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Physiological processes are driven by the coordinated action of organs, tissues and cells. Coordination of these activities allows organisms to respond appropriately to their changing environment. Within cells themselves, important metabolic processes are often compartmentalised by membranes, which necessitates the flow of information between compartments. How is this information integrated into the appropriate downstream response? We try to understand the basic principles that govern the flow of information in cells with particular emphasis on the role of lipid second messengers. By understanding the mechanisms by which these signals are transduced and propagated, we can better answer why and how things go wrong in disease.
We study how lipids regulate the activity of signaling enzymes, including both protein kinases and phosphatases. We use biochemical and cell biological assays supported by biophysical and structural techniques to deduce how, where, and when the signal is transduced. Our work is underpinned by quantitative biochemistry performed with precisely defined macromolecules. The insights we derive have the potential to rationalize disease pathogenesis at the molecular and atomic levels. For example, in the pro-growth and survival kinase Akt, we have characterized the mechanism by which a mutation associated with cancer and overgrowth disorders leads to kinase activity that is both spatially and temporally de-regulated. Determining how specific mutations drive the development of disease is essential for effective therapeutic intervention.
Thomas studied Biochemistry at the University of Bristol, U.K. before obtaining a PhD in Structural Biology at the MRC Laboratory of Molecular Biology in Cambridge. Thomas moved to the USA in 2005 as an EMBO postdoctoral fellow at the National Institutes of Health in Bethesda, MD and started his own lab as an independent investigator at the Max Perutz Labs in 2012.
Campus Vienna Biocenter 5
1030 Vienna
Room: 1.616
+43-1-4277-52205
Phosphoinositide-dependent kinase 1 (PDK1) is an essential protein kinase that controls cellular and organismal growth. We have elucidated the mechanism by which PDK1 is activated by phosphatidylinositol-3,4,5-trisphosphate (PIP3) at the plasma membrane in response to growth factor-mediated activation of cell surface receptors. Our work reveals previously unknown mechanisms of autoinhibition and trans-autoactivation, with opportunities for the development of novel therapeutics in the treatment of cancer (Levina et al, Nature Communications, 2022).
© Illustration by Dorotea Fracchiolla (Art&Science)
The lipid second messengers PI(3,4,5)P3 and PI(3,4)P2 have long been known to activate Akt by recruiting it to membranes, where it is activated by phosphorylation. We have determined the structure of autoinhibited Akt1, revealing the molecular basis of a disease-causing mutation in the PH domain which gives rise to Proteus Syndrome and some cancers. Phosphorylation is insufficient to fully activate Akt1. Our work implies that Akt signaling is restricted to discrete membrane locations in the cell (Truebestein et al, PNAS, 2021).
Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is activated by the phospholipid phosphatidylinsoitol 3-phosphate (PI3P) in the PI3 kinase pathway. Up-regulation of Sgk3 activity has increasingly been implicated in cancers that exhibit paradoxically low Akt activity. We have discovered that Sgk3 is dependent on PI3P for its activity, which restricts its activity to PI3P-rich endosomes in cells. We have biochemically reconstituted Sgk3 activation downstream of the class III PI 3-kinase Vps34 in vitro (Pokorny et al, Journal of Biological Chemistry, 2021).
Protein Kinase D (PKD) is an essential ser/thr kinase involved in vesicular transport of cargo from the trans-Golgi network to the plasma membrane. We have discovered a novel, ubiquitin-like domain in PKD that mediates its dimerization on diacylglycerol-containing membranes, thereby driving trans-autophosphorylation and activation of its kinase domain (Elsner et al, Journal of Biological Chemistry, 2019).
The protein kinase Akt integrates signals from membrane-embedded lipid second messengers and signals in the form of phosphorylation by upstream protein kinases. We have shown that one without the other is insufficient for Akt activation and that membrane dissociation triggers rapid dephosphorylation and inactivation of Akt (Lučić et al, PNAS, 2018).
We recently demonstrated that the activity of a protein kinase called Akt, which promotes cell growth and proliferation, is strictly governed by the engagement of two specific lipids in cell membranes (Ebner & Lučić et al, Molecular Cell, 2017). Bypassing this requirement leads to uncontrolled growth and cancer.
We have discovered an allosteric switch in the Src and Tec kinases that converts them into active enzymes by promoting the exchange of ADP for ATP (von Raußendorf et al, Scientific Reports, 2017). The switch depends on recognition of a polyproline motif in the tail of activated receptors at the plasma membrane.
Rho-associated coiled-coil kinase (ROCK) is a key signal transducer in regulating the cytoskeleton. Substrate engagement is controlled by the precise positioning of its kinase domains, which is achieved via a long coiled-coil domain that bridges its membrane binding domains to its kinase domains (Truebestein et al., Nature Communications, 2016).
Membranes are sites of intense signaling activity in eukaryotic cells. Essential processes such as autophagy, cytokinesis, exo- and endo- cytosis, and cytoskeletal remodeling depend on signal propagation at cellular membranes. Dysregulation of signal transduction at these sites is the cause of a number of hereditary and non-hereditary diseases, including Coffin-Lowry syndrome, spinocerebellar ataxia, myotonic dystrophy, and various cancers. Over 500 kinases and 130 phosphatases regulate signal transduction by phosphorylating or dephosphorylating their target proteins. Given that the chemistry of phosphoryl transfer is conserved, there is a clear need for compartmentalization of what are essentially the same chemical reactions.
One of the most important consequences of the activation of cell surface receptors is the generation of small molecule second messengers. In addition to the freely diffusible second messengers such as cAMP and inositol-1,4,5-triphosphate (IP3), a number of cellular second messengers are lipids. Despite being of fundamental importance to the exquisite spatial and temporal regulation of many cellular processes, the molecular mechanisms of lipid-mediated signal transduction are not well understood. Our goal is to understand how lipid second messengers can turn on signaling pathways at the membrane. To achieve this, we are using a spectrum of biophysical (including X-ray crystallography), biochemical, and cell biological techniques. Recently, we have determined the structure of a novel ubiquitin-like domain in Protein Kinase D (PKD) which mediates its dimerization and activation by trans-autophosphorylation on membranes in response to diacylglycerol production downstream of RTK or GPCR signaling (Elsner et al., Journal of Biological Chemistry 2019). PKD is an essential mammalian kinase involved in trafficking of cargo destined for secretion from the trans-Golgi network to the plasma membrane.
Many of the lipid responsive human protein kinases belong to the AGC family of kinases, of which paradigmatic lipid-activated kinases are Akt and protein kinase C (PKC). In 2017 we demonstrated the allosteric activation of Akt by the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2 for the first time. A mutation in the kinase domain associated with cancer and overgrowth disorders of the brain causes Akt hyperactivation by relieving autoinhibition (Ebner and Lučić et al., Molecular Cell 2017). In our most recent work on Akt, we describe the mechanism of activation in more detail and identify the allosteric coupling between PH domain-mediated autoinhibition and the inactivation of Akt by dephosphorylation (Lučić et al.,PNAS 2018; Leonard [Reply to Letter to Editor], PNAS 2018). Conceptually, Akt can be thought of as an AND gate that integrates multiple signals to drive the biological response.
Fundamentally, we aim to describe signal transduction processes with deep mechanistic insight. By combining structure with quantitative in vitro biochemistry on rigorously validated samples, we can probe the structure-function relationship in absolute terms. We have recently applied these principles to study the Tec and Src family tyrosine kinases, work which has revealed a previously unknown switch in nucleotide binding that drives kinase activation (von Raußendorf et al., Sci Rep 2017).
Protein kinase C (PKC) is regulated by multiple membrane binding domains that respond to calcium, phospholipids, and the lipid second messenger diacylglycerol (DAG). PKC is held in an inactive conformation in resting cells by a complex network of intramolecular interactions that sequester its membrane binding domains and prevent substrate binding by its kinase domain. Using a dual color in vivo membrane translocation assay, we have shown that the ten mammalian PKCs adopt a conserved three-dimensional architecture despite domain rearrangements in their primary sequences (Lučić et al., Journal of Molecular Biology, 2016).
