Search Results

Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients.

2023 Scientific reports.;13(1):6839.
PMID: 37100830

Klussmann, Jens Peter; Grosheva, Maria; Meiser, Peter; Lehmann, Clara; Nagy, Eszter; Szijártó, Valéria; Nagy, Gábor; Konrat, Robert; Flegel, Michael; Holzer, Frank; Groß, Dorothea; Steinmetz, Charlotte; Scherer, Barbara; Gruell, Henning; Schlotz, Maike; Klein, Florian; de Aragão, Paula Aguiar; Morr, Henning; Al Saleh, Helal; Bilstein, Andreas; Russo, Belisa; Müller-Scholtz, Susanne; Acikel, Cengizhan; Sahin, Hacer; Werkhäuser, Nina; Allekotte, Silke; Mösges, Ralph

Stabilization of the Quadruplex-Forming G-Rich Sequences in the Rhinovirus Genome Inhibits Uncoating-Role of Na+ and K.

2023 Viruses;15(4)
PMID: 37112983

Real-Hohn, Antonio; Groznica, Martin; Kontaxis, Georg; Zhu, Rong; Chaves, Otávio Augusto; Vazquez, Leonardo; Hinterdorfer, Peter; Kowalski, Heinrich; Blaas, Dieter

Non-uniform sampling of similar NMR spectra and its application to studies of the interaction between alpha-synuclein and liposomes.

2023 J BIOMOL NMR;77(4):149-163.
PMID: 37237169

Shchukina, Alexandra; Schwarz, Thomas C; Nowakowski, Micha?; Konrat, Robert; Kazimierczuk, Krzysztof

High-resolution structural information of membrane-bound ?-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599.

2023 P NATL ACAD SCI USA;120(15):e2201910120.
PMID: 37027427

Schwarz, Thomas C; Beier, Andreas; Ledolter, Karin; Gossenreiter, Thomas; Höfurthner, Theresa; Hartl, Markus; Baker, Terry S; Taylor, Richard J; Konrat, Robert

The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue.

2022 Frontiers in pharmacology ;13:861295.
PMID: 35846988

Konrat, Robert; Papp, Henrietta; Kimpel, Janine; Rössler, Annika; Szijártó, Valéria; Nagy, Gábor; Madai, Mónika; Zeghbib, Safia; Kuczmog, Anett; Lanszki, Zsófia; Gesell, Tanja; Helyes, Zsuzsanna; Kemenesi, Gábor; Jakab, Ferenc; Nagy, Eszter

Long-range structural preformation in yes-associated protein precedes encounter complex formation with TEAD.

2022 iScience.;25(4):104099.
PMID: 35378854

Feichtinger, Michael; Beier, Andreas; Migotti, Mario; Schmid, Matthias; Bokhovchuk, Fedir; Chène, Patrick; Konrat, Robert

A Step toward NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods.

2021 ChemMedChem.
PMID: 34524728

Brüschweiler, Sven; Fuchs, Julian E; Bader, Gerd; McConnell, Darryl B; Konrat, Robert; Mayer, Moriz

Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin.

2021 Science Advances;7(22)
PMID: 34049882

Sponga, Antonio; Arolas, Joan L; Schwarz, Thomas C; Jeffries, Cy M; Rodriguez Chamorro, Ariadna; Kostan, Julius; Ghisleni, Andrea; Drepper, Friedel; Polyansky, Anton; De Almeida Ribeiro, Euripedes; Pedron, Miriam; Zawadzka-Kazimierczuk, Anna; Mlynek, Georg; Peterbauer, Thomas; Doto, Pierantonio; Schreiner, Claudia; Hollerl, Eneda; Mateos, Borja; Geist, Leonhard; Faulkner, Georgine; Kozminski, Wiktor; Svergun, Dmitri I; Warscheid, Bettina; Zagrovic, Bojan; Gautel, Mathias; Konrat, Robert; Djinovi?-Carugo, Kristina

Binding Mode Characterization of Osteopontin on Hydroxyapatite by Solution NMR Spectroscopy.

2021 CHEMBIOCHEM
PMID: 33914399

Holzinger, Julian; Kotisch, Harald; Richter, Klaus W; Konrat, Robert

Cosolute modulation of protein oligomerization reactions in the homeostatic timescale.

2021 BIOPHYS J
PMID: 33794151

Mateos, Borja; Bernardo-Seisdedos, Ganeko; Dietrich, Valentin; Zalba, Nicanor; Ortega, Gabriel; Peccati, Francesca; Jiménez-Osés, Gonzalo; Konrat, Robert; Tollinger, Martin; Millet, Oscar

Hyperphosphorylation of Human Osteopontin and Its Impact on Structural Dynamics and Molecular Recognition.

2021 BIOCHEMISTRY-US
PMID: 33876640

Mateos, Borja; Holzinger, Julian; Conrad-Billroth, Clara; Platzer, Gerald; Zerko, Szymon; Sealey-Cardona, Marco; Anrather, Dorothea; Kozminski, Wiktor; Konrat, Robert

Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR.

2021 J PHYS CHEM B;125(11):2929-2941.
PMID: 33719460

Amos, Sarah-Beth T A; Schwarz, Thomas C; Shi, Jiye; Cossins, Benjamin P; Baker, Terry S; Taylor, Richard J; Konrat, Robert; Sansom, Mark S P

Molecular basis of F-actin regulation and sarcomere assembly via myotilin.

2021 PLOS BIOLOGY;19(4):e3001148.
PMID: 33844684

Kostan, Julius; Pavsic, Miha; Puz, Vid; Schwarz, Thomas C; Drepper, Friedel; Molt, Sibylle; Graewert, Melissa Ann; Schreiner, Claudia; Sajko, Sara; van der Ven, Peter F M; Onipe, Adekunle; Svergun, Dmitri I; Warscheid, Bettina; Konrat, Robert; Fürst, Dieter O; Lenarcic, Brigita; Djinovic-Carugo, Kristina

Using Cross-Correlated Spin Relaxation to Characterize Backbone Dihedral Angle Distributions of Flexible Protein Segments.

2021 CHEMPHYSCHEM
PMID: 33119214

Kauffmann, Clemens; Zawadzka-Kazimierczuk, Anna; Kontaxis, Georg; Konrat, Robert

Temperature as an extra dimension in multidimensional protein NMR.

2021 CHEM-EUR J
PMID: 32985764

Shchukina, Alexandra; Malecki, Pawel; Mateos, Borja; Nowakowski, Michal; Urbanczyk, Mateusz; Kontaxis, Georg; Kasprzak, Pawel; Conrad-Billroth, Clara; Konrat, Robert; Kazimierczuk, Krzysztof

Mannosylated hemagglutinin peptides bind cyanovirin-N independent of disulfide-bonds in complementary binding sites

2020 RSC Advances;10:11079-11087.

Schilling, Phillip E.; Kontaxis, Georg; Dragosits, Martin; Schiestl, Robert H.; Becker, Christian F.W.; Maier, Irene

Metabolic landscape of the mouse liver by quantitative 31 P-NMR analysis of the phosphorome

2020 HEPATOLOGY
PMID: 33284502

Bernardo-Seisdedos, Ganeko; Bilbao, Jon; Fernández-Ramos, David; Lopitz-Otsoa, Fernando; Gutierrez de Juan, Virginia; Bizkarguenaga, Maider; Mateos, Borja; Fondevila, Marcos F; Abril-Fornaguera, Jordi; Diercks, Tammo; Lu, Shelly C; Nogueiras, Rubén; Mato, José M; Millet, Oscar

A Switch between Two Intrinsically Disordered Conformational Ensembles Modulates the Active Site of a Basic-Helix-Loop-Helix Transcription Factor.

2020 J Phys Chem Lett:8944-8951.
PMID: 33030907

Sicoli, Giuseppe; Kress, Thomas; Vezin, Hervé; Ledolter, Karin; Kurzbach, Dennis

Osteopontin regulates biomimetic calcium phosphate crystallization from disordered mineral layers covering apatite crystallites.

2020 Scientific reports.;10(1):15722.
PMID: 32973201

Iline-Vul, Taly; Nanda, Raju; Mateos, Borja; Hazan, Shani; Matlahov, Irina; Perelshtein, Ilana; Keinan-Adamsky, Keren; Althoff-Ospelt, Gerhard; Konrat, Robert; Goobes, Gil

PI by NMR: Probing CH-π Interactions in Protein-Ligand Complexes by NMR.

2020 ANGEW CHEM INT EDIT
PMID: 32421895

Platzer, Gerald; Mayer, Moriz; Beier, Andreas; Brüschweiler, Sven; Fuchs, Julian E; Engelhardt, Harald; Geist, Leonhard; Bader, Gerd; Schörghuber, Julia; Lichtenecker, Roman; Wolkersdorfer, Bernhard; Kessler, Dirk; McConnell, Darryl B; Konrat, Robert

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