“I am really honored and happy to receive this award. I want to thank the jury and organizers who have recognized our work”, says Anete Romanauska. Originally from Latvia she first joined the Köhler lab as a Vienna BioCenter Summer School student in 2015. During her subsequent PhD work in Alwin’s lab she made an unexcepted discovery, culminating in a two-author paper in Cell in 2018. She discovered lipid metabolism at the inner nuclear membrane, a region that was assumed to be metabolically passive. In her work, Anete showed that lipid turnover at the inner nuclear membrane can lead to the formation of a new type of energy storing organelle inside the nucleus, so called nuclear lipid droplets. This finding raises important questions about the functions of these droplets and the link between inner nuclear lipid metabolism and gene regulation. “I continue to work together with Alwin and currently we are investigating how membrane lipid properties affect membrane morphology and functionality”, Anete says.
The award is named in honor of Denise P. Barlow. Born in Yorkshire, UK, she was first trained as a nurse and later decided to enroll at the university to study Zoology, Physiology, and Biochemistry. After a PhD at Warwick University and postdoctoral research at the EMBL she came to Austria in 1988 to become the first female group leader at the newly established IMP. In 1991 she discovered the first imprinted gene, becoming a pioneer in this field. To the surprise of many, she found that DNA methylation is not on the silent allele but on the active allele, something that was contrary to expectations. In the course of her career, Denise was affiliated with four research institutions in Austria. She was a professor at the Max Perutz Labs (University of Vienna), a principal investigator at CeMM, and was associated with the IMBA. After her death in 2017 the four institutes established the award in her memory. The prize is endowed with € 5000, aiming to help young researchers transition from PhD student to Postdoctoral researcher.
Gene regulatory mechanisms governing human development, evolution and variation
Regulation of Cerebral Cortex Morphogenesis by Migrating Cells
Phage therapy for treating bacterial infections: a double-edged sword
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
SLiMs and SHelMs: Decoding how short linear and helical motifs direct PPP specificity to direct signaling
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Engineered nanocarriers for imaging of small proteins by CryoEM
Bacterial cell envelope homeostasis at the (post)transcriptional level
Title to be announced
Hydrologic extremes alter mechanisms and pathways of carbon export from mountainous floodplain soils
Dissecting post-transcriptional gene expression regulation in humans and viruses
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
Polyploidy and rediploidisation in stressful times
Title to be announced
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced