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Mon

28

Sep 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: DIMITROVA Mariya (Peters), MASSELINK Wouter (Tanaka), JUNG Pauline (Obenauf)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Tue

29

Sep 2020
Impromptu Seminar

The impact of DNA-RNA hybrids on genomic stability and the formation of chromosome structures
  11:00 - 12:00
  Zoom

Speaker: Lorenzo Costantino
Institute: UC Berkeley
Host: Elif Karagöz, Yasin Dagdas

Fri

02

Oct 2020
PhD Defense

Functional characterization of Ustilago maydis effector proteins that suppress plant immunity
  13:00 - 14:00
  MS Teams

Speaker: Fernando Navarrete
Institute: GMI - Djamei Group

Mon

05

Oct 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: FALCON CHAVEZ Francisco Javier (Tanaka), CALDERON DOMINGUEZ Lesly (Busslinger), ANDREEV Veselin Ivanov (Brennecke)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Tue

06

Oct 2020
Max Perutz Labs Impromptu Seminar

Single-molecule imaging of cytoplasmic dynein reveals the mechanism of motor activation and cargo capture
  10:00 - 11:00
  Zoom

Speaker: Vaishnavi Ananthanarayanan
Institute: IISC Bangalore
Host: Roland Foisner

Thu

08

Oct 2020
Seminar Series on Modern Concepts in Structural Biology

Title to be announced
  14:00 - 15:00
  Zoom

Speaker: Jörg Menche
Institute: Universtity of Vienna, Department of Structural and Computational Biology
Host: Kristina Djinovic-Carugo

Mon

12

Oct 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: ASANOVIC Igor (Martinez), TAVERNINI Katherina (Urban), KNOCH Eva (Becker)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

19

Oct 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: REY Ulises (Zimmer), UIJTTEWAAL Esther (Elling), SCHNEIDER Maximilian (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

22

Oct 2020
Impromptu Seminar

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall/Zoom

Speaker: Lora Sweeney
Institute: IST Austria
Host: Elly Tanaka

Mon

02

Nov 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: STOCK Jessica (Pauli), PICCHIANTI Lorenzo (Dagdas), SIDHAYE Jaydeep (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

09

Nov 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: GABARRO SOLANAS Rut (Urban), KAGAWA Harunobu (Rivron), BECERRIL PEREZ Fernando (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

16

Nov 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LEE Joonsun (Elling), DEYETT Alison Ann (Mendjan), VÖLKL Isabella (Bücker)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

23

Nov 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: SCHENK Robyn (Busslinger), HOFBAUER Lorena (Stark), RODRIGUES VIANA Angela Maria (Ameres)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

30

Nov 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: MILJKOVIC Frane (Köhler), STOCKINGER Alexander (Raible), SUGIURA Takuji (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

02

Dec 2020
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Patrick Cramer
Institute: MPI for Biophysical Chemistry
Host: Alexander Stark, Clemens Plaschka

Thu

03

Dec 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Naama Barkai
Institute: Weizmann Institute of Science
Host: Luisa Cochella

Mon

07

Dec 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: FAHRENBERGER Martin (Von Haeseler), BRAGULAT TEIXIDOR Helena (Otuska), DA CUNHA E SILVA MARTINS COSTA Catarina (Knoblich),
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

14

Dec 2020
VDS Lecture

Title to be announced
  17:00 - 18:00
  IMBA/GMI Lecture Hall

Speaker: John Marioni
Institute: EMBL-EBI
Host: Arndt von Haeseler

Mon

14

Dec 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: DUXBURY Zane (Becker), RAUSCHMEIER Rene (Busslinger), CERRON ALVAN Luis Miguel (Leeb)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

17

Dec 2020
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Christopher Vakoc
Institute: Cold Spring Harbor Laboratory
Host: Johannes Zuber

Mon

21

Dec 2020
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: ANISIMOVA Aleksandra (Karagöz), LIN Tzi-Yang (Tanaka), ANDREATTA Gabriele (Raible)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

11

Jan 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: KHANDEKAR Ameya (Martinez), LOUBIERE Vincent (Stark), NGUYEN Vu (Mittelsten Scheid)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

18

Jan 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: PINTER Theresa (Busslinger), MANDLBAUER Ariane (Cochella), CLARKE Amy (Zagrovic)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

21

Jan 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Clifford Brangwynne
Institute: Princeton University
Host: Daniel Gelrich

Thu

28

Jan 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Genevieve Almouzni
Institute: Institute Curie
Host: Fred Berger

Mon

01

Feb 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: HAENDELER Simon (Von Haeseler), KRAMMER Teresa (Tanaka), DENEKE Victoria (Pauli)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

04

Feb 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Arjun Raj
Institute: University of Pennsylvania
Host: Alex Stark

Mon

08

Feb 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LEITNER Marie-Christin (Mendjan), YU Changwei (Brennecke), ALMEIDA Bernardo (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

15

Feb 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LORENZO ORTS Laura (Pauli), HORN Sabrina (Peters), SEONG Jinwoo (Rivron)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

22

Feb 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: SAAD RODRIGUES Carolina (Schloegelhofer), OTSUKI Leo (Tanaka), SCHMIDT Clara (Mendjan)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

25

Feb 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Linda Partridge
Institute: MPI for Biology of Aeging
Host: Noelia Urban

Mon

01

Mar 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LÖFKE Christian (Dagdas), SAVOVA Adriana(Martens), TAKACS Zsuzsanna (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Tue

02

Mar 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Oliver Hobert
Institute: Columbia University
Host: Luisa Cochella, Elly Tanaka

Tue

02

Mar 2021
Symposium

SFB plenary meeting on "Stem Cell Modulation in Neural Development and Regeneration"
  09:00 - 10:00
  IMP Lecture Hall
Wed

03

Mar 2021
Symposium

SY-Stem
  09:00 - 10:00
  IMP Lecture Hall
Mon

08

Mar 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: BATTY Paul Daniel (Gerlich), JACOBS Jelle (Stark), BAUMANN Verena (Martens)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

11

Mar 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Silvia Cappello
Institute: MPI of Psychiatry Munich
Host: Sofia Grade

Mon

15

Mar 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: RITSCHKA Birgit (Tanaka), LEIENDECKER Lukas (Obenauf), PISUPATI Rahul Bharadwaj (Nordborg)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

22

Mar 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: VOGEL Antonia (Clausen), INCARBONE Marco (Mittelsten Scheid), TELONI Federico (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

25

Mar 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Thijn Brummelkamp
Institute: Netherlands Cancer Institute
Host: Johannes Zuber

Mon

29

Mar 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: AYALA MUNOZ Farja Isabel (Plaschka), HOLZMANN Viktoria (Rivron), STALTNER Moritz (Ameres)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

01

Apr 2021
Cancelled

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Doug Higgs
Institute: MRC Weatherall Institute of Medicine
Host: Rushad Pavri

Mon

12

Apr 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: BASSAT Elad (Tanaka), RUANGROENGKULRITH Siwat (Tachibana), DOMBEY Rodolphe (Mari-Ordonez)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

15

Apr 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Jennifer Lippincott-Schwartz
Institute: Janelia Farm
Host: Kristina Djinovic Carugo

Mon

19

Apr 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: FEDL Anna (Busslinger), TERIYAPIROM Isaree (Koo), LI Chong (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

21

Apr 2021
Symposium

Microsymposium on Small RNA Biology
  09:00 - 10:00
  IMP Lecture Hall
Mon

26

Apr 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LIU Haijun (Nordborg), GEHRE Maja (Brennecke), NEMCKO Filip (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

28

Apr 2021
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Joan Massague
Institute: Memorial Sloan Kettering Cancer Center
Host: Anna Obenauf

Thu

29

Apr 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Martin Beck
Institute: MPI of Biophysics
Host: Clemens Plaschka, Shotaro Otsuka

Mon

03

May 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: NAVALAYEU Tsimafei (Ameres), ZMAJKOVIC Jakub (Zuber), JONSSON Gustav (Penninger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

05

May 2021
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Richard Flavell
Institute: Yale University School of Medicine
Host: Meinrad Busslinger

Thu

06

May 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Rahul Satija
Institute: New York Genome Center
Host: Andi Pauli

Mon

10

May 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: HINTERNDORFER Matthias (Zuber), KORESHOVA Alevtina (Burga), REUMANN Daniel (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

17

May 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: NOGALES MORAL Adrian (Köhler), NAJM Ramsey K. (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Wed

26

May 2021
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: Ulrich Hartl
Institute: Max Planck Institute of Biochemistry
Host: Tim Clausen

Thu

27

May 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: David Gilbert
Institute: Florida State University
Host: Rushad Pavri

Mon

31

May 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: CHUGUNOVA Anastasia (Pauli), REITER Franziska (Stark), SGROMO Annamaria (Ameres)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

07

Jun 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: PHILLIPS Alexander William (Keays), WIDEN Sonya Angeline (Burga), VOICHEK Yoav (Nordborg)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

10

Jun 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Hitoshi Kurumizaka
Institute: University of Tokyo
Host: Kikue Tachibana

Mon

14

Jun 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: RODIRUGEZ TERRONES Diego (Tanaka), KORDIC Darja (Clausen), PERSCHY Lorenz (Haselbach)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

17

Jun 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Gioacchino Natoli
Institute: Humanitas University
Host: Meinrad Busslinger

Mon

21

Jun 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: GARCIA LEON Marta (Dagdas), KLAUS Loni (Stark), JAVALI Alok (Rivron)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

28

Jun 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: VOICHEK Maya Shinan (Brennecke), PETRZILEK Jan (Ameres), KALIS Robert (Zuber)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

08

Jul 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Fanni Gergely
Institute: Cancer Research UK, Cambridge Institute
Host: Alex Dammermann

Mon

12

Jul 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: ELEWAUT Anais (Obenauf), ANDRIONE Mara (Zimmer), DAO Pauline (Tessmar)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

15

Jul 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Valter Longo
Institute: USC Leonard David School of Gerontology
Host: Noelia Urban

Mon

19

Jul 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: SALAZAR THULA Oriana Ylida (Zimmer), DUKIC Dejan (Nordborg), HANDLER Dominik (Brennecke)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

22

Jul 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Stefano Di Talia
Institute: Duke University Medical Center
Host: Andi Pauli

Mon

26

Jul 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: LEE Du-Hwa (Belkhadir), PACHINGER Claudia (Dammermann lab), BAUMGARTNER Lisa (Brennecke)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

02

Aug 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: TRASSER Marieke (Mari-Ordonez), JUNKER Sabryna (Clausen), GERT Krista (Pauli)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

09

Aug 2021

Monday Seminar (Internal)
  12:30 - 13:30

Speaker: HOI David (Clausen), HENDY Oliver (Stark)

Mon

16

Aug 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: DE ALMEIDA Melanie (Zuber), BRADAMANTE Gabriele (Mittelsten Scheid), VEEDIN RAJAN Vinoth Babu (Urban)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Mon

23

Aug 2021
Monday Seminar

Monday Seminar (Internal)
  12:30 - 13:30
  IMP Lecture Hall

Speaker: HARVEY Zachary (Berger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs

Thu

02

Sep 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Taekjip Ha
Institute: Johns Hopkins University
Host: Clemens Plaschka

Thu

09

Sep 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Holger Puchta
Institute: Karlsruhe Institute of Technology (KIT)
Host: Ortrun Mittelsten Scheid

Thu

16

Sep 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Didier Stainier
Institute: MPI for Heart and Lung Research
Host: Elly Tanaka

Thu

23

Sep 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Richard Youle
Institute: NIH
Host: Sascha Martens

Thu

30

Sep 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Andrew Dillin
Institute: University of California, Berkeley
Host: Yasin Dagdas

Thu

14

Oct 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Nevan Krogan
Institute: UCSF - Gladstone Institute
Host: Manuela Baccarini

Wed

20

Oct 2021
Max Birnstiel Lecture

Title to be announced
  11:00 - 12:00
  IMP Lecture Hall

Speaker: John Diffley
Institute: The Francis Crick Institute
Host: Rushad Pavri, Jan-Michael Peters

Thu

21

Oct 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Azim Surani
Institute: Gurdon Institute, University of Cambridge
Host: Andi Pauli

Thu

28

Oct 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Michael Lichten
Institute: NIH
Host: Peter Schlögelhofer

Thu

11

Nov 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Julia Mahamid
Institute: EMBL
Host: Shamba Saha

Thu

18

Nov 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Alejandro Sanchez Alvarado
Institute: Stowers Inst. for Medical Research
Host: Elly Tanaka

Thu

25

Nov 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Steve Jackson
Institute: Gurdon Research Institute
Host: Rushad Pavri

Thu

02

Dec 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Adele Marston
Institute: Wellcome Centre Cell Biology, University of Edinburgh
Host: Daniel Gerlich, Joao Matos

Thu

16

Dec 2021
VBC Regular Seminar

Title to be announced
  11:00 - 12:00
  IMBA/GMI Lecture Hall

Speaker: Xin Chen
Institute: Johns Hopkins University
Host: Fred Berger

  • Name
    Phone
    Mail
    Function
    Group
    Room
  • A
  • Dana Abdeen
    +43-1-4277-56261
    PhD Student
    Jantsch V
    5.522
    Main Building
  • Omer Rashid Abdi
    +43-1-4277-61643
    Apprentice
    Köhler A
    3.524
    Main Building
  • Christiane Agreiter
    +43-1-4277-56221
    Technician
    Loidl
    5.515
    Main Building
  • Tanino Albanese
    +43-1-4277-54632
    PhD Student
    Moll
    4.129
    Main Building
  • Bernhard Alber
    +43-1-4277-61631
    Diploma/Master Student
    Blaas
    3.127
    Main Building
  • Manuel Alonso Y Adell
    +43-1-4277-52808
    PostDoc
    Campbell
    5.512/5.513
    Main Building
  • Thomas Altmutter
    +43-1-4277-24003
    IT Support
    3.117
    Main Building
  • Jolanta Ambroz-Kumorowski
    +43-1-4277-24061
    Facility Technician
    8.318
    Main Building
  • Gustav Ammerer
    +43-1-4277-52816
    Group Leader
    Ammerer
    5.113
    Main Building
  • Gabriele Andreatta
    +43-1-4277-74636
    PostDoc
    Raible
    4.501
    Main Building
  • Yasmine Angerer
    +43-1-4277-24072
    Facility Staff
    1.117
    Main Building
  • Aleksandra Anisimova
    +43-1-4277-61653
    PhD Student
    Karagöz
    3.507/ 3.508
    Main Building
  • Dorothea Anrather
    +43-1-4277-52846
    Senior PostDoc
    5.10
    IMP/IMBA
  • Lisa Appel
    +43-1-4277-52807
    PhD Student
    Slade
    5.508
    Main Building
  • Silvia Arce Solano
    +43-1-4277-52225
    PhD Student
    Djinovic
    0612
    VBC 5
  • Alexis Arizpe
    +43-1-79044-9942
    PhD Student
    Swarts
    1104
    VBC 5
  • Hossein Arzani
    +43-1-4277-61812
    PhD Student
    Kuchler
    2.107
    Main Building
  • Igor Asanovic
    +43-1-4277-61815
    PhD Student
    Martinez
    2.512
    Main Building
  • Gerlinde Aschauer
    +43-1-4277-52851
    Program manager
    5.119
    Main Building
  • Alexandros-Vaios Athanasiou
    +43-1-4277-54613
    Diploma/Master Student
    Witte
    4.125/4.127
    Main Building
  • Grace Abiola Atteh
    +43-1-4277-52236
    Diploma/Master Student
    Djinovic
    0326
    VBC 5
  • Zahra Ayatollahi
    +43-1-4277-61609
    PostDoc
    Barta
    3.518
    Main Building
  • B
  • Manuela Baccarini
    +43-1-4277-54607
    Group Leader
    Baccarini
    4.628
    Main Building
  • Andreas Bachmair
    +43-1-4277-74811
    Group Leader
    Bachmair
    5.110
    Main Building
  • Matthias Bärnthaler
    +43-1-4277-24041
    Head of IT
    4.420
    Main Building
  • Andrea Barta
    +43-1-4277-61640
    Lecturer
    Barta
    3.520
    Main Building
  • Antoine Baudrimont
    +43-1-4277-56261
    PostDoc
    Jantsch V
    5.522
    Main Building
  • Verena Baumann
    +43-1-4277-52838
    PhD Student
    Martens
    5.401
    Main Building
  • Andreas Beier
    +43-1-4277-52227
    PhD Student
    Konrat
    0614
    VBC 5
  • Andrej Belokurov
    +43-1-4277-24080
    Facility Technician
    Tessmar
    0.413
    Main Building
  • Johannes Benedum
    +43-1-4277-52807
    Diploma/Master Student
    Slade
    5.508
    Main Building
  • Maximilian Benesch
    +43-1-4277-56221
    Klein
    5.528/5.530
    Main Building
  • Christian Bernhart
    +43-1-4277-52812
    IT Support
    5.617
    Main Building
  • Daniel Bernklau
    +43-1-4277-52805
    PhD Student
    Martens
    5.502
    Main Building
  • Patrick Berthold
    +43-1-4277-24072
    Facility Staff
    1.117
    Main Building
  • Annika Bestehorn
    +43-1-4277-54626
    PhD Student
    Kovarik
    4.514
    Main Building
  • Angela Bienert
    +43-1-4277-61811
    Administration
    Kuchler
    2.107
    Main Building
  • Ivana Bilusic
    +43-1-4277-52804
    PhD Student
    Schroeder
    5.502
    Main Building
  • Wolfgang Binder
    +43-1-4277-24060
    Technician
    3.501
    Main Building
  • Michael Bindl
    +43-1-4277-61645
    Diploma/Master Student
    Leeb
    3.123/3.125
    Main Building
  • Head of Biooptics Facility
    +43-1-4277-61672
    PostDoc
    1.618
    VBC 5
  • Nora Bischoff
    +43-1-4277-54627
    Technician
    Kovarik
    4.514
    Main Building
  • Dieter Blaas
    +43-1-4277-61630
    Group Leader
    Blaas
    3.026
    Main Building
  • Udo Bläsi
    +43-1-4277-54609
    Group Leader
    Bläsi
    4.121
    Main Building
  • Laura Boccuni
    +43-1-4277-54628
    PhD Student
    Decker
    4.522/4.524
    Main Building
  • Jörg Böckelmann
    +43-1-4277-52206
    Administration
    Djinovic
    1.604
    VBC 5
  • Martina Borroni
    +43-1-4277-54627
    PhD Student
    Kovarik
    4.514
    Main Building
  • Margaryta Borysova
    +43-1-4277-74639
    Facility Technician
    0.310
    Main Building
  • Veronika Boskova
    +43-1-4277-74330
    PostDoc
    v. Haeseler
    1.812.3
    VBC 5
  • Michaela Bradlerova
    +43-1-4277-54628
    Diploma/Master Student
    Decker
    4.522/4.524
    Main Building
  • Helena Bragulat Teixidor
    +43-1-4277-61668
    PhD Student
    Otsuka
    3.505
    Main Building
  • Daniel Braun
    +43-1-4277-52272
    PostDoc
    Zagrovic
    1.114
    VBC 5
  • Barbara Brumec
    +43-1-4277-61661
    Technician
    3.518
    Main Building
  • Sven Brüschweiler
    +43-1-4277-52227
    Senior PostDoc
    Konrat
    0614
    VBC 5
  • Michael Bryant
    +43-1-4277-54607
    Diploma/Master Student
    Baccarini
    4.525/4.527
    Main Building
  • Valentina Budroni
    +43-1-4277-54164
    PhD Student
    Versteeg
    4.108
    Main Building
  • Christa Buecker
    +43-1-4277-74646
    Group Leader
    Bücker
    3.626
    Main Building
  • Pisanu Buphamalai
    +43-1-4277-74391
    PhD Student
    Menche
    1803
    VBC 5
  • Sebastian Burgstaller-Muehlbacher
    +43-1-4277-74324
    PostDoc
    v. Haeseler
    1.812.4
    VBC 5
  • C
  • Michael Caldera
    +43-1-4277-74391
    PhD Student
    Menche
    1104
    VBC 5
  • Christopher Campbell
    +43-1-4277-52808
    Group Leader
    Campbell
    5.610
    Main Building
  • Oliviero Carugo
    +43-1-4277-52208
    Djinovic
    1.120
    VBC 5
  • Irene Ceccolini
    +43-1-4277-52229
    PhD Student
    Konrat
    0614
    VBC 5
  • Luis Miguel Cerron Alvan
    +43-1-4277-74645
    PhD Student
    Leeb
    3.123/3.125
    Main Building
  • Weiqiang Chen
    +43-1-4277-52846
    Senior PostDoc
    5.10
    IMP/IMBA
  • Doris Chen
    +43-1-4277-74328
    PostDoc
    Klein
    1.812.3
    VBC 5
  • Martin Chiettini
    +43-1-4277-74390
    Technician
    Menche
    1803
    VBC 5
  • Marius Constantin Chirita Mihaila
    +43-1-4277-52213
    PhD Student
    Juffmann
    1.614
    VBC 5
  • Woong Jae Choi
    +43-1-4277-52241
    Leonard
    1.222
    VBC 5
  • Anastasia Cianciulli Sesso
    +43-1-4277-54631
    PhD Student
    Bläsi
    4.122/4.124
    Main Building
  • Matthew Clarke
    +43-1-4277-52808
    PhD Student
    Campbell
    5.512/5.513
    Main Building
  • Clara Conrad-Billroth
    +43-1-4277-52213
    PhD Student
    Juffmann
    1.614
    VBC 5
  • Aida Coric
    +43-1-4277-74636
    PhD Student
    Tessmar
    4.501
    Main Building
  • Nicolas Coudevylle
    +43-1-4277-52838
    PostDoc
    Martens
    5.401
    Main Building
  • Renate Coufal
    +43-1-4277-24071
    Facility Staff
    1.117
    Main Building
  • Kitti Dora Csalyi
    +43-1-4277-74645
    PostDoc
    Leeb
    3.123/3.125
    Main Building
  • Andrea Czerny
    +43-1-4277-61606
    Lab Assistant
    3.515
    Main Building
  • D
  • Alexander Dammermann
    +43-1-4277-54681
    Group Leader
    Dammermann
    4.609
    Main Building
  • Alberto Danieli
    +43-1-4277-52805
    PhD Student
    Martens
    5.503
    Main Building
  • Pauline Dao
    +43-1-4277-54618
    PhD Student
    Tessmar
    4.510/4.512
    Main Building
  • Lovro Davidovski
    +43-1-4277-54631
    Diploma/Master Student
    Bläsi
    4.122/4.124
    Main Building
  • Thomas Decker
    +43-1-4277-54605
    Group Leader
    Decker
    4.112
    Main Building
  • Isabel Del Pino Gomez
    +43-1-4277-54601
    Lab Assistant
    Bläsi
    4.211/4.411
    Main Building
  • Maria Rosaria Dello Stritto
    +43-1-4277-56261
    PostDoc
    Jantsch V
    5.522
    Main Building
  • Duygu Demiröz
    +43-1-4277-54628
    PhD Student
    Decker
    4.522/4.524
    Main Building
  • Sebastian Didusch
    +43-1-4277-54629
    PhD Student
    Baccarini
    4.525/4.527
    Main Building
  • Ines Dittrich
    +43-1-4277-56241
    Technician
    5.524/5.526
    Main Building
  • Leila Djerlek
    +43-1-4277-61760
    Weitzer
    2.522
    Main Building
  • Kristina Djinovic-Carugo
    +43-1-4277-52203
    Group Leader
    Djinovic
    1.606
    VBC 5
  • Paula Dlugosz
    +43-1-4277-61809
    PostDoc
    Nimpf
    2.110
    Main Building
  • Jeroen Dobbelaere
    +43-1-4277-54619
    PostDoc
    Dammermann
    4.510/4.512
    Main Building
  • Mihaela Dodaj
    +43-1-4277-24072
    Lab Assistant
    1.117
    Main Building
  • Gang Dong
    +43-1-4277-61625
    Group Leader
    Dong
    3.501
    Main Building
  • Coralie Dorard
    +43-1-4277-54630
    PostDoc
    Baccarini
    4.529
    Main Building
  • Pierantonio Doto
    +43-1-4277-52225
    Diploma/Master Student
    Djinovic
    0612
    VBC 5
  • Corinne Drexler
    +43-1-4277-52866
    PhD Student
    Fuchs
    5.506
    Main Building
  • Sharif Duale
    +43-1-4277-61785
    Technician
    2.527
    Main Building
  • E
  • Magdalena Ebinger
    +43-1-4277-74320
    v. Haeseler
    1.812.3
    VBC 5
  • Cornelia Egoldt
    +43-1-4277-56241
    PhD Student
    Schlögelhofer
    5.524/5.526
    Main Building
  • Karin Ehrenreiter
    +43-1-4277-54617
    Administration
    Baccarini
    4.114
    Main Building
  • Janina Eislmayr
    +43-1-4277-54626
    Diploma/Master Student
    Kovarik
    4.516
    Main Building
  • Kevin Eislmayr
    +43-1-4277-54626
    PhD Student
    Kovarik
    4.516
    Main Building
  • Aybala Eker
    +43-1-4277-61812
    Lab Assistant
    Kuchler
    2.107
    Main Building
  • Christiane Elgert
    +43-1-4277-74325
    PostDoc
    v. Haeseler
    1.812.4
    VBC 5
  • Rainer Ettelt
    +43-1-4277-54630
    PhD Student
    Baccarini
    4.529
    Main Building
  • F
  • Martin Fahrenberger
    +43-1-4277-74330
    PhD Student
    v. Haeseler
    1.812.2
    VBC 5
  • Sebastian Falk
    +43-1-4277-74360
    Group Leader
    Falk
    1.622.1
    VBC 5
  • Renate Fauland
    +43-1-4277-50115
    Administration
    6.111a
    Main Building
  • Markus Faulend
    +43-1-4277-24043
    IT Support
    2.116
    Main Building
  • Michael Feichtinger
    +43-1-4277-52227
    PhD Student
    Konrat
    0614
    VBC 5
  • Simona Ferraioli
    +43-1-4277-61681
    PhD Student
    Foisner
    3.110
    Main Building
  • Luca Ferrari
    +43-1-4277-52828
    PostDoc
    Martens
    5.502
    Main Building
  • Inês Ferreira Coelho
    +43-1-4277-74320
    PhD Student
    v. Haeseler
    1.812.3
    VBC 5
  • Jeanne Fesselet
    +43-1-4277-54626
    Diploma/Master Student
    Kovarik
    4.516
    Main Building
  • Petra Fichtinger
    +43-1-4277-61681
    Lab Manager
    Foisner
    3.110
    Main Building
  • Daria Filipczak
    +43-1-4277-61681
    PhD Student
    Foisner
    3.110
    Main Building
  • Sarah Fink
    +43-1-4277-52808
    Technician
    Campbell
    5.512/5.513
    Main Building
  • Philipp Fischer
    +43-1-4277-54628
    Technician
    Decker
    4.525/4.527
    Main Building
  • Katrin Fischer
    +43-1-4277-54628
    PhD Student
    Decker
    4.522/4.524
    Main Building
  • Sabine Fischer
    +43-1-4277-24014
    Administration
    3.117
    Main Building
  • Irmgard Fischer
    +43-1-4277-52866
    Imaging Specialist (In House Microscopes)
    5.401
    Main Building
  • Roland Foisner
    +43-1-4277-61680
    Group Leader
    Foisner
    3.113
    Main Building
  • Maurizio Forte
    +43-1-4277-54626
    PhD Student
    Kovarik
    4.516
    Main Building
  • Dorotea Fracchiolla
    +43-1-4277-52805
    PostDoc
    Martens
    5.502
    Main Building
  • Ingrid Frohner
    +43-1-4277-61740
    PostDoc
    Ogris
    2.130
    Main Building
  • Peter Fuchs
    +43-1-4277-52855
    Group Leader
    Fuchs
    5.024
    Main Building
  • Sándor Fülöp
    +43-1-4277-24013
    Administration
    3.117
    Main Building
  • G
  • Laura Gallego
    +43-1-4277-61641
    PostDoc
    Köhler A
    3.522
    Main Building
  • Joachim Garbrecht
    +43-1-4277-54621
    PhD Student
    Dammermann
    4.508
    Main Building
  • Julia Garcia Baucells
    +43-1-4277-24001
    PhD Student
    Dammermann
    4.508
    Main Building
  • Konstantina Georgiou
    +43-1-4277-61681
    PhD Student
    Foisner
    3.110
    Main Building
  • Clemens Geppner
    +43-1-4277-61668
    Diploma/Master Student
    Otsuka
    3.505
    Main Building
  • Flora Gere
    +43-1-4277-52828
    Diploma/Master Student
    Martens
    5.503
    Main Building
  • Gabriela Gerecova
    +43-1-4277-52806
    PostDoc
    Ammerer
    2.122
    Main Building
  • Devon Germain
    +43-1-4277-61823
    PostDoc
    Martinez
    2.515
    Main Building
  • Netsanet Getachew
    +43-1-4277-74636
    Technician
    Tessmar
    4.501
    Main Building
  • Santhosh Kumar Ghadge
    +43-1-4277-61671
    PostDoc
    Foisner
    3.009
    Main Building
  • Marion Goldeck
    +43-1-4277-61816
    PostDoc
    Martinez
    2.512
    Main Building
  • Boris Görke
    +43-1-4277-54603
    Group Leader
    Görke
    4.113
    Main Building
  • Irene Gösler
    +43-1-4277-61632
    Lab Manager
    Blaas
    3.129
    Main Building
  • Josef Gotzmann
    +43-1-4277-61672
    Head of Facility
    1.618
    VBC 5
  • Angela Graf
    +43-1-4277-56261
    Technician
    Jantsch V
    5.522
    Main Building
  • Claudia Graf
    +43-1-4277-24012
    Administration
    6.109
    Main Building
  • Christa Gregori-Schüller
    +43-1-4277-61806
    Administration
    Kuchler
    2.111
    Main Building
  • Rokas Grigaitis
    +43-1-4277-56231
    PhD Student
    Matos
    5.122/5.123
    Main Building
  • Tamara Groffics
    +43-1-4277-61668
    Lab Manager
    Otsuka
    3.505
    Main Building
  • Martin Groznica
    +43-1-4277-61631
    Technician
    Kowalski
    3.126
    Main Building
  • Katarzyna Gruber
    +43-1-4277-24075
    Lab Assistant
    1.117
    Main Building
  • Iris Gruber
    +43-1-4277-74320
    Administration
    v. Haeseler
    1.604
    VBC 5
  • Stephan Grüner
    +43-1-4277-54628
    Technician
    Decker
    4.522/4.524
    Main Building
  • Ricardo Mauricio Gudino Carrillo
    +43-1-4277-61641
    Technician
    Köhler A
    3.522
    Main Building
  • H
  • Katharina Haberler
    +43-1-4277-56201
    Administration
    5.115
    Main Building
  • Kathrin Hacker
    +43-1-4277-54614
    Technician
    Versteeg
    4.108
    Main Building
  • Thomas Haden
    +43-1-4277-24042
    IT Support
    2.116
    Main Building
  • Simon Haendeler
    +43-1-4277-74329
    PhD Student
    v. Haeseler
    1.812.2
    VBC 5
  • Sören Häfker
    +43-1-4277-74641
    PostDoc
    Tessmar
    4.504/4.506
    Main Building
  • Anna Hakobyan
    +43-1-4277-74391
    PhD Student
    Menche
    1803
    VBC 5
  • Barbara Hamilton
    +43-1-4277-52814
    Administration
    6.111a
    Main Building
  • Joel Hancock
    +43-1-4277-74391
    PhD Student
    Menche
    1803
    VBC 5
  • Robert Happel
    +43-1-4277-74322
    IT Support
    v. Haeseler
    1.812.1
    VBC 5
  • Andreas Hartig
    +43-1-4277- 52817
    Lecturer
    Hartig
    5.110
    Main Building
  • Natascha Hartl
    +43-1-4277-52846
    Technician
    5.10
    IMP/IMBA
  • Markus Hartl
    +43-1-4277-52846
    Head of Facility
    5.10
    IMP/IMBA
  • Lisa Haselbach
    +43-1-4277-61801
    Administration
    2.115
    Main Building
  • Adrian Henggeler
    +43-1-4277-56231
    PhD Student
    Matos
    5.122/5.123
    Main Building
  • Paola Hentges Pinto
    +43-1-4277-61821
    PhD Student
    Martinez
    2.512
    Main Building
  • Joachim Hermisson
    +43-1-4277-74351
    Group Leader
    Hermisson
    1.722.1
    VBC 5
  • Reinhold Hofbauer
    +43-1-4277-61750
    Group Leader
    Hofbauer
    2.519
    Main Building
  • Tatsiana Hofer
    +43-1-4277-74326
    PhD Student
    v. Haeseler
    1.812.5
    VBC 5
  • Juergen Hoffmann
    +43-1-4277-52213
    Technician
    1.620
    VBC 5
  • Theresa Höfurthner
    +43-1-4277-52263
    PhD Student
    Konrat
    0114
    VBC 5
  • Laurenz Holcik
    +43-1-4277-74325
    PhD Student
    v. Haeseler
    1.812.3
    VBC 5
  • Kay Holleis
    +43-1-4277-61656
    Diploma/Master Student
    Falk
    1.614
    VBC 5
  • David Hollenstein
    +43-1-4277-52838
    PhD Student
    Martens
    5.401
    Main Building
  • Eneda Höllerl
    +43-1-4277-52236
    Technician
    Djinovic
    0326
    VBC 5
  • Elisabeth Holzer
    +43-1-4277-54681
    Diploma/Master Student
    Dammermann
    4.510/4.512
    Main Building
  • Julian Holzinger
    +43-1-4277-52219
    PostDoc
    Konrat
    1.608
    VBC 5
  • Astrid Maria Hölzle
    +43-1-4277-74638
    Technician
    Bläsi
    4.116
    Main Building
  • Harald Hornegger
    +43-1-4277-61653
    PhD Student
    Karagöz
    3.507/ 3.508
    Main Building
  • Lingzhi Huang
    +43-1-4277-56221
    PostDoc
    Klein
    5.401
    Main Building
  • Marie Huber
    +43-1-4277-74647
    Technician
    Bücker
    3.510/3.512
    Main Building
  • Michelle Huth
    +43-1-4277-74644
    Technician
    Leeb
    3.123/3.125
    Main Building
  • I
  • Kyojiro Ikeda
    +43-1-4277-74636
    PostDoc
    Raible
    4.501
    Main Building
  • Lydia Ioannidi
    +43-1-4277-54619
    Schlögelhofer
    5.524/5.526
    Main Building
  • Johanna Irnstorfer
    +43-1-4277-61823
    Diploma/Master Student
    Martinez
    2.512
    Main Building
  • Natale-Erwin Ivessa
    +43-1-4277-61805
    Group Leader
    Ivessa
    2.118
    Main Building
  • J
  • Verena Jantsch-Plunger
    +43-1-4277-56250
    Group Leader
    Jantsch V
    5.118
    Main Building
  • Swathi Jayaram
    +43-1-4277-74646
    PhD Student
    Bücker
    3.510/3.512
    Main Building
  • Sabrina Jenull
    +43-1-4277-61818
    Kuchler
    2.509
    Main Building
  • Aleksandra Jovanovic
    +43-1-4277-52806
    Lab Manager
    Ammerer
    2.122
    Main Building
  • Thomas Juffmann
    +43-1-4277-72520
    Group Leader
    Juffmann
    1.610
    VBC 5
  • Melanie Jungwirth
    +43-1-4277-52236
    Diploma/Master Student
    Djinovic
    0326
    VBC 5
  • Elisabeth Jursa
    +43-1-4277-52875
    Lab Assistant
    5.325
    Main Building
  • K
  • Kristoffer Kainzmayer
    +43-1-4277-54606
    Diploma/Master Student
    Moll
    4.028
    Main Building
  • Thomas Kapral
    +43-1-4277-52272
    Technician
    Zagrovic
    1.114
    VBC 5
  • Elif Karagöz
    +43-1-4277-61635
    Group Leader
    Karagöz
    3.507/ 3.508
    Main Building
  • Ruben Kastner
    +43-1-4277-56241
    Apprentice
    Schlögelhofer
    5.524/5.526
    Main Building
  • Clemens Kauffmann
    +43-1-4277-52292
    PhD Student
    Konrat
    0614
    VBC 5
  • Helga Kaufmann
    +43-1-4277-52801
    Lab Assistant
    5.210/5.410
    Main Building
  • Tanja Kaufmann
    +43-1-4277-52807
    PhD Student
    Slade
    5.508
    Main Building
  • Muna Ayesha Khan
    +43-1-4277-74610
    PostDoc
    Moll
    4.110
    Main Building
  • AMEYA RAKESH KHANDEKAR
    +43-1-4277-61823
    PhD Student
    Martinez
    2.512
    Main Building
  • Sami Khawam
    +43-1-4277-74320
    PostDoc
    Juffmann
    1.610
    VBC 5
  • Narakorn Khunweeraphong
    +43-1-4277-61818
    PostDoc
    Kuchler
    2.509
    Main Building
  • Martin Kiendl
    +43-1-4277-52236
    Diploma/Master Student
    Djinovic
    0326
    VBC 5
  • SEYDA KIGILI
    +43-1-4277-54613
    Diploma/Master Student
    Witte
    4.125/4.127
    Main Building
  • Cornelia Klein
    +43-1-4277-61806
    Administration
    Kuchler
    2.111
    Main Building
  • Franz Klein
    +43-1-4277-56220
    Group Leader
    Klein
    5.114
    Main Building
  • Ava Kleinwaechter
    +43-1-4277-52807
    Diploma/Master Student
    Slade
    5.508
    Main Building
  • Tamara Klockner
    +43-1-4277-52808
    PhD Student
    Campbell
    5.512/5.513
    Main Building
  • Alwin Köhler
    +43-1-4277-61685
    Group Leader
    Köhler A
    3.626
    Main Building
  • Manuela Sophie Koller
    +43-1-4277-53808
    Technician
    Campbell
    5.512/5.513
    Main Building
  • Dhaarsini Koneswarakantha
    +43-1-4277-61821
    PhD Student
    Martinez
    2.515
    Main Building
  • Werner König
    +43-1-4277-52210
    Technician
    1.620
    VBC 5
  • Robert Konrat
    +43-1-4277-52202
    Group Leader
    Konrat
    1.602
    VBC 5
  • Georg Kontaxis
    +43-1-4277-52218
    Facility Manager
    1.608
    VBC 5
  • Katharina Korbula
    +43-1-4277-61626
    Lab Manager
    Dong
    3.501
    Main Building
  • Julius Kostan
    +43-1-4277-52263
    Senior PostDoc
    Djinovic
    0114
    VBC 5
  • Pavel Kovarik
    +43-1-4277-54608
    Group Leader
    Kovarik
    4.615
    Main Building
  • Heinrich Kowalski
    +43-1-4277-61612
    Group Leader
    Kowalski
    3.026
    Main Building
  • Felix Krepler
    +43-1-4277-24065
    Technician
    3.501
    Main Building
  • Karl Kuchler
    +43-1-4277-61807
    Group Leader
    Kuchler
    2.111
    Main Building
  • Claudia Kuntner
    +43-1-4277-56221
    Klein
    5.528/5.530
    Main Building
  • Marie-Therese Kurzbauer
    +43-1-4277-56202
    Program manager
    Schlögelhofer
    5.119
    Main Building
  • L
  • Triin Laos
    +43-1-4277-54621
    PhD Student
    Dammermann
    4.508
    Main Building
  • Cristina Lazar
    +43-1-4277-52236
    Diploma/Master Student
    Djinovic
    0326
    VBC 5
  • Anita Le Heron
    +43-1-4277-54626
    PostDoc
    Kovarik
    4.516
    Main Building
  • Karin Ledolter
    +43-1-4277-52260
    Lab Manager
    Konrat
    0122
    VBC 5
  • Martin Leeb
    +43-1-4277-74644
    Group Leader
    Leeb
    3.123/3.125
    Main Building
  • Günther Leitgeb
    +43-1-4277-54633
    IT Management
    4.420
    Main Building
  • Thomas Lenert
    +43-1-4277-61602
    Administration
    3.115
    Main Building
  • Thomas Leonard
    +43-1-4277-52205
    Group Leader
    Leonard
    1.616
    VBC 5
  • Alina Leuchtenberger
    +43-1-4277-74330
    PhD Student
    v. Haeseler
    1.812.2
    VBC 5
  • Aleksandra Levina
    +43-1-4277-52275
    PhD Student
    Leonard
    1.321
    VBC 5
  • Raffael Lichtenberger
    +43-1-4277-61656
    Technician
    Falk
    1.624
    VBC 5
  • Branislav Lilic
    +43-1-4277-54631
    PhD Student
    Bläsi
    4.122/4.124
    Main Building
  • Sarah Linauer
    +43-1-4277-61760
    Weitzer
    2.522
    Main Building
  • Eszter Lodinsky
    +43-1-4277-52263
    Diploma/Master Student
    Djinovic
    0114
    VBC 5
  • Josef Loidl
    +43-1-4277-56210
    Group Leader
    Loidl
    5.515
    Main Building
  • Salvo Danilo Lombardo
    +43-1-4277-74391
    PhD Student
    Menche
    1803
    VBC 5
  • Joan Lopez Arolas
    +43-1-4277-52225
    Senior PostDoc
    Djinovic
    0612
    VBC 5
  • M
  • Moritz Madern
    +43-1-79044-4291
    Diploma/Master Student
    5.10
    IMP/IMBA
  • Silvia Madritsch
    +43-1-4277-74324
    PhD Student
    v. Haeseler
    1.812.4
    VBC 5
  • Dante Maestre
    +43-1-4277-52213
    PhD Student
    Juffmann
    1.722
    VBC 5
  • Daniel Malzl
    +43-1-4277-74390
    Menche
    1803
    VBC 5
  • Christina Manakanatas
    +43-1-4277-74644
    PhD Student
    Foisner
    3.123/3.125
    Main Building
  • Richard Manning
    +43-1-4277-54613
    Diploma/Master Student
    Witte
    4.125/4.127
    Main Building
  • Toni Manolova
    +43-1-4277-61656
    Diploma/Master Student
    Falk
    1.624
    VBC 5
  • Raphaël Marchand
    +43-1-4277-72523
    PostDoc
    Juffmann
    1.614
    VBC 5
  • Theodor Marsoner
    +43-1-4277-52808
    PhD Student
    Campbell
    5.512/5.513
    Main Building
  • Sascha Martens
    +43-1-4277-52876
    Group Leader
    Martens
    5.113
    Main Building
  • Javier Martinez
    +43-1-4277-61803
    Group Leader
    Martinez
    2.113
    Main Building
  • Fabien Martins
    +43-1-4277-24010
    Financial Director
    6.107
    Main Building
  • Angela Martins
    +43-1-4277-54601
    Administration
    4.114
    Main Building
  • Joao Matos
    +43-1-4277-74419
    Group Leader
    Matos
    5.024
    Main Building
  • Theresa Matzinger
    +43-1-4277-61761
    Weitzer
    2.522
    Main Building
  • Rounik Mazumdar
    +43-1-4277-61818
    PostDoc
    Kuchler
    2.509
    Main Building
  • Jörg Menche
    +43-1-4277-74370
    Group Leader
    Menche
    1804
    VBC 5
  • Mario Migotti
    +43-1-4277-52263
    PhD Student
    Konrat
    0114
    VBC 5
  • Dalibor Milic
    +43-1-4277-52215
    Senior PostDoc
    Djinovic
    1.120
    VBC 5
  • Frane Miljkovic
    +43-1-4277-61643
    PhD Student
    Köhler A
    3.524
    Main Building
  • Milana Mirkovic
    +43-1-4277-52272
    Diploma/Master Student
    Zagrovic
    1.114
    VBC 5
  • Alexandru-Stefan Mixich
    +43-1-4277-24042
    IT Support
    2.116
    Main Building
  • Georg Mlynek
    +43-1-4277-52263
    PostDoc
    Djinovic
    0114
    VBC 5
  • Katharina Mohr
    +43-1-4277-61704
    Technician
    Ogris
    2.127
    Main Building
  • Isabella Moll
    +43-1-4277-54606
    Group Leader
    Moll
    4.028
    Main Building
  • Luisa Morelli
    +43-1-4277-54626
    Diploma/Master Student
    Kovarik
    4.516
    Main Building
  • Anna-Marina Mrak
    +43-1-4277-52272
    Technician
    Zagrovic
    1.321
    VBC 5
  • Ingrid Mudrak
    +43-1-4277-61740
    Lab Manager
    Ogris
    2.030
    Main Building
  • Christian Müller
    +43-1-4277-54613
    PhD Student
    Moll
    4.125/4.127
    Main Building
  • Ernst Müllner
    +43-1-4277-61783
    Group Leader
    Müllner
    2.523
    Main Building
  • N
  • Nana Naetar-Kerenyi
    +43-1-4277-61671
    PostDoc
    Foisner
    3.108
    Main Building
  • Marc Nägeli
    +43-1-4277-61761
    Weitzer
    2.522
    Main Building
  • Michael Nagy
    +43-1-4277-52263
    Diploma/Master Student
    Djinovic
    0114
    VBC 5
  • Marintia Mayola Nava Garcia
    +43-1-4277-61628
    PhD Student
    Köhler A
    3.527
    Main Building
  • Lilian Nehlin
    +43-1-4277-52810
    PostDoc
    Bachmair
    5.108/5.109
    Main Building
  • Mandy Neumann
    +43-1-4277-74610
    PhD Student
    Görke
    4.110
    Main Building
  • Tobias Nimpf
    +43-1-4277-61810
    Lab Assistant
    Nimpf
    2.110
    Main Building
  • Johannes Nimpf
    +43-1-4277-61808
    Group Leader
    Nimpf
    2.112
    Main Building
  • Adrian Nogales Moral
    +43-1-4277-61643
    PhD Student
    Köhler A
    3.524
    Main Building
  • Filomena Nogueira
    +43-1-4277-61817
    PostDoc
    Kuchler
    2.505
    Main Building
  • O
  • Egon Ogris
    +43-1-4277-61730
    Group Leader
    Ogris
    2.127
    Main Building
  • Karin Olek
    +43-1-4277-61611
    PhD Student
    Skern
    3.121
    Main Building
  • Cornelia Oppitz
    +43-1-4277-74640
    Program manager
    Baccarini
    4.116
    Main Building
  • Lukas Orel
    +43-1-4277-74636
    Lab Manager
    Tessmar
    4.501
    Main Building
  • Lucija Orlić
    +43-1-4277-56231
    PhD Student
    Matos
    5.122/5.123
    Main Building
  • Ana Orsolic
    +43-1-4277-52236
    Diploma/Master Student
    Djinovic
    0326
    VBC 5
  • Shotaro Otsuka
    +43-1-4277-61665
    Group Leader
    Otsuka
    3.506
    Main Building
  • Ö
  • Sidar Özer
    +43-1-4277-24042
    IT Support
    2.116
    Main Building
  • P
  • Claudia Pachinger
    +43-1-4277-54621
    PhD Student
    Dammermann
    4.508
    Main Building
  • Nathan Palmer
    +43-1-4277-56231
    PostDoc
    Matos
    5.122/5.123
    Main Building
  • Dimitra Paouneskou
    +43-1-4277-56261
    PostDoc
    Jantsch V
    5.522
    Main Building
  • Lara Lucija Paparic
    +43-1-4277-74610
    Diploma/Master Student
    Görke
    4.110
    Main Building
  • Paulina Parafiniuk-Borzecki
    +43-1-4277-52801
    Administration
    5.115
    Main Building
  • Djurdja Pasajlic
    +43-1-4277-61823
    PhD Student
    Martinez
    2.515
    Main Building
  • Julia Pazmandi
    +43-1-4277-74391
    Menche
    1104
    VBC 5
  • Martin Pechhacker
    +43-1-4277-61751
    Hofbauer
    2.519
    Main Building
  • Philipp Penninger
    +43-1-4277-61812
    PhD Student
    Kuchler
    2.107
    Main Building
  • Cassius Manuel Perez de los Cobos Hermosa
    +43-1-4277-74326
    PhD Student
    v. Haeseler
    1.812.5
    VBC 5
  • Thomas Peterbauer
    +43-1-4277-61676
    Senior Imaging Specialist
    1.618
    VBC 5
  • Vicky Petroulaki
    +43-1-4277-56231
    PhD Student
    Matos
    5.122/5.123
    Main Building
  • Andriy Petryshyn
    +43-1-4277-61812
    Technician
    Kuchler
    2.107
    Main Building
  • Karin Pfeiffer
    +43-1-4277-52201
    Administration
    1.604
    VBC 5
  • Florian Pflug
    +43-1-4277-74323
    PostDoc
    v. Haeseler
    1.812.1
    VBC 5
  • Parvaneh Piran
    +43-1-4277-24004
    Administration
    6.109
    Main Building
  • Sebastian Pirch
    +43-1-4277-74391
    Technician
    Menche
    1803
    VBC 5
  • Ekaterini Platanitis
    +43-1-4277-54628
    PostDoc
    Decker
    4.525/4.527
    Main Building
  • Gerald Platzer
    +43-1-4277-52227
    PostDoc
    Konrat
    0614
    VBC 5
  • Marina Pletzer
    +43-1-4277-61656
    PhD Student
    Falk
    1.624
    VBC 5
  • Elke Podgorschek
    +43-1-4277-54628
    Diploma/Master Student
    Decker
    4.522/4.524
    Main Building
  • Birgit Poehn
    +43-1-4277-74636
    PhD Student
    Tessmar
    4.501
    Main Building
  • Daniel Pokorný
    +43-1-4277-52241
    PhD Student
    Leonard
    1.321.1
    VBC 5
  • Miroslav Poláček
    +43-1-4277-74320
    Technician
    Swarts
    1.722.1
    VBC 5
  • Anton Polyansky
    +43-1-4277-52271
    Staff Scientist
    Zagrovic
    1.612
    VBC 5
  • Hauptgebäude Portier
    +43-1-4277-12894
    1.106
    Main Building
  • Viktoria Prast
    +43-1-4277-56221
    PhD Student
    Klein
    5.401
    Main Building
  • Silvia Prieler
    +43-1-4277-56221
    PostDoc
    Klein
    5.401
    Main Building
  • Günther Prohaczka
    +43-1-4277-74636
    Diploma/Master Student
    Tessmar
    4.501
    Main Building
  • Friedrich Propst
    +43-1-4277-52858
    Guest Researcher
    Propst
    5.528/5.530
    Main Building
  • Ignacio Prusén
    +43-1-4277-56241
    PhD Student
    Schlögelhofer
    5.524/5.526
    Main Building
  • Sylvia Prutti
    +43-1-4277-24001
    Administration
    6.108
    Main Building
  • Dominic Pühringer
    +43-1-4277-52225
    PhD Student
    Djinovic
    0612
    VBC 5
  • Q
  • Yue Qiu
    +43-1-4277-56201
    Diploma/Master Student
    Martens
    5.503
    Main Building
  • Laura Quell
    +43-1-4277-74610
    Diploma/Master Student
    Görke
    4.110
    Main Building
  • R
  • Stefan Rabong
    +43-1-4277-61822
    Diploma/Master Student
    Ivessa
    2.504
    Main Building
  • Katarina Radisavljevic
    +43-1-4277-61641
    PhD Student
    Köhler A
    3.522
    Main Building
  • Florian Raible
    +43-1-4277-54616
    Group Leader
    Raible
    4.115
    Main Building
  • Vinod Rajendra
    +43-1-4277-56220
    PostDoc
    Klein
    5.114
    Main Building
  • Julia Ramesmayer
    +43-1-4277-74645
    Lab Manager
    Leeb
    3.123/3.125
    Main Building
  • Birgit Rapp
    +43-1-4277-54628
    Lab Manager
    Decker
    4.522/4.524
    Main Building
  • Eva Rasch
    +43-1-4277-52820
    Facility Technician
    5.116
    Main Building
  • Sonia Ratajczyk
    +43-1-4277-52862
    PhD Student
    Fuchs
    5.125/5.127
    Main Building
  • Aarathy Ravi sundar Jose Geetha
    +43-1-4277-54628
    PhD Student
    Decker
    4.522/4.524
    Main Building
  • Mihaela Raykova
    +43-1-4277-61653
    Technician
    Karagöz
    3.507/ 3.508
    Main Building
  • Antonio Real-Hohn
    +43-1-4277-61631
    PostDoc
    Blaas
    3.127
    Main Building
  • Elisabeth Rebhan
    +43-1-4277-54629
    Diploma/Master Student
    Baccarini
    4.525/4.527
    Main Building
  • Michael Rechberger
    +43-1-4277-61653
    Diploma/Master Student
    Karagöz
    3.507/ 3.508
    Main Building
  • Ronja Reinhardt
    +43-1-4277-52275
    PhD Student
    Leonard
    1.321
    VBC 5
  • Wolfgang Ludwig Reiter
    +43-1-4277-52846
    PostDoc
    5.10
    IMP/IMBA
  • Lena Reitinger
    +43-1-4277-52272
    Zagrovic
    1.114
    VBC 5
  • Armin Resch
    +43-1-4277-54631
    Lab Manager
    Bläsi
    4.122/4.124
    Main Building
  • Roger Revilla-i-Domingo
    +43-1-4277-54618
    PostDoc
    Raible
    4.510/4.512
    Main Building
  • Julia Riefler
    +43-1-79044-9942
    Lab Manager
    Swarts
    1.722.1
    VBC 5
  • Marianne Rocha Hasler
    +43-1-4277-52201
    Technician
    Köhler A
    4620
    VBC 5
  • Dunja Rokvic
    +43-1-4277-74636
    Technician
    Tessmar
    4.501
    Main Building
  • Anete Romanauska
    +43-1-4277-61628
    PostDoc
    Köhler A
    3.527
    Main Building
  • Julia Romanov
    +43-1-4277-52805
    Lab Manager
    Martens
    5.502
    Main Building
  • Merrit Romeike
    +43-1-4277-74647
    PhD Student
    Bücker
    3.510/3.512
    Main Building
  • Dagmar Roschitz
    +43-1-4277-24072
    Facility Staff
    1.117
    Main Building
  • Katrin Rose
    +43-1-4277-52810
    Diploma/Master Student
    Bachmair
    5.108/5.109
    Main Building
  • Johann Rotheneder
    +43-1-4277-61720
    Group Leader
    Rotheneder
    2.125
    Main Building
  • Marlena Rozner
    +43-1-4277-54631
    PhD Student
    Bläsi
    4.122/4.124
    Main Building
  • Claudia Rudolf
    +43-1-4277-61761
    Apprentice
    Weitzer
    2.522
    Main Building
  • Cornelia Rumpf-Kienzl
    +43-1-4277-54619
    PostDoc
    Dammermann
    4.510/4.512
    Main Building
  • Harald Rumpler
    +43-1-4277-61810
    Technician
    Nimpf
    2.110
    Main Building
  • S
  • Carolina Saad
    +43-1-4277-56241
    PhD Student
    Schlögelhofer
    5.524/5.526
    Main Building
  • Dunia Sahir
    +43-1-4277-52236
    Diploma/Master Student
    Djinovic
    0326
    VBC 5
  • Ulrich Salzer
    +43-1-4277-61669
    PostDoc
    Müllner
    2.523
    Main Building
  • Laura Santini
    +43-1-4277-74645
    PhD Student
    Leeb
    3.123/3.125
    Main Building
  • Thomas Sauer
    +43-1-4277-61782
    Facility Manager
    2.126
    Main Building
  • Adriana Savova
    +43-1-4277-52805
    PhD Student
    Martens
    5.503
    Main Building
  • Justyna Sawa-Makarska
    +43-1-4277-52805
    PostDoc
    Martens
    5.502
    Main Building
  • Natascha Scherzer
    +43-1-4277-24072
    Facility Staff
    1.117
    Main Building
  • Alexandra Schilder
    +43-1-4277-74610
    PhD Student
    Görke
    4.110
    Main Building
  • Peter Schlögelhofer
    +43-1-4277-56240
    Group Leader
    Schlögelhofer
    5.623
    Main Building
  • Heiko Schmidt
    +43-1-4277-74321
    Senior PostDoc
    v. Haeseler
    1.812.1
    VBC 5
  • Maren Schneider
    +43-1-4277-61643
    Staff Scientist
    Köhler A
    3.524
    Main Building
  • Matthias Schneller
    +43-1-4277-52213
    Diploma/Master Student
    Juffmann
    1.614
    VBC 5
  • Šárka Schořová
    +43-1-4277-56241
    PostDoc
    Schlögelhofer
    5.524/5.526
    Main Building
  • Julia Scholz
    +43-1-4277-61668
    Diploma/Master Student
    Otsuka
    3.505
    Main Building
  • Claudia Schreiner
    +43-1-4277-52233
    Lab Manager
    Djinovic
    0124
    VBC 5
  • Dominik Schrempf
    +43-1-4277-74328
    PostDoc
    v. Haeseler
    1.812.3
    VBC 5
  • Renée Schroeder
    +43-1-4277-54690
    Group Leader
    Schroeder
    5.113
    Main Building
  • Stefan Schuechner
    +43-1-4277-61731
    PostDoc
    Ogris
    2.127
    Main Building
  • Martina Schuschnig
    +43-1-4277-52838
    Technician
    Martens
    5.401
    Main Building
  • Maximilian Schwab
    +43-1-4277-61810
    Diploma/Master Student
    Nimpf
    2.110
    Main Building
  • Irene Schwartz
    +43-1-4277-54614
    PhD Student
    Versteeg
    4.108
    Main Building
  • Thomas Schwarz
    +43-1-4277-52263
    PostDoc
    Konrat
    0114
    VBC 5
  • Alois Schweighofer
    +43-1-4277-76528
    6.111a
    Main Building
  • Nina Schweitzer
    +43-1-4277-54630
    Technician
    Baccarini
    4.529
    Main Building
  • Sara Scinicariello
    +43-1-4277-54164
    PhD Student
    Versteeg
    4.108
    Main Building
  • Michaela Sekljic
    +43-1-4277-24001
    Administration
    6.108
    Main Building
  • Mehrta Shirzadian
    +43-1-79044-9942
    PhD Student
    Swarts
    1.722.1
    VBC 5
  • Raju Shivarathri
    +43-1-4277-61818
    Kuchler
    2.509
    Main Building
  • Katharina Siess
    +43-1-4277-52241
    PhD Student
    Leonard
    1.222
    VBC 5
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office@mfpl.ac.at

+43 1 4277 240 01
Today: 9am - 5pm

Vienna Biocenter (VBC)
Dr. Bohr-Gasse 9, 1030 Vienna

Group Thomas Leonard

Structural Biology of Lipid-Activated Signal Transduction

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The Question

Physiological processes are driven by the coordinated action of organs, tissues and cells. Coordination of these activities allows organisms to respond appropriately to their changing environment. Within cells themselves, important metabolic processes are often compartmentalised by membranes, which necessitates the flow of information between compartments. How is this information integrated into the appropriate downstream response? We try to understand the basic principles that govern the flow of information in cells with particular emphasis on the role of lipid second messengers. By understanding the mechanisms by which these signals are transduced and propagated, we can better answer why and how things go wrong in disease.

The Approach

We study how lipids regulate the activity of signaling enzymes, including both protein kinases and phosphatases. We use biochemical and cell biological assays supported by biophysical and structural techniques to deduce how, where, and when the signal is transduced. Our work is underpinned by quantitative biochemistry performed with precisely defined macromolecules. The insights we derive have the potential to rationalize disease pathogenesis at the molecular and atomic levels. For example, in the pro-growth and survival kinase Akt, we have characterized the mechanism by which a mutation associated with cancer and overgrowth disorders leads to kinase activity that is both spatially and temporally de-regulated. Determining how specific mutations drive the development of disease is essential for effective therapeutic intervention.

Thomas Leonard

Thomas studied Biochemistry at the University of Bristol, U.K. before obtaining a PhD in Structural Biology at the Laboratory of Molecular Biology in Cambridge. Thomas moved to the USA in 2005 as an EMBO postdoctoral fellow at the National Institutes of Health in Bethesda, MD and started his own lab as an independent investigator at the Max Perutz Labs in 2012.

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Campus Vienna Biocenter 5
1030 Vienna
Room: 1.616

   +43-1-4277-52205

Spotlights

It takes two to tango

Protein Kinase D (PKD) is an essential ser/thr kinase involved in vesicular transport of cargo from the trans-Golgi network to the plasma membrane. We have discovered a novel, ubiquitin-like domain in PKD that mediates its dimerization on diacylglycerol-containing membranes, thereby driving trans-autophosphorylation and activation of its kinase domain. 

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Akt-ing up in cancer

We recently demonstrated that the activity of a protein kinase called Akt, which promotes cell growth and proliferation, is strictly governed by the engagement of two specific lipids in cell membranes. Bypassing this requirement leads to uncontrolled growth and cancer.

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Location, location, location

The protein kinase Akt integrates signals from membrane-embedded lipid second messengers and signals in the form of phosphorylation by upstream protein kinases. We have shown that one without the other is insufficient for Akt activation and that membrane dissociation triggers rapid dephosphorylation and inactivation of Akt. 

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Switching off with ADP

We have discovered an allosteric switch in the Src and Tec kinases that converts them into active enzymes by promoting the exchange of ADP for ATP. The switch depends on recognition of a polyproline motif in the tail of activated receptors at the plasma membrane.

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Bridging the gap

Rho-associated coiled-coil kinase (ROCK) is a key signal transducer in regulating the cytoskeleton. Substrate engagement is controlled by the precise positioning of its kinase domains, which is achieved via a long coiled-coil domain that bridges its membrane binding domains to its kinase domains.

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    Research

    Membranes are sites of intense signaling activity in eukaryotic cells. Essential processes such as autophagy, cytokinesis, exo- and endo- cytosis, and cytoskeletal remodeling depend on signal propagation at cellular membranes. Dysregulation of signal transduction at these sites is the cause of a number of hereditary and non-hereditary diseases, including Coffin-Lowry syndrome, spinocerebellar ataxia, myotonic dystrophy, and various cancers. Over 500 kinases and 130 phosphatases regulate signal transduction by phosphorylating or dephosphorylating their target proteins. Given that the chemistry of phosphoryl transfer is conserved, there is a clear need for compartmentalization of what are essentially the same chemical reactions.

    Signal Transduction by Lipid Second Messengers

    One of the most important consequences of the activation of cell surface receptors is the generation of small molecule second messengers. In addition to the freely diffusible second messengers such as cAMP and inositol-1,4,5-triphosphate (IP3), a number of cellular second messengers are lipids. Despite being of fundamental importance to the exquisite spatial and temporal regulation of many cellular processes, the molecular mechanisms of lipid-mediated signal transduction are not well understood. Our goal is to understand how lipid second messengers can turn on signaling pathways at the membrane. To achieve this, we are using a spectrum of biophysical (including X-ray crystallography), biochemical, and cell biological techniques. Recently, we have determined the structure of a novel ubiquitin-like domain in Protein Kinase D (PKD) which mediates its dimerization and activation by trans-autophosphorylation on membranes in response to diacylglycerol production downstream of RTK or GPCR signaling (Elsner et al., Journal of Biological Chemistry 2019). PKD is an essential mammalian kinase involved in trafficking of cargo destined for secretion from the trans-Golgi network to the plasma membrane. 

    Akt – a Logic Gate Signal Processor

    Many of the lipid responsive human protein kinases belong to the AGC family of kinases, of which paradigmatic lipid-activated kinases are Akt and protein kinase C (PKC). In 2017 we demonstrated the allosteric activation of Akt by the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2 for the first time. A mutation in the kinase domain associated with cancer and overgrowth disorders of the brain causes Akt hyperactivation by relieving autoinhibition (Ebner and Lučić et al., Molecular Cell 2017). In our most recent work on Akt, we describe the mechanism of activation in more detail and identify the allosteric coupling between PH domain-mediated autoinhibition and the inactivation of Akt by dephosphorylation (Lučić et al.,PNAS 2018; Leonard [Reply to Letter to Editor], PNAS 2018). Conceptually, Akt can be thought of as an AND gate that integrates multiple signals to drive the biological response.

    Switching Off with ADP

    Fundamentally, we aim to describe signal transduction processes with deep mechanistic insight. By combining structure with quantitative in vitro biochemistry on rigorously validated samples, we can probe the structure-function relationship in absolute terms. We have recently applied these principles to study the Tec and Src family tyrosine kinases, work which has revealed a previously unknown switch in nucleotide binding that drives kinase activation (von Raußendorf et al., Sci Rep 2017).

    Probing Structure In Vivo

    Protein kinase C (PKC) is regulated by multiple membrane binding domains that respond to calcium, phospholipids, and the lipid second messenger diacylglycerol (DAG). PKC is held in an inactive conformation in resting cells by a complex network of intramolecular interactions that sequester its membrane binding domains and prevent substrate binding by its kinase domain. Using a dual color in vivo membrane translocation assay, we have shown that the ten mammalian PKCs adopt a conserved three-dimensional architecture despite domain rearrangements in their primary sequences (Lučić et al., Journal of Molecular Biology, 2016).

    Membrane Scaffolding of Signaling Pathways

    We are also interested in how signal transduction pathways are organized. Scaffolding of signaling proteins in the same pathway enhances specificity, promotes signal amplification by reducing noise, and, ultimately, improves signal propagation through the pathway. Membranes act as the scaffolds for many signaling reactions, including those involved in regulation of the actin cytoskeleton (Truebestein et al., Nature Communications 2016). Our studies are aimed at understanding how diverse signals are integrated, how substrate specificity is encoded not just at the kinase level, and the influence of the membrane environment on multi-component signaling hubs. This is an exciting area of research with frontiers in ageing, cancer, metabolic diseases such as diabetes, and obesity.

    Team

    Woong Jae Choi

       +43-1-4277-52241
    Room: 1.222

    Thomas Leonard
    Group Leader
       +43-1-4277-52205
    Room: 1.616

    Aleksandra Levina
    PhD Student
       +43-1-4277-52275
    Room: 1.321

    Daniel Pokorný
    PhD Student
       +43-1-4277-52241
    Room: 1.321.1

    Ronja Reinhardt
    PhD Student
       +43-1-4277-52275
    Room: 1.321

    Katharina Siess
    PhD Student
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    Room: 1.222

    Linda Trübestein
    PostDoc
       +43-1-4277-52241
    Room: 1.222

    News

    The PI is perfectly normal - honestly. 2 years after his students bought him a bungee jump for becoming a tenured Professor at the Max Perutz Labs, Thomas thanked them all and stepped off Jauntalbrücke in Carinthia, Austria for a 96 m plunge towards the river below. Sadly, none of his students could be convinced to jump with him. Check out the video to see what students can do for their PI!

    Protein kinase D (PKD) senses the lipid second messenger diacylglycerol (DAG) and transduces the signal into downstream protein phosphorylation. A novel ubiquitin-like domain (ULD) is required for PKD dimerization and activation on membranes in the cell. In this review article we discuss the structural and biochemical basis of PKD activation by DAG. 

    BioEssays OnlineOpen

    Congratulations Kathi on the cover of Biochemical Society Transactions! In this mini-review, we discuss the mechanisms by which Akt is activated and inactivated with a particular focus on the roles of the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2. We also examine how redistribution of these lipids within the endomembrane system has the potential to both spatially and temporally control Akt activity at cellular compartments distal to the plasma membrane.

    Read more

    Congratulations Kathi on being awarded an Austrian Academy of Sciences DOC Fellowship! Kathi's proposal focuses on the role of the membrane-associated PH domain leucine rich repeat-containing protein phosphatase (PHLPP) in Akt signaling. 

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    December 2019 - the Leonard lab has been funded by the Austrian Science Fund to continue their work on Akt signaling. This grant will fund research on the upstream kinases and downstream phosphatases in the activation and inactivation of Akt respectively.

    Link to FWF

      Selected Publications

      A ubiquitin-like domain controls Protein Kinase D dimerization and activation by trans-autophosphorylation.

      2019 J BIOL CHEM
      PMID:  31406020

      Elsner, Daniel J; Siess, Katharina M; Gossenreiter, Thomas; Hartl, Markus; Leonard, Thomas A

      Conformational sampling of membranes by Akt controls its activation and inactivation.

      2018 P NATL ACAD SCI USA
      PMID:  29632185

      Lučić, Iva; Rathinaswamy, Manoj K; Truebestein, Linda; Hamelin, David J; Burke, John E; Leonard, Thomas A

      A switch in nucleotide affinity governs activation of the Src and Tec family kinases

      2017 Scientific reports.;7(1):17405.
      PMID:  29234112

      von Raußendorf, Freia; de Ruiter, Anita; Leonard, Thomas A.

      PI(3,4,5)P3 Engagement Restricts Akt Activity toCellular Membranes

      2017 MOL CELL;65(3):416-431.
      PMID:  28157504

      Michael Ebner, Iva Lučić, Thomas A. Leonard, and Ivan Yudushkin

      A molecular ruler regulates cytoskeletal remodelling by the Rho kinases.

      2015 NAT COMMUN;6:10029.
      PMID:  26620183

      Truebestein, Linda; Elsner, Daniel J; Fuchs, Elisabeth; Leonard, Thomas A

      View all Publications of Group Leonard

      Collaborations & Funding

      National Scientific Research Fund (FWF) Project

      Project title: 'PI3K signaling - navigating upstream and downstream of Akt' (P 33066)

      Hertha Firnberg Postdoctoral Fellowship (FWF)

      Dr. Linda Trübestein is a recipient of a Hertha Firnberg Postdoctoral Fellowship (FWF).

      Project title: 'Bridging the Gap - Regulation of the Cytoskeleton by the DMPK kinases' (T 915)

      National Scientific Research Fund (FWF) Project

      Project title: 'Structure, Function, and Regulation of Protein Kinase D' (P 30584)

      Austrian Academy of Sciences DOC Fellowship: Katharina Siess

      Project title: 'Regulation of the membrane-associated tumor suppressor phosphatase PHLPP'

      National Scientific Research Fund (FWF) Project

      Project title: 'Lipid-activated kinases in cell shape and motility' (P 28135)

      FWF Doctoral Program

      The Leonard Group is a member of the special doctoral program 'Signaling Mechanisms in Cellular Homeostasis (W1261)', reviewed and funded by the Austrian Science Fund (start 2017).

      Previous Group: Leeb

      Molecular Control of Cell Identity

      Overview

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      Molecular Mechanisms of Autophagy