In the early 20th century, a German doctor observed unusual protein aggregates in the brain that would come to be known as Lewy bodies, a common feature of several neurodegenerative diseases. A major component of Lewy bodies is alpha synuclein, a poorly understood protein that has since become a therapeutic target. “Alpha synuclein is one of the most abundant proteins in the brain and aggregates of the protein are a hallmark of Parkinson’s,” says Thomas Schwarz, a postdoc in the Konrat lab and co-corresponding author of the study. “Although the pathological relevance of alpha synuclein is well established, both the mechanism by which it causes toxicity and its physiological function are still unclear”.
Alpha synuclein is what is known as an intrinsically disordered protein, or IDP. However, when bound to membranes, it adopts a stable, folded conformation that forms oligomeric assemblies involved in neuronal vesicle trafficking. When these protein assemblies are altered, grow much larger, and leave the membrane, alpha synuclein can form aggregates characteristic of Parkinson’s disease. Whether the membrane-bound aggregates are themselves toxic is controversial. Structural characterization of membrane-bound alpha synuclein could, however, help to explain the biological functions of alpha synuclein and provide a glimpse into its pathophysiology.
The team now used a combination of nuclear magnetic resonance (NMR) spectroscopy and cross-linking mass spectrometry (XL-MS) in collaboration with the Mass Spectrometry Facility at the Max Perutz Labs, to gain a deeper understanding of how membrane-bound alpha synuclein molecules assemble into higher order oligomers. They identified two distinct assemblies of alpha synuclein: a ring-like structure that exhibits features that may aid membrane insertion and an extended assembly that may facilitate its aggregation. “Our structural data also provide a possible explanation for known familial gene mutations that are associated with a higher risk of Parkinson’s disease,” explains Robert Konrat.
The scientists teamed up with the pharmaceutical company UCB to understand the mode of action of a potential Parkinson’s drug. A precursor compound to UCB0599 effectively clears membrane-bound alpha synuclein aggregates in mouse models. The scientists now demonstrate that UCB0599 disrupts membrane-bound alpha synuclein. “We observed that UBC0599 loosens the interactions between individual alpha synuclein molecules in the studied oligomers, which provides a plausible mode of action of the drug,” explains Thomas Schwarz. The team hopes that these findings will now aid in the further development of UCB0599 and its use. “Our findings will help to plan the decisive phase 3 trial, particularly with regard to dosage and development of efficient tests to probe biological efficacy,” says Robert Konrat.
Publication:
Thomas C. Schwarz, Andreas Beier, Karin Ledolter, Thomas Gossenreiter, Theresa Höfurthner, Markus Hartl, Terry S. Baker, Richard J. Taylor, and Robert Konrat: High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599. Proceedings of the National Academy of Sciences. 2023
https://doi.org/10.1073/pnas.2201910120
Monday Seminar (Internal)
Date: 2024-07-29, Time: 12:30:00, Speaker: MAURER Eric (Peters)DOCAVO GARCIA Antonio (Jachowicz)BABADEI Olga (Decker), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2024-08-05, Time: 12:30:00, Speaker: DEL CHIARO Alessia (Dagdas)HUETTER Christiane (Menche)SHETTY Kavya (Hein), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Understanding cell fate patterning with minimal in vitro models of early human development
Date: 2024-08-08, Time: 11:30:00, Speaker: Guillaume Blin, Location: GMI Orange Seminar Room, Type: Impromptu Seminar, Institute: MRC, Edinburgh, Host: Teresa Krammer
Title to be announced
Date: 2024-08-08, Time: 11:00:00, Speaker: Elisa Marti, Location: GMI Orange Seminar Room, Type: Impromptu Seminar, Institute: Instituto de Biologia Molecular de Barcelona, Host: Teresa Krammer
An alternative mechanism to form an organizing center in mouse neural tube organoids
Date: 2024-08-08, Time: 15:00:00, Speaker: Teresa Krammer, Location: IMBA/GMI Lecture Hall, Type: PhD Defense, Institute: IMBA - Tanaka Lab, Host: None
Advanced Concepts of Super-Resolution Fluorescence Microscopy
Date: 2024-08-09, Time: 10:00:00, Speaker: Jörg Enderlein, Location: IMP Lecture Hall, Type: IMP Impromptu Seminar, Institute: Georg August University, Host: Francisco Balzarotti
Monday Seminar (Internal)
Date: 2024-08-12, Time: 12:30:00, Speaker: ANTONIOLI Sumire (Leonard)EMTENANI Shamsi(Knoblich)BASSAT Elad (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Publishing in high impact journals: Lessons from Cell Press
Date: 2024-08-13, Time: 11:00:00, Speaker: Sara Miller, Location: GMI Orange Seminar Room, Type: Impromptu Seminar, Institute: Scientific Editor - Molecular Cell, Host: Alex Stark
Pervasive mislocalization of pathogenic variants underlying genetic disorders
Date: 2024-08-14, Time: 11:00:00, Speaker: Mikko Taipale, Location: IMBA/GMI Lecture Hall, Type: Impromptu Seminar, Institute: University of Toronto, Host: Alex Stark
Monday Seminar (Internal)
Date: 2024-08-19, Time: 12:30:00, Speaker: BENEDUM Johannes (Slade)KALIS Robert (Zuber)PATEL Rajvi (Matos), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Monday Seminar (Internal)
Date: 2024-08-26, Time: 12:30:00, Speaker: JANSEN Ralf (Brennecke)SILVA Raquel (Foisner), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2024-09-02, Time: 12:30:00, Speaker: SCHAAR Benjamin (Zimmer)IGOLKINA Anna (Nordborg)PROTSENKO Liudmila (Brennecke), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Striking physiology and cell biology of (marine) environmental microorganisms
Date: 2024-09-03, Time: 11:30:00, Speaker: Ralf Rabus, Location: Seminar room 4.120, Max Perutz Labs (4th floor), Type: New Developments in Chromosome Biology, Institute: ICBM, Carl von Ossietzky Universität Oldenburg, Host: Kristin Tessmar-Raible
Title to be announced
Date: 2024-09-05, Time: 11:00:00, Speaker: Alexander Van Oudenaarden, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Hubrecht Institute, Host: Daniel Gerlich
Monday Seminar (Internal)
Date: 2024-09-09, Time: 12:30:00, Speaker: STUART Hannah (Tanaka)ROVERA Emanuele (Zuber)KLOSS Linda (Technau), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Mechanisms controlling maintenance of cohesin dependent loops
Date: 2024-09-10, Time: 11:30:00, Speaker: Frederic Beckouet, Location: Max Perutz Labs SR 1 (6.501), Type: SFB Seminar, Institute: Toulouse Centre de Biologie Intégrative, Host: Franz Klein
Title to be announced
Date: 2024-09-11, Time: 11:00:00, Speaker: Matthias Peter, Location: IMBA/GMI Lecture Hall, Type: Max Perutz Labs Impromptu Seminar, Institute: ETH Zürich, Host: Joao Matos
Understanding the ecology of Contarinia gall midge-host plant interactions
Date: 2024-09-12, Time: 13:00:00, Speaker: Boyd A. Mori, Location: GMI Orange Seminar room, Type: GMI Seminar, Institute: University of Alberta, Host: Yan Ma
Title to be announced
Date: 2024-09-12, Time: 11:00:00, Speaker: Elcin Ünal, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: UC Berkeley, Host: Silvia Ramundo, Fred Berger
Cycles of centromere evolution
Date: 2024-09-13, Time: 11:30:00, Speaker: Ian Henderson, Location: GMI Orange Seminar room, Type: VBC Regular Seminar, Institute: University of Cambridge, Host: Magnus Nordborg
Monday Seminar (Internal)
Date: 2024-09-16, Time: 12:30:00, Speaker: WUN Cheuk Ling (Ramundo)MÜLLER Marlene (Rivron)RAUSCHMEIER Rene (Van der Veeken), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2024-09-19, Time: 11:00:00, Speaker: Noam Stern-Ginossar, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Weizmann Institute of Science, Host: Marco Hein
Title to be announced
Date: 2024-09-23, Time: 10:00:00, Speaker: Randy Schekman, Location: IMBA/GMI Lecture Hall, Type: GMI Seminar, Institute: University of California Berkeley, Host: Silvia Ramundo
Monday Seminar (Internal)
Date: 2024-09-23, Time: 12:30:00, Speaker: ESTIVILL I CAPARROS Guillem (Obenauf)VOJTEK Matus (Stark)DA COSTA Barbara (Berger), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2024-09-24, Time: 10:00:00, Speaker: Sabeeha Merchant, Location: IMBA/GMI Lecture Hall, Type: GMI Seminar, Institute: University of California, Berkeley, Host: Silvia Ramundo
Title to be announced
Date: 2024-09-26, Time: 11:00:00, Speaker: Maria Mota, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Lisbon, Host: Joao Matos
Title to be announced
Date: 2024-09-27, Time: 11:00:00, Speaker: Deborah Bourc'his, Location: IMBA/GMI Lecture Hall, Type: Impromptu Seminar, Institute: Institut Curie, Host: Julius Brennecke
Monday Seminar (Internal)
Date: 2024-09-30, Time: 12:30:00, Speaker: JÄGER Christina (Van der Veeken)SHUKLA Vikas (Berger)RODRIGUEZ TERRONES Diego (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Monday Seminar (Internal)
Date: 2024-10-07, Time: 12:30:00, Speaker: KANNO Tatsuo (Berger)SCHIMMER Clara (Ellis)DE SANTIS Martina (Rivron), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2024-10-10, Time: 11:00:00, Speaker: Cedric Blanpain, Location: , Type: , Institute: Universite Libres Bruxelles, Host: Stephanie Ellis
How plants sense temperature
Date: 2024-10-11, Time: 11:30:00, Speaker: Philip Wigge, Location: GMI Orange Seminar Room, Type: GMI Seminar, Institute: IGZ Leibnitz, Host: Fred Berger
Monday Seminar (Internal)
Date: 2024-10-14, Time: 12:30:00, Speaker: GAO Peng (Dagdas)HANDLER Dominik (Brennecke)FRIDRICH Arie (Berger), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2024-10-17, Time: 11:00:00, Speaker: Ralf Jungmann, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: LMU, MPI, Host: Alex Stark, Francisco Balzarotti
Title to be announced
Date: 2024-10-18, Time: 11:30:00, Speaker: Gergo Gogl, Location: GMI Orange Seminar Room, Type: GMI Seminar, Institute: IGBMC, Illkirch, Host: Fred Berger
Monday Seminar (Internal)
Date: 2024-10-21, Time: 12:30:00, Speaker: MILOJKOVIC Lidija (Urban)SPENCER Victoria (Dolan)AUGUSTO Pedro (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2024-10-24, Time: 11:00:00, Speaker: Andrea Ablasser, Location: IMP Lecture Hall, Type: VBC Regular Seminar, Institute: EPFL, Host: Moritz Gaidt
Monday Seminar (Internal)
Date: 2024-10-28, Time: 12:30:00, Speaker: GOMEZ SEGALAS Alba (Balzarotti)KLEINFERCHER Sebastian (Stark)PRADHAN Saurabh (Rivron), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2024-11-04, Time: 12:30:00, Speaker: SCHEPERS Sandra (Knoblich)BUSETTO Virginia (Falk)DMITRIEV Vladimir (Goloborodko), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
VBC PhD Symposium
Date: 2024-11-07, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
Monday Seminar (Internal)
Date: 2024-11-11, Time: 12:30:00, Speaker: GARCIA GALLARDO Maria (Bücker)HARVEY Zachary (Berger)SAKALLI Enes (Von Haeseler,Menche), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2024-11-14, Time: 11:00:00, Speaker: Benoit Bruneau, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Gladstone Institute of Cardiovascular Disease, UCSF, Host: Sasha Menjdan
Title to be announced
Date: 2024-11-18, Time: 11:00:00, Speaker: Lacramioara Bintu, Location: IMBA/GMI Lecture Hall, Type: Impromptu Seminar, Institute: Stanford University, Host: Alex Stark
Monday Seminar (Internal)
Date: 2024-11-18, Time: 12:30:00, Speaker: FESSELET Jeanne (Kovarik)PAPAREDDY Ranjith (Dagdas)SHEN Jingyi (Obenauf), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2024-11-21, Time: 11:00:00, Speaker: Martin Jinek, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Zurich, Host: Irma Querques
Monday Seminar (Internal)
