Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation.
Loeff Luuk, Kroupova Alena, Asanović Igor, Boneberg Franziska M, Pfleiderer Moritz M, Riermeier Luca, Leitner Alexander, Ferdigg Andrè, Ackle Fabian, Martinez Javier, Jinek Martin
Thioredoxin regulates the redox state and the activity of the human tRNA ligase complex.
Jaksch Dhaarsini, Irnstorfer Johanna, Kalman Petra-Franziska, Martinez Javier
Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes.
Köferle Anna, Schlattl Andreas, Hörmann Alexandra, Thatikonda Venu, Popa Alexandra, Spreitzer Fiona, Ravichandran Madhwesh C, Supper Verena, Oberndorfer Sarah, Puchner Teresa, Wieshofer Corinna, Corcokovic Maja, Reiser Christoph, Wöhrle Simon, Popow Johannes, Pearson Mark, Martinez Javier, Weitzer Stefan, Mair Barbara, Neumüller Ralph A
Molecular architecture of the human tRNA ligase complex.
Kroupova Alena, Ackle Fabian, Asanović Igor, Weitzer Stefan, Boneberg Franziska M, Faini Marco, Leitner Alexander, Chui Alessia, Aebersold Ruedi, Martinez Javier, Jinek Martin
Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.
Sekulovski Samoil, Devant Pascal, Panizza Silvia, Gogakos Tasos, Pitiriciu Anda, Heitmeier Katharina, Ramsay Ewan Phillip, Barth Marie, Schmidt Carla, Tuschl Thomas, Baas Frank, Weitzer Stefan, Martinez Javier, Trowitzsch Simon
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection.
Kamel Wael, Noerenberg Marko, Cerikan Berati, Chen Honglin, Järvelin Aino I, Kammoun Mohamed, Lee Jeffrey Y, Shuai Ni, Garcia-Moreno Manuel, Andrejeva Anna, Deery Michael J, Johnson Natasha, Neufeldt Christopher J, Cortese Mirko, Knight Michael L, Lilley Kathryn S, Martinez Javier, Davis Ilan, Bartenschlager Ralf, Mohammed Shabaz, Castello Alfredo
The oxidoreductase PYROXD1 uses NAD(P) as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Asanović Igor, Strandback Emilia, Kroupova Alena, Pasajlic Djurdja, Meinhart Anton, Tsung-Pin Pai, Djokovic Nemanja, Anrather Dorothea, Schuetz Thomas, Suskiewicz Marcin Józef, Sillamaa Sirelin, Köcher Thomas, Beveridge Rebecca, Nikolic Katarina, Schleiffer Alexander, Jinek Martin, Hartl Markus, Clausen Tim, Penninger Josef, Macheroux Peter, Weitzer Stefan, Martinez Javier
ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Pinto Paola H, Kroupova Alena, Schleiffer Alexander, Mechtler Karl, Jinek Martin, Weitzer Stefan, Martinez Javier
The RNA ligase RtcB reverses MazF-induced ribosome heterogeneity in Escherichia coli.
Temmel Hannes, Müller Christian, Sauert Martina, Vesper Oliver, Reiss Ariela, Popow Johannes, Martinez Javier, Moll Isabella
A code within a code: how codons influence mRNA stability.
Martinez Javier, Zagrovic Bojan
Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.
Gebeshuber Christoph A, Kornauth Christoph, Dong Lihua, Sierig Ralph, Seibler Jost, Reiss Martina, Tauber Stefanie, Bilban Martin, Wang Shijun, Kain Renate, Böhmig Georg A, Moeller Marcus J, Gröne Hermann-Josef, Englert Christoph, Martinez Javier, Kerjaschki Dontscho
CLP1 links tRNA metabolism to progressive motor-neuron loss.
Hanada Toshikatsu, Weitzer Stefan, Mair Barbara, Bernreuther Christian, Wainger Brian J, Ichida Justin, Hanada Reiko, Orthofer Michael, Cronin Shane J, Komnenovic Vukoslav, Minis Adi, Sato Fuminori, Mimata Hiromitsu, Yoshimura Akihiko, Tamir Ido, Rainer Johannes, Kofler Reinhard, Yaron Avraham, Eggan Kevin C, Woolf Clifford J, Glatzel Markus, Herbst Ruth, Martinez Javier, Penninger Josef M
The impact of target site accessibility on the design of effective siRNAs.
Tafer Hakim, Ameres Stefan L, Obernosterer Gregor, Gebeshuber Christoph A, Schroeder Renée, Martinez Javier, Hofacker Ivo L
Molecular basis for target RNA recognition and cleavage by human RISC.
Ameres Stefan Ludwig, Martinez Javier, Schroeder Renée
Cleavage of the siRNA passenger strand during RISC assembly in human cells.
Leuschner Philipp J F, Ameres Stefan L, Kueng Stephanie, Martinez Javier