We are also interested in how signal transduction pathways are organized. Scaffolding of signaling proteins in the same pathway enhances specificity, promotes signal amplification by reducing noise, and, ultimately, improves signal propagation through the pathway. Membranes act as the scaffolds for many signaling reactions, including those involved in regulation of the actin cytoskeleton (Truebestein et al., Nature Communications 2016). Our studies are aimed at understanding how diverse signals are integrated, how substrate specificity is encoded not just at the kinase level, and the influence of the membrane environment on multi-component signaling hubs. This is an exciting area of research with frontiers in ageing, cancer, metabolic diseases such as diabetes, and obesity.
Sumire Antonioli
PhD Student +43-1-4277-52241
Room: 1.222
Julia Gobl
+43-1-4277-52275
Room: 1.321.1
Thomas Leonard
Group Leader +43-1-4277-52205
Room: 1.616
Aleksandra Levina
PhD Student +43-1-4277-52275
Room: 1.321
Ronja Reinhardt
PhD Student +43-1-4277-52275
Room: 1.321
Katharina Siess
PhD Student +43-1-4277-52241
Room: 1.222
The regulation of protein kinase activity by activation loop phosphorylation is a well-characterized mechanism. Protein kinases that auto-phosphorylate usually do so in trans: dimerization results in reciprocal phosphorylation of the activation loop by the other protomer. However, we have discovered that Protein Kinase D (PKD) has evolved the inverse solution to the same problem. PKD is an inactive dimer that is activated by kinase domain dissociation followed by cis-autophosphorylation.
Thomas will present at the upcoming FASEB Science Research Conference 'Protein Kinases and Protein Phosphorylation: Mechanisms to Therapeutics', which is being held in Nova Scotia, Canada. He will discuss our recent work on the 'master' kinase PDK1, the implications of the work for cellular signaling downstream of PDK1, and therapeutic opportunities in cancer treatment.
The myotonic dystrophy kinases of the DMPK family are conserved regulators of actomyosin contractility. The four prototypical DMPK members are obligate homodimers with a conserved architecture of N-terminal kinase domains, a central coiled-coil, and C-terminal membrane binding domains. Remarkably, the length of the coiled-coil domain of each family member varies between 10 and 145 nm, but is astonishingly well conserved. We present a model in which the activity of these kinases is regulated by their spatial positioning with respect to the membrane.
Congratulations, Linda and Harald, whose work has been featured in the ESRF Highlights 2021 magazine. To read about their work on Akt activation by PIP3, click on the link below to download the magazine.
Congratulations, Dr. Pokorny! Good luck in your next career step and thanks for everything you have contributed to the lab over the last 4 years. It has been a pleasure having you in the lab and we will for sure miss you. Daniel starts work in January at DIANA Biotechnologies, a biotech spin-off of the Institute of Organic Chemistry and Biochemistry, Prague. We wish him all the best in his new career!
April 15th 2021 - launch of a new Master's course in Molecular Precision Medicine. The program is dedicated to an understanding of human pathogenesis and the treatment of disease at a molecular and mechanistic level. The course brings basic, translational, and clinical scientists together with doctors to educate students in the opportunities, challenges, and future perspectives of precision medicine. Curriculum Director: Thomas Leonard.
The PI is perfectly normal - honestly. 2 years after his students bought him a bungee jump for becoming a tenured Professor at the Max Perutz Labs, Thomas thanked them all and stepped off Jauntalbrücke in Carinthia, Austria for a 96 m plunge towards the river below. Sadly, none of his students could be convinced to jump with him. Check out the video to see what students can do for their PI!
Congratulations Kathi on the cover of Biochemical Society Transactions! In this mini-review, we discuss the mechanisms by which Akt is activated and inactivated with a particular focus on the roles of the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2. We also examine how redistribution of these lipids within the endomembrane system has the potential to both spatially and temporally control Akt activity at cellular compartments distal to the plasma membrane.
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.
Levina, Aleksandra; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation.
Truebestein, Linda; Hornegger, Harald; Anrather, Dorothea; Hartl, Markus; Fleming, Kaelin D; Stariha, Jordan T B; Pardon, Els; Steyaert, Jan; Burke, John E; Leonard, Thomas A
In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.
Pokorny, Daniel; Truebestein, Linda; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A
A ubiquitin-like domain controls Protein Kinase D dimerization and activation by trans-autophosphorylation.
Elsner, Daniel J; Siess, Katharina M; Gossenreiter, Thomas; Hartl, Markus; Leonard, Thomas A
Conformational sampling of membranes by Akt controls its activation and inactivation.
Lučić, Iva; Rathinaswamy, Manoj K; Truebestein, Linda; Hamelin, David J; Burke, John E; Leonard, Thomas A
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
Michael Ebner, Iva Lučić, Thomas A. Leonard, and Ivan Yudushkin
A molecular ruler regulates cytoskeletal remodelling by the Rho kinases
Truebestein, L., Elsner, D.J., Fuchs, E., Leonard, T.A.
Project title: 'PI3K signaling - navigating upstream and downstream of Akt' (P 33066)
Dr. Linda Trübestein is a recipient of a Hertha Firnberg Postdoctoral Fellowship (FWF).
Project title: 'Bridging the Gap - Regulation of the Cytoskeleton by the DMPK kinases' (T 915)
Project title: 'Structure, Function, and Regulation of Protein Kinase D' (P 30584)
Project title: 'Regulation of the membrane-associated tumor suppressor phosphatase PHLPP'
Project title: 'Lipid-activated kinases in cell shape and motility' (P 28135)
The Leonard Group is a member of the special doctoral program 'Signaling Mechanisms in Cellular Homeostasis (W1261)', reviewed and funded by the Austrian Science Fund (start 2017).
Breathing at High Altitude
May 19 - Jun 15
University of Vienna, Inner court (Arkadenhof), Universitätsring 1“Breathing at High Altitude” is an exhibition dedicated to the personal life and science of Max F. Perutz, a pioneer of 20thcentury molecular biology. The exhibition sheds light on Max Perutz’s fascinating life, celebrates his love for mountains, and visualizes “breathing” in a unique way. It will be a rewarding experience for scientists and non-scientists alike.
May 19 – June 15 Mon – Fri 9:00 – 18:00 University of Vienna, Inner court (Arkadenhof), Universitätsring 1, 1010 Vienna
How cells defend their cytosol against cytosol-invading bacteria: LPS ubiquitylation and other tricks
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Felix RandowInstitute: MRC-LMPHost: Moritz Gaidt
Identifying new disease-related mechanisms for genetic cardiomyopathy
16:00 - 17:00 IMP Lecture HallSpeaker: Eva van RooijInstitute: Hubrecht InstituteHost: Sasha Mendjan
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SCHMÖLLERL Johannes (Zuber), FAAS Victoria (Clausen), ANISIMOVA Aleksandra (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Max Perutz: a not so quiet life
May 31 - May 31 University of Vienna, Marietta Blau lecture hall and courtyard (Arkadenhof), Universitätsring 1Max Perutz’ scientific journey from the Theresianum in Vienna to the Cavendish Laboratory in Cambridge arguably laid the foundations of modern molecular biology. Awarded the Nobel Prize in 1962 for his work on hemoglobin, Max’ legacy continues today at the research institute that bears his name in the city where he was born.
You will hear about Max’ natural curiosity, the scientific question that he dedicated most of his life to answering - how does hemoglobin transport oxygen? - and the tireless perseverance required to achieve his goal.
Gene transcription: from mechanisms to regulation
11:00 - 12:00 IMP Lecture HallSpeaker: Patrick CramerInstitute: MPI for Biophysical ChemistryHost: Alex Stark, Clemens Plaschka
A detailed analysis of the (static and dynamic) local conformations of proteins
14:00 - 15:00 Lecture hall AandB, VBC5/ZoomSpeaker: Alexandre G de BrevernInstitute: INSERM - French National Institute of Health and Medical ResearchHost: Oliviero Carugo
The genetic basis for diversification of leaf form: from understanding to reconstructing
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Miltos TsiantisInstitute: MPI for Plant Breeding ResearchHost: Yasin Dagdas
HistONe and HistOFF: Measuring Nucleosome Exchange Dynamics
11:30 - 12:30 GMI Orange Seminar roomSpeaker: Gilad YaakovInstitute: Weizmann Institute of Science, RehovotHost: Fred Berger
Molecular mechanism and folding dynamics of large non-coding RNAs
14:00 - 15:00 VBC5 Lecture Hall A+B/ZoomSpeaker: Marco MarciaInstitute: EMBL GrenobleHost: Kristina Djinovic-Carugo
Microbial Storage Compounds
12:00 - 13:00 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Michaela DippoldInstitute: Georg-August-Universität GöttingenHost: Andreas Richter, Wolfgang Wanek
Title to be announced
09:00 - 10:00 IMP Lecture HallSpeaker: Uli TechnauInstitute: University of Vienna
Remembering who we are: how chromatin controls cell identity
18:00 - 19:00 Lecture Hall 1 (HS1) - University of Vienna Biology BuildingSpeaker: Susan GasserInstitute: University of Lausanne
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BRAGULAT TEIXIDOR Helena (Otsuka), SALEWSKIJ Kirill (Penninger), KAGAWA Harunobu (Rivron)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
09:00 - 10:00 MFPL main building, 6th floor, Room 6.501 (SR1)Speaker: Kelly SwartsInstitute: GMI
Title to be announced
09:00 - 10:00 IMP Lecture HallSpeaker: Jan-Michael PetersInstitute: IMP
Single-cell and population mechanisms controlling neural stem cell maintenance in the zebrafish adult brain
14:00 - 15:00 ZoomSpeaker: Laure Bally-CuifInstitute: Institut Pasteur and CNRS UMR3738Host: SFB Neuro Stem Modulation
Title to be announced
09:00 - 10:00 IMBA/GMI Lecture HallSpeaker: David HaselbachInstitute: IMP
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: CASEY Alexandra (Dolan), CERRON ALVAN Luis Miguel (Leeb), SIDHAYE Jaydeep (Knoblich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Dual inhibition of angiotensin-converting enzyme (ACE) and neprilysin - a potential new therapy for hypertension and heart failure
14:00 - 15:00 Lecture hall AandB, VBC5/ZoomSpeaker: Ed SturrockInstitute: University of KapstadtHost: Tim Skern
Title to be announced
09:00 - 10:00 MFPL main building, 6th floor, Room 6.501 (SR1)Speaker: Bojan ZagrovicInstitute: Max Perutz Labs
Antarctic Research on Methane Production in Oxygenated Waters in Ice Covered Lakes
16:00 - 17:00 ZoomSpeaker: Wei LiInstitute: Lawrence Livermore National LaboratoryHost: Christopher Sedlacek
Structural insights into tail-anchored membrane protein biogenesis by the GET insertase complex
14:00 - 15:00 VBC5 Lecture Hall A+B/ZoomSpeaker: Melanie McDowellInstitute: MPI for BiophysicsHost: Sebastian Falk
Imaging processes of cell division across scales
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Jan EllenbergInstitute: EMBL HeidelbergHost: Shotaro Otsuka
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LOUBIERE Vincent (Stark), NGUYEN Vu (Mittelsten Scheid), STANKUNAS Edvinas (Köhler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
09:00 - 10:00 IMBA/GMI Lecture HallSpeaker: Uli EllingInstitute: IMBA
Title to be announced
09:00 - 10:00 IMBA/GMI Lecture HallSpeaker: Gus VersteegInstitute: Max Perutz Labs
Leveraging the patient as the model to dissect and target metastasis
15:00 - 16:00 GMI Orange Seminar RoomSpeaker: Karuna GaneshInstitute: Sloan Kettering InstituteHost: Anna Obenauf
Title to be announced
14:00 - 15:00 VBC5 Lecture Hall A+B/ZoomSpeaker: Tom MillerInstitute: University of CopenhagenHost: Clemens Plaschka
Life at Nature Genetics: what we do, how scientific publishing works, and how I got here
13:30 - 14:30 GMI Orange Seminar RoomSpeaker: Michael FletcherInstitute: Editor at Nature GeneticsHost: Alex Stark
Long-term single-cell quantification: New tools for old questions
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Timm SchroederInstitute: ETH ZurichHost: Manuela Baccarini
Title to be announced
09:00 - 10:00 IMP Lecture HallSpeaker: Stephanie EllisInstitute: Max Perutz Labs
Title to be announced
09:00 - 10:00 IMP Lecture HallSpeaker: Noelia UrbanInstitute: IMBA
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LEYVA GONZALEZ Marco (Tanaka), MILJKOVIC Frane (Köhler), PINTER Theresa (Busslinger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Andreas MartinInstitute: University of California, BerkeleyHost: David Haselbach
Title to be announced
11:30 - 12:30 GMI Orange Seminar roomSpeaker: Alexey AmuntsInstitute: Science for Life Laboratory, Stockholm UniversityHost: Silvia Ramundo
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KHANDEKAR Ameya (Martinez), SCHOLZ Julia (Otsuka), BAUER Bernd (Martens)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Jay ShendureInstitute: University of WashingtonHost: Alex Stark
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PASSERA Alessandro (Balzarotti), MILIVOJEV Nadja (Raible), HOLCIK Laurenz (Von Haeseler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: IGOLKINA Anna (Nordborg), KRAMMER Teresa (Tanaka), AMANN Sascha Josef (Haselbach)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
European Worm Meeting 2022
Jul 27 - Jul 30We cordially invite you to the 2022 European Worm Meeting (EWM) taking place in Vienna, July 27-30. The meeting is hosted by the University of Vienna.
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SCHMIDT Clara (Mendjan), GOGOVA Rebeca (Clausen), SAAD RODRIGUES Carolina (Schlögelhofer)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: YU Changwei (Brennecke), HAENDELER Simon (Von Haeseler), ALMEIDA Bernardo (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SEONG Jinwoo (Rivron), NAVA GARCIA Marintia Mayola (Dagdas), DENEKE Victoria (Pauli)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Xin ChenInstitute: Johns Hopkins UniversityHost: Fred Berger
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KELLNER Max Josef (Penninger), LEITNER Marie-Christin (Mendjan), HORN Sabrina (Peters)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Mark DawsonInstitute: Peter MacCallum Cancer CentreHost: Johannes Zuber
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: OTSUKI Leo (Tanaka), LEV Itamar (Zimmer), HODAKOVA Zuzana (Haselbach)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Dominique BergmannInstitute: Stanford UniversityHost: Liam Dolan
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BABADEI Olga (Decker), HOLZMANN Viktoria (Rivron), AYALA MUNOZ Farja (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Yves BarralInstitute: ETH ZurichHost: Shotaro Otsuka
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: TAKACS Zsuzsanna (Gerlich), DE LA CONCEPCION Juan Carlos (Dagdas), FEDL Anna (Busslinger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Sophie PetropoulosInstitute: Karolinska InstitutetHost: Nicolas Rivron
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Benoit BruneauInstitute: Gladstone InstitutesHost: Sasha Mendjan
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: GALLI Lucrezia (Tanaka), TERIYAPIROM Isaree (Koo), JACOBS Jelle (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Richard FlavellInstitute: Yale University School of MedicineHost: Meinrad Busslinger
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Bernd BukauInstitute: ZMBHHost: Elif Karagäz
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: POPOVA Mariia (Peters), RITSCHKA Birgit (Tanaka), DOMBEY Rodolphe (Mari-Ordonez)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: INCARBONE Marco (Mittelsten Scheid), GRUNDMANN Lorenz (Haselbach), NEMCKO Filip (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: TELONI Federico (Gerlich), WALLNER Eva-Sophie (Dolan), PUSHPA BOSE Greeshma (Urban)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LIU Haijun (Nordborg), NAVALAYE Tsimafei (Ameres), NAAS Julia (Von Haeseler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:00 - 13:00 IMP Lecture HallSpeaker: CHUGUNOVA Anastasia (Pauli), RÖTZER Johannes (Dolan), JONSSON Gustav (Penninger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KLAUS Loni (Stark), BENEDUM Johannes (Slade), LITTLEBOY Jamie (Knoblich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Daniel MucidaInstitute: Rockefeller UniversityHost: Meinrad Busslinger
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ANTONIOLI Sumire (Leonard), LI Chong (Knoblich), PABST Gabriel (Zuber)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Lacra BintuInstitute: Stanford UniversityHost: Alex Stark
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DIEZMA Laura (Nordborg/Mari-Ordonez), GHOSH Dipannita (Grade), PATEL Rajvi (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be annouced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Adele MarstonInstitute: Wellcome Centre Cell Biology, University of EdinburghHost: Daniel Gerlich, Joao Matos
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KORDIC Darja (Clausen), DEIBER Sebastian (Dolan), GEHRE Maja (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ZMAJKOVIC Jakub (Zuber), MAURER Eric (Peters), NOGALES MORAL Adrian (Köhler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HUETTER Christiane (Menche), BASSAT Elad (Tanaka), PETRZILEK Jan (Ameres)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KALIS Robert (Zuber), NAJM Ramsey (Knoblich), GEROCZ Emoke (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: AUGUSTO Pedro (Zimmer), POLISSENI Claudio (Tanaka), ELEWAUT Anais (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: GUO Pin (Dolan), DAO Pauline (Tessmar), JAVALI Alok(Rivron)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: STUART Hannah (Tanaka), KORESHOVA Alevtina (Burga), ZHAN Ni (Dagdas)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: CRONIN Shona (Obenauf), KANNO Tatsuo (Berger), PACHINGER Claudia (Dammermann)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SHUKLA Vikas (Berger), RODRIGUEZ TERRONES Diego (Tanaka), WIDEN Sonya (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VOICHEK Yoav (Norborg), SESTINI Giovanni (Rivron), PETROULAKI Vasiliki (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BRUNNER Hanna (Haselbach), FRIDRICH Arie (Berger), AKULOVA Vasilina (Swarts)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DE SANTIS Martina (Rivron), BUENDIA Daniel (Mari-Ordonez), VISANPATTANASIN Supapat (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VOJTEK Matus (Stark), LEHMANN Christian (Knoblich), LEE Du-Hwa (Belkhadir)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SPICER Maximilian (Gerlich), ESTIVILL I CAPAAROS Guillem (Obenauf), MURPHY Paul (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: JÄGER Christina (Van der Veeken), PRADHAN Saurabh (Rivron), RAFANEL Baptiste (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BELACIC Katarina (Haselbach), HARVEY Zachary (Berger), MILOJKOVIC Lidija (Urban)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: GOMEZ SEGALAS Alba (Balzarotti), KOLESNIKOVA Sofia (Gerlich), HANDLER Dominik (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BAUCELLS Julia (Dammermann), PANAROTTO-PERICLES Melanie (Peters), VOICHEK Maya Shinan (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DMITRIEV Vladimir (Goloborodko), HISANAGA Tetsuya (Berger), KHALDIEH Nina (Ameres)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SOMMER Theresa (Rivron), SHIRZADIAN YAZD Mehrta (Balzarotti), VERTESY Abel (Knoblich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: POLIKARPOVA Anastasia (Tanaka), CHAKRABORTY Oisorjo (Grade), CORSI Flavia (Goloborodko)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: FESSELET Jeanne (Kovarik), KHAURATOVIC Uladzislava (Matos/Golobordko), SHEN Jingyi (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PERNEBRINK Mattias (Tanaka), HOHMANN Ulrich (Brennecke/Plaschka), MANOLOVA Toni (Falk)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: WU Shuangyang (Dolan), SCARAMUZZA Federico (Tessmar), KROGULL Daniel (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HEIDARI KHOEI Heidar (Rivron), BELL Caelan (Gerlich), GALUSKA Philipp (Djinovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ABDRAKHMANOV Alibek (Dagdas), WILLIAMS Thomas (Clausen), GEISMANN Maximilian (Balzarotti)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: JELENIC Stela (Saha), PACHECO FIALLOS Franics Belen (Plaschka), FONTES OLIVEIRA Tiago Manuel (Penninger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: NAGUMO WONG Sakurako (Knoblich), LORENZO ORTS Laura (Pauli), ROSS James (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RAFFL Gerald (Ameres), SAJTOS Bettina (Zuber), ISHIHARA Keisuke (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: STEINACKER Thomas (Gerlich), EDER Stephanie (Zimmer), TIKANOVA Polina (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SCHELLHAAS Ulla (Plaschka/Ameres), RUSCH Emma (Goloborodko), CLAVEL Marion (Dagdas)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RADHAKRISHNA PILLAI Balashankar (Saha), ADELMANN Leonie (Raible), BLAHA Andreas (Pauli)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VULIN Milica (Obenauf), MEREITER Stefan (Penninger), BINDL Michael (Leeb)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LORBEER Franziska (Stark), MULVEY Hugh (Dolan), PÜHRINGER Florian (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
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Today: 9am - 5pm
Vienna Biocenter (VBC)
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