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Mon

06

Apr 2020
Monday Seminar

Monday Seminar (Internal) - via Zoom
  12:30 - 13:30
  IMP Lecture Hall

Speaker: MITTER Michael (Gerlich), STEPHANIE Madlen (Dagdas), GERT Krista (Pauli)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

09

Apr 2020
Cancelled

Cancelled
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Doug Higgs
Institute: MRC Weatherall Institute of Medicine
Host: Rushad Pavri

Tue

14

Apr 2020
Cancelled

Cancelled
  11:00 - 12:00
  GMI Orange Seminar Room

Speaker: Petra Bulankova
Institute: VIB-UGent Center for Plant Systems Biology
Host: Ortrun Mittelsten Scheid

Tue

14

Apr 2020
Symposium

POSTPONED - Inside: The Dark Side of the Cell
  Apr 14 - Apr 15
  Universität Wien

The "Inside: The dark side of the cell" symposium will take place on 14-15 April at the University of Vienna. An interesting lineup of keynote speakers will provide an overview of current research, challenges and advances in the field of proteostasis, autophagy, stem cells, gene expression and inflammation. The symposium is organised by students of the doctoral programme “Signaling mechanisms in cellular homeostasis” based at the Max Perutz Labs, University of Vienna and Medical University of Vienna.

 

Wed

15

Apr 2020
An exhibition on the life and science of Max F. Perutz

POSTPONED - Breathing at High Altitude
  Apr 15 - May 20
  University of Vienna

“Breathing at High Altitude” is an exhibition dedicated to the personal life and science of Max F. Perutz, a pioneer of 20thcentury molecular biology. The exhibition sheds light on Max Perutz’s fascinating life, celebrates his love for mountains, and visualizes “breathing” in a unique way. It will be a rewarding experience for scientists and non-scientists alike.

Opening event: 

April 15, 5:30 p.m.
University of Vienna
Small Ceremonial Hall

Thu

16

Apr 2020
VBC Regular Seminar via Zoom

Immune Complexity of Metastatic Breast Cancer - Towards Personalized Immune-Intervention Strategies
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Karin De Visser
Institute: NKI
Host: Anna Obenauf

Fri

17

Apr 2020
Cancelled

Cancelled
  11:30 - 12:30
  GMI Orange Seminar room

Speaker: Ian Henderson
Institute: University of Cambridge
Host: Magnus Nordborg

Mon

20

Apr 2020
Monday Seminar

Monday Seminar (Internal) - via Zoom
  12:30 - 13:30
  IMP Lecture Hall

Speaker: PFLUG Florian (Von Haesseler), GASSLER Johanna (Tachibana), MONTGOMERY Sean (Berger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

22

Apr 2020
Max Birnstiel Lecture

The electron cryomicroscopy revolution in structural biology
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Richard Henderson
Institute: MRC Laboratory of Molecular Biology
Host: Clemens Plaschka

Thu

23

Apr 2020
Cancelled

Cancelled
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Karen Oegema
Institute: UCSF
Host: Alex Dammermann

Fri

24

Apr 2020
GMI Seminar

Title to be announced
  11:30 - 12:30
  GMI Orange Seminar Room

Speaker: Silvia Ramunda
Institute: UCSF
Host: Yasin Dagdas

Mon

27

Apr 2020
Monday Seminar

Monday Seminar (Internal) - via Zoom
  12:30 - 13:30
  IMP Lecture Hall

Speaker: TRASSER Marieke (Mari-Ordinez), HAAS Lisa (Obenauf), HOI David (Clausen)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

04

May 2020
Monday Seminar

Monday Seminar (Internal) - via Zoom
  12:30 - 13:30
  IMP Lecture Hall

Speaker: SERRA Nuria (Becker), DE ALMEIDA Melanie Talata (Zuber),
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

06

May 2020
Symposium

Microsymposium on Small RNA Biology
  09:00 - 10:00
  IMP Lecture Hall

Speaker: CANCELLED

Wed

06

May 2020
Symposium

CANCELLED --15th Microsymposium on Small RNA Biology
  May 06 - May 08
  Vienna BioCenter

The "Microsymposium on Small RNA Biology“ is a three day international conference that brings together young scientists, junior and senior group leaders, and company representatives from all over the world to present and discuss their latest findings in the exciting field of small RNAs. The Microsymposium was founded in 2005 and has established itself as the major small RNA meeting in Europe. It is organized by IMBA, IMP, GMI and the Max Perutz Labs as well as by the RNA community of the Vienna BioCenter. 

 

Fri

08

May 2020
GMI Seminar

Title to be announced
  11:30 - 12:30
  GMI Orange Seminar room

Speaker: Paul Neve
Institute: Rothamsted Research, Harpenden
Host: Claude Becker

Mon

11

May 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: OSAKABE Akihisa (Berger), CRONIN Shona Mary (Obenauf), WU Szu-Hsien (Koo)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

14

May 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Andrea Schietinger
Institute: Memorial Sloan Kettering Cancer Center
Host: Elly Tanaka

Thu

14

May 2020
Symposium

Ubiquitin Symposium
  09:00 - 10:00
  IMP Lecture Hall
Mon

18

May 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: HENDY Oliver James (Stark), PARINOV Anton (Zimmer), MORREALE Francesca (Clausen)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

20

May 2020
DK RNA Biology Impromptu Seminar

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Giovanni Capranico
Institute: University of Bologna
Host: DK RNA Biology and Dea Slade

Mon

25

May 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: HISANAGA Tetsuya (Berger), SHANMUGANATHAN Reshi (Becker), NAGASAKA Kota (Peters)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

28

May 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Julia Mahamid
Institute: Shambaditya Saha
Host: European Molecular Biology Laboratory

Fri

29

May 2020
GMI Seminar

Title to be announced
  11:30 - 12:30
  GMI Orange Seminar room

Speaker: Ted Farmer
Institute: University of Lausanne
Host: Yasin Dagdas

Wed

03

Jun 2020
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Rudolf Jaenisch
Institute: MIT, Whitehead Institut
Host: Elly Tanaka

Wed

03

Jun 2020
Symposium

Organoid Workshop
  09:00 - 10:00
  Online

Speaker: Online Workshop

Mon

08

Jun 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: GRÜNBACHER Sarah (Busslinger), POLIKARPOVA Anastasia (Tanaka), PETROVIC Mina (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

15

Jun 2020
Monday Seminar

Monday Seminar (Internal)

  12:30 - 13:30
  IMP Lecture Hall

Speaker: LEE Ji-Hyun (Koo), BELACIC Katarina (Haselbach), UMKEHRER Christian (Obenauf)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

18

Jun 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Alistair Boettiger
Institute: Stanford University
Host: Christa Bücker, Daniel Gerlich

Mon

22

Jun 2020
Monday Seminar

Monday Seminar (Internal)

  12:30 - 13:30
  IMP Lecture Hall

Speaker: LEESCH Katrin Friederike (Pauli), BYKOV Aleksandr (Cochella), LEE Ho-Seok (Belkhadir)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

25

Jun 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Valter Longo
Institute: USC Leonard David School of Gerontology
Host: Noelia Urban

Mon

29

Jun 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: NEUMAYR Christoph (Stark), CRESPO ENRIQUEZ Ivan (Urban), MARSONER Theodor (Campbell)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

01

Jul 2020
Impromptu Seminar

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Eva Nogales
Institute: Lawrence Berkeley National Lab
Host: David Haselbach

Thu

02

Jul 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Rahul Satija
Institute: New York Genome Center
Host: Andi Pauli

Thu

09

Jul 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: John Wherry
Institute: University of Pennsylvania
Host: Johannes Zuber

Mon

13

Jul 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: HOLSTEIN Felix (Obenauf), CUSHION Thomas David (Keays)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

16

Jul 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Gunnar Rätsch
Institute: ETH Zurich
Host: Alex Stark

Mon

20

Jul 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: JAEGLE Benjamin (Nordborg), RIESER Sarah Christine (Zuber), KOLESNIKOVA Sofia (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

27

Jul 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: TARDIVO Pietro (Tanaka), HOHMANN Urlich (Brennecke/Plaschka), JAMGE Bhagyshree (Berger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

