Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.
Rasool, Reyaz Ur; O'Connor, Caitlin M; Das, Chandan Kanta; Alhusayan, Mohammed; Verma, Brijesh Kumar; Islam, Sehbanul; Frohner, Ingrid E; Deng, Qu; Mitchell-Velasquez, Erick; Sangodkar, Jaya; Ahmed, Aqila; Linauer, Sarah; Mudrak, Ingrid; Rainey, Jessica; Zawacki, Kaitlin P; Suhan, Tahra K; Callahan, Catherine G; Rebernick, Ryan; Natesan, Ramakrishnan; Siddiqui, Javed; Sauter, Guido; Thomas, Dafydd; Wang, Shaomeng; Taylor, Derek J; Simon, Ronald; Cieslik, Marcin; Chinnaiyan, Arul M; Busino, Luca; Ogris, Egon; Narla, Goutham; Asangani, Irfan A
PP2A Rts1 antagonizes Rck2-mediated hyperosmotic stress signaling in yeast
Hollenstein, D M; Veis, J; Romanov, N; Gérecová, G; Ogris, E; Hartl, M; Ammerer, G; Reiter, W
The expression, localisation and interactome of pigeon CRY2.
Balay, Spencer D; Hochstoeger, Tobias; Vilceanu, Alexandra; Malkemper, E Pascal; Snider, William; Dürnberger, Gerhard; Mechtler, Karl; Schuechner, Stefan; Ogris, Egon; Nordmann, Gregory C; Ushakova, Lyubov; Nimpf, Simon; Keays, David A
A phosphatase-centric mechanism drives stress signaling response.
Hollenstein, David Maria; Gérecová, Gabriela; Romanov, Natalie; Ferrari, Jessica; Veis, Jiri; Janschitz, Marion; Beyer, Reinhard; Schüller, Christoph; Ogris, Egon; Hartl, Markus; Ammerer, Gustav; Reiter, Wolfgang
The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.
Hochstoeger, Tobias; Al Said, Tarek; Maestre, Dante; Walter, Florian; Vilceanu, Alexandra; Pedron, Miriam; Cushion, Thomas D; Snider, William; Nimpf, Simon; Nordmann, Gregory Charles; Landler, Lukas; Edelman, Nathaniel; Kruppa, Lennard; Dürnberger, Gerhard; Mechtler, Karl; Schuechner, Stefan; Ogris, Egon; Malkemper, E Pascal; Weber, Stefan; Schleicher, Erik; Keays, David A
Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies.
Mayrhofer, Johanna E; Enzler, Florian; Feichtner, Andreas; Röck, Ruth; Fleischmann, Jakob; Raffeiner, Andrea; Tschaikner, Philipp; Ogris, Egon; Huber, Roland G; Hartl, Markus; Schneider, Rainer; Troppmair, Jakob; Torres-Quesada, Omar; Stefan, Eduard
Selective PP2A Enhancement through Biased Heterotrimer Stabilization.
Leonard, Daniel; Huang, Wei; Izadmehr, Sudeh; O'Connor, Caitlin M; Wiredja, Danica D; Wang, Zhizhi; Zaware, Nilesh; Chen, Yinghua; Schlatzer, Daniela M; Kiselar, Janna; Vasireddi, Nikhil; Schüchner, Stefan; Perl, Abbey L; Galsky, Matthew D; Xu, Wenqing; Brautigan, David L; Ogris, Egon; Taylor, Derek J; Narla, Goutham
PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation.
Frohner, Ingrid E; Mudrak, Ingrid; Schüchner, Stefan; Anrather, Dorothea; Hartl, Markus; Sontag, Jean-Marie; Sontag, Estelle; Wadzinski, Brian E; Preglej, Teresa; Ellmeier, Wilfried; Ogris, Egon
A high sensitivity ZENK monoclonal antibody to map neuronal activity in Aves.
Nordmann, Gregory Charles; Malkemper, Erich Pascal; Landler, Lukas; Ushakova, Lyubov; Nimpf, Simon; Heinen, Robert; Schuechner, Stefan; Ogris, Egon; Keays, David Anthony
Antibodies recognizing the C terminus of PP2A catalytic subunit are unsuitable for evaluating PP2A activity and holoenzyme composition.
Frohner, Ingrid E; Mudrak, Ingrid; Kronlachner, Stephanie; Schüchner, Stefan; Ogris, Egon
The Myc tag monoclonal antibody 9E10 displays highly variable epitope recognition dependent on neighboring sequence context.
Schüchner, Stefan; Behm, Christian; Mudrak, Ingrid; Ogris, Egon
Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis.
Lee, Ha Yin; Itahana, Yoko; Schuechner, Stefan; Fukuda, Masahiro; Je, H Shawn; Ogris, Egon; Virshup, David M; Itahana, Koji
Specificity of research antibodies: "trust is good, validation is better".
Ogris, Egon; Sontag, Estelle; Wadzinski, Brian; Narla, Goutham
Anti-RAINBOW dye-specific antibodies as universal tools for the visualization of prestained protein molecular weight markers in Western blot analysis.
Schüchner, Stefan; Andorfer, Peter; Mudrak, Ingrid; Ogris, Egon
Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation.
Yabe, Ryotaro; Miura, Akane; Usui, Tatsuya; Mudrak, Ingrid; Ogris, Egon; Ohama, Takashi; Sato, Koichi
The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways.
Tscherner, Michael; Zwolanek, Florian; Jenull, Sabrina; Sedlazeck, Fritz J; Petryshyn, Andriy; Frohner, Ingrid E; Mavrianos, John; Chauhan, Neeraj; von Haeseler, Arndt; Kuchler, Karl
Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum.
Montgomery, Therese R; Steinkellner, Thomas; Sucic, Sonja; Koban, Florian; Schüchner, Stefan; Ogris, Egon; Sitte, Harald H; Freissmuth, Michael
Genotoxic Stress Prevents Ndd1-Dependent Transcriptional Activation of G2/M-Specific Genes in Saccharomyces cerevisiae.
Yelamanchi, Syam Kumar; Veis, Jiri; Anrather, Dorothea; Klug, Helene; Ammerer, Gustav
Budding Yeast Greatwall and Endosulfines Control Activity and Spatial Regulation of PP2A(Cdc55) for Timely Mitotic Progression.
Juanes, Maria Angeles; Khoueiry, Rita; Kupka, Thomas; Castro, Anna; Mudrak, Ingrid; Ogris, Egon; Lorca, Thierry; Piatti, Simonetta
Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation.
Romanov, Julia; Walczak, Marta; Ibiricu, Iosune; Schüchner, Stefan; Ogris, Egon; Kraft, Claudine; Martens, Sascha
Dissecting the turgor sensing mechanisms in the blast fungus Magnaporthe oryzae
Pikobodies: What does it take to bioengineer NLR immune receptor-nanobody fusions
scRNA and phylogenetics
Gene regulatory mechanisms governing human development, evolution and variation
Regulation of Cerebral Cortex Morphogenesis by Migrating Cells
Phage therapy for treating bacterial infections: a double-edged sword
Suckers and segments of the octopus arm
Using the house mouse radiation to study the rapid evolution of genes and genetic processes
CRISPR jumps ahead: mechanistic insights into CRISPR-associated transposons
SLiMs and SHelMs: Decoding how short linear and helical motifs direct PPP specificity to direct signaling
Title to be announced
Enigmatic evolutionary origin and multipotency of the neural crest cells - major drivers of vertebrate evolution
Visualising mitotic chromosomes and nuclear dynamics by correlative light and electron microscopy
Engineered nanocarriers for imaging of small proteins by CryoEM
Bacterial cell envelope homeostasis at the (post)transcriptional level
Title to be announced
Hydrologic extremes alter mechanisms and pathways of carbon export from mountainous floodplain soils
Dissecting post-transcriptional gene expression regulation in humans and viruses
Polyploidy and rediploidisation in stressful times
Prdm9 control of meiotic synapsis of homologs in intersubspecific hybrids
Title to be announced
RNA virus from museum specimens
Programmed DNA double-strand breaks during meiosis: Mechanism and evolution
Title to be announced