Date: 2024-11-25, Time: 12:30:00, Speaker: BOREIKAITE Vytaute (Plaschka)SRINIVASAN Navaneeth (Peters)DODOMANI Ananya (Campbell), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2024-11-28, Time: 18:00:00, Speaker: David Baker, Location: Zoom, Type: VBC Regular Seminar via Zoom, Institute: UW Dept. of Biochemistry, Host: Alwin Köhler
Understanding starch granule biosynthesis in plants using insights from natural variation
Date: 2024-11-29, Time: 11:45:00, Speaker: David Seung, Location: GMI Orange Seminar room, Type: GMI Seminar, Institute: John Innes Centre, Norwich, Host: Yan Ma
Exploring the cell biology that enables efficient photosynthesis in C4 plants
Date: 2024-11-29, Time: 11:00:00, Speaker: Tina Schreier, Location: GMI Orange Seminar Room, Type: GMI Seminar, Institute: University of Oxford, Host: Yan Ma
Monday Seminar (Internal)
Date: 2024-12-02, Time: 12:30:00, Speaker: SOMMER Theresa (Rivron)KRACHT Laura (Knoblich)MAIR Zahar (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2024-12-05, Time: 11:00:00, Speaker: Ian Hickson, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Copenhagen, Host: Joao Matos
Monday Seminar (Internal)
Date: 2024-12-09, Time: 12:30:00, Speaker: BREHM Martin (Falk)PLATZER Sebastian (Hein)RAFANEL Baptiste (Brennecke), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2024-12-12, Time: 11:00:00, Speaker: Stephen West, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: The Francis Crick Institute, Host: Joao Matos
Monday Seminar (Internal)
Date: 2024-12-16, Time: 12:30:00, Speaker: DAHAN Tal (Nordborg)CHUGUNOVA Anastasia (Pauli)VON WIREN Julius (Kovarik), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-01-09, Time: 11:00:00, Speaker: Uri Ben-David, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Tel Aviv University, Host: Anna Obenauf
Monday Seminar (Internal)
Date: 2025-01-13, Time: 12:30:00, Speaker: KRASNOVID Filipp (Mari-Ordonez)ROTHE Patricia (Plaschka)KROGULL Daniel (Burga), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2025-01-16, Time: 11:00:00, Speaker: Stan Brouns, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Delft University of Technology, Host: Irma Querques
Monday Seminar (Internal)
Date: 2025-01-20, Time: 12:30:00, Speaker: VICIC Ziga (Jachowicz)GRÜNEWALD Jakob (Obenauf)MANOLOVA Toni (Falk), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2025-01-23, Time: 11:00:00, Speaker: Anne Bertolotti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: MCR Laboratory of Molecular Biology, Host: Egon Ogris
Monday Seminar (Internal)
Date: 2025-01-27, Time: 12:30:00, Speaker: SCARAMUZZA Federico (Tessmar) WALTER Mateusz (Querques)WILLIAMS Thomas (Clausen), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2025-01-30, Time: 11:00:00, Speaker: Maria-Elena Torres-Padilla, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Ludwig-Maximilians-University Munich, Host: Julius Brennecke
Monday Seminar (Internal)
Date: 2025-02-03, Time: 12:30:00, Speaker: CRUZ Joseph (Gerlich)GHEORGHITA Andreea (Clausen)GALUSKA Philipp (Djinovic), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host:
Title to be announced
Date: 2025-02-06, Time: 11:00:00, Speaker: Thibaut Brunet, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Institut Pasteur, University Paris-Cite, Host: Fred Berger
Monday Seminar (Internal)
Date: 2025-02-10, Time: 12:30:00, Speaker: GRIGOREVA Elizaveta (Nordborg)KOHOUTKOVA Eliska (Clausen)STEINACKER Thomas (Gerlich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-02-13, Time: 11:00:00, Speaker: Jeff Boeke, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: NYU Langdone Health, Host: Fred Berger
Monday Seminar (Internal)
Date: 2025-02-17, Time: 12:30:00, Speaker: RAFFL Gerald (Ameres)VULIN Milica (Obenauf)FISCHER Andre (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-02-20, Time: 11:00:00, Speaker: Gaia Novarino, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: ISTA, Host: Dea Slade
Monday Seminar (Internal)
Date: 2025-02-24, Time: 12:30:00, Speaker: BAYERL Jonas (Zuber)ZABOLOCKI Michael (Knoblich)EDER Stephanie (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-02-27, Time: 11:00:00, Speaker: Cedric Feschotte, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Cornell University, Host: Joanna Jachowicz
Monday Seminar (Internal)
Date: 2025-03-03, Time: 12:30:00, Speaker: KROETENHEERDT Eva (Leonard)RÖHSNER Josef (Pauli)RIABOV Daria (Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-03-10, Time: 12:30:00, Speaker: CHO Chung Hyun (Berger)SEIDL Carina (Tanaka)MIGOTTI Mario (Konrat), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-03-17, Time: 12:30:00, Speaker: CHEN Shenzhi (Stark)BINDL Michael (Leeb)JÄGER Martin (Obenauf), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-03-20, Time: 11:00:00, Speaker: Geert Kops, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Hubrecht Institute, Host: Joao Matos
Monday Seminar (Internal)
Date: 2025-03-24, Time: 12:30:00, Speaker: MAYA Juan (Balzarotti)DOSA Anna (Clausen)KOBER Julia (Ramundo), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-03-27, Time: 11:00:00, Speaker: Martin Beck, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max Planck Institute for Biophysics, Host: Alwin Köhler
Monday Seminar (Internal)
Date: 2025-03-31, Time: 12:30:00, Speaker: HOLZER Elisabeth (Martens)THEMANN Jan (Knoblich)GROSS Angelina (Dagdas), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-04-07, Time: 12:30:00, Speaker: GROH Roan (Dagdas)CHAO Victor (Huis)KHANDEKAR Ameya (Ellis), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-04-10, Time: 11:00:00, Speaker: Fabian Theis, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Computational Health Center, Helmholtz Munich, Host: Alex Stark
Monday Seminar (Internal)
Date: 2025-04-14, Time: 12:30:00, Speaker: OKUN Anastasia (Karagöz)COLLISON Robert (Ramundo)WELZL Paul (Balzarotti/Plaschka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-04-24, Time: 11:00:00, Speaker: Maria Cristina Gambetta, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Lausanne, Host: Anton Goloborodko
Monday Seminar (Internal)
Date: 2025-04-28, Time: 12:30:00, Speaker: SUWITA Johannes (Pauli)GRABARCZYK Daniel (Clausen)PANDA Aswini (Falk), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-05-05, Time: 12:30:00, Speaker: KIM Olena (Knoblich)JOB Nikhil (Dolan)ADELMANN Leonie (Raible), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Microsymposium on Small RNA Biology
Date: 2025-05-07, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
Microsymposium on RNA Biology
Date: 2025-05-07, Time: 09:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
EMBO meeting on RNA meets Protein decay
Date: 2025-05-11, Time: 14:00:00, Speaker: , Location: IMP Lecture Hall, Type: Symposium, Institute: None, Host: None
Monday Seminar (Internal)
Date: 2025-05-12, Time: 12:30:00, Speaker: SCIBISZ Grzegorz (Karagöz)VAN GENDEREN Emiel (Rivron)BOZKURT Miray (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-05-15, Time: 11:00:00, Speaker: Chuna Ram Choudhary, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Copenhagen, Host: Alex Stark
Monday Seminar (Internal)
Date: 2025-05-19, Time: 12:30:00, Speaker: POTTENDORFER Elisabeth (Obenauf)WALLNER Eva-Sophie (Dolan)BECKER Moritz (Leeb), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-05-22, Time: 11:00:00, Speaker: Manuel Leonetti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: CZ Biohub San Francisco, Host: Elif Karagöz
Monday Seminar (Internal)
Date: 2025-05-26, Time: 12:30:00, Speaker: DIMITROVA Polina (Van der Veeken)STRAVS Ana (Knoblich)SCHÖNLEIN Martin (Obenauf), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-06-02, Time: 12:30:00, Speaker: SABATH Kevin (Plaschka/Stark)MANCHENO JUNCOSA Estela (Mendjan)HORENKAMP Simone (Tanaka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-06-12, Time: 11:00:00, Speaker: Stefan Mundlos, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max Planck Institute for Molecular Genetics, Host: Julius Brennecke
