PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor.
Husremović Tarik, Meier Vanessa, Piëch Lucas, Siess Katharina M, Antonioli Sumire, Grishkovskaya Irina, Kircheva Nikoleta, Angelova Silvia E, Wenzl Karoline, Brandstätter Andreas, Veis Jiri, Miočić-Stošić Fran, Anrather Dorothea, Hartl Markus, Truebestein Linda, Cerron-Alvan Luis M, Leeb Martin, Žagrović Bojan, Hann Stephan, Bock Christoph, Ogris Egon, Dudev Todor, Irwin Nicholas A T, Haselbach David, Leonard Thomas A
FoxO transcription factors actuate the formative pluripotency specific gene expression programme.
Santini Laura, Kowald Saskia, Cerron-Alvan Luis Miguel, Huth Michelle, Fabing Anna Philina, Sestini Giovanni, Rivron Nicolas, Leeb Martin
Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.
Lando David, Ma Xiaoyan, Cao Yang, Jartseva Aleksandra, Stevens Tim J, Boucher Wayne, Reynolds Nicola, Montibus Bertille, Hall Dominic, Lackner Andreas, Ragheb Ramy, Leeb Martin, Hendrich Brian D, Laue Ernest D
Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.
Ferlazzo Giorgia Maria, Gambetta Anna Maria, Amato Sonia, Cannizzaro Noemi, Angiolillo Silvia, Arboit Mattia, Diamante Linda, Carbognin Elena, Romani Patrizia, La Torre Federico, Galimberti Elena, Pflug Florian, Luoni Mirko, Giannelli Serena, Pepe Giuseppe, Capocci Luca, Di Pardo Alba, Vanzani Paola, Zennaro Lucio, Broccoli Vania, Leeb Martin, Moro Enrico, Maglione Vittorio, Martello Graziano
Enhancers of the PAIR4 regulatory module promote distal V gene recombination at the Igh locus.
Hill Louisa, Jaritz Markus, Tagoh Hiromi, Schindler Karina, Kostanova-Poliakova Daniela, Sun Qiong, Schwickert Tanja A, Leeb Martin, Busslinger Meinrad
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.
Huth Michelle, Santini Laura, Galimberti Elena, Ramesmayer Julia, Titz-Teixeira Fabian, Sehlke Robert, Oberhuemer Michael, Stummer Sarah, Herzog Veronika, Garmhausen Marius, Romeike Merrit, Chugunova Anastasia, Leesch Friederike, Holcik Laurenz, Weipoltshammer Klara, Lackner Andreas, Schoefer Christian, von Haeseler Arndt, Buecker Christa, Pauli Andrea, Ameres Stefan L, Smith Austin, Beyer Andreas, Leeb Martin
PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.
Appel Lisa-Marie, Franke Vedran, Bruno Melania, Grishkovskaya Irina, Kasiliauskaite Aiste, Kaufmann Tanja, Schoeberl Ursula E, Puchinger Martin G, Kostrhon Sebastian, Ebenwaldner Carmen, Sebesta Marek, Beltzung Etienne, Mechtler Karl, Lin Gen, Vlasova Anna, Leeb Martin, Pavri Rushad, Stark Alexander, Akalin Altuna, Stefl Richard, Bernecky Carrie, Djinovic-Carugo Kristina, Slade Dea
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3.
Santini Laura, Halbritter Florian, Titz-Teixeira Fabian, Suzuki Toru, Asami Maki, Ma Xiaoyan, Ramesmayer Julia, Lackner Andreas, Warr Nick, Pauler Florian, Hippenmeyer Simon, Laue Ernest, Farlik Matthias, Bock Christoph, Beyer Andreas, Perry Anthony C F, Leeb Martin
Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency.
Lackner Andreas, Sehlke Robert, Garmhausen Marius, Giuseppe Stirparo Giuliano, Huth Michelle, Titz-Teixeira Fabian, van der Lelij Petra, Ramesmayer Julia, Thomas Henry F, Ralser Meryem, Santini Laura, Galimberti Elena, Sarov Mihail, Stewart A Francis, Smith Austin, Beyer Andreas, Leeb Martin
Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
Thomas Henry F, Kotova Elena, Jayaram Swathi, Pilz Axel, Romeike Merrit, Lackner Andreas, Penz Thomas, Bock Christoph, Leeb Martin, Halbritter Florian, Wysocka Joanna, Buecker Christa
Genetic exploration of the exit from self-renewal using haploid embryonic stem cells.
Leeb Martin, Dietmann Sabine, Paramor Maike, Niwa Hitoshi, Smith Austin
Derivation of haploid embryonic stem cells from mouse embryos.
Leeb Martin, Wutz Anton
Polycomb complexes act redundantly to repress genomic repeats and genes.
Leeb Martin, Pasini Diego, Novatchkova Maria, Jaritz Markus, Helin Kristian, Wutz Anton