A Novel HMBC-CC-HMQC NMR Strategy for Methyl Assignment Using Triple-C-Labeled α-Ketoisovalerate Integrated with UCBShift 2.0.
Knödlstorfer Sonja, Toscano Giorgia, Ptaszek Aleksandra L, Kontaxis Georg, Napoli Federico, Schneider Jakob, Maier Katharina, Kapitonova Anna, Lichtenecker Roman J, Schanda Paul, Konrat Robert
Isotopologues of a metabolic precursor for selective N-15 and C-13 histidine labelling.
Brüschweiler Sven, Hlavac Matus, Kratzwald Sarah, Schörghuber Julia, Siess Katharina M, Wimmer Alisa, Platzer Gerald, Konrat Robert, Lichtenecker Roman J
NMR-driven structure-based drug discovery by unveiling molecular interactions.
Platzer Gerald, Mayer Moriz, McConnell Darryl B, Konrat Robert
From Weak Interactions to High Stability: Deciphering the Streptavidin-Biotin Interaction through NMR and Computational Analysis.
Ptaszek Aleksandra L, Kratzwald Sarah, Sagan Filip, Migotti Mario, Sánchez-Murcia Pedro A, Konrat Robert, Platzer Gerald
A complete set of cross-correlated relaxation experiments for determining the protein backbone dihedral angles.
Bartosińska-Marzec Paulina, Banaś Bartłomiej, Kauffmann Clemens, Beier Andreas, Braun Daniel, Ceccolini Irene, Koźmiński Wiktor, Konrat Robert, Zawadzka-Kazimierczuk Anna
Local structure propensities in disordered proteins from cross-correlated NMR spin relaxation.
Braun Daniel, Kauffmann Clemens, Beier Andreas, Ceccolini Irene, Lebedenko Olga O, Skrynnikov Nikolai R, Konrat Robert
Synthesis of a C/H Labeled Building Block to Probe the Phosphotyrosine Interactome Using Biomolecular NMR Spectroscopy.
Kratzwald Sarah, Schwarz Thomas C, Ledolter Karin, Hlavac Matus, Felkl Manuel, Becker Christian F W, Konrat Robert, Lichtenecker Roman J
UCBShift 2.0: Bridging the Gap from Backbone to Side Chain Protein Chemical Shift Prediction for Protein Structures.
Ptaszek Aleksandra L, Li Jie, Konrat Robert, Platzer Gerald, Head-Gordon Teresa
The synthesis of specifically isotope labelled fluorotryptophan and its use in mammalian cell-based protein expression for F-NMR applications.
Toscano Giorgia, Rosati Martina, Barbieri Letizia, Maier Katharina, Banci Lucia, Luchinat Enrico, Konrat Robert, Lichtenecker Roman J
Disentangling the Complexity in Protein Complexes Using Complementary Isotope-Labeling and Multiple-Receiver NMR Spectroscopy.
Knödlstorfer Sonja, Schiavina Marco, Rodella Maria Anna, Ledolter Karin, Konrat Robert, Pierattelli Roberta, Felli Isabella C
Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3 E3 Ligase KRAS Complex.
Piech Sophie, Brüschweiler Sven, Westphalen Josepha, Siess Katharina M, García Murias Julio, Konrat Robert, Bigenzahn Johannes W, Superti-Furga Giulio
Towards cost-effective side-chain isotope labelling of proteins expressed in human cells.
Rosati Martina, Barbieri Letizia, Hlavac Matus, Kratzwald Sarah, Lichtenecker Roman J, Konrat Robert, Luchinat Enrico, Banci Lucia
Probing Protein-Ligand Methyl-π Interaction Geometries through Chemical Shift Measurements of Selectively Labeled Methyl Groups.
Beier Andreas, Platzer Gerald, Höfurthner Theresa, Ptaszek Aleksandra L, Lichtenecker Roman J, Geist Leonhard, Fuchs Julian E, McConnell Darryl B, Mayer Moriz, Konrat Robert
A set of cross-correlated relaxation experiments to probe the correlation time of two different and complementary spin pairs.
Ceccolini Irene, Kauffmann Clemens, Holzinger Julian, Konrat Robert, Zawadzka-Kazimierczuk Anna
Decorating phenylalanine side-chains with triple labeled C/F/H isotope patterns.
Toscano Giorgia, Holzinger Julian, Nagl Benjamin, Kontaxis Georg, Kählig Hanspeter, Konrat Robert, Lichtenecker Roman J
Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail.
Vogl Dominik P, Mateos Borja, Migotti Mario, Felkl Manuel, Conibear Anne C, Konrat Robert, Becker Christian F W
Cβ-Valine and Cγ-Leucine Methine Labeling To Probe Protein Ligand Interaction.
Toscano Giorgia, Höfurthner Theresa, Nagl Benjamin, Beier Andreas, Mayer Moriz, Geist Leonhard, McConnell Darryl B, Weinstabl Harald, Konrat Robert, Lichtenecker Roman J
Optimal C NMR investigation of intrinsically disordered proteins at 1.2 GHz.
Schiavina Marco, Bracaglia Lorenzo, Rodella Maria Anna, Kümmerle Rainer, Konrat Robert, Felli Isabella C, Pierattelli Roberta
Ligand H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution.
Platzer Gerald, Ptaszek Aleksandra L, Böttcher Jark, Fuchs Julian E, Geist Leonhard, Braun Daniel, McConnell Darryl B, Konrat Robert, Sánchez-Murcia Pedro A, Mayer Moriz
Synthesis of a C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics.
Höfurthner Theresa, Toscano Giorgia, Kontaxis Georg, Beier Andreas, Mayer Moriz, Geist Leonhard, McConnell Darryl B, Weinstabl Harald, Lichtenecker Roman, Konrat Robert