The research group led by Karl Kuchler at the Max Perutz Labs, a joint venture of the Medical University of Vienna and the University of Vienna, has discovered for the first time, how the fungus Candida glabrata can tap the host iron pools and use this essential metal ion scavenged from immune cells to escape immune defenses. These results have been published in the journal "Cell Host & Microbe" and also point to potential new ways of combating the pathogenic fungus in the human host by blocking iron accumulation in the pathogen.
Trace elements such as iron are essential for all higher cells including humans, but are extremely toxic at high concentrations. For example, iron is a central component of haemoglobin, the essential molecule for oxygen transport within the body. However, microbial pathogens also require trace elements to sustain their own growth and survival once a host is infected. Thus, both host and the pathogen are competing for iron sources. Owing to its potential toxicity, the host immune response restrains iron pools by sequestering iron in dedicated storage organelles such as so-called phagolysosomes, which is also the organelle where engulfed pathogens are cleared. Eating machines of the immune defense, so called macrophages, play a central role in iron metabolism. Further, macrophages use specialised mechanisms for microbial clearance within defined organelles (phagolysosomes) as for instance through oxidative stress. Additionally, when macrophages have taken up intracellular fungal pathogens into phagolysosomes for fungal killing, surplus iron is also shuttled out of these organelles by iron transport proteins, in order to impede the growth of the fungus.
The group led by Karl Kuchler and lead author Michael Riedelberger now show that the host immune response by the so-called type I interferons dysregulate the host iron metabolism upon infections by Candida glabrata. Interferons are immune signaling molecules which control microbial and fungal infections. However, infections by Candida glabrata set-off interferons that disrupt normal expression of iron transport proteins in macrophages. Therefore, iron inadvertently accumulates within phagolysosomes of macrophages, thereby facilitating iron scavenging by the pathogen. Consequently, Candida glabrata can exploit phagolysosomal iron pools, thus promoting fungal replication and survival from immune defenses. A single macrophage can engulf up to 50 fungal cells, which can survive within this immune cell for months. Of note, physical damage of infected macrophages can further promote the dissemination of Candida glabrata within the host and therefore enhances the fungal dissemination.
The scientists identified two fungal transporters that are central for fungal iron acquisition by the pathogen. “Blocking the ability of Candida glabrata to scavenge iron from the host by genetically removing these iron uptake transporters abrogates the ability of Candida glabrata to survive in the host" explains Karl Kuchler. The researchers conclude that it might be possible to identify therapeutic compounds to inhibit these fungal iron transporters, thus promising new therapeutic options for multidrug-resistant fungal pathogens such as Candida glabrata.
Publication:
Michael Riedelberger, Philipp Penninger, Michael Tscherner, Markus Seifert, Sabrina Jenull, Carina Brunnhofer, Bernhard Scheidl, Irina Tsymala, Christelle Bourgéois, Andriy Petryshyn, Walter Glaser, Andreas Limbeck, Birgit Strobl, Guenter Weiss, and Karl Kuchler: Type I interferon response dysregulates host iron homeostasis and enhances Candida glabrata infection. Cell Host & Microbe (2020)
Dissection of the Function and Deposition of the histone variant H2A.W in Arabidopsis thaliana
Speaker: Anna SchmückerInstitute: GMI - Berger Lab
Monday Seminar (Internal)
Speaker: LOUBIERE Vincent (Stark), STANKUNAS Edvinas (Köhler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
How cohesin organizes the genome
Speaker: Jan-Michael PetersInstitute: IMP
Virus-host strategies to gain the upper hand during infections
Speaker: Gus VersteegInstitute: Max Perutz Labs
