The Bachmair group studies the molecular mechanisms that help plants to thrive even if environmental conditions are not optimal, knowledge that is essential to improve food quality. To adapt to environmental stress, plant cells first need to process outside signals. This signal transduction involves modifying proteins already present in the cell. Andreas Bachmair’s research focuses on two regulatory proteins, called Ubiquitin and small-ubiquitin-related modifier (SUMO), which can be appended to other proteins for signalling purposes.
Both regulators are involved in homeostatic mechanisms that help plants to correctly adapt to a changing environment, for example flood or salt stress. Andreas Bachmair has made numerous contributions to ubiquitin and SUMO signalling in plants. His current projects focus on the “N-end rule”, a Ubiquitin code that helps to remove certain proteins during environmental stress, signalling or differentiation.
Andreas Bachmair finished his PhD at the University of Vienna and started his career as a Postdoctoral Fellow at the MIT and the Max Planck Institute for Plant Breeding research in Cologne, Germany. After holding assistant and associate professorships at the Institute of Botany of the University of Vienna he became group leader at the MPI, a position he held until 2008. He then returned to Vienna as group leader and associate professor at the Max F. Perutz Laboratories.
Dissecting the turgor sensing mechanisms in the blast fungus Magnaporthe oryzae
Pikobodies: What does it take to bioengineer NLR immune receptor-nanobody fusions
scRNA and phylogenetics
Gene regulatory mechanisms governing human development, evolution and variation
Regulation of Cerebral Cortex Morphogenesis by Migrating Cells
Phage therapy for treating bacterial infections: a double-edged sword
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
SLiMs and SHelMs: Decoding how short linear and helical motifs direct PPP specificity to direct signaling
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Engineered nanocarriers for imaging of small proteins by CryoEM
Bacterial cell envelope homeostasis at the (post)transcriptional level
Title to be announced
Hydrologic extremes alter mechanisms and pathways of carbon export from mountainous floodplain soils
Dissecting post-transcriptional gene expression regulation in humans and viruses
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
Title to be announced
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced