Our recent work has uncovered a novel connection between α-syn and Processing bodies (P-bodies) - RNA granules that play key roles in RNA metabolism (Hallacli et.al, Cell, 2022). We aim to understand how these structures contribute to α-syn-induced toxicity and how RNA granules interact with lipid membranes in both healthy and diseased neurons.
Building on our previous discoveries, this project investigates how α-syn overexpression disrupts RNA-binding protein (RBP) function.
Your work will include:
Using a dual fluorescent reporter technology developed in our lab to measure protein perturbation in a systematic and high-throughput manner.
Performing flow cytometry as a readout
Generating and screening stable cell lines for RBP-α-syn interactions
Validating findings in HEK293 and/or iPSC-derived human neurons
We are looking for a highly motivated Master’s student with:
A Bachelor’s degree in Molecular Biology, Biochemistry, Neuroscience, or related fields, with strong academic performance
Strong experience in human cell culture and molecular biology techniques (e.g., cloning, RNA techniques, Western blotting, microscopy)
Familiarity with or interest in high-throughput screening and flow cytometry
Excellent organizational skills, attention to detail, and accurate lab documentation
A proactive mindset, curiosity for neurodegenerative disease mechanisms, and ability to work independently and collaboratively
Prior research experience and knowledge of RNA biology, bioinformatics, or stem cell work are a plus.
The position begins with a rotation, with continuation into the Master’s thesis contingent on successful performance and mutual agreement.
CV
Motivation Letter
1-2 Letters of Recommendation
Position start date: November 2025
Elizabeth Ethier
elizabeth.ethier@meduniwien.ac.at