Monday Seminar (Internal)
Date: 2025-06-16, Time: 12:30:00, Speaker: BERGER Sonja (Goloborodko)KOWALD Saskia (Gaidt)KAPRAL Thomas (Zagrovic), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-06-23, Time: 12:30:00, Speaker: BUCHERON Chloe (Menche)KRUMWIEDE Luisa (Gaidt)PACHANO Tomas (Stark), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-06-26, Time: 11:00:00, Speaker: Nikhil Joshi, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Yale University, Host: Joris Van der Veeken
Monday Seminar (Internal)
Date: 2025-06-30, Time: 12:30:00, Speaker: SCHINDLER Lukas (Schlögelhofer)MANDLBURGER Nikolaus (Stark)OTTO Magdalena (Leonard), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-07-03, Time: 11:00:00, Speaker: Matthias Mann, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Max-Planck Institute of Biochemistry, Host: Marco Hein
Monday Seminar (Internal)
Date: 2025-07-07, Time: 12:30:00, Speaker: TRUS Palina (Peters)KOBAKHIDZE George (Dong)KONGSTED Thea (Dolan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-07-10, Time: 11:00:00, Speaker: Simon Alberti, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: TU Dresden, Host: Erinc Hallacli
Monday Seminar (Internal)
Date: 2025-07-14, Time: 12:30:00, Speaker: RUSCH Emma (Golobordko)VELIKOV Daniel (Matos)VOGEL Alexander (Clausen/Yudushkin), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-07-17, Time: 11:00:00, Speaker: Vishva Dixit, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Genentech, Host: Moritz Gaidt
Monday Seminar (Internal)
Date: 2025-07-21, Time: 12:30:00, Speaker: ANGELOPOULOU Eleni (Ellis)SCHAFFER Petra (Grade)RAMIREZ America (Köhler), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-07-28, Time: 12:30:00, Speaker: DIMITRIADI Anna (Mendjan)LEITNER Moritz (Martinez)RAUH Felix (Stark), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-04, Time: 12:30:00, Speaker: LI Wenxin (Zimmer)FISCHER Felix (Zagrovic)ABESAMIS Kim Ivan (Dong), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-11, Time: 12:30:00, Speaker: KLEIFELD Justus (Urban)MCATEER Tara (Pinheiro)BHATTACHARYA Mrinnanda (Zimmer), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-18, Time: 12:30:00, Speaker: BELL Lillie (Clausen)MIHAILOVIC Milica (Karagöz)GUYNES Keroshini (Jachowicz), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-08-25, Time: 12:30:00, Speaker: BOHL VIALLEFONT Gregoire (Nordborg)MARCHIORI Elisa (Van der Veeken)JAHNEL Stefan (Mendjan), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-01, Time: 12:30:00, Speaker: KIRCHGATTERER Paul (Gaidt)ACHLEITNER Sonja (Martens)KAYA Oguzhan (Knoblich), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-08, Time: 12:30:00, Speaker: HUTH Michelle (Leeb)RADHAKRISHNA PILLAI Balashankar (Brennecke)REN Kaike (Otsuka), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Monday Seminar (Internal)
Date: 2025-09-15, Time: 12:30:00, Speaker: GONZALEZ ALVARADO Maria Nazareth (Grade)KASHKO Nataliia (Matos)OBERHUEMER Michael (Leeb), Location: IMP Lecture Hall, Type: Monday Seminar, Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs, Host: None
Title to be announced
Date: 2025-09-18, Time: 11:00:00, Speaker: Katja Wassmann, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Institute Jacques Monod, Host: Joao Matos, Peter Schlögelhofer
Title to be announced
Date: 2025-10-16, Time: 11:00:00, Speaker: Anne Brunet, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: Stanford University, Host: Andrea Pauli
Title to be announced
Date: 2025-10-23, Time: 11:00:00, Speaker: Aydan Bulut-Karslioglu, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: MPI Berlin, Host: Joanna Jachowicz, Martin Leeb
Title to be announced
Date: 2025-10-30, Time: 11:00:00, Speaker: Kresten Lindorff-Larssen, Location: IMBA/GMI Lecture Hall, Type: VBC Regular Seminar, Institute: University of Copenhagen, Host: David Haselbach