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Physiological processes are driven by the coordinated action of organs, tissues and cells. Coordination of these activities allows organisms to respond appropriately to their changing environment. Within cells themselves, important metabolic processes are often compartmentalised by membranes, which necessitates the flow of information between compartments. How is this information integrated into the appropriate downstream response? We try to understand the basic principles that govern the flow of information in cells with particular emphasis on the role of lipid second messengers. By understanding the mechanisms by which these signals are transduced and propagated, we can better answer why and how things go wrong in disease.
We study how lipids regulate the activity of signaling enzymes, including both protein kinases and phosphatases. We use biochemical and cell biological assays supported by biophysical and structural techniques to deduce how, where, and when the signal is transduced. Our work is underpinned by quantitative biochemistry performed with precisely defined macromolecules. The insights we derive have the potential to rationalize disease pathogenesis at the molecular and atomic levels. For example, in the pro-growth and survival kinase Akt, we have characterized the mechanism by which a mutation associated with cancer and overgrowth disorders leads to kinase activity that is both spatially and temporally de-regulated. Determining how specific mutations drive the development of disease is essential for effective therapeutic intervention.
Thomas studied Biochemistry at the University of Bristol, U.K. before obtaining a PhD in Structural Biology at the Laboratory of Molecular Biology in Cambridge. Thomas moved to the USA in 2005 as an EMBO postdoctoral fellow at the National Institutes of Health in Bethesda, MD and started his own lab as an independent investigator at the Max Perutz Labs in 2012.
Campus Vienna Biocenter 5
1030 Vienna
Room: 1.616
+43-1-4277-52205
Protein Kinase D (PKD) is an essential ser/thr kinase involved in vesicular transport of cargo from the trans-Golgi network to the plasma membrane. We have discovered a novel, ubiquitin-like domain in PKD that mediates its dimerization on diacylglycerol-containing membranes, thereby driving trans-autophosphorylation and activation of its kinase domain (Elsner et al, Journal of Biological Chemistry, 2019).
We recently demonstrated that the activity of a protein kinase called Akt, which promotes cell growth and proliferation, is strictly governed by the engagement of two specific lipids in cell membranes (Ebner & Lučić et al, Molecular Cell, 2017). Bypassing this requirement leads to uncontrolled growth and cancer.
The protein kinase Akt integrates signals from membrane-embedded lipid second messengers and signals in the form of phosphorylation by upstream protein kinases. We have shown that one without the other is insufficient for Akt activation and that membrane dissociation triggers rapid dephosphorylation and inactivation of Akt (Lučić et al, PNAS, 2018).
We have discovered an allosteric switch in the Src and Tec kinases that converts them into active enzymes by promoting the exchange of ADP for ATP (von Raußendorf et al, Scientific Reports, 2017). The switch depends on recognition of a polyproline motif in the tail of activated receptors at the plasma membrane.
Rho-associated coiled-coil kinase (ROCK) is a key signal transducer in regulating the cytoskeleton. Substrate engagement is controlled by the precise positioning of its kinase domains, which is achieved via a long coiled-coil domain that bridges its membrane binding domains to its kinase domains (Truebestein et al., Nature Communications, 2016).
Membranes are sites of intense signaling activity in eