Search Results

RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status.

2023 ONCOGENE;42(20):1649-1660.
PMID: 37020037

Dorard, Coralie; Madry, Claire; Buhard, Olivier; Toifl, Stefanie; Didusch, Sebastian; Ratovomanana, Toky; Letourneur, Quentin; Dolznig, Helmut; Garnett, Mathew J; Duval, Alex; Baccarini, Manuela

amica: an interactive and user-friendly web-platform for the analysis of proteomics data.

2022 BMC GENOMICS;23(1):817.
PMID: 36494623

Didusch, Sebastian; Madern, Moritz; Hartl, Markus; Baccarini, Manuela

BRAF increases endothelial cell stiffness through reorganization of the actin cytoskeleton.

2022 FASEB J;36(9):e22478.
PMID: 35916021

Hollósi, Anna; Pászty, Katalin; Bunta, Bálint Levente; Bozó, Tamás; Kellermayer, Miklós; Debreczeni, Márta Lídia; Cervenak, László; Baccarini, Manuela; Varga, Andrea

Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells.

2022 AUTOPHAGY:1-11.
PMID: 35435804

Desideri, Enrico; Castelli, Serena; Dorard, Coralie; Toifl, Stefanie; Grazi, Gian Luca; Ciriolo, Maria Rosa; Baccarini, Manuela

Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons.

2021 PLOS PATHOG;17(7):e1009697.
PMID: 34237114

Demiroz, Duygu; Platanitis, Ekaterini; Bryant, Michael; Fischer, Philipp; Prchal-Murphy, Michaela; Lercher, Alexander; Lassnig, Caroline; Baccarini, Manuela; Müller, Mathias; Bergthaler, Andreas; Sexl, Veronika; Dolezal, Marlies; Decker, Thomas

ERK phosphorylation is RAF independent in naïve and activated B cells but RAF dependent in plasma cell differentiation.

2021 Sci Signal;14(682)
PMID: 33975980

Scheffler, Laura; Feicht, Samantha; Babushku, Tea; Kuhn, Laura B; Ehrenberg, Stefanie; Frankenberger, Samantha; Lehmann, Frank M; Hobeika, Elias; Jungnickel, Berit; Baccarini, Manuela; Bornkamm, Georg W; Strobl, Lothar J; Zimber-Strobl, Ursula

RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell-cell junctions.

2019 FEBS J;286(12):2277-2294.
PMID: 30828992

Dorard, Coralie; Cseh, Botond; Ehrenreiter, Karin; Wimmer, Reiner; Varga, Andrea; Hirschmugl, Tatjana; Maier, Barbara; Kramer, Karina; Fürlinger, Sabine; Doma, Eszter; Baccarini, Manuela

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

2019 CANCER CELL
PMID: 31031016

Elgendy, Mohamed; Cirò, Marco; Hosseini, Amir; Weiszmann, Jakob; Mazzarella, Luca; Ferrari, Elisa; Cazzoli, Riccardo; Curigliano, Giuseppe; DeCensi, Andrea; Bonanni, Bernardo; Budillon, Alfredo; Pelicci, Pier Giuseppe; Janssens, Veerle; Ogris, Manfred; Baccarini, Manuela; Lanfrancone, Luisa; Weckwerth, Wolfram; Foiani, Marco; Minucci, Saverio

Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis.

2018 Sci Signal;11(554)
PMID: 30377225

Yuan, Jimin; Ng, Wan Hwa; Tian, Zizi; Yap, Jiajun; Baccarini, Manuela; Chen, Zhongzhou; Hu, Jiancheng

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants.

2018 ONCOGENE
PMID: 29930381

Yuan, Jimin; Ng, Wan Hwa; Lam, Paula Y P; Wang, Yu; Xia, Hongping; Yap, Jiajun; Guan, Shou Ping; Lee, Ann S G; Wang, Mei; Baccarini, Manuela; Hu, Jiancheng

An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion.

2018 Cell stem cell.;22(6):879-892.e6.
PMID: 29804890

Baumgartner, Christian; Toifl, Stefanie; Farlik, Matthias; Halbritter, Florian; Scheicher, Ruth; Fischer, Irmgard; Sexl, Veronika; Bock, Christoph; Baccarini, Manuela

From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib.

2017 Frontiers in pharmacology ;8:718.
PMID: 29066973

Abdel-Aziz, Amal Kamal; Abdel-Naim, Ashraf B; Shouman, Samia; Minucci, Saverio; Elgendy, Mohamed

RAF proteins exert both specific and compensatory functions during tumour progression of NRAS-driven melanoma.

2017 NAT COMMUN;8:15262.
PMID: 28497782

Dorard, Coralie; Estrada, Charlène; Barbotin, Céline; Larcher, Magalie; Garancher, Alexandra; Leloup, Jessy; Beermann, Friedrich; Baccarini, Manuela; Pouponnot, Celio; Larue, Lionel; Eychène, Alain; Druillennec, Sabine

The yin yang of sunitinib: One drug, two doses, and multiple outcomes.

2017 PMC Biophys;4(2):e1285385.
PMID: 28401187

Elgendy, Mohamed

RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα

2017 Sci Signal;10(469)
PMID: 28270557

Varga, Andrea; Ehrenreiter, Karin; Aschenbrenner, Bertram; Kocieniewski, Pawel; Kochanczyk, Marek; Lipniacki, Tomasz; Baccarini, Manuela

Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.

2017 J BIOL CHEM;292(8):3164-3171.
PMID: 28073913

Papaioannou, Garyfallia; Petit, Elizabeth T; Liu, Eva S; Baccarini, Manuela; Pritchard, Catrin; Demay, Marie B

Deciphering the RAS/ERK pathway in vivo

2017 BIOCHEM SOC T;45(1):27-36.
PMID: 28202657

Coralie Dorard, Georg Vucak, Manuela Baccarini

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.

2016 NAT COMMUN;7:13781.
PMID: 28000790

Jeric, Ines; Maurer, Gabriele; Cavallo, Anna Lina; Raguz, Josipa; Desideri, Enrico; Tarkowski, Bartosz; Parrini, Matthias; Fischer, Irmgard; Zatloukal, Kurt; Baccarini, Manuela

Epidermal RAF prevents allergic skin disease.

2016 eLife;5
PMID: 27431613

Raguz, Josipa; Jeric, Ines; Niault, Theodora; Nowacka, Joanna Daniela; Kuzet, Sanya Eduarda; Rupp, Christian; Fischer, Irmgard; Biggi, Silvia; Borsello, Tiziana; Baccarini, Manuela

MEK1 is required for the development of NRAS-driven leukemia.

2016 Oncotarget;7(49):80113-80130.
PMID: 27741509

Nowacka, Joanna D; Baumgartner, Christian; Pelorosso, Cristiana; Roth, Mareike; Zuber, Johannes; Baccarini, Manuela

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