Leveraging the patient as the model to dissect and target metastasis
Speaker: Karuna GaneshInstitute: Sloan Kettering InstituteHost: Anna Obenauf
Mechanism of MCM helicase loading and regulation by CDK revealed by cryo-EM
Speaker: Tom MillerInstitute: University of CopenhagenHost: Clemens Plaschka
Life at Nature Genetics: what we do, how scientific publishing works, and how I got here
Speaker: Michael FletcherInstitute: Editor at Nature GeneticsHost: Alex Stark
Long-term single-cell quantification: New tools for old questions
Speaker: Timm SchroederInstitute: ETH ZurichHost: Manuela Baccarini
Cell competition: a paradigm to understand growth control and heterogeneity in complex tissues
Speaker: Stephanie EllisInstitute: Max Perutz Labs
Title to be announced
Speaker: Noelia UrbanInstitute: IMBA
Monday Seminar (Internal)
Speaker: LEYVA GONZALEZ Marco (Tanaka), MILJKOVIC Frane (Köhler), PINTER Theresa (Busslinger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Illuminating protein degradation by the 26S proteasome and its regulation by ubiquitin
Speaker: Andreas MartinInstitute: University of California, BerkeleyHost: David Haselbach
Cryo-EM reveals a structural diversity of bioenergetic complexes
Speaker: Alexey AmuntsInstitute: Science for Life Laboratory, Stockholm UniversityHost: Silvia Ramundo
Monday Seminar (Internal)
Speaker: SCHOLZ Julia (Otsuka), BAUER Bernd (Martens)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Global Views of Mammalian Development
Speaker: Jay ShendureInstitute: University of WashingtonHost: Alex Stark
Monday Seminar (Internal)
Speaker: ALMEIDA Bernardo (Stark), MILIVOJEV Nadja (Raible), HOLCIK Laurenz (Von Haeseler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: IGOLKINA Anna (Nordborg), KRAMMER Teresa (Tanaka), AMANN Sascha Josef (Haselbach)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
European Worm Meeting 2022
We cordially invite you to the 2022 European Worm Meeting (EWM) taking place in Vienna, July 27-30. The meeting is hosted by the University of Vienna.
Monday Seminar (Internal)
Speaker: SCHMIDT Clara (Mendjan), GOGOVA Rebeca (Clausen), SAAD RODRIGUES Carolina (Schlögelhofer)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: YU Changwei (Brennecke), HAENDELER Simon (Von Haeseler), PASSERA Alessandro (Balzarotti)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SEONG Jinwoo (Rivron), NAVA GARCIA Marintia Mayola (Dagdas), DENEKE Victoria (Pauli)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Xin ChenInstitute: Johns Hopkins UniversityHost: Fred Berger
Monday Seminar (Internal)
Speaker: KELLNER Max Josef (Penninger), LEITNER Marie-Christin (Mendjan), TERIYAPIROM Isaree (Koo)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Mark DawsonInstitute: Peter MacCallum Cancer CentreHost: Johannes Zuber
Monday Seminar (Internal)
Speaker: HOLZMANN Viktoria (Rivron), LEV Itamar (Zimmer), HODAKOVA Zuzana (Haselbach)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Dominique BergmannInstitute: Stanford UniversityHost: Liam Dolan
Monday Seminar (Internal)
Speaker: BABADEI Olga (Decker), OTSUKI Leo (Tanaka), AYALA MUNOZ Farja (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Yves BarralInstitute: ETH ZurichHost: Shotaro Otsuka
Monday Seminar (Internal)
Speaker: TAKACS Zsuzsanna (Gerlich), DE LA CONCEPCION Juan Carlos (Dagdas), FEDL Anna (Busslinger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Sophie PetropoulosInstitute: Karolinska InstitutetHost: Nicolas Rivron
Title to be announced
Speaker: Benoit BruneauInstitute: Gladstone InstitutesHost: Sasha Mendjan
Monday Seminar (Internal)
Speaker: GALLI Lucrezia (Tanaka), HORN Sabrina (Peters), JACOBS Jelle (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Richard FlavellInstitute: Yale University School of MedicineHost: Meinrad Busslinger
Title to be announced
Speaker: Bernd BukauInstitute: ZMBHHost: Elif Karagäz
Monday Seminar (Internal)
Speaker: POPOVA Mariia (Peters), RITSCHKA Birgit (Tanaka), DOMBEY Rodolphe (Mari-Ordonez)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: INCARBONE Marco (Mittelsten Scheid), GRUNDMANN Lorenz (Haselbach), NEMCKO Filip (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: TELONI Federico (Gerlich), WALLNER Eva-Sophie (Dolan), PUSHPA BOSE Greeshma (Urban)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LIU Haijun (Nordborg), NAVALAYE Tsimafei (Ameres), NAAS Julia (Von Haeseler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: CHUGUNOVA Anastasia (Pauli), RÖTZER Johannes (Dolan), JONSSON Gustav (Penninger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KLAUS Loni (Stark), BENEDUM Johannes (Slade), LITTLEBOY Jamie (Knoblich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Daniel MucidaInstitute: Rockefeller UniversityHost: Meinrad Busslinger
Monday Seminar (Internal)
Speaker: ANTONIOLI Sumire (Leonard), LI Chong (Knoblich), PABST Gabriel (Zuber)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Lacra BintuInstitute: Stanford UniversityHost: Alex Stark
Monday Seminar (Internal)
Speaker: DIEZMA Laura (Nordborg/Mari-Ordonez), GHOSH Dipannita (Grade), PATEL Rajvi (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be annouced
Speaker: Adele MarstonInstitute: Wellcome Centre Cell Biology, University of EdinburghHost: Daniel Gerlich, Joao Matos
Monday Seminar (Internal)
Speaker: KORDIC Darja (Clausen), DEIBER Sebastian (Dolan), GEHRE Maja (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ZMAJKOVIC Jakub (Zuber), MAURER Eric (Peters), NOGALES MORAL Adrian (Köhler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HUETTER Christiane (Menche), BASSAT Elad (Tanaka), PETRZILEK Jan (Ameres)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KALIS Robert (Zuber), NAJM Ramsey (Knoblich), GEROCZ Emoke (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
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Monday Seminar (Internal)
Speaker: GUO Pin (Dolan), DAO Pauline (Tessmar), JAVALI Alok(Rivron)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: STUART Hannah (Tanaka), KORESHOVA Alevtina (Burga), ZHAN Ni (Dagdas)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: CRONIN Shona (Obenauf), KANNO Tatsuo (Berger), PACHINGER Claudia (Dammermann)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SHUKLA Vikas (Berger), RODRIGUEZ TERRONES Diego (Tanaka), WIDEN Sonya (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: VOICHEK Yoav (Norborg), SESTINI Giovanni (Rivron), PETROULAKI Vasiliki (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BRUNNER Hanna (Haselbach), FRIDRICH Arie (Berger), AKULOVA Vasilina (Swarts)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: DE SANTIS Martina (Rivron), BUENDIA Daniel (Mari-Ordonez), VISANPATTANASIN Supapat (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: VOJTEK Matus (Stark), LEHMANN Christian (Knoblich), LEE Du-Hwa (Belkhadir)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SPICER Maximilian (Gerlich), ESTIVILL I CAPAAROS Guillem (Obenauf), MURPHY Paul (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: JÄGER Christina (Van der Veeken), PRADHAN Saurabh (Rivron), RAFANEL Baptiste (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BELACIC Katarina (Haselbach), HARVEY Zachary (Berger), MILOJKOVIC Lidija (Urban)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: GOMEZ SEGALAS Alba (Balzarotti), KOLESNIKOVA Sofia (Gerlich), HANDLER Dominik (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BAUCELLS Julia (Dammermann), PANAROTTO-PERICLES Melanie (Peters), VOICHEK Maya Shinan (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: DMITRIEV Vladimir (Goloborodko), HISANAGA Tetsuya (Berger), KHALDIEH Nina (Ameres)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SOMMER Theresa (Rivron), SHIRZADIAN YAZD Mehrta (Balzarotti), VERTESY Abel (Knoblich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: POLIKARPOVA Anastasia (Tanaka), CHAKRABORTY Oisorjo (Grade), CORSI Flavia (Goloborodko)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: FESSELET Jeanne (Kovarik), KHAURATOVIC Uladzislava (Matos/Golobordko), SHEN Jingyi (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: PERNEBRINK Mattias (Tanaka), HOHMANN Ulrich (Brennecke/Plaschka), MANOLOVA Toni (Falk)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: WU Shuangyang (Dolan), SCARAMUZZA Federico (Tessmar), KROGULL Daniel (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HEIDARI KHOEI Heidar (Rivron), BELL Caelan (Gerlich), GALUSKA Philipp (Djinovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ABDRAKHMANOV Alibek (Dagdas), WILLIAMS Thomas (Clausen), GEISMANN Maximilian (Balzarotti)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: JELENIC Stela (Saha), PACHECO FIALLOS Franics Belen (Plaschka), FONTES OLIVEIRA Tiago Manuel (Penninger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: NAGUMO WONG Sakurako (Knoblich), LORENZO ORTS Laura (Pauli), ROSS James (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RAFFL Gerald (Ameres), SAJTOS Bettina (Zuber), ISHIHARA Keisuke (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: STEINACKER Thomas (Gerlich), EDER Stephanie (Zimmer), TIKANOVA Polina (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SCHELLHAAS Ulla (Plaschka/Ameres), RUSCH Emma (Goloborodko), CLAVEL Marion (Dagdas)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RADHAKRISHNA PILLAI Balashankar (Saha), ADELMANN Leonie (Raible), BLAHA Andreas (Pauli)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: VULIN Milica (Obenauf), MEREITER Stefan (Penninger), BINDL Michael (Leeb)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LORBEER Franziska (Stark), MULVEY Hugh (Dolan), PÜHRINGER Florian (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HOLZER Elisabeth (Martens), COLOZZA Gabriele (Koo), FALCON CHAVEZ Francisco (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RÖHSNER Josef (Pauli), OKUN Anastasia (Karagöz), JUNG Pauline (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LICHT-MAYER Simon (Penninger), CAYGILL Samuel (Dolan), MIGOTTI Mario (Konrat)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SHUNMUGAM Dhanlakshmi (Baccarini), CECI GINISTRELLI Lavinia (Mendjan), VORLÄNDER Matthias (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KOK Jian Yi (Berger), HUMER Theresa (Pauli), SODERHOLM Adrian (Versteeg)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: STRAVS Ana (Knoblich), SANCHEZ DE MEDINA HERNANDEZ Victor (Dagdas), KRUMWIEDE Luisa (Gaidt)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: TAVERINI Katherina (Urban), SHETTY Kavya Krishna (Stark), CORIC Aida (Tessmar)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: GRABARCZYK Daniel (Clausen), PROTELL I DE MONTSERRAT Julia (Brennecke/Plaschka), MANCHENO JUNCOSA Estela (Mendjan)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ATTRILL Sarah (Dolan), UIJTTEWAAL Esther (Elling), SCIBISZ Grzegorz (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: DOLESCHALL Balint (Knoblich), FENG Sonjie (Bücker), BOURGUET Pierre (Berger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HORENKAMP Simone (Tanaka), CASEY Chloe (Dolan), KAPRAL Thomas (Zagrovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KOBAKHIDZE George (Dong), ANGELOPOULOU Eleni (Ellis), PACHANO Tomas (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RAMIREZ America (Köhler), VÖLKL Isabella (Bücker), HOANG Oi Pui (Technau)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LEITNER Moritz (Martinez), VOGEL Alexander (Yudushkin), KETTEL Paulina (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: TSAREV Aleksandr (Ameres), FIESELER Charlie (Zimmer), ABESAMIS Kim Ivan (Dong)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: STREUBEL Susanna (Dolan), KLEIFELD Justus (Urban), ORLIC Lucija (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SHULKINA Alexandra (Versteeg), GEETHA Sowmya (Jantsch), MADHUSUDHANAN Jalaja (Zimmer)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KOLLER Manuela (Campbell), GUPTA Ankit (Goloborodko), SCHMÖLLERL Johannes (Zuber)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: MARCHIORI Elisa (Van der Veeken), ACHLEITNER Anja (Martens), FAAS Victoria (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SALEWSKIJ Kirill (Penninger), KIRCHGATTERER Paul (Gaidt), REN Kaike (Otsuka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: MIHAILOVIC Milica (Karagöz), BELL Lillie (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
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