03

Aug 2020
Monday Seminar

Monday Seminar (Internal)

  12:30 - 13:30
  IMP Lecture Hall

Speaker: ROMANAUSKA Anete (Koehler), VOGT Vivien (Zuber), TREPTE Philipp (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

10

Aug 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: SEREBRENI Leonid (Stark), GARBRECHT Joachim (Dammermann), VALLEBUENO Miguel (Swarts)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

17

Aug 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: JELENIC Stela (Saha), SCHMUECKER Anne (Berger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

24

Aug 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: ZHAO Jierui (Dagdas), KOBAYASHI Wataru (Tachibana), HAJDUSITS Bence (Clausen)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

27

Aug 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Jef Boeke
Institute: NYU Langone Health
Host: Luisa Cochella

Thu

27

Aug 2020
Symposium

VBC Summer School Symposium
  09:00 - 10:00
  IMP Lecture Hall
Mon

31

Aug 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: ROSS James Julian (Brennecke), GUTIERREZ PEREZ Paula (Cochella), VALLOT Antoine (Tachibana)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

02

Sep 2020
Symposium

Proteomics Workshop
  14:00 - 15:00
  IMP Lecture Hall
Thu

03

Sep 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Joanna Wysocka
Institute: Stanford University
Host: Christa Bücker, Kikue Tachibana

Mon

07

Sep 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LUST Katharina (Tanaka), NAGUMO WONG Sakurako (Knoblich), CLAVEL Marion (Dagdas)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

14

Sep 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: MEREITER Stefan (Penninger), TIKANOVA Polina (Burga), CTORTECKA Claudia (Mendjan)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

17

Sep 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Eran Segal
Institute: Weizmann Institute
Host: Ortrun Mittelsten Scheid

Mon

21

Sep 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: BOSONE Camilla (Knoblich), BLAHA Andreas (Pauli)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

24

Sep 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Richard Youle
Institute: NIH
Host: Sascha Martens

Fri

25

Sep 2020
GMI Seminar

Title to be announced
  11:30 - 12:30
  GMI Orange Seminar room

Speaker: Stefanie Sprunck
Institute: Regensburg University
Host: Andi Pauli/Ortrun Mittelsten Scheid

Mon

28

Sep 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: BENNABI Isma (Gerlich), DIMITROVA Mariya (Peters), MASSELINK Wouter (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

01

Oct 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Oliver Hobert
Institute: Columbia University
Host: Luisa Cochella

Mon

05

Oct 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: FALCON CHAVEZ Francisco Javier (Tanaka), CALDERON DOMINGUEZ Lesly (Busslinger), ANDREEV Veselin Ivanov (Brennecke)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

12

Oct 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: ASANOVIC Igor (Martinez), TAVERNINI Katherina (Urban), GUTIERREZ PEREZ Irene (Peters)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

15

Oct 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Andrew Dillin
Institute: University of California, Berkeley
Host: Yasin Dagdas

Fri

16

Oct 2020
GMI Seminar

Title to be announced
  11:30 - 12:30
  GMI Orange Seminar room

Speaker: Fay-Wie Li
Institute: Cornell University
Host: Fred Berger

Mon

19

Oct 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: REY Ulises (Zimmer), UIJTTEWAAL Esther (Elling), SCHNEIDER Maximilian (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

21

Oct 2020
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: John Diffley
Institute: The Francis Crick Institute
Host: Rushad Pavri, Jan-Michael Peters

Thu

22

Oct 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Jennifer Lippincott-Schwartz
Institute: Janelia Farm
Host: Kristina Djinovic Carugo

Mon

02

Nov 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: STOCK Jessica (Pauli), PICCHIANTI Lorenzo (Dagdas), SIDHAYE Jaydeep (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

05

Nov 2020
Symposium

VBC PhD Symposium
  09:00 - 10:00
  IMP Lecture Hall
Mon

09

Nov 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: GABARRO SOLANAS Rut (Urban), KAGAWA Harunobu (Rivron), BECERRIL PEREZ Fernando (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

11

Nov 2020
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Richard Flavell
Institute: Yale University School of Medicine
Host: Meinrad Busslinger

Mon

16

Nov 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LEE Joonsun (Elling), DEYETT Alison Ann (Mendjan), VUNJAK Milica (Versteeg)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

19

Nov 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Steve Jackson
Institute: Gurdon Research Institute
Host: Rushad Pavri

Mon

23

Nov 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: SCHENK Robyn (Busslinger), HOFBAUER Lorena (Stark), RODRIGUES VIANA Angela Maria (Ameres)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

26

Nov 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Valentina Greco
Institute: Yale University School of Medicine
Host: Noelia Urban

Mon

30

Nov 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: MILJKOVIC Frane (Köhler), STOCKINGER Alexander (Raible), SUGIURA Takuji (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

02

Dec 2020
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Patrick Cramer
Institute: MPI for Biophysical Chemistry
Host: Alexander Stark, Clemens Plaschka

Thu

03

Dec 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Naama Barkai
Institute: Weizmann Institute of Science
Host: Luisa Cochella

Mon

07

Dec 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: DA CUNHA E SILVA MARTINS COSTA Catarina (Knoblich), FAHRENBERGER Martin (Von Haeseler)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

14

Dec 2020
VDS Lecture

Title to be announced
  17:00 - 18:00
  IMBA/GMI Lecture Hall

Speaker: John Marioni
Institute: EMBL-EBI
Host: Arndt von Haeseler

Mon

14

Dec 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: DUXBURY Zane (Becker), RAUSCHMEIER Rene (Busslinger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

17

Dec 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Christopher Vakoc
Institute: Cold Spring Harbor Laboratory
Host: Johannes Zuber

Mon

21

Dec 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: ANISIMOVA Aleksandra (Karagöz), LIN Tzi-Yang (Tanaka), ANDREATTA Gabriele (Raible)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

11

Jan 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: KHANDEKAR Ameya (Martinez), LOUBIERE Vincent (Stark), NGUYEN Vu (Mittelsten Scheid)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

18

Jan 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: PINTER Theresa (Busslinger), REUMANN Daniel (Knoblich), CLARKE Amy (Zagrovic)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

21

Jan 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Clifford Brangwynne
Institute: Princeton University
Host: Daniel Gelrich

Mon

01

Feb 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: HAENDELER Simon (Von Haeseler), KRAMMER Teresa (Tanaka), DENEKE Victoria (Pauli)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

08

Feb 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LEITNER Marie-Christin (Mendjan), YU Changwei (Brennecke), ALMEIDA Bernardo (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

15

Feb 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LORENZO ORTS Laura (Pauli), HORN Sabrina (Peters), SEONG Jinwoo (Rivron)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

22

Feb 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: SAAD RODRIGUES Carolina (Schloegelhofer), OTSUKI Leo (Tanaka), SCHMIDT Clara (Mendjan)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

01

Mar 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LÖFKE Christian (Dagdas), SAVOVA Adriana(Martens), TAKACS Zsuzsanna (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

08

Mar 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: BATTY Paul Daniel (Gerlich), JACOBS Jelle (Stark), BAUMANN Verena (Martens)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

15

Mar 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: RITSCHKA Birgit (Tanaka), LEIENDECKER Lukas (Obenauf), PISUPATI Rahul Bharadwaj (Nordborg)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

22

Mar 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: VOGEL Antonia (Clausen), INCARBONE Marco (Mittelsten Scheid), TELONI Federico (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

29

Mar 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: AYALA MUNOZ Farja Isabel (Plaschka), PETROVA Olga (Clausen), STALTNER Moritz (Ameres)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

12

Apr 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: BASSAT Elad (Tanaka), RUANGROENGKULRITH Siwat (Tachibana), DOMBEY Rodolphe (Mari-Ordonez)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

19

Apr 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: FEDL Anna (Busslinger), TERIYAPIROM Isaree (Koo), LI Chong (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

26

Apr 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LIU Haijun (Nordborg), GEHRE Maja (Brennecke), NEMCKO Filip (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

28

Apr 2021
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Joan Massague
Institute: Memorial Sloan Kettering Cancer Center
Host: Anna Obenauf

Mon

03

May 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: NAVALAYEU Tsimafei (Ameres), ZMAJKOVIC Jakub (Zuber), JONSSON Gustav (Penninger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

10

May 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: HINTERNDORFER Matthias (Zuber), KORESHOVA Alevtina (Burga), VOLKNER Manuela (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

17

May 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: NOGALES MORAL Adrian (Köhler), NAJM Ramsey K. (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

26

May 2021
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Ulrich Hartl
Institute: Max Planck Institute of Biochemistry
Host: Tim Clausen

Thu

27

May 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: David Sabatini
Institute: MIT, Whitehead Institute
Host: Yasin Dagdas

Mon

31

May 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: CHUGUNOVA Anastasia (Pauli), REITER Franziska (Stark), SGROMO Annamaria (Ameres)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

07

Jun 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: PHILLIPS Alexander William (Keays), WIDEN Sonya Angeline (Burga), VOICHEK Yoav (Nordborg)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

14

Jun 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: RODIRUGEZ TERRONES Diego (Tanaka), KORDIC Darja (Clausen), PERSCHY Lorenz (Haselbach)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

21

Jun 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: GARCIA LEON Marta (Dagdas), KLAUS Loni (Stark), JAVALI Alok (Rivron)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

28

Jun 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: VOICHEK Maya Shinan (Brennecke), PETRZILEK Jan (Ameres), KALIS Robert (Zuber)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

  • Name
    Phone
    Mail
    Function
    Group
    Room
  • A
  • Dana Abdeen
    +43-1-4277-5522
    PhD Student
    Jantsch V
    5.522
    Main Building
  • Omer Rashid Abdi
    +43-1-4277-61643
    Apprentice
    Köhler A
    3.524
    Main Building
  • Sonja Achleitner
    +43-1-4277-54632
    Diploma/Master Student
    Moll
    4.129
    Main Building
  • Christiane Agreiter
    +43-1-4277-56221
    Technician
    Loidl
    5.515
    Main Building
  • Mariam Al-Rawi
    +43-1-4277-54618
    Diploma/Master Student
    Tessmar
    4.510/4.512
    Main Building
  • Tanino Albanese
    +43-1-4277-54632
    PhD Student
    Moll
    4.129
    Main Building
  • Bernhard Alber
    +43-1-4277-61631
    Diploma/Master Student
    Blaas
    3.127
    Main Building
  • Manuel Alonso Y Adell
    +43-1-4277-52808
    PostDoc
    Campbell
    5.512/5.513
    Main Building
  • Thomas Altmutter
    +43-1-4277-24003
    IT Support
    3.117
    Main Building
  • Jolanta Ambroz-Kumorowski
    +43-1-4277-24061
    Facility Technician
    8.318
    Main Building
  • Gustav Ammerer
    +43-1-4277-52816
    Group Leader
    Ammerer
    5.113
    Main Building
  • Gabriele Andreatta
    +43-1-4277-74636
    PostDoc
    Raible
    4.501
    Main Building
  • Aleksandra Anisimova
    +43-1-4277-61653
    PhD Student
    Karagöz
    3.507/ 3.508
    Main Building
  • Dorothea Anrather
    +43-1-4277-52846
    Senior PostDoc
    5.10
    IMP/IMBA
  • Lisa Appel
    +43-1-4277-52807
    PhD Student
    Slade
    5.508
    Main Building
  • Silvia Arce Solano
    +43-1-4277-52225
    PhD Student
    Djinovic
    0612
    VBC 5
  • Alexis Arizpe
    +43-1-79044-9942
    PhD Student
    Swarts
    1104
    VBC 5
  • Hossein Arzani
    +43-1-4277-61812
    PhD Student
    Kuchler
    2.107
    Main Building
  • Igor Asanovic
    +43-1-4277-61815
    PhD Student
    Martinez
    2.512
    Main Building
  • Gerlinde Aschauer
    +43-1-4277-52851
    Program manager
    5.119
    Main Building
  • Alexandros-Vaios Athanasiou
    +43-1-4277-54613
    Diploma/Master Student
    Witte
    4.125/4.127
    Main Building
  • Theresa Auer
    +43-1-4277-61668
    Diploma/Master Student
    Otsuka
    3.505
    Main Building
  • Zahra Ayatollahi
    +43-1-4277-61609
    PostDoc
    Barta
    3.518
    Main Building
  • Daniel F. Azar
    +43-1-4277-61611
    PhD Student
    Skern
    3.121
    Main Building
  • B
  • Manuela Baccarini
    +43-1-4277-54607
    Group Leader
    Baccarini
    4.628
    Main Building
  • Andreas Bachmair
    +43-1-4277-74811
    Group Leader
    Bachmair
    5.110
    Main Building
  • Florian Badt
    +43-1-4277-61760
    Weitzer
    2.522
    Main Building
  • Andrea Barta
    +43-1-4277-61640
    Group Leader
    Barta
    3.520
    Main Building
  • Flavia Bassani
    +43-1-4277-54631
    PostDoc
    Bläsi
    4.121
    Main Building
  • Antoine Baudrimont
    +43-1-4277-56261
    PostDoc
    Jantsch V
    5.522
    Main Building
  • Verena Baumann
    +43-1-4277-52838
    PhD Student
    Martens
    5.401
    Main Building
  • Andreas Beier
    +43-1-4277-52227
    PhD Student
    Konrat
    0614
    VBC 5
  • Andrej Belokurov
    +43-1-4277-29837
    Facility Technician
    0.412
    Main Building
  • Johannes Benedum
    +43-1-4277-52807
    Diploma/Master Student
    Slade
    5.508
    Main Building
  • Maximilian Benesch
    +43-1-4277-56221
    Klein
    5.528/5.530
    Main Building
  • Peter Benkö
    +43-1-4277-54630
    PhD Student
    Baccarini
    4.529
    Main Building
  • Kerstin Berchtold
    +43-1-4277-56221
    Klein
    5.528/5.530
    Main Building
  • Christian Bernhart
    +43-1-4277-52812
    IT Support
    5.617
    Main Building
  • Daniel Bernklau
    +43-1-4277-52805
    PhD Student
    Martens
    5.502
    Main Building
  • Patrick Berthold
    +43-1-4277-24072
    Facility Staff
    1.117
    Main Building
  • Annika Bestehorn
    +43-1-4277-54626
    PhD Student
    Kovarik
    4.514
    Main Building
  • Angela Bienert
    +43-1-4277-61811
    Administration
    Kuchler
    2.107
    Main Building
  • Ivana Bilusic
    +43-1-4277-52804
    PhD Student
    Schroeder
    5.502
    Main Building
  • Wolfgang Binder
    +43-1-4277-24060
    Technician
    3.501
    Main Building
  • Michael Bindl
    +43-1-4277-61645
    Diploma/Master Student
    Leeb
    3.123/3.125
    Main Building
  • Head of Biooptics Facility
    +43-1-4277-61672
    PostDoc
    1.618
    VBC 5
  • Nora Bischoff
    +43-1-4277-54627
    Diploma/Master Student
    Kovarik
    4.514
    Main Building
  • Dieter Blaas
    +43-1-4277-61630
    Group Leader
    Blaas
    3.026
    Main Building
  • Udo Bläsi
    +43-1-4277-54609
    Group Leader
    Bläsi
    4.121
    Main Building
  • Laura Boccuni
    +43-1-4277-54628
    PhD Student
    Decker
    4.522/4.524
    Main Building
  • Johannes Bock
    +43-1-4277-54614
    Diploma/Master Student
    Versteeg
    4.108
    Main Building
  • Jörg Böckelmann
    +43-1-4277-52206
    Administration
    Djinovic
    1.604
    VBC 5
  • Martina Borroni
    +43-1-4277-54627
    PhD Student
    Kovarik
    4.514
    Main Building
  • Margaryta Borysova
    +43-1-4277-74639
    Facility Technician
    0.310
    Main Building
  • Veronika Boskova
    +43-1-4277-74330
    PostDoc
    v. Haeseler
    1.812.3
    VBC 5
  • Helena Bragulat Teixidor
    +43-1-4277-61668
    PhD Student
    Otsuka
    3.505
    Main Building
  • Daniel Braun
    +43-1-4277-52272
    PostDoc
    Zagrovic
    1.114
    VBC 5
  • Barbara Brumec
    +43-1-4277-61661
    Technician
    3.518
    Main Building
  • Sven Brüschweiler
    +43-1-4277-52227
    Senior PostDoc
    Konrat
    0614
    VBC 5
  • Valentina Budroni
    +43-1-4277-54164
    PhD Student
    Versteeg
    4.108
    Main Building
  • Christa Buecker
    +43-1-4277-74646
    Group Leader
    Bücker
    3.626
    Main Building
  • Sebastian Burgstaller-Muehlbacher
    +43-1-4277-74324
    PostDoc
    v. Haeseler
    1.812.4
    VBC 5
  • C
  • Madhwesh C. Ravichandran
    +43-1-4277-53808
    PhD Student
    Campbell
    5.512/5.513
    Main Building
  • Christopher Campbell
    +43-1-4277-52808
    Group Leader
    Campbell
    5.610
    Main Building
  • Oliviero Carugo
    +43-1-4277-52208
    Djinovic
    1.120
    VBC 5
  • Luis Miguel Cerron Alvan
    +43-1-4277-74645
    PhD Student
    Leeb
    3.123/3.125
    Main Building
  • Doris Chen
    +43-1-4277-74328
    PostDoc
    Klein
    1.812.3
    VBC 5
  • Marius Constantin Chirita Mihaila
    +43-1-4277-52213
    PhD Student
    Juffmann
    1.614
    VBC 5
  • Anastasia Cianciulli Sesso
    +43-1-4277-54631
    PhD Student
    Bläsi
    4.122/4.124
    Main Building
  • Matthew Clarke
    +43-1-4277-52808
    PhD Student
    Campbell
    5.512/5.513
    Main Building
  • Amy Clarke
    +43-1-4277-52272
    PhD Student
    Zagrovic
    1.114
    VBC 5
  • Inês Coelho
    +43-1-4277-74320
    PhD Student
    v. Haeseler
    1.812.3
    VBC 5
  • Clara Conrad-Billroth
    +43-1-4277-52213
    PhD Student
    Juffmann
    1.614
    VBC 5
  • Aida Coric
    +43-1-4277-74636
    Diploma/Master Student
    Tessmar
    4.501
    Main Building
  • Nicolas Coudevylle
    +43-1-4277-52838
    PostDoc
    Martens
    5.401
    Main Building
  • Renate Coufal
    +43-1-4277-24071
    Facility Staff
    1.117
    Main Building
  • Kitti Dora Csalyi
    +43-1-4277-74645
    PostDoc
    Leeb
    3.123/3.125
    Main Building
  • Andrea Czerny
    +43-1-4277-61606
    Lab Assistant
    3.515
    Main Building
  • D
  • Alexander Dammermann
    +43-1-4277-54681
    Group Leader
    Dammermann
    4.609
    Main Building
  • Alberto Danieli
    +43-1-4277-52805
    PhD Student
    Martens
    5.503
    Main Building
  • Pauline Dao
    +43-1-4277-54618
    PhD Student
    Tessmar
    4.510/4.512
    Main Building
  • Thomas Decker
    +43-1-4277-54605
    Group Leader
    Decker
    4.112
    Main Building
  • Isabel Del Pino Gomez
    +43-1-4277-54601
    Lab Assistant
    Bläsi
    4.211/4.411
    Main Building
  • Maria Rosaria Dello Stritto
    +43-1-4277-56261
    PostDoc
    Jantsch V
    5.522
    Main Building
  • Duygu Demiröz
    +43-1-4277-54628
    PhD Student
    Decker
    4.522/4.524
    Main Building
  • Sebastian Didusch
    +43-1-4277-54629
    Technician
    Baccarini
    4.525/4.527
    Main Building
  • Ines Dittrich
    +43-1-4277-56241
    Technician
    5.524/5.526
    Main Building
  • Leila Djerlek
    +43-1-4277-61760
    Weitzer
    2.522
    Main Building
  • Kristina Djinovic-Carugo
    +43-1-4277-52203
    Group Leader
    Djinovic
    1.606
    VBC 5
  • Paula Dlugosz
    +43-1-4277-61809
    PostDoc
    Nimpf
    2.110
    Main Building
  • Jeroen Dobbelaere
    +43-1-4277-54619
    PostDoc
    Dammermann
    4.510/4.512
    Main Building
  • Gang Dong
    +43-1-4277-61625
    Group Leader
    Dong
    3.501
    Main Building
  • Coralie Dorard
    +43-1-4277-54630
    PostDoc
    Baccarini
    4.529
    Main Building
  • Corinne Drexler
    +43-1-4277-52862
    Diploma/Master Student
    Fuchs
    5.125/5.127
    Main Building
  • Sharif Duale
    +43-1-4277-61785
    Technician
    2.527
    Main Building
  • Svetlana Durica
    +43-1-4277-74610
    PostDoc
    Görke
    4.110
    Main Building
  • E
  • Folke Ebert
    +43-1-4277-54632
    PhD Student
    Moll
    4.129
    Main Building
  • Karin Ehrenreiter
    +43-1-4277-54617
    Administration
    Baccarini
    4.114
    Main Building
  • Janina Eislmayr
    +43-1-4277-54626
    Diploma/Master Student
    Kovarik
    4.516
    Main Building
  • Kevin Eislmayr
    +43-1-4277-54626
    PhD Student
    Kovarik
    4.516
    Main Building
  • Aybala Eker
    +43-1-4277-61812
    Lab Assistant
    Kuchler
    2.107
    Main Building
  • Christiane Elgert
    +43-1-4277-74325
    PostDoc
    v. Haeseler
    1.812.4
    VBC 5
  • Rainer Ettelt
    +43-1-4277-54630
    PhD Student
    Baccarini
    4.529
    Main Building
  • F
  • Martin Fahrenberger
    +43-1-4277-74330
    PhD Student
    v. Haeseler
    1.812.2
    VBC 5
  • Sebastian Falk
    +43-1-4277-74360
    Group Leader
    Falk
    1.622.1
    VBC 5
  • Renate Fauland
    +43-1-4277-50115
    Administration
    6.111a
    Main Building
  • Markus Faulend
    +43-1-4277-24043
    IT Support
    2.116
    Main Building
  • Michael Feichtinger
    +43-1-4277-52227
    PhD Student
    Konrat
    0614
    VBC 5
  • Simona Ferraioli
    +43-1-4277-61681
    PhD Student
    Foisner
    3.110
    Main Building
  • Luca Ferrari
    +43-1-4277-52828
    PostDoc
    Martens
    5.502
    Main Building
  • Petra Fichtinger
    +43-1-4277-61681
    Lab Manager
    Foisner
    3.110
    Main Building
  • Daria Filipczak
    +43-1-4277-61681
    PhD Student
    Foisner
    3.110
    Main Building
  • Sarah Fink
    +43-1-4277-52808
    Technician
    Campbell
    5.512/5.513
    Main Building
  • Philipp Fischer
    +43-1-4277-54628
    Technician
    Decker
    4.525/4.527
    Main Building
  • Katrin Fischer
    +43-1-4277-54628
    PhD Student
    Decker
    4.522/4.524
    Main Building
  • Sabine Fischer
    +43-1-4277-24014
    Administration
    3.117
    Main Building
  • Irmgard Fischer
    +43-1-4277-52866
    Imaging Specialist (In House Microscopes)
    5.401
    Main Building
  • Roland Foisner
    +43-1-4277-61680
    Group Leader
    Foisner
    3.113
    Main Building
  • Dorotea Fracchiolla
    +43-1-4277-52805
    PostDoc
    Martens
    5.502
    Main Building
  • Ingrid Frohner
    +43-1-4277-61740
    PostDoc
    Ogris
    2.130
    Main Building
  • Benjamin Frühbauer
    +43-1-4277-52272
    Diploma/Master Student
    Zagrovic
    1.114
    VBC 5
  • Peter Fuchs
    +43-1-4277-52855
    Group Leader
    Fuchs
    5.024
    Main Building
  • Sándor Fülöp
    +43-1-4277-24013
    Administration
    3.117
    Main Building
  • G
  • Laura Gallego
    +43-1-4277-61641
    PostDoc
    Köhler A
    3.522
    Main Building
  • Joachim Garbrecht
    +43-1-4277-54621
    PhD Student
    Dammermann
    4.508
    Main Building
  • Konstantina Georgiou
    +43-1-4277-61681
    PhD Student
    Foisner
    3.110
    Main Building
  • Flora Gere
    +43-1-4277-52828
    Diploma/Master Student
    Martens
    5.503
    Main Building
  • Gabriela Gerecova
    +43-1-4277-52806
    PostDoc
    Ammerer
    2.122
    Main Building
  • Devon Germain
    +43-1-4277-61823
    PostDoc
    Martinez
    2.515
    Main Building
  • Tanja Gesell
    +43-1-4277-52292
    Konrat
    1.610
    VBC 5
  • Netsanet Getachew
    +43-1-4277-74636
    Technician
    Tessmar
    4.501
    Main Building
  • Jakob Gierlinger
    +43-1-4277-06766983838
    Weitzer
    2.522
    Main Building
  • Marion Goldeck
    +43-1-4277-61816
    PostDoc
    Martinez
    2.512
    Main Building
  • Boris Görke
    +43-1-4277-54603
    Group Leader
    Görke
    4.113
    Main Building
  • Irene Gösler
    +43-1-4277-61632
    Lab Manager
    Blaas
    3.129
    Main Building
  • Josef Gotzmann
    +43-1-4277-61672
    Head of Facility
    1.618
    VBC 5
  • Sarah Grabner
    +43-1-4277-61656
    Technician
    Falk
    1.624
    VBC 5
  • Angela Graf
    +43-1-4277-56261
    Technician
    Jantsch V
    5.522
    Main Building
  • Claudia Graf
    +43-1-4277-24012
    Administration
    6.109
    Main Building
  • Christa Gregori-Schüller
    +43-1-4277-61806
    Administration
    Kuchler
    2.111
    Main Building
  • Tamara Groffics
    +43-1-4277-61668
    Lab Manager
    Otsuka
    3.505
    Main Building
  • Martin Groznica
    +43-1-4277-61631
    Technician
    Kowalski
    3.126
    Main Building
  • Katarzyna Gruber
    +43-1-4277-24075
    Lab Assistant
    1.117
    Main Building
  • Iris Gruber
    +43-1-4277-74320
    Administration
    v. Haeseler
    1.604
    VBC 5
  • Stephan Grüner
    +43-1-4277-54628
    Technician
    Decker
    4.522/4.524
    Main Building
  • Ricardo Mauricio Gudino Carrillo
    +43-1-4277-61641
    Technician
    Köhler A
    3.522
    Main Building
  • H
  • Katharina Haberler
    +43-1-4277-56201
    Administration
    5.115
    Main Building
  • Kathrin Hacker
    +43-1-4277-54614
    Technician
    Versteeg
    4.108
    Main Building
  • Thomas Haden
    +43-1-4277-24042
    IT Support
    2.116
    Main Building
  • Simon Haendeler
    +43-1-4277-74329
    PhD Student
    v. Haeseler
    1.812.2
    VBC 5
  • Sören Häfker
    +43-1-4277-54622
    PostDoc
    Tessmar
    4.504/4.506
    Main Building
  • Barbara Hamilton
    +43-1-4277-52814
    Administration
    6.111a
    Main Building
  • Robert Happel
    +43-1-4277-74322
    IT Support
    v. Haeseler
    1.812.1
    VBC 5
  • Andreas Hartig
    +43-1-4277- 52817
    Lecturer
    Hartig
    5.110
    Main Building
  • Natascha Hartl
    +43-1-4277-52846
    Technician
    5.10
    IMP/IMBA
  • Markus Hartl
    +43-1-4277-52846
    Facility Head
    5.10
    IMP/IMBA
  • Lisa Haselbach
    +43-1-4277-74001
    Administration
    3.115
    Main Building
  • Paola Hentges Pinto
    +43-1-4277-61821
    PhD Student
    Martinez
    2.512
    Main Building
  • Joachim Hermisson
    +43-1-4277-74351
    Group Leader
    Hermisson
    1.722.1
    VBC 5
  • Reinhold Hofbauer
    +43-1-4277-61750
    Group Leader
    Hofbauer
    2.519
    Main Building
  • Tatsiana Hofer
    +43-1-4277-74326
    PhD Student
    v. Haeseler
    1.812.5
    VBC 5
  • Juergen Hoffmann
    +43-1-4277-52213
    Technician
    1.620
    VBC 5
  • Daniel Hoffmann
    +43-1-4277-52272
    Diploma/Master Student
    Zagrovic
    1.114
    VBC 5
  • Theresa Höfurthner
    +43-1-4277-52263
    PhD Student
    Konrat
    0114
    VBC 5
  • Laurenz Holcik
    +43-1-4277-74325
    PhD Student
    v. Haeseler
    1.812.3
    VBC 5
  • Kay Holleis
    +43-1-4277-61656
    Diploma/Master Student
    Falk
    1.614
    VBC 5
  • David Hollenstein
    +43-1-4277-52838
    PhD Student
    Martens
    5.401
    Main Building
  • Eneda Höllerl
    +43-1-4277-52236
    Technician
    Djinovic
    0326
    VBC 5
  • Elisabeth Holzer
    +43-1-4277-54681
    Diploma/Master Student
    Dammermann
    4.510/4.512
    Main Building
  • Julian Holzinger
    +43-1-4277-52219
    PostDoc
    Konrat
    1.608
    VBC 5
  • Astrid Maria Hölzle
    +43-1-4277-74638
    Technician
    Bläsi
    4.116
    Main Building
  • Harald Hornegger
    +43-1-4277-61653
    PhD Student
    Karagöz
    3.507/ 3.508
    Main Building
  • Lingzhi Huang
    +43-1-4277-56221
    PostDoc
    Klein
    5.401
    Main Building
  • Marie Huber
    +43-1-4277-74647
    Technician
    Bücker
    3.510/3.512
    Main Building
  • Michelle Huth
    +43-1-4277-74644
    Technician
    Leeb
    3.123/3.125
    Main Building
  • I
  • Kyojiro Ikeda
    +43-1-4277-74636
    PostDoc
    Raible
    4.501
    Main Building
  • Lydia Ioannidi
    +43-1-4277-54619
    Diploma/Master Student
    Dammermann
    4.510/4.512
    Main Building
  • Johanna Irnstorfer
    +43-1-4277-61823
    Diploma/Master Student
    Martinez
    2.512
    Main Building
  • Natale-Erwin Ivessa
    +43-1-4277-61805
    Group Leader
    Ivessa
    2.118
    Main Building
  • J
  • Michael Janisiw
    +43-1-4277-56241
    Lab Scientist
    Schlögelhofer
    5.524/5.526
    Main Building
  • Verena Jantsch-Plunger
    +43-1-4277-56250
    Group Leader
    Jantsch V
    5.118
    Main Building
  • Swathi Jayaram
    +43-1-4277-74646
    PhD Student
    Bücker
    3.510/3.512
    Main Building
  • Sabrina Jenull
    +43-1-4277-61818
    Kuchler
    2.509
    Main Building
  • Aleksandra Jovanovic
    +43-1-4277-52806
    Lab Manager
    Ammerer
    2.122
    Main Building
  • Thomas Juffmann
    +43-1-4277-72520
    Group Leader
    Juffmann
    1.610
    VBC 5
  • Elisabeth Jursa
    +43-1-4277-52875
    Lab Assistant
    5.325
    Main Building
  • K
  • Andrea Kahlbacher
    +43-1-4277-52236
    Technician
    Djinovic
    0326
    VBC 5
  • Petra-Franziska Kalman
    +43-1-4277-61761
    Technician
    Weitzer
    2.522
    Main Building
  • Thomas Kapral
    +43-1-4277-52272
    Diploma/Master Student
    Zagrovic
    1.612
    VBC 5
  • Elif Karagöz
    +43-1-4277-61635
    Group Leader
    Karagöz
    3.507/ 3.508
    Main Building
  • Ruben Kastner
    +43-1-4277-56241
    Apprentice
    Schlögelhofer
    5.524/5.526
    Main Building
  • Clemens Kauffmann
    +43-1-4277-52272
    PhD Student
    Konrat
    1.114
    VBC 5
  • Helga Kaufmann
    +43-1-4277-52801
    Lab Assistant
    5.210/5.410
    Main Building
  • Tanja Kaufmann
    +43-1-4277-52807
    PhD Student
    Slade
    5.508
    Main Building
  • Muna Ayesha Khan
    +43-1-4277-74610
    PostDoc
    Görke
    4.110
    Main Building
  • AMEYA RAKESH KHANDEKAR
    +43-1-4277-61823
    PhD Student
    Martinez
    2.512
    Main Building
  • Sami Khawam
    +43-1-4277-74320
    PostDoc
    Juffmann
    1.610
    VBC 5
  • Narakorn Khunweeraphong
    +43-1-4277-61818
    PostDoc
    Kuchler
    2.509
    Main Building
  • Martin Kiendl
    +43-1-4277-52236
    Diploma/Master Student
    Djinovic
    0326
    VBC 5
  • SEYDA KIGILI
    +43-1-4277-54613
    Diploma/Master Student
    Witte
    4.125/4.127
    Main Building
  • Cornelia Klein
    +43-1-4277-61806
    Administration
    Kuchler
    2.111
    Main Building
  • Franz Klein
    +43-1-4277-56220
    Group Leader
    Klein
    5.114
    Main Building
  • Tamara Klockner
    +43-1-4277-52808
    PhD Student
    Campbell
    5.512/5.513
    Main Building
  • Alwin Köhler
    +43-1-4277-61685
    Group Leader
    Köhler A
    3.626
    Main Building
  • Manuela Sophie Koller
    +43-1-4277-53808
    Technician
    Campbell
    5.512/5.513
    Main Building
  • Dhaarsini Koneswarakantha
    +43-1-4277-61821
    PhD Student
    Martinez
    2.515
    Main Building
  • Werner König
    +43-1-4277-52210
    Technician
    1.620
    VBC 5
  • Robert Konrat
    +43-1-4277-52202
    Group Leader
    Konrat
    1.602
    VBC 5
  • Georg Kontaxis
    +43-1-4277-52218
    Facility Manager
    1.608
    VBC 5
  • Katharina Korbula
    +43-1-4277-61626
    Lab Manager
    Dong
    3.501
    Main Building
  • Julius Kostan
    +43-1-4277-52263
    Senior PostDoc
    Djinovic
    0114
    VBC 5
  • Pavel Kovarik
    +43-1-4277-54608
    Group Leader
    Kovarik
    4.615
    Main Building
  • Heinrich Kowalski
    +43-1-4277-61612
    Group Leader
    Kowalski
    3.026
    Main Building
  • Felix Krepler
    +43-1-4277-24065
    Technician
    3.501
    Main Building
  • Karl Kuchler
    +43-1-4277-61807
    Group Leader
    Kuchler
    2.111
    Main Building
  • Claudia Kuntner
    +43-1-4277-56221
    Klein
    5.528/5.530
    Main Building
  • Marie-Therese Kurzbauer
    +43-1-4277-56202
    Program manager
    Schlögelhofer
    5.119
    Main Building
  • L
  • Aleksandar Lalic
    +43-1-4277-56221
    Diploma/Master Student
    Klein
    5.528/5.530
    Main Building
  • Triin Laos
    +43-1-4277-54621
    PhD Student
    Dammermann
    4.508
    Main Building
  • Anita Le Heron
    +43-1-4277-54626
    PostDoc
    Kovarik
    4.516
    Main Building
  • Karin Ledolter
    +43-1-4277-52260
    Lab Manager
    Konrat
    0122
    VBC 5
  • Martin Leeb
    +43-1-4277-74644
    Group Leader
    Leeb
    3.123/3.125
    Main Building
  • Günther Leitgeb
    +43-1-4277-54633
    IT Management
    4.420
    Main Building
  • Lucia Leitner
    +43-1-4277-61760
    PostDoc
    Weitzer
    2.522
    Main Building
  • Marina Leiwe
    +43-1-4277-61761
    PhD Student
    Weitzer
    2.522
    Main Building
  • Thomas Lenert
    +43-1-4277-61602
    Administration
    3.115
    Main Building
  • Thomas Leonard
    +43-1-4277-52205
    Group Leader
    Leonard
    1.616
    VBC 5
  • Alina Leuchtenberger
    +43-1-4277-74330
    PhD Student
    v. Haeseler
    1.812.2
    VBC 5
  • Aleksandra Levina
    +43-1-4277-52275
    PhD Student
    Leonard
    1.321
    VBC 5
  • Raffael Lichtenberger
    +43-1-4277-61656
    Technician
    Falk
    1.624
    VBC 5
  • Branislav Lilic
    +43-1-4277-54631
    PhD Student
    Bläsi
    4.122/4.124
    Main Building
  • Lukas Lindorfer
    +43-1-4277-56240
    Diploma/Master Student
    Schlögelhofer
    5.523
    Main Building
  • Josef Loidl
    +43-1-4277-56210
    Group Leader
    Loidl
    5.515
    Main Building
  • Joan Lopez Arolas
    +43-1-4277-52225
    Senior PostDoc
    Djinovic
    0612
    VBC 5
  • M
  • Moritz Madern
    +43-1-79044-4291
    Diploma/Master Student
    5.10
    IMP/IMBA
  • Silvia Madritsch
    +43-1-4277-74324
    PhD Student
    v. Haeseler
    1.812.4
    VBC 5
  • Dante Maestre
    +43-1-4277-52213
    PhD Student
    Juffmann
    1.722
    VBC 5
  • Christina Manakanatas
    +43-1-4277-74644
    PhD Student
    Foisner
    3.123/3.125
    Main Building
  • Toni Manolova
    +43-1-4277-61656
    Diploma/Master Student
    Falk
    1.624
    VBC 5
  • Caterina Manzato
    +43-1-4277-56261
    PhD Student
    Jantsch V
    5.522
    Main Building
  • Raphaël Marchand
    +43-1-4277-72523
    PostDoc
    Juffmann
    1.614
    VBC 5
  • Theodor Marsoner
    +43-1-4277-52808
    PhD Student
    Campbell
    5.512/5.513
    Main Building
  • Sascha Martens
    +43-1-4277-52876
    Group Leader
    Martens
    5.113
    Main Building
  • Javier Martinez
    +43-1-4277-61803
    Group Leader
    Martinez
    2.113
    Main Building
  • Fabien Martins
    +43-1-4277-24010
    Financial Director
    6.107
    Main Building
  • Angela Martins
    +43-1-4277-54601
    Administration
    4.114
    Main Building
  • Natalie Mastna
    +43-1-4277-54630
    Technician
    Baccarini
    4.529
    Main Building
  • Marialaura Mastrovito
    +43-1-4277-54164
    PostDoc
    Versteeg
    4.108
    Main Building
  • Mario Migotti
    +43-1-4277-52263
    Diploma/Master Student
    Konrat
    0114
    VBC 5
  • Dalibor Milic
    +43-1-4277-52215
    Senior PostDoc
    Djinovic
    1.120
    VBC 5
  • Frane Miljkovic
    +43-1-4277-61643
    PhD Student
    Köhler A
    3.524
    Main Building
  • Georg Mlynek
    +43-1-4277-52263
    PostDoc
    Djinovic
    0114
    VBC 5
  • Katharina Mohr
    +43-1-4277-61704
    Technician
    Ogris
    2.127
    Main Building
  • Isabella Moll
    +43-1-4277-54606
    Group Leader
    Moll
    4.028
    Main Building
  • Luisa Morelli
    +43-1-4277-54626
    Diploma/Master Student
    Kovarik
    4.516
    Main Building
  • Ingrid Mudrak
    +43-1-4277-61740
    Lab Manager
    Ogris
    2.030
    Main Building
  • Christian Müller
    +43-1-4277-54613
    PhD Student
    Moll
    4.125/4.127
    Main Building
  • Ernst Müllner
    +43-1-4277-61783
    Group Leader
    Müllner
    2.523
    Main Building
  • Melitta Münster
    +43-1-4277-56240
    Technician
    Schlögelhofer
    5.623
    Main Building
  • N
  • Nana Naetar-Kerenyi
    +43-1-4277-61671
    PostDoc
    Foisner
    3.108
    Main Building
  • Michael Nagy
    +43-1-4277-52263
    Diploma/Master Student
    Djinovic
    0114
    VBC 5
  • Kuldeep Nangalia
    +43-1-4277-56221
    PhD Student
    Klein
    5.401
    Main Building
  • Lilian Nehlin
    +43-1-4277-52810
    PostDoc
    Bachmair
    5.108/5.109
    Main Building
  • Tobias Nimpf
    +43-1-4277-61810
    Lab Assistant
    Nimpf
    2.110
    Main Building
  • Johannes Nimpf
    +43-1-4277-61808
    Group Leader
    Nimpf
    2.112
    Main Building
  • Adrian Nogales Moral
    +43-1-4277-61643
    PhD Student
    Köhler A
    3.524
    Main Building
  • Filomena Nogueira
    +43-1-4277-61817
    PostDoc
    Kuchler
    2.505
    Main Building
  • O
  • Egon Ogris
    +43-1-4277-61730
    Group Leader
    Ogris
    2.127
    Main Building
  • Karin Olek
    +43-1-4277-61611
    PhD Student
    Skern
    3.121
    Main Building
  • Cornelia Oppitz
    +43-1-4277-74640
    Program manager
    Baccarini
    4.116
    Main Building
  • Lukas Orel
    +43-1-4277-74636
    Lab Manager
    Tessmar
    4.501
    Main Building
  • Lucija Orlic
    +43-1-4277-56241
    Erasmus Student
    Schlögelhofer
    5.524/5.526
    Main Building
  • Ana Orsolic
    +43-1-4277-52225
    Djinovic
    0326
    VBC 5
  • Shotaro Otsuka
    +43-1-4277-61665
    Group Leader
    Otsuka
    3.506
    Main Building
  • Ö
  • Sidar Özer
    +43-1-4277-24042
    IT Support
    2.116
    Main Building
  • P
  • Jan Pac
    +43-1-4277-72524
    Diploma/Master Student
    Juffmann
    1.211
    VBC 5
  • Claudia Pachinger
    +43-1-4277-54621
    PhD Student
    Dammermann
    4.508
    Main Building
  • Silvia Panizza
    +43-1-4277-61823
    Martinez
    2.515
    Main Building
  • Dimitra Paouneskou
    +43-1-4277-56261
    PostDoc
    Jantsch V
    5.522
    Main Building
  • Lara Lucija Paparic
    +43-1-4277-74610
    Diploma/Master Student
    Görke
    4.110
    Main Building
  • Paulina Parafiniuk-Borzecki
    +43-1-4277-52801
    Administration
    5.115
    Main Building
  • Philipp Penninger
    +43-1-4277-61811
    PhD Student
    Kuchler
    2.107
    Main Building
  • Cassius Manuel Perez de los Cobos Hermosa
    +43-1-4277-74326
    PhD Student
    v. Haeseler
    1.812.5
    VBC 5
  • Thomas Peterbauer
    +43-1-4277-61676
    Senior Imaging Specialist
    1.618
    VBC 5
  • Andriy Petryshyn
    +43-1-4277-61812
    Technician
    Kuchler
    2.107
    Main Building
  • Karin Pfeiffer
    +43-1-4277-52201
    Administration
    1.604
    VBC 5
  • Florian Pflug
    +43-1-4277-74323
    PostDoc
    v. Haeseler
    1.812.1
    VBC 5
  • Parvaneh Piran
    +43-1-4277-24004
    Administration
    6.109
    Main Building
  • Yulia Pivovarova
    +43-1-4277-61626
    PhD Student
    Dong
    3.502
    Main Building
  • Ekaterini Platanitis
    +43-1-4277-54628
    PostDoc
    Decker
    4.525/4.527
    Main Building
  • Gerald Platzer
    +43-1-4277-52227
    PostDoc
    Konrat
    0614
    VBC 5
  • Marina Pletzer
    +43-1-4277-61656
    PhD Student
    Falk
    1.624
    VBC 5
  • Elke Podgorschek
    +43-1-4277-54628
    Diploma/Master Student
    Decker
    4.522/4.524
    Main Building
  • Birgit Poehn
    +43-1-4277-74636
    PhD Student
    Tessmar
    4.501
    Main Building
  • Daniel Pokorný
    +43-1-4277-52241
    PhD Student
    Leonard
    1.321.1
    VBC 5
  • Miroslav Poláček
    +43-1-4277-74320
    Technician
    Swarts
    1.722.1
    VBC 5
  • Anton Polyansky
    +43-1-4277-52271
    Staff Scientist
    Zagrovic
    1.612
    VBC 5
  • Hauptgebäude Portier
    +43-1-4277-12894
    1.106
    Main Building
  • Viktoria Prast
    +43-1-4277-56221
    PhD Student
    Klein
    5.401
    Main Building
  • Silvia Prieler
    +43-1-4277-56221
    PostDoc
    Klein
    5.401
    Main Building
  • Günther Prohaczka
    +43-1-4277-74636
    Diploma/Master Student
    Tessmar
    4.501
    Main Building
  • Ignacio Prusén
    +43-1-4277-56241
    PhD Student
    Schlögelhofer
    5.524/5.526
    Main Building
  • Sylvia Prutti
    +43-1-4277-24001
    Administration
    6.108
    Main Building
  • Dominic Pühringer
    +43-1-4277-52225
    PhD Student
    Djinovic
    0612
    VBC 5
  • Q
  • Laura Quell
    +43-1-4277-74610
    Diploma/Master Student
    Görke
    4.110
    Main Building
  • R
  • Stefan Rabong
    +43-1-4277-61822
    Diploma/Master Student
    Ivessa
    2.504
    Main Building
  • Katarina Radisavljevic
    +43-1-4277-61641
    PhD Student
    Köhler A
    3.522
    Main Building
  • Florian Raible
    +43-1-4277-54616
    Group Leader
    Raible
    4.115
    Main Building
  • Julia Ramesmayer
    +43-1-4277-74645
    Lab Manager
    Leeb
    3.123/3.125
    Main Building
  • Lucía Ramos Lage
    +43-1-4277-74647
    Diploma/Master Student
    Bücker
    3.510/3.512
    Main Building
  • Birgit Rapp
    +43-1-4277-54628
    Lab Manager
    Decker
    4.522/4.524
    Main Building
  • Eva Rasch
    +43-1-4277-52820
    Facility Technician
    5.116
    Main Building
  • Sonia Ratajczyk
    +43-1-4277-52862
    PhD Student
    Fuchs
    5.125/5.127
    Main Building
  • Felix Rauh
    +43-1-4277-56221
    Diploma/Master Student
    Klein
    5.528/5.530
    Main Building
  • Aarathy Ravi sundar Jose Geetha
    +43-1-4277-54628
    PhD Student
    Decker
    4.522/4.524
    Main Building
  • Antonio Real-Hohn
    +43-1-4277-61631
    PostDoc
    Blaas
    3.127
    Main Building
  • Elisabeth Rebhan
    +43-1-4277-54629
    Diploma/Master Student
    Baccarini
    4.525/4.527
    Main Building
  • Michael Rechberger
    +43-1-4277-61653
    Diploma/Master Student
    Karagöz
    3.507/ 3.508
    Main Building
  • Ronja Reinhardt
    +43-1-4277-52275
    PhD Student
    Leonard
    1.321
    VBC 5
  • Wolfgang Ludwig Reiter
    +43-1-4277-52806
    PostDoc
    Ammerer
    2.122
    Main Building
  • Armin Resch
    +43-1-4277-54631
    Lab Manager
    Bläsi
    4.122/4.124
    Main Building
  • Roger Revilla-i-Domingo
    +43-1-4277-54618
    PostDoc
    Raible
    4.510/4.512
    Main Building
  • Michael Riedelberger
    +43-1-4277-61812
    PhD Student
    Kuchler
    2.107
    Main Building
  • Christian Riedl
    +43-1-4277-61701
    Diploma/Master Student
    Rotheneder
    2.125
    Main Building
  • Julia Riefler
    +43-1-79044-9942
    Lab Manager
    Swarts
    1.722.1
    VBC 5
  • Anete Romanauska
    +43-1-4277-61628
    PhD Student
    Köhler A
    3.527
    Main Building
  • Julia Romanov
    +43-1-4277-52805
    Lab Manager
    Martens
    5.502
    Main Building
  • Merrit Romeike
    +43-1-4277-74647
    PhD Student
    Bücker
    3.510/3.512
    Main Building
  • Dagmar Roschitz
    +43-1-4277-24072
    Facility Staff
    1.117
    Main Building
  • Katrin Rose
    +43-1-4277-52810
    Diploma/Master Student
    Bachmair
    5.108/5.109
    Main Building
  • Johann Rotheneder
    +43-1-4277-61720
    Group Leader
    Rotheneder
    2.125
    Main Building
  • Marlena Rozner
    +43-1-4277-54631
    PhD Student
    Bläsi
    4.122/4.124
    Main Building
  • Claudia Rudolf
    +43-1-4277-61761
    Apprentice
    Weitzer
    2.522
    Main Building
  • Cornelia Rumpf-Kienzl
    +43-1-4277-54619
    PostDoc
    Dammermann
    4.510/4.512
    Main Building
  • Harald Rumpler
    +43-1-4277-61810
    Technician
    Nimpf
    2.110
    Main Building
  • S
  • Carolina Saad
    +43-1-4277-56241
    PhD Student
    Schlögelhofer
    5.524/5.526
    Main Building
  • Ulrich Salzer
    +43-1-4277-61669
    PostDoc
    Müllner
    2.523
    Main Building
  • Laura Santini
    +43-1-4277-74645
    PhD Student
    Leeb
    3.123/3.125
    Main Building
  • Thomas Sauer
    +43-1-4277-61782
    Facility Manager
    2.126
    Main Building
  • Adriana Savova
    +43-1-4277-52805
    PhD Student
    Martens
    5.503
    Main Building
  • Justyna Sawa-Makarska
    +43-1-4277-52805
    PostDoc
    Martens
    5.502
    Main Building
  • Christian Scherhäufl
    +43-1-4277-61751
    Diploma/Master Student
    Hofbauer
    2.519
    Main Building
  • Natascha Scherzer
    +43-1-4277-24072
    Facility Staff
    1.117
    Main Building
  • Alexandra Schilder
    +43-1-4277-74610
    PhD Student
    Görke
    4.110
    Main Building
  • Peter Schlögelhofer
    +43-1-4277-56240
    Group Leader
    Schlögelhofer
    5.623
    Main Building
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Key Discovery

Dropping anchor in the Z-disc

Most animals require muscles to feed, flee, or fight. Force generation during skeletal muscle contraction requires that actin filaments are firmly anchored in a structure called the Z-disc, an essential component of the sarcomere, which is the repeating building block of muscle fibres. An essential and major component of the Z-disc, α-actinin, is responsible for cross-linking actin filaments as well as anchoring the protein Titin, which controls sarcomere length. Mutations in α-actinin cause muscular dystrophies and cardiomyopathies. In work published in Cell, scientists at the Max Perutz Labs, led by Kristina Djinovic, have determined the three-dimensional structure of α-actinin, shedding new light on its regulation.

Scientists led by Kristina Djinović-Carugo at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna have elucidated the molecular structure and regulation of the essential muscle protein α-actinin. The new findings allow unprecedented insights into the protein’s mode of action and its role in muscle disorders. The findings, made in collaboration with King’s College London (KCL), may lead to improved treatments, and are published in the top-class journal Cell.

Most animals rely on muscles to move, irrespective whether it is feed, fight or flee. The smallest building block of a muscle is the sarcomere, hundreds of which are successively arranged to form muscle fibers. “Sarcomeres are mainly made up of actin and myosin protein strands called filaments. Muscle shortening or contraction depends on these filaments sliding against each other, and requires that the actin filaments are anchored in planes, called Z-discs. The major Z-disc protein is α-actinin, which is also responsible for anchoring another protein called titin. Titin ensures that the actin and myosin filaments of a sarcomere are positioned correctly and re-adjusts the sarcomere to its original length after muscle activity”, explains structural biologist Kristina Djinović-Carugo.

Important role in heart and muscle disorders

α-Actinin is clearly an essential protein – embryos of organisms that cannot produce it die. If, however, α-actinin is produced but does not function properly, the organism suffers from diseases such as muscular dystrophies and cardiomyopathies. Knowing the detailed structure of α-actinin and muscle would not only better our understanding of the role of mutant proteins in disease, but would also aid accurate diagnosis and may ultimately assist designing new therapies.

Muscle protein structure is a research topic of Kristina Djinović-Carugo at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Department for Structural and Computational Biology. The head of the “Laura Bassi Centre of Optimized Structural Studies” explains: “We determined the structure of α-actinin using a technique called X-ray crystallography. It took us several years to produce sufficient high-quality protein necessary to obtain quality crystals for our analysis.” With patience and innovative ideas the team eventually teased out the detailed structure of α-actinin, and in collaboration with Mathias Gautel at the British Heart Foundation Centre of Research Excellence at KCL could also show how the protein is regulated.

The structure is similar to fusilli pasta

The structure showed that α-actinin forms a symmetrical complex made of two molecules. Each molecule has a head, short neck region and a rod-shaped body that looks like four fusilli pasta aligned in a zigzag. The head of α-actinin binds actin whilst two small L-shaped parts sit at the end of the rod and interact with the neck of the other molecule. However, the structure revealed to be more than the sum of its parts: placing two diametrically opposing α-actinin molecules does not only allow simultaneous binding of actin and titin filaments and so anchoring them in the Z-disc, but also confers regulation.

The fatty acid PIP2 regulates α-actinin function

“It was a long standing hypothesis, that the interaction of α-actinin with titin is regulated via a fatty acid molecule termed PIP2 which switches the molecule on and off. Our structural data now for the first time reveals how a fatty acid opens and closes the muscle protein α-actinin, modifying its ability to bind actin and titin”, explains Kristina Djinović-Carugo. If there is no PIP2, one of the L-shaped parts of an α-actinin molecule binds a titin-lookalike region in the neck of the opposing molecule. If PIP2 is present, the L-shaped part detaches from the neck and binds titin. The team complemented the structural picture of the interaction of PIP2 with α-actinin by analyzing the dynamic life of α-actinin in collaboration with Katharina Pirker (University of Natural Resources and Life Sciences Vienna), and Bojan Žagrović (MFPL). Mathias Gautel’s team also discovered that, when they destroyed α-actinin’s binding site for PIP2 or locked it in a position which can permanently bind titin, ordered sarcomeres were lost; the muscle was broken.

Long-term funding and international collaborations were essential

“Our findings give new insights into how muscle is built and flexes at the molecular level. This will help to better understand both inherited and acquired muscular diseases, and aid therapy development”, sums up Kristina Djinović-Carugo. She adds: “Without long-term funding through the FWF, the University of Vienna, the FFG, the EU-FP7 Marie Curie Action ‘Networks for Initial Training’ program, the British Heart Foundation, as well as the long standing collaborations with Mathias Gautel and Katharina Pirker, this research would have been impossible. This paper is the fruit of eight years of hard of labor!”

 

Publication in Cell:
Euripedes de Almeida Ribeiro, Nikos Pinotsis, Andrea Ghisleni, Anita Salmazo, Petr V. Konarev, Julius Kostan, Bjoern Sjoeblom, Claudia Schreiner, Anton A. Polyansky, Eirini A. Gkougkoulia, Mark R. Holt, Finn L. Aachmann, Bojan Žagrović, Enrica Bordignon, Katharina F. Pirker, Dmitri I. Svergun, Mathias Gautel and Kristina Djinović-Carugo: The structure and regulation of human muscle α-actinin. 

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