HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.
Scinicariello, Sara; Soderholm, Adrian; Schäfer, Markus; Shulkina, Alexandra; Schwartz, Irene; Hacker, Kathrin; Gogova, Rebeca; Kalis, Robert; Froussios, Kimon; Budroni, Valentina; Bestehorn, Annika; Clausen, Tim; Kovarik, Pavel; Zuber, Johannes; Versteeg, Gijs A
Stress signaling boosts interferon-induced gene transcription in macrophages.
Boccuni, Laura; Podgorschek, Elke; Schmiedeberg, Moritz; Platanitis, Ekaterini; Traxler, Peter; Fischer, Philipp; Schirripa, Alessia; Novoszel, Philipp; Nebreda, Angel R; Arthur, J Simon C; Fortelny, Nikolaus; Farlik, Matthias; Sexl, Veronika; Bock, Christoph; Sibilia, Maria; Kovarik, Pavel; Müller, Mathias; Decker, Thomas
Impaired Mucosal Homeostasis in Short-Term Fiber Deprivation Is Due to Reduced Mucus Production Rather Than Overgrowth of Mucus-Degrading Bacteria.
Overbeeke, Annelieke; Lang, Michaela; Hausmann, Bela; Watzka, Margarete; Nikolov, Georgi; Schwarz, Jasmin; Kohl, Gudrun; De Paepe, Kim; Eislmayr, Kevin; Decker, Thomas; Richter, Andreas; Berry, David
Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection.
Eislmayr, Kevin; Bestehorn, Annika; Morelli, Luisa; Borroni, Martina; Walle, Lieselotte Vande; Lamkanfi, Mohamed; Kovarik, Pavel
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.
Gomez-Diaz, Carlos; Jonsson, Gustav; Schodl, Katrin; Deszcz, Luiza; Bestehorn, Annika; Eislmayr, Kevin; Almagro, Jorge; Kavirayani, Anoop; Seida, Mayu; Fennell, Lilian M; Hagelkruys, Astrid; Kovarik, Pavel; Penninger, Josef M; Ikeda, Fumiyo
Conceptual Advances in Control of Inflammation by the RNA-Binding Protein Tristetraprolin.
Kovarik, Pavel; Bestehorn, Annika; Fesselet, Jeanne
Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons.
Demiroz, Duygu; Platanitis, Ekaterini; Bryant, Michael; Fischer, Philipp; Prchal-Murphy, Michaela; Lercher, Alexander; Lassnig, Caroline; Baccarini, Manuela; Müller, Mathias; Bergthaler, Andreas; Sexl, Veronika; Dolezal, Marlies; Decker, Thomas
Context-Dependent IL-1 mRNA-Destabilization by TTP Prevents Dysregulation of Immune Homeostasis Under Steady State Conditions.
Sneezum, Lucy; Eislmayr, Kevin; Dworak, Helene; Sedlyarov, Vitaly; Le Heron, Anita; Ebner, Florian; Fischer, Irmgard; Iwakura, Yoichiro; Kovarik, Pavel
Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.
Kralova, Jarmila; Drobek, Ales; Prochazka, Jan; Spoutil, Frantisek; Fabisik, Matej; Glatzova, Daniela; Borna, Simon; Pokorna, Jana; Skopcova, Tereza; Angelisova, Pavla; Gregor, Martin; Kovarik, Pavel; Sedlacek, Radislav; Brdicka, Tomas
Transcriptional Responses to IFN-gamma Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions.
Steinparzer, Iris; Sedlyarov, Vitaly; Rubin, Jonathan D; Eislmayr, Kevin; Galbraith, Matthew D; Levandowski, Cecilia B; Vcelkova, Terezia; Sneezum, Lucy; Wascher, Florian; Amman, Fabian; Kleinova, Renata; Bender, Heather; Andrysik, Zdenek; Espinosa, Joaquin M; Superti-Furga, Giulio; Dowell, Robin D; Taatjes, Dylan J; Kovarik, Pavel
Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo.
