PARP7 as a new target for activating anti-tumor immunity in cancer.
Popova Katerina, Benedum Johannes, Engl Magdalena, Lütgendorf-Caucig Carola, Fossati Piero, Widder Joachim, Podar Klaus, Slade Dea
Can we develop effective direct or indirect inhibitors of transcription factors? On the clinical evolution of protein degraders for multiple myeloma therapy.
Meli Rajeshwari, Aksoy Osman, Vallet Sonia, Slade Dea, Podar Klaus
ADAT3 variants disrupt the activity of the ADAT tRNA deaminase complex and impair neuronal migration.
Del-Pozo-Rodriguez Jordi, Tilly Peggy, Lecat Romain, Vaca Hugo Rolando, Mosser Laureline, Brivio Elena, Balla Till, Gomes Marina Vitoria, Ramos-Morales Elizabeth, Schwaller Noémie, Salinas-Giegé Thalia, VanNoy Grace, England Eleina M, Kern Lovgren Alysia, O'Leary Melanie, Chopra Maya, Meave Ojeda Naomi, Toosi Mehran Beiraghi, Eslahi Atieh, Alerasool Masoome, Mojarrad Majid, Pais Lynn S, Yeh Rebecca C, Gable Dustin L, Hashem Mais O, Abdulwahab Firdous, Rakiz Alqurashi Muath, Sbeih Loai Z, Adas Blanco Omar Abu, Khater Renad Abu, Oprea Gabriela, Rad Aboulfazl, Alzaidan Hamad, Aldhalaan Hesham, Tous Ehab, Alsagheir Afaf, Alowain Mohammed, Tamim Abdullah, Alfayez Khowlah, Alhashem Amal, Alnuzha Aisha, Kamel Mona, Al-Awam Bashayer S, Elnaggar Walaa, Almenabawy Nihal, O'Donnell-Luria Anne, Neil Jennifer E, Gleeson Joseph G, Walsh Christopher A, Alkuraya Fowzan S, AlAbdi Lama, Elkhateeb Nour, Selim Laila, Srivastava Siddharth, Nedialkova Danny D, Drouard Laurence, Romier Christophe, Bayam Efil, Godin Juliette D
A complete set of cross-correlated relaxation experiments for determining the protein backbone dihedral angles.
Bartosińska-Marzec Paulina, Banaś Bartłomiej, Kauffmann Clemens, Beier Andreas, Braun Daniel, Ceccolini Irene, Koźmiński Wiktor, Konrat Robert, Zawadzka-Kazimierczuk Anna
HaloPROTAC3 treatment activates the unfolded protein response of the endoplasmic reticulum in nonengineered mammalian cell lines.
Anisimova Aleksandra S, Karagöz G Elif
Rapid evolution of flucytosine resistance in .
Phan-Canh Trinh, Nguyen-Le Duc-Minh, Luu Phuc-Loi, Khunweeraphong Narakorn, Kuchler Karl
MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers.
Georgiou Konstantina, Sarigol Fatih, Nimpf Tobias, Knapp Christian, Filipczak Daria, Foisner Roland, Naetar Nana
Integrative spatiotemporal modeling of biomolecular processes: Application to the assembly of the nuclear pore complex.
Latham Andrew P, Zhang Wanlu, Tempkin Jeremy O B, Otsuka Shotaro, Ellenberg Jan, Sali Andrej
Overlapping and separable activities of BRA-2 and HIM-17 promote occurrence and regulation of pairing and synapsis during Caenorhabditis elegans meiosis.
Blazickova Jitka, Trivedi Shalini, Bowman Richard, Sivakumar Geetha Sowmya, Subah Silma, Scuzzarella Michelle, Chang Alexander, Chandran Uma R, Yanowitz Judith L, Smolikove Sarit, Jantsch Verena, Zetka Monique, Silva Nicola
Convergent Assembly of Homo- and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol-Ene Chemistry.
Becker Christian F W, Urschbach Moritz, Huhmann Susanne, Appel Dominik, Ferrari Luca, Vogl Dominik, Martens Sascha
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation.
Loeff Luuk, Kroupova Alena, Asanović Igor, Boneberg Franziska M, Pfleiderer Moritz M, Riermeier Luca, Leitner Alexander, Ferdigg Andrè, Ackle Fabian, Martinez Javier, Jinek Martin
SUMO style defense: How post-translational modification via SUMO conjugation promotes plant defense.
Stael Simon, Lois L Maria, Bachmair Andreas
The Gcn5 lysine acetyltransferase mediates cell wall remodeling, antifungal drug resistance, and virulence of .
Chauhan Manju, Shivarathri Raju, Aptekmann Ariel A, Chowdhary Anuradha, Kuchler Karl, Desai Jigar V, Chauhan Neeraj
Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions.
Karjalainen Anzhelika, Witalisz-Siepracka Agnieszka, Prchal-Murphy Michaela, Martin David, Sternberg Felix, Krunic Milica, Dolezal Marlies, Fortelny Nikolaus, Farlik Matthias, Macho-Maschler Sabine, Lassnig Caroline, Meissl Katrin, Amenitsch Lena, Lederer Therese, Pohl Elena, Gotthardt Dagmar, Bock Christoph, Decker Thomas, Strobl Birgit, Müller Mathias
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation.
Neuwirth Teresa, Malzl Daniel, Knapp Katja, Tsokkou Panagiota, Kleissl Lisa, Gabriel Anna, Reininger Baerbel, Freystätter Christian, Marella Nara, Kutschat Ana P, Ponweiser Elisabeth, Haschemi Arvand, Seruggia Davide, Menche Jörg, Wagner Erwin F, Stary Georg
CFAP410 has a bimodular architecture with a conserved surface patch on its N-terminal leucine-rich repeat motif for binding interaction partners.
Stadler Alexander, Gabriel Heloisa B, De Liz Laryssa V, Alonso-Gil Santiago, Deng Xuan, Crickley Robbie, Korbula Katharina, Mikolaskova Barbora, Vaughan Sue, Huang Kaiyao, Žagrović Bojan, Sunter Jack D, Dong Gang
The interkinetic envelope: A guardian or just a freeloader?
Velez-Aguilera Griselda, Jantsch Verena
A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions.
Meeusen Bob, Ambjørn Sara M, Veis Jiri, Riley Rachel C, Vit Gianmatteo, Brauer Brooke L, Møller Mads H, Greiner Elora C, Chan Camilla B, Weisser Melanie B, Garvanska Dimitriya H, Zhu Hao, Davey Norman E, Kettenbach Arminja N, Ogris Egon, Nilsson Jakob
Guiding Light: Mechanisms and Adjustments of Environmental Light Interpretation with Insights from and Other Selected Examples.
Wulf Paul O, Häfker N Sören, Hofmann Kaelin, Tessmar-Raible Kristin
ATG8ylation of vacuolar membrane protects plants against cell wall damage.
Julian Jose, Gao Peng, Del Chiaro Alessia, Carlos De La Concepcion Juan, Armengot Laia, Somssich Marc, Duverge Heloise, Clavel Marion, Grujic Nenad, Kobylinska Roksolana, Polivka Ingo, Besten Maarten, Andersen Tonni Grube, Dank Christian, Korbei Barbara, Bachmair Andreas, Coll Nuria S, Minina Elena A, Sprakel Joris, Dagdas Yasin