao Guodong, Collier Miranda P, Qiu Xingyu, Broadway-Stringer Sophie, Šaman Dominik, Ng Jediael Z Y, Sen Navoneel, Azad Amar J, Hooper Charlotte, Zimmermann Johannes, McDonough Michael A, Brem Jürgen, Rabe Patrick, Song Haigang, Alderson T Reid, Schofield Christopher J, Bolla Jani R, Djinovic-Carugo Kristina, Fürst Dieter O, Warscheid Bettina, Degiacomi Matteo T, Allison Timothy M, Hochberg Georg K A, Robinson Carol V, Gehmlich Katja, Benesch Justin L P

Ampicillin treatment in persister cell studies may cause non-physiological artifacts.

2025 Microbial cell (Graz, Austria);12:53, 64, 53-64.
PMID:  40302931

Fasnacht Michel, Comic Hena, Moll Isabella

TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases.

2025 Nature communications;16(1):3894.
PMID:  40274822

Shulkina Alexandra, Hacker Kathrin, Ehrmann Julian F, Budroni Valentina, Mandlbauer Ariane, Bock Johannes, Grabarczyk Daniel B, Edobor Genevieve, Cochella Luisa, Clausen Tim, Versteeg Gijs A

Lessons from RatA: Why the Basics in Molecular Biology Are Still Crucial!

2025 International journal of molecular sciences;26(7)
PMID:  40243733

Fasnacht Michel, Schratt Denise, Moll Isabella

Concerns about data integrity of randomized clinical trials from one author in the European Journal of Gastroenterology & Hepatology.

2025 European journal of gastroenterology & hepatology;37(5):675, 677, 675-677.
PMID:  40207471

Zhou Kelly X, Meyerowitz-Katz Gideon, Skern Tim, Mol Ben W

Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation.

2025 Science immunology;10(106):eadp6231.
PMID:  40184438

Radhouani Mariem, Farhat Asma, Hakobyan Anna, Zahalka Sophie, Pimenov Lisabeth, Fokina Alina, Hladik Anastasiya, Lakovits Karin, Brösamlen Jessica, Dvorak Vojtech, Nunes Natalia, Zech Andreas, Idzko Marco, Krausgruber Thomas, Köhl Jörg, Uluckan Ozge, Kovarik Jiri, Hoehlig Kai, Vater Axel, Eckhard Margret, Sombke Andy, Fortelny Nikolaus, Menche Jörg, Knapp Sylvia, Starkl Philipp

RAF1 kinase contributes to autophagic lysosome reformation.

2025 Cell reports;44(4):115490.
PMID:  40184255

Toifl Stefanie, Didusch Sebastian, Ehrenreiter Karin, Desideri Enrico, Dorard Coralie, Baccarini Manuela

PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor.

2025 Proceedings of the National Academy of Sciences of the United States of America(14)
PMID:  40168118

Husremović Tarik, Meier Vanessa, Piëch Lucas, Siess Katharina M, Antonioli Sumire, Grishkovskaya Irina, Kircheva Nikoleta, Angelova Silvia E, Wenzl Karoline, Brandstätter Andreas, Veis Jiri, Miočić-Stošić Fran, Anrather Dorothea, Hartl Markus, Truebestein Linda, Cerron-Alvan Luis M, Leeb Martin, Žagrović Bojan, Hann Stephan, Bock Christoph, Ogris Egon, Dudev Todor, Irwin Nicholas A T, Haselbach David, Leonard Thomas A

The human ABCG2 transporter engages three gates to control multidrug extrusion.

2025 iScience;28(3):112125.
PMID:  40165990

Khunweeraphong Narakorn, Kuchler Karl

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence.

2025 Science immunology;10(105):eadk5041.
PMID:  40153488

Farhat Asma, Radhouani Mariem, Deckert Florian, Zahalka Sophie, Pimenov Lisabeth, Fokina Alina, Hakobyan Anna, Oberndorfer Felicitas, Brösamlen Jessica, Hladik Anastasiya, Lakovits Karin, Meng Fanzhe, Quattrone Federica, Boon Louis, Vesely Cornelia, Starkl Philipp, Boucheron Nicole, Menche Jörg, van der Veeken Joris, Ellmeier Wilfried, Gorki Anna-Dorothea, Campbell Clarissa, Gawish Riem, Knapp Sylvia

Gene dosage of modulates azole susceptibility in .

2025 Microbiology spectrum;13(5):e0265924.
PMID:  40130854

Phan-Canh Trinh, Bitencourt Tamires, Kuchler Karl

PARP7 as a new target for activating anti-tumor immunity in cancer.

2025 EMBO molecular medicine
PMID:  40128585

Popova Katerina, Benedum Johannes, Engl Magdalena, Lütgendorf-Caucig Carola, Fossati Piero, Widder Joachim, Podar Klaus, Slade Dea

Can we develop effective direct or indirect inhibitors of transcription factors? On the clinical evolution of protein degraders for multiple myeloma therapy.

2025 Expert opinion on therapeutic targets
PMID:  40122131

Meli Rajeshwari, Aksoy Osman, Vallet Sonia, Slade Dea, Podar Klaus

ADAT3 variants disrupt the activity of the ADAT tRNA deaminase complex and impair neuronal migration.

2025 Brain : a journal of neurology(9)
PMID:  40120092

Del-Pozo-Rodriguez Jordi, Tilly Peggy, Lecat Romain, Vaca Hugo Rolando, Mosser Laureline, Brivio Elena, Balla Till, Gomes Marina Vitoria, Ramos-Morales Elizabeth, Schwaller Noémie, Salinas-Giegé Thalia, VanNoy Grace, England Eleina M, Kern Lovgren Alysia, O'Leary Melanie, Chopra Maya, Meave Ojeda Naomi, Toosi Mehran Beiraghi, Eslahi Atieh, Alerasool Masoome, Mojarrad Majid, Pais Lynn S, Yeh Rebecca C, Gable Dustin L, Hashem Mais O, Abdulwahab Firdous, Rakiz Alqurashi Muath, Sbeih Loai Z, Adas Blanco Omar Abu, Khater Renad Abu, Oprea Gabriela, Rad Aboulfazl, Alzaidan Hamad, Aldhalaan Hesham, Tous Ehab, Alsagheir Afaf, Alowain Mohammed, Tamim Abdullah, Alfayez Khowlah, Alhashem Amal, Alnuzha Aisha, Kamel Mona, Al-Awam Bashayer S, Elnaggar Walaa, Almenabawy Nihal, O'Donnell-Luria Anne, Neil Jennifer E, Gleeson Joseph G, Walsh Christopher A, Alkuraya Fowzan S, AlAbdi Lama, Elkhateeb Nour, Selim Laila, Srivastava Siddharth, Nedialkova Danny D, Drouard Laurence, Romier Christophe, Bayam Efil, Godin Juliette D

A complete set of cross-correlated relaxation experiments for determining the protein backbone dihedral angles.

2025 Journal of biomolecular NMR
PMID:  40111570

Bartosińska-Marzec Paulina, Banaś Bartłomiej, Kauffmann Clemens, Beier Andreas, Braun Daniel, Ceccolini Irene, Koźmiński Wiktor, Konrat Robert, Zawadzka-Kazimierczuk Anna

Rapid evolution of flucytosine resistance in .

2025 mSphere;10(4):e0097724.
PMID:  40099908

Phan-Canh Trinh, Nguyen-Le Duc-Minh, Luu Phuc-Loi, Khunweeraphong Narakorn, Kuchler Karl

MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers.

2025 Nature communications;16(1):2614.
PMID:  40097443

Georgiou Konstantina, Sarigol Fatih, Nimpf Tobias, Knapp Christian, Filipczak Daria, Foisner Roland, Naetar Nana

Integrative spatiotemporal modeling of biomolecular processes: Application to the assembly of the nuclear pore complex.

2025 Proceedings of the National Academy of Sciences of the United States of America(11)
PMID:  40085653

Latham Andrew P, Zhang Wanlu, Tempkin Jeremy O B, Otsuka Shotaro, Ellenberg Jan, Sali Andrej

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