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Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis.

2025 Science advances;11(35):eadw9952.
PMID:  40864703

Boccuni Laura, Marka Frieda, Salzmann Manuel, Schirripa Alessia, Ableitner Elisabeth, Siller Magdalena, Brekalo Mira, Haider Patrick, Stojkovic Stefan, Neumayer Christoph, Örd Tiit, Kollmann Karoline, Assinger Alice, Decker Thomas, Köcher Thomas, Fischer Michael B, Mußbacher Marion, Bergthaler Andreas, Hengstenberg Christian, Podesser Bruno K, Kaikkonen Minna U, Wojta Johann, Hohensinner Philipp J

Integrated time-series analysis and high-content CRISPR screening delineate the dynamics of macrophage immune regulation.

2025 Cell systems:101346.
PMID:  40782800

Traxler Peter, Reichl Stephan, Folkman Lukas, Shaw Lisa, Fife Victoria, Nemc Amelie, Pasajlic Djurdja, Kusienicka Anna, Barreca Daniele, Fortelny Nikolaus, Rendeiro André F, Halbritter Florian, Weninger Wolfgang, Decker Thomas, Farlik Matthias, Bock Christoph

Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions.

2025 Cellular and molecular life sciences : CMLS;82(1):98.
PMID:  40025196

Karjalainen Anzhelika, Witalisz-Siepracka Agnieszka, Prchal-Murphy Michaela, Martin David, Sternberg Felix, Krunic Milica, Dolezal Marlies, Fortelny Nikolaus, Farlik Matthias, Macho-Maschler Sabine, Lassnig Caroline, Meissl Katrin, Amenitsch Lena, Lederer Therese, Pohl Elena, Gotthardt Dagmar, Bock Christoph, Decker Thomas, Strobl Birgit, Müller Mathias

Baseline Liquid Biopsy in Relation to Tissue-Based Parameters in Metastatic Colorectal Cancer: Results From the Randomized FIRE-4 (AIO-KRK-0114) Study.

2025 Journal of clinical oncology : official journal of the American Society of Clinical Oncology;43(12):1463, 1473, 1463-1473.
PMID:  39903881

Stintzing Sebastian, Klein-Scory Susanne, Fischer von Weikersthal Ludwig, Fuchs Martin, Kaiser Florian, Heinrich Kathrin, Modest Dominik Paul, Hofheinz Ralf-Dieter, Decker Thomas, Gerger Armin, Angermeier Stefan, Rumpold Holger, Dickhut Andreas, Öhler Leopold, Gruenberger Birgit, Niedersuess-Beke Dora, Sandmann Matthias, Winder Thomas, Trojan Joerg, Prager Gerald, Held Swantje, Kumbrink Jörg, Schmiegel Wolff, Baraniskin Alexander, Heinemann Volker

Transcriptional control of interferon-stimulated genes.

2024 The Journal of biological chemistry;300(10):107771.
PMID:  39276937

Babadei Olga, Strobl Birgit, Müller Mathias, Decker Thomas

JAK-STAT signaling maintains homeostasis in T cells and macrophages.

2024 Nature immunology;25(5):847, 859, 847-859.
PMID:  38658806

Fortelny Nikolaus, Farlik Matthias, Fife Victoria, Gorki Anna-Dorothea, Lassnig Caroline, Maurer Barbara, Meissl Katrin, Dolezal Marlies, Boccuni Laura, Ravi Sundar Jose Geetha Aarathy, Akagha Mojoyinola Joanna, Karjalainen Anzhelika, Shoebridge Stephen, Farhat Asma, Mann Ulrike, Jain Rohit, Tikoo Shweta, Zila Nina, Esser-Skala Wolfgang, Krausgruber Thomas, Sitnik Katarzyna, Penz Thomas, Hladik Anastasiya, Suske Tobias, Zahalka Sophie, Senekowitsch Martin, Barreca Daniele, Halbritter Florian, Macho-Maschler Sabine, Weninger Wolfgang, Neubauer Heidi A, Moriggl Richard, Knapp Sylvia, Sexl Veronika, Strobl Birgit, Decker Thomas, Müller Mathias, Bock Christoph

Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling.

2024 The EMBO journal;43(11):2233, 2263, 2233-2263.
PMID:  38658796

Ravi Sundar Jose Geetha Aarathy, Fischer Katrin, Babadei Olga, Smesnik Georg, Vogt Alex, Platanitis Ekaterini, Müller Mathias, Farlik Matthias, Decker Thomas

Vγ9+Vδ2+ T cell control of Listeria monocytogenes growth in infected epithelial cells requires butyrophilin 3A genes.

2023 Scientific reports;13(1):18651.
PMID:  37903831

Fischer Katrin, Bradlerova Michaela, Decker Thomas, Supper Verena

SPOP targets the immune transcription factor IRF1 for proteasomal degradation.

2023 eLife;12
PMID:  37622993

Schwartz Irene, Vunjak Milica, Budroni Valentina, Cantoran García Adriana, Mastrovito Marialaura, Soderholm Adrian, Hinterndorfer Matthias, de Almeida Melanie, Hacker Kathrin, Wang Jingkui, Froussios Kimon, Jude Julian, Decker Thomas, Zuber Johannes, Versteeg Gijs A

Pseudorabies virus hijacks DDX3X, initiating an addictive "mad itch" and immune suppression, to facilitate viral spread.

2023 bioRxiv : the preprint server for biology
PMID:  37214906

Cronin Shane J F, Tejada Miguel A, Song Ren, Laval Kathlyn, Cikes Domagoj, Ji Ming, Brai Annalaura, Stadlmann Johannes, Novatchikova Maria, Perlot Thomas, Ali Omar Hasan, Botta Lorenzo, Decker Thomas, Lazovic Jelena, Hagelkruys Astrid, Enquist Lynn, Rao Shuan, Koyuncu Orkide O, Penninger Josef M

Stress signaling boosts interferon-induced gene transcription in macrophages.

2022 Science signaling;15(764):eabq5389.
PMID:  36512641

Boccuni Laura, Podgorschek Elke, Schmiedeberg Moritz, Platanitis Ekaterini, Traxler Peter, Fischer Philipp, Schirripa Alessia, Novoszel Philipp, Nebreda Angel R, Arthur J Simon C, Fortelny Nikolaus, Farlik Matthias, Sexl Veronika, Bock Christoph, Sibilia Maria, Kovarik Pavel, Müller Mathias, Decker Thomas

Impaired Mucosal Homeostasis in Short-Term Fiber Deprivation Is Due to Reduced Mucus Production Rather Than Overgrowth of Mucus-Degrading Bacteria.

2022 Nutrients;14(18)
PMID:  36145178

Overbeeke Annelieke, Lang Michaela, Hausmann Bela, Watzka Margarete, Nikolov Georgi, Schwarz Jasmin, Kohl Gudrun, De Paepe Kim, Eislmayr Kevin, Decker Thomas, Richter Andreas, Berry David

Interferons reshape the 3D conformation and accessibility of macrophage chromatin.

2022 iScience;25(3):103840.
PMID:  35243225

Platanitis Ekaterini, Gruener Stephan, Ravi Sundar Jose Geetha Aarathy, Boccuni Laura, Vogt Alexander, Novatchkova Maria, Sommer Andreas, Barozzi Iros, Müller Mathias, Decker Thomas

Pro-atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation.

2021 FASEB journal : official publication of the Federation of American Societies for Experimental Biology;35(10):e21892.
PMID:  34569651

Al-Ahmadi Wijdan, Webberley Thomas S, Joseph Alex, Harris Ffion, Chan Yee-Hung, Alotibi Reem, Williams Jessica O, Alahmadi Alaa, Decker Thomas, Hughes Timothy R, Ramji Dipak P

The early interferon catches the SARS-CoV-2.

2021 The Journal of experimental medicine;218(10)
PMID:  34424267

Decker Thomas

Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons.

2021 PLoS pathogens;17(7):e1009697.
PMID:  34237114

Demiroz Duygu, Platanitis Ekaterini, Bryant Michael, Fischer Philipp, Prchal-Murphy Michaela, Lercher Alexander, Lassnig Caroline, Baccarini Manuela, Müller Mathias, Bergthaler Andreas, Sexl Veronika, Dolezal Marlies, Decker Thomas

The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4 T Cells via a Novel CDK8-GATA3-FOXP3 Pathway.

2021 Molecular and cellular biology;41(9):e0008521.
PMID:  34124936

Arnett Azlann, Moo Keagan G, Flynn Kaitlin J, Sundberg Thomas B, Johannessen Liv, Shamji Alykhan F, Gray Nathanael S, Decker Thomas, Zheng Ye, Gersuk Vivian H, Rahman Ziaur S, Levy David E, Marié Isabelle J, Linsley Peter S, Xavier Ramnik J, Khor Bernard

The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity.

2021 Cell death and differentiation;28(8):2404, 2420, 2404-2420.
PMID:  33758366

Novoszel Philipp, Drobits Barbara, Holcmann Martin, Fernandes Cristiano De Sa, Tschismarov Roland, Derdak Sophia, Decker Thomas, Wagner Erwin F, Sibilia Maria

Infection Induces Type I Interferon Synthesis Through the cGAS-STING Pathway.

2020 Frontiers in immunology;11:571334.
PMID:  33178195

Fischer Katrin, Tschismarov Roland, Pilz Andreas, Straubinger Susy, Carotta Sebastian, McDowell Andrew, Decker Thomas

Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization.

2020 Nature communications;11(1):5104.
PMID:  33037214

Pereira Fátima C, Wasmund Kenneth, Cobankovic Iva, Jehmlich Nico, Herbold Craig W, Lee Kang Soo, Sziranyi Barbara, Vesely Cornelia, Decker Thomas, Stocker Roman, Warth Benedikt, von Bergen Martin, Wagner Michael, Berry David

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