Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation.
Loeff Luuk, Kroupova Alena, Asanović Igor, Boneberg Franziska M, Pfleiderer Moritz M, Riermeier Luca, Leitner Alexander, Ferdigg Andrè, Ackle Fabian, Martinez Javier, Jinek Martin
Thioredoxin regulates the redox state and the activity of the human tRNA ligase complex.
Jaksch Dhaarsini, Irnstorfer Johanna, Kalman Petra-Franziska, Martinez Javier
Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes.
Köferle Anna, Schlattl Andreas, Hörmann Alexandra, Thatikonda Venu, Popa Alexandra, Spreitzer Fiona, Ravichandran Madhwesh C, Supper Verena, Oberndorfer Sarah, Puchner Teresa, Wieshofer Corinna, Corcokovic Maja, Reiser Christoph, Wöhrle Simon, Popow Johannes, Pearson Mark, Martinez Javier, Weitzer Stefan, Mair Barbara, Neumüller Ralph A
Molecular architecture of the human tRNA ligase complex.
Kroupova Alena, Ackle Fabian, Asanović Igor, Weitzer Stefan, Boneberg Franziska M, Faini Marco, Leitner Alexander, Chui Alessia, Aebersold Ruedi, Martinez Javier, Jinek Martin
Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.
Sekulovski Samoil, Devant Pascal, Panizza Silvia, Gogakos Tasos, Pitiriciu Anda, Heitmeier Katharina, Ramsay Ewan Phillip, Barth Marie, Schmidt Carla, Tuschl Thomas, Baas Frank, Weitzer Stefan, Martinez Javier, Trowitzsch Simon
Autophagy in major human diseases.
Klionsky Daniel J, Petroni Giulia, Amaravadi Ravi K, Baehrecke Eric H, Ballabio Andrea, Boya Patricia, Bravo-San Pedro José Manuel, Cadwell Ken, Cecconi Francesco, Choi Augustine M K, Choi Mary E, Chu Charleen T, Codogno Patrice, Colombo Maria Isabel, Cuervo Ana Maria, Deretic Vojo, Dikic Ivan, Elazar Zvulun, Eskelinen Eeva-Liisa, Fimia Gian Maria, Gewirtz David A, Green Douglas R, Hansen Malene, Jäättelä Marja, Johansen Terje, Juhász Gábor, Karantza Vassiliki, Kraft Claudine, Kroemer Guido, Ktistakis Nicholas T, Kumar Sharad, Lopez-Otin Carlos, Macleod Kay F, Madeo Frank, Martinez Jennifer, Meléndez Alicia, Mizushima Noboru, Münz Christian, Penninger Josef M, Perera Rushika M, Piacentini Mauro, Reggiori Fulvio, Rubinsztein David C, Ryan Kevin M, Sadoshima Junichi, Santambrogio Laura, Scorrano Luca, Simon Hans-Uwe, Simon Anna Katharina, Simonsen Anne, Stolz Alexandra, Tavernarakis Nektarios, Tooze Sharon A, Yoshimori Tamotsu, Yuan Junying, Yue Zhenyu, Zhong Qing, Galluzzi Lorenzo, Pietrocola Federico
Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection.
Kamel Wael, Noerenberg Marko, Cerikan Berati, Chen Honglin, Järvelin Aino I, Kammoun Mohamed, Lee Jeffrey Y, Shuai Ni, Garcia-Moreno Manuel, Andrejeva Anna, Deery Michael J, Johnson Natasha, Neufeldt Christopher J, Cortese Mirko, Knight Michael L, Lilley Kathryn S, Martinez Javier, Davis Ilan, Bartenschlager Ralf, Mohammed Shabaz, Castello Alfredo
The oxidoreductase PYROXD1 uses NAD(P) as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Asanović Igor, Strandback Emilia, Kroupova Alena, Pasajlic Djurdja, Meinhart Anton, Tsung-Pin Pai, Djokovic Nemanja, Anrather Dorothea, Schuetz Thomas, Suskiewicz Marcin Józef, Sillamaa Sirelin, Köcher Thomas, Beveridge Rebecca, Nikolic Katarina, Schleiffer Alexander, Jinek Martin, Hartl Markus, Clausen Tim, Penninger Josef, Macheroux Peter, Weitzer Stefan, Martinez Javier
ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Pinto Paola H, Kroupova Alena, Schleiffer Alexander, Mechtler Karl, Jinek Martin, Weitzer Stefan, Martinez Javier
A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.
Elling Ulrich, Wimmer Reiner A, Leibbrandt Andreas, Burkard Thomas, Michlits Georg, Leopoldi Alexandra, Micheler Thomas, Abdeen Dana, Zhuk Sergei, Aspalter Irene M, Handl Cornelia, Liebergesell Julia, Hubmann Maria, Husa Anna-Maria, Kinzer Manuela, Schuller Nicole, Wetzel Ellen, van de Loo Nina, Martinez Jorge Arturo Zepeda, Estoppey David, Riedl Ralph, Yang Fengtang, Fu Beiyuan, Dechat Thomas, Ivics Zoltán, Agu Chukwuma A, Bell Oliver, Blaas Dieter, Gerhardt Holger, Hoepfner Dominic, Stark Alexander, Penninger Josef M
Molecular definitions of autophagy and related processes.
Galluzzi Lorenzo, Baehrecke Eric H, Ballabio Andrea, Boya Patricia, Bravo-San Pedro José Manuel, Cecconi Francesco, Choi Augustine M, Chu Charleen T, Codogno Patrice, Colombo Maria Isabel, Cuervo Ana Maria, Debnath Jayanta, Deretic Vojo, Dikic Ivan, Eskelinen Eeva-Liisa, Fimia Gian Maria, Fulda Simone, Gewirtz David A, Green Douglas R, Hansen Malene, Harper J Wade, Jäättelä Marja, Johansen Terje, Juhasz Gabor, Kimmelman Alec C, Kraft Claudine, Ktistakis Nicholas T, Kumar Sharad, Levine Beth, Lopez-Otin Carlos, Madeo Frank, Martens Sascha, Martinez Jennifer, Melendez Alicia, Mizushima Noboru, Münz Christian, Murphy Leon O, Penninger Josef M, Piacentini Mauro, Reggiori Fulvio, Rubinsztein David C, Ryan Kevin M, Santambrogio Laura, Scorrano Luca, Simon Anna Katharina, Simon Hans-Uwe, Simonsen Anne, Tavernarakis Nektarios, Tooze Sharon A, Yoshimori Tamotsu, Yuan Junying, Yue Zhenyu, Zhong Qing, Kroemer Guido
The RNA ligase RtcB reverses MazF-induced ribosome heterogeneity in Escherichia coli.
Temmel Hannes, Müller Christian, Sauert Martina, Vesper Oliver, Reiss Ariela, Popow Johannes, Martinez Javier, Moll Isabella
A code within a code: how codons influence mRNA stability.
Martinez Javier, Zagrovic Bojan
Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.
Gebeshuber Christoph A, Kornauth Christoph, Dong Lihua, Sierig Ralph, Seibler Jost, Reiss Martina, Tauber Stefanie, Bilban Martin, Wang Shijun, Kain Renate, Böhmig Georg A, Moeller Marcus J, Gröne Hermann-Josef, Englert Christoph, Martinez Javier, Kerjaschki Dontscho
CLP1 links tRNA metabolism to progressive motor-neuron loss.
Hanada Toshikatsu, Weitzer Stefan, Mair Barbara, Bernreuther Christian, Wainger Brian J, Ichida Justin, Hanada Reiko, Orthofer Michael, Cronin Shane J, Komnenovic Vukoslav, Minis Adi, Sato Fuminori, Mimata Hiromitsu, Yoshimura Akihiko, Tamir Ido, Rainer Johannes, Kofler Reinhard, Yaron Avraham, Eggan Kevin C, Woolf Clifford J, Glatzel Markus, Herbst Ruth, Martinez Javier, Penninger Josef M
The impact of target site accessibility on the design of effective siRNAs.
Tafer Hakim, Ameres Stefan L, Obernosterer Gregor, Gebeshuber Christoph A, Schroeder Renée, Martinez Javier, Hofacker Ivo L
Molecular basis for target RNA recognition and cleavage by human RISC.
Ameres Stefan Ludwig, Martinez Javier, Schroeder Renée
Cleavage of the siRNA passenger strand during RISC assembly in human cells.
Leuschner Philipp J F, Ameres Stefan L, Kueng Stephanie, Martinez Javier