Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.
Schwartz Irene, Budroni Valentina, Meyenberg Mathilde, Hodakova Zuzana, Hornegger Harald, Hacker Kathrin, Schwartz Siegfried, Grabarczyk Daniel B, Ehrmann Julian F, Scinicariello Sara, Haselbach David, Menche Jörg, Clausen Tim, Karagöz G Elif, Versteeg Gijs A
Temporal and demographic patterns of peripheral nerve proteomes in preclinical neuropathic pain.
Grundtner Sabrina, Xian Feng, Malzl Daniel, Radits Tina, Barry Allison Marie, Sondermann Julia Regina, Menche Jörg, Gómez-Varela David, Schmidt Manuela
Multimodal learning enables chat-based exploration of single-cell data.
Schaefer Moritz, Peneder Peter, Malzl Daniel, Lombardo Salvo Danilo, Peycheva Mihaela, Burton Jake, Hakobyan Anna, Sharma Varun, Krausgruber Thomas, Sin Celine, Menche Jörg, Tomazou Eleni M, Bock Christoph
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis.
Nguyen Tuan-Anh, Lin Jung-Ming G, Marques Anne-Sophie M C, Fottner Maximilian, Bauer Ludwig G, Reicher Andreas, Daum Diana, Scrofani Lorenzo, Liu Yusi, Cheng Carol, D'Angelo L D D Luna, Sanchez Juan, Bueschl Christoph, Marella Nara, Buphamalai Pisanu, Traversi Florian, Bereš Maša, Moll Herwig P, Siklos Marton, Genger Jakob-Wendelin, Hofstaetter Gerald, Villanti Ludovica, Malik Monika, Klimek Christoph, Runggatscher Kathrin, Guertl Bettina, Hansen Jesper S, Dobner Sarah, Babosova Olga, Becirovic Tina, de Rooij Laura P M H, Casanova Emilio, Koren Anna, Froese D Sean, Rosenblatt David S, Klavins Kristaps, Bergthaler Andreas, Menche Jörg, Hannich J Thomas, Abele Miriam, Sdelci Sara, Lang Kathrin, Huber Kilian V M, Kubicek Stefan
Artificial Intelligence and Network Medicine: Path to Precision Medicine.
Altucci Lucia, Badimon Lina, Balligand Jean-Luc, Baumbach Jan, Catapano Alberico L, Cheng Feixong, DeMeo Dawn, Gupta Rajat, Hacker Marcus, Liu Yang-Yu, Loscalzo Joseph, Maniscalco Sabrina, Menche Jörg, Menichetti Giulia, Parini Paolo, Schmidt Harald H H W, Zitnik Marinka
Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation.
Radhouani Mariem, Farhat Asma, Hakobyan Anna, Zahalka Sophie, Pimenov Lisabeth, Fokina Alina, Hladik Anastasiya, Lakovits Karin, Brösamlen Jessica, Dvorak Vojtech, Nunes Natalia, Zech Andreas, Idzko Marco, Krausgruber Thomas, Köhl Jörg, Uluckan Ozge, Kovarik Jiri, Hoehlig Kai, Vater Axel, Eckhard Margret, Sombke Andy, Fortelny Nikolaus, Menche Jörg, Knapp Sylvia, Starkl Philipp
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence.
Farhat Asma, Radhouani Mariem, Deckert Florian, Zahalka Sophie, Pimenov Lisabeth, Fokina Alina, Hakobyan Anna, Oberndorfer Felicitas, Brösamlen Jessica, Hladik Anastasiya, Lakovits Karin, Meng Fanzhe, Quattrone Federica, Boon Louis, Vesely Cornelia, Starkl Philipp, Boucheron Nicole, Menche Jörg, van der Veeken Joris, Ellmeier Wilfried, Gorki Anna-Dorothea, Campbell Clarissa, Gawish Riem, Knapp Sylvia
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation.
Neuwirth Teresa, Malzl Daniel, Knapp Katja, Tsokkou Panagiota, Kleissl Lisa, Gabriel Anna, Reininger Baerbel, Freystätter Christian, Marella Nara, Kutschat Ana P, Ponweiser Elisabeth, Haschemi Arvand, Seruggia Davide, Menche Jörg, Wagner Erwin F, Stary Georg
Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia.
Grundtner Sabrina, Sondermann Julia R, Xian Feng, Malzl Daniel, Segelcke Daniel, Pogatzki-Zahn Esther M, Menche Jörg, Gómez-Varela David, Schmidt Manuela
Pan-cancer analysis of the interplay between mutational signatures and cellular signaling.
Hakobyan Anna, Meyenberg Mathilde, Vardazaryan Nelli, Hancock Joel, Vulliard Loan, Loizou Joanna I, Menche Jörg
Coordinated ARP2/3 and glycolytic activities regulate the morphological and functional fitness of human CD8 T cells.
Kamnev Anton, Mehta Tanvi, Wielscher Matthias, Chaves Beatriz, Lacouture Claire, Mautner Anna-Katharina, Shaw Lisa E, Caldera Michael, Menche Jörg, Weninger Wolfgang P, Farlik Matthias, Boztug Kaan, Dupré Loïc
Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model.
Horánszky Alex, Shashikadze Bachuki, Elkhateib Radwa, Lombardo Salvo Danilo, Lamberto Federica, Zana Melinda, Menche Jörg, Fröhlich Thomas, Dinnyés András
AutoCore: A network-based definition of the core module of human autoimmunity and autoinflammation.
Guthrie Julia, Köstel Bal Sevgi, Lombardo Salvo Danilo, Müller Felix, Sin Celine, Hütter Christiane V R, Menche Jörg, Boztug Kaan
Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet.
Meyenberg Mathilde, Hakobyan Anna, Papac-Milicevic Nikolina, Göderle Laura, Langner Franziska L, Markovic Mateo, Lee Ji-Hyun, Koo Bon-Kyoung, Busslinger Georg A, da Silva Israel Tojal, Binder Christoph J, Menche Jörg, Loizou Joanna I
Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model.
Lamberto Federica, Shashikadze Bachuki, Elkhateib Radwa, Lombardo Salvo Danilo, Horánszky Alex, Balogh Andrea, Kistamás Kornél, Zana Melinda, Menche Jörg, Fröhlich Thomas, Dinnyés András
Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model.
Shashikadze Bachuki, Valla Libera, Lombardo Salvo Danilo, Prehn Cornelia, Haid Mark, Riols Fabien, Stöckl Jan Bernd, Elkhateib Radwa, Renner Simone, Rathkolb Birgit, Menche Jörg, Hrabĕ de Angelis Martin, Wolf Eckhard, Kemter Elisabeth, Fröhlich Thomas
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Block Jana, Rashkova Christina, Castanon Irinka, Zoghi Samaneh, Platon Jessica, Ardy Rico C, Fujiwara Mitsuhiro, Chaves Beatriz, Schoppmeyer Rouven, van der Made Caspar I, Jimenez Heredia Raul, Harms Frederike L, Alavi Samin, Alsina Laia, Sanchez Moreno Paula, Ávila Polo Rainiero, Cabrera-Pérez Rocío, Kostel Bal Sevgi, Pfajfer Laurène, Ransmayr Bernhard, Mautner Anna-Katharina, Kondo Ryohei, Tinnacher Anna, Caldera Michael, Schuster Michael, Domínguez Conde Cecilia, Platzer René, Salzer Elisabeth, Boyer Thomas, Brunner Han G, Nooitgedagt-Frons Judith E, Iglesias Estíbaliz, Deyà-Martinez Angela, Camacho-Lovillo Marisol, Menche Jörg, Bock Christoph, Huppa Johannes B, Pickl Winfried F, Distel Martin, Yoder Jeffrey A, Traver David, Engelhardt Karin R, Linden Tobias, Kager Leo, Hannich J Thomas, Hoischen Alexander, Hambleton Sophie, Illsinger Sabine, Da Costa Lydie, Kutsche Kerstin, Chavoshzadeh Zahra, van Buul Jaap D, Antón Jordi, Calzada-Hernández Joan, Neth Olaf, Viaud Julien, Nishikimi Akihiko, Dupré Loïc, Boztug Kaan
Large neutral amino acid levels tune perinatal neuronal excitability and survival.
Knaus Lisa S, Basilico Bernadette, Malzl Daniel, Gerykova Bujalkova Maria, Smogavec Mateja, Schwarz Lena A, Gorkiewicz Sarah, Amberg Nicole, Pauler Florian M, Knittl-Frank Christian, Tassinari Marianna, Maulide Nuno, Rülicke Thomas, Menche Jörg, Hippenmeyer Simon, Novarino Gaia
Assessment of community efforts to advance network-based prediction of protein-protein interactions.
Wang Xu-Wen, Madeddu Lorenzo, Spirohn Kerstin, Martini Leonardo, Fazzone Adriano, Becchetti Luca, Wytock Thomas P, Kovács István A, Balogh Olivér M, Benczik Bettina, Pétervári Mátyás, Ágg Bence, Ferdinandy Péter, Vulliard Loan, Menche Jörg, Colonnese Stefania, Petti Manuela, Scarano Gaetano, Cuomo Francesca, Hao Tong, Laval Florent, Willems Luc, Twizere Jean-Claude, Vidal Marc, Calderwood Michael A, Petrillo Enrico, Barabási Albert-László, Silverman Edwin K, Loscalzo Joseph, Velardi Paola, Liu Yang-Yu
Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension.
Wertheim Bradley M, Wang Rui-Sheng, Guillermier Christelle, Hütter Christiane Vr, Oldham William M, Menche Jörg, Steinhauser Matthew L, Maron Bradley A