Hafner, Anna; Kolbe, Ulrike; Freund, Isabel; Castiglia, Virginia; Kovarik, Pavel; Poth, Tanja; Herster, Franziska; Weigand, Markus A; Weber, Alexander N R; Dalpke, Alexander H; Eigenbrod, Tatjana
The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment.
Parrini, Matthias; Meissl, Katrin; Ola, Mojoyinola Joanna; Lederer, Therese; Puga, Ana; Wienerroither, Sebastian; Kovarik, Pavel; Decker, Thomas; Müller, Mathias; Strobl, Birgit
Competition of Candida glabrata against Lactobacillus is Hog1 dependent.
Beyer, Reinhard; Jandric, Zeljkica; Zutz, Christoph; Gregori, Christa; Willinger, Birgit; Jacobsen, Ilse D; Kovarik, Pavel; Strauss, Joseph; Schüller, Christoph
The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification.
Sedlyarov, Vitaly; Eichner, Ruth; Girardi, Enrico; Essletzbichler, Patrick; Goldmann, Ulrich; Nunes-Hasler, Paula; Srndic, Ismet; Moskovskich, Anna; Heinz, Leonhard X; Kartnig, Felix; Bigenzahn, Johannes W; Rebsamen, Manuele; Kovarik, Pavel; Demaurex, Nicolas; Superti-Furga, Giulio
Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection
Masa Ivin, Amy Dumigan, Filipe N. de Vasconcelos, Florian Ebner, Martina Borroni, Anoop Kavirayani, Kornelia N. Przybyszewska, Rebecca J. Ingram, Stefan Lienenklaus, Ulrich Kalinke, Dagmar Stoiber, Jose A. Bengoechea, Pavel Kovarik
The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection.
Ebner F, Sedlyarov V, Tasciyan S, Ivin M, Kratochvill F, Gratz N, Kenner L, Villunger A, Sixt M, Kovarik P
HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.
Lang, Michaela; Berry, David; Passecker, Katharina; Mesteri, Ildiko; Bhuju, Sabin; Ebner, Florian; Sedlyarov, Vitaly; Evstatiev, Rayko; Dammann, Kyle; Loy, Alexander; Kuzyk, Orest; Kovarik, Pavel; Khare, Vineeta; Beibel, Martin; Roma, Guglielmo; Meisner-Kober, Nicole; Gasche, Christoph
Posttranscriptional regulation of cytokine expression.
Kovarik, Pavel; Ebner, Florian; Sedlyarov, Vitaly
Type I Interferons in Bacterial Infections: A Balancing Act.
Kovarik, Pavel; Castiglia, Virginia; Ivin, Masa; Ebner, Florian
The Influence of Programmed Cell Death in Myeloid Cells on Host Resilience to Infection with Legionella pneumophila or Streptococcus pyogenes.
Gamradt, Pia; Xu, Yun; Gratz, Nina; Duncan, Kellyanne; Kobzik, Lester; Högler, Sandra; Kovarik, Pavel; Decker, Thomas; Jamieson, Amanda M
Chromatin as a gatekeeper of chromosome replication
Mind matters. VBC mental health awareness
The multiple facets of Hop1 during meiotic prophase
Chromosomes as Mechanical Objects: from E.coli to Meiosis to Mammalian cells
Convergent evolution of CO2-fixing liquid-liquid phase separation
Viral envelope engineering for cell type specific delivery
New ways of leading: inclusive leadership and revising academic hierarchies
How an opportunistic human pathogen colonizes surfaces - From pathogen behavior to new drugs
Title to be announced
Decoding Molecular Plasticity in the Dark Proteome of the Nuclear Pore Complex
Probing the 3D genome architectural basis of neurodevelopment and aging in vivo
How to tango with four - the evolution of meiotic chromosome segregation after genome duplication
Multidimensional approach to decoding the mysteries of animal development
Connecting mitotic chromosomes to dynamic microtubules - insight from biochemical reconstitution
Membrane remodeling proteins at the junction between prokaryotes and eukaryotes
Neurodiversity in academia: strengths and challenges of neurodivergence
Gene expression dynamics during the awakening of the zygotic genome
When all is lost? Measuring historical signals
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Bacterial cell envelope homeostasis at the (post)transcriptional level
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced