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We address fundamental questions in developmental biology: How are we made? How are cell identities defined and maintained in order to provide the right cell type at the right time for proper development? What are the central molecular players for cell-fate choice? Our main research efforts focus on some of the first differentiation decisions taken during embryonic stem cell commitment.
The Leeboratory approaches cell fate choice from multiple angles. We study epigenetics, RNA biology and signalling to pursue a holistic approach to understand differentiation. We use genetics and high-throughput methodology combined with systems biology approaches to delineate the molecular rules of cell-fate decision. Embryonic stem cells and various differentiation strategies are our main experimental model systems.
Martin performed his PhD thesis in the Wutz lab at the IMP in Vienna. From 2011 to 2015 he was a post-doc in the lab of Austin Smith at the Cambridge Stem Cell Institute. Since 2015 he is group leader and since 2021 Associate Professor at the Max Perutz Labs where the Leeboratory works on deciphering the molecular control of cell fate decisions.
In 2011, together with Anton Wutz, we reporter the first stable and fully pluripotent haploid mouse ES cell lines. This breakthrough discovery has since enabled a multitude of genetic screens and has also been instrumental in high resolution single cell based nuclear structures as well as the birth of monoparental mice.
In 2014 we utilized the potential of haploid ES cells in an insertional mutagenesis screen to identify genes that regulate the first cell fate decision in ES cell differentiation, the exit from pluripotency. We showed that haploid ES cells are a highly efficient platform for genetic screens in a developmentally relevant context.
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.
Huth, Michelle; Santini, Laura; Galimberti, Elena; Ramesmayer, Julia; Titz-Teixeira, Fabian; Sehlke, Robert; Oberhuemer, Michael; Stummer, Sarah; Herzog, Veronika; Garmhausen, Marius; Romeike, Merrit; Chugunova, Anastasia; Leesch, Friederike; Holcik, Laurenz; Weipoltshammer, Klara; Lackner, Andreas; Schoefer, Christian; von Haeseler, Arndt; Buecker, Christa; Pauli, Andrea; Ameres, Stefan L; Smith, Austin; Beyer, Andreas; Leeb, Martin
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3.
Santini, Laura; Halbritter, Florian; Titz-Teixeira, Fabian; Suzuki, Toru; Asami, Maki; Ma, Xiaoyan; Ramesmayer, Julia; Lackner, Andreas; Warr, Nick; Pauler, Florian; Hippenmeyer, Simon; Laue, Ernest; Farlik, Matthias; Bock, Christoph; Beyer, Andreas; Perry, Anthony C F; Leeb, Martin
Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency.
Lackner, Andreas; Sehlke, Robert; Garmhausen, Marius; Giuseppe Stirparo, Giuliano; Huth, Michelle; Titz-Teixeira, Fabian; van der Lelij, Petra; Ramesmayer, Julia; Thomas, Henry F; Ralser, Meryem; Santini, Laura; Galimberti, Elena; Sarov, Mihail; Stewart, A Francis; Smith, Austin; Beyer, Andreas; Leeb, Martin
Genetic exploration of the exit from self-renewal using haploid embryonic stem cells.
Leeb, Martin; Dietmann, Sabine; Paramor, Maike; Niwa, Hitoshi; Smith, Austin
Derivation of haploid embryonic stem cells from mouse embryos.
Leeb, Martin; Wutz, Anton
Polycomb complexes act redundantly to repress genomic repeats and genes.
Leeb, Martin; Pasini, Diego; Novatchkova, Maria; Jaritz, Markus; Helin, Kristian; Wutz, Anton
The Leeb Group is supported through the "Vienna Research Groups for Young Investigators" program.
The Group Leeb is a member of the special Doctoral Program "Signaling Mechanisms in Cellular Homeostasis" reviewed and funded by the Austrian Research Fund FWF.
Mechanisms of endo-mesodermal lineage choice (P35637; 2022-2025)
Execution of cell fate choice by cooperative gene activities (I5958; cooperation with Prof. Andreas Beyer, CECAD Cologne; 2023-2026)
Regulation of ES cell differentiation by NMD (P 31334; 2019-2022)
Systems Level Analysis of ES Cell Differentiation (I 3786; 2019-2021)
Schroedinger return fellowship: "Mechanisms of ES cell differentiation"
Decoding the cis-regulatory information of enhancer sequences
Speaker: Bernardo AlmeidaInstitute: IMP - Stark Lab
From planarians to parasites: unexpected roles for monoamine transmitters
Speaker: Phil NewmarkInstitute: University of Wisconsin-MadisonHost: Elly Tanaka
Title to be announced
Speaker: Jim NaismithInstitute: The Rosalind Franklin Institute, OxfordshireHost: David Haselbach
The Birth and Death of Macromolecular Complexes in Eukaryotic Evolution
Speaker: Berend SnelInstitute: Utrecht UniversityHost: Fred Berger
Probing chromosome mechanics in the interphase nucleus
Speaker: Antoine CoulonInstitute: Institut CurieHost: Anton Goloborodko and Daniel Gerlich
Monday Seminar (Internal)
Speaker: JONASSON Mattias (Tanaka), HOHMANN Ulrich (Brennecke/Plaschka), MANOLOVA Toni (Falk)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
The Earth BioGenome Project: Progress Toward a New Synthesis in Evolution Science
Speaker: Harris LewinInstitute: UC DavisHost: Darrin Schultz and Oleg Simakov
Is cohesin necessary for transcription? Molecular entities of transcriptional dysregulation in the absence of cohesin revealed by analysis of transcription elongation complexes
Speaker: Katsuhiko ShirahigeInstitute: Karolinska InstituteHost: Franz Klein
Monday Seminar (Internal)
Speaker: WU Shuangyang (Dolan), SCARAMUZZA Federico (Tessmar), KROGULL Daniel (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
The recently discovered ties between teeth and infants in human evolution
Speaker: Leslea HluskoInstitute: CENIEHHost: Nicole Grunstra
Characterisation of Vpr1, a novel protein involved in DSB repair
Speaker: Mustafa AlaaboInstitute: Dept. Chromosome Biology, Univ. ViennaHost: Franz Klein
Title to be announced
Speaker: Roberto CerbinoInstitute: University of ViennaHost: Arthur Sedivy
Marine symbioses fueled by wood
Speaker: Dan DistelInstitute: Ocean Genome Legacy CenterHost: Jillian Petersen
New insights in gene regulation and chromatin folding by enhancers and cohesin
Speaker: Wouter de LaatInstitute: Hubrecht InstituteHost: Christa Bücker
Molecular mechanism analysis involved in mitochondrial sheath formation and spermiation processes using gene-manipulated mice
Speaker: Keisuke ShimadaInstitute: Research Institute for Microbial Diseases, Osaka UniversityHost: Andrea Pauli
Monday Seminar (Internal)
Speaker: JELENIC Stela (Saha), ABDRAKHMANOV Alibek (Dagdas), GALUSKA Philipp (Djinovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Christoph KreutzInstitute: University of InnsbruckHost: Georg Kontaxis
Microbial trait-based scaling from single populations to communities with consequences for ecosystem processes
Speaker: Ashish MalikInstitute: University of AberdeenHost: Andreas Richter
How chromosome architecture shapes brain architecture
Speaker: Daniele CanzioInstitute: UCSFHost: Anton Goloborodko
Monday Seminar (Internal)
Speaker: MAYER Rupert (Proteomics Tech Hub), WILLIAMS Thomas (Clausen), GEISMANN Maximilian (Balzarotti)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Comprehensive and quantitative characterization of aneuploidy phenotypes
Speaker: Manuela Sophie KollerInstitute: Dept. Chromosome Biology, Univ. ViennaHost: Chris Campbell
Cellular crosstalk in Neurodevelopmental Disorders
Speaker: Silvia CappelloInstitute: MPI of Psychiatry MunichHost: Jürgen Knoblich
Top down and bottom up exploration of human gut microbial communities
Speaker: Karoline FaustInstitute: KU LeuvenHost: Lucia Fuchslueger
Title to be announced
Speaker: Chris OostenbrinkInstitute: BOKU WienHost: Kristina Djinovic-Carugo
Monday Seminar (Internal)
Speaker: PACHECO FIALLOS Franics Belen (Plaschka), FONTES OLIVEIRA Tiago Manuel (Penninger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
The Mirage of Biosocial Complexity: Critique and Collaboration Around the Tools of Epigenetics
Speaker: Luca ChiapperinoInstitute: Institute of Social Sciences (ISS), University of LausanneHost: Vienna Open Lab
Monday Seminar (Internal)
Speaker: KHALDIEH Nina (Ameres), LORENZO ORTS Laura (Pauli), ROSS James (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Samer HattarInstitute: NIHHost: Kristin Tessmar
Monday Seminar (Internal)
Speaker: RAFFL Gerald (Ameres), SAJTOS Bettina (Zuber), LANGER Christoph (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Anshul KundajeInstitute: Stanford UniversityHost: Alex Stark
Monday Seminar (Internal)
Speaker: STEINACKER Thomas (Gerlich), EDER Stephanie (Zimmer), TIKANOVA Polina (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SCHELLHAAS Ulla (Plaschka/Ameres), RUSCH Emma (Goloborodko), VULIN Milica (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RADHAKRISHNA PILLAI Balashankar (Saha), MIGOTTI Mario (Konrat), RÖHNSER Josef (Pauli)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BELL Caelan (Gerlich), MEREITER Stefan (Penninger), BINDL Michael (Leeb)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LORBEER Franziska (Stark), MULVEY Hugh (Dolan), PÜHRINGER Florian (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HOLZER Elisabeth (Martens), COLOZZA Gabriele (Koo), FALCON CHAVEZ Francisco (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BLAHA Andreas (Pauli), OKUN Anastasia (Karagöz), JUNG Pauline (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Sir Philip CohenInstitute: University of DundeeHost: Egon Ogris
Monday Seminar (Internal)
Speaker: LICHT-MAYER Simon (Penninger), CAYGILL Samuel (Dolan), ADELMANN Leonie (Raible)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Feng ShaoInstitute: National Institute of Biological Sciences, BeijingHost: Pavel Kovarik
Monday Seminar (Internal)
Speaker: SHUNMUGAM Dhanlakshmi (Baccarini), CECI GINISTRELLI Lavinia (Mendjan), VORLÄNDER Matthias (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Jan LöweInstitute: MRC Laboratory of Molecular BiologyHost: Jan-Michael Peters
Monday Seminar (Internal)
Speaker: KOK Jian Yi (Berger), GROH Roan (Dagdas), SODERHOLM Adrian (Versteeg)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Stephan GruberInstitute: University of LausanneHost: Franz Klein
Title to be announced
Speaker: Lydia FinleyInstitute: Memorial Sloan Kettering Cancer CenterHost: Johannes Zuber
Monday Seminar (Internal)
Speaker: STRAVS Ana (Knoblich), SANCHEZ DE MEDINA HERNANDEZ Victor (Dagdas), HORENKAMP Simone (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: PROTELL I DE MONTSERRAT Julia (Brennecke/Plaschka), NAGUMO WONG Sakurako (Knoblich), CORIC Aida (Tessmar)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Nancy KlecknerInstitute: Harvard UniversityHost: Franz Klein
Title to be announced
Speaker: Vera Gorbunova and Andrei SeluanovInstitute: University of RochesterHost: EDI group at GMI/IMBA/IMP
Monday Seminar (Internal)
Speaker: GRABARCZYK Daniel (Clausen), TAVERINI Katherina (Urban), MANCHENO JUNCOSA Estela (Mendjan)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Edward LemkeInstitute: IMB MainzHost: David Haselbach
Monday Seminar (Internal)
Speaker: ATTRILL Sarah (Dolan), UIJTTEWAAL Esther (Elling), SCIBISZ Grzegorz (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: DOLESCHALL Balint (Knoblich), FENG Sonjie (Bücker), BOURGUET Pierre (Berger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Rotem SorekInstitute: Weizmann Institute of Science, RehovotHost: Julius Brennecke
Monday Seminar (Internal)
Speaker: KRUMWIEDE Luisa (Gaidt), CASEY Chloe (Dolan), KAPRAL Thomas (Zagrovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KOBAKHIDZE George (Dong), ANGELOPOULOU Eleni (Ellis), PACHANO Tomas (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Stephan GrillInstitute: MPI of Molecular Cell Biology and GeneticsHost: Clemens Plaschka
Monday Seminar (Internal)
Speaker: RAMIREZ America (Köhler), VÖLKL Isabella (Bücker), HOANG Oi Pui (Technau)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Mounia LaghaInstitute: Institut de Genetique Moleculaire de MontpellierHost: Andrea Pauli
Monday Seminar (Internal)
Speaker: LEITNER Moritz (Martinez), VOGEL Alexander (Yudushkin), KETTEL Paulina (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Martin HetzerInstitute: IST AustriaHost: Jürgen Knoblich
Monday Seminar (Internal)
Speaker: TSAREV Aleksandr (Ameres), FIESELER Charlie (Zimmer), ABESAMIS Kim Ivan (Dong)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Laurent NguyenInstitute: University of LiegeHost: Noelia Urban
Monday Seminar (Internal)
Speaker: HEIDARI KHOEI Heidar (Rivron), KLEIFELD Justus (Urban), ORLIC Lucija (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Ian HicksonInstitute: University of CopenhagenHost: Joao Matos
Monday Seminar (Internal)
Speaker: SHULKINA Alexandra (Versteeg), GEETHA Sowmya (Jantsch), MADHUSUDHANAN Jalaja (Zimmer)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KOLLER Manuela (Campbell), GUPTA Ankit (Goloborodko), SCHMÖLLERL Johannes (Zuber)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: MARCHIORI Elisa (Van der Veeken), ACHLEITNER Anja (Martens), FAAS Victoria (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SALEWSKIJ Kirill (Penninger), KIRCHGATTERER Paul (Gaidt), REN Kaike (Otsuka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: MIHAILOVIC Milica (Karagöz), BELL Lillie (Clausen), TELONI Federico (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: STANKUNAS Edvinas (Köhler), CASEY Alexandra (Dolan), LEV Itamar (Zimmer)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: OBERHUEMER Michael (Leeb), GONAZLEZ ALVARADO Maria (Grade), SCHOLZ Julia (Otsuka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: AMANN Sascha (Haselbach), KASHKO Nataliia (Matos), BAUER Bernd (Martens)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LEE Joonsun (Elling), LEYVA GONZALEZ Marco (Tanaka), MILIVOJEV Nadja (Raible)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: GAO Peng (Dagdas), GOGOVA Rebeca (Clausen), PAVLOVA Anzhela (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: AYALA MUNOZ Farja (Plaschka), VETRANO Pamela (Ramundo), YU Changwei (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KONSTANTINOU Andri (Obenauf), NAVA GARCIA Marintia (Dagdas), WOLFF Uyen Le Phuong (Jantsch V.)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HARTMANN Felix (Matos), PASSERA Alessandro (Balzarotti), SANCHEZ BURGOS Laura (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HODAKOVA Zuzana (Haselbach), MYLARSHCHIKOV Dmitry (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Johannes WalterInstitute: Harvard Medical SchoolHost: Jan-Michael Peters
Monday Seminar (Internal)
Speaker: PIECH Lucas (Leonard), DE LA CONCEPCION Juan Carlos (Dagdas), POPOVA Mariia (Peters)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: GALLI Lucrezia (Tanaka), DIAS Ana Beatriz (Slade), TAKACS Zsuzsanna (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KNIEST Judith (Haselbach), KELLNER Max (Penninger), BABADEI Olga (Decker)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BOHAUMILITZKY Lena (Pinheiro), RAIDERS Stephan (Tanaka), PRLESI Ines (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: PITASI Mattia (Leeb), HEINZL Monika (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: VELETI Lalitha (Pauli), NAAS Julia (Van Haeseler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: FARAWAY Rupert (Plaschka), GRUNDMANN Lorenz (Haselbach), KLEINWAECHTER Ava (Slade)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RÖTZER Johannes (Dolan), MIOCIC-STOSIC Fran (Zagrovic), RITSCHKA Birgit (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: PUSHPA BOSE Greeshma (Urban), RAINA Shiviya (Dammermann)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: COUTURIER Jeanne (Jachowicz), PABST Gabriel (Zuber), ROFFAY Chloe (Pinheiro)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RUSSETT Colleen (Berger), NAJM Ramsey (Knoblich), HOLLAUS David (Gaidt)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SHARMA Sanskriti (Ellis), JANKOWSKA Julia (Ameres), PAPAREDDY Ranjith (Dagdas)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: MAURER Eric (Peters), BHARDWAJ Vishakha (Schlögelhofer), DIEZMA Laura (Nordborg/Mari-Ordonez)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: GUZMAN PEREZ Sebastian (Martinez), LITTLEBOY Jamie (Knoblich), RIABOV Daria (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ZEILER Christina (Kovarik), DOCAVO GARCIA Antonio (Jachowicz), Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ZMAJKOVIC Jakub (Zuber), DEL CHIARO Alessia (Dagdas), ANTONIOLI Sumire (Leonard)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HUETTER Christiane (Menche), KRACHT Laura (Knoblich), SANDRU Ana Maria (Baccarini)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BENEDUM Johannes (Slade), KALIS Robert (Zuber), PATEL Rajvi (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: PROTSENKO Liudmila (Brennecke), SHETTY Kavya (Hein), BASSAT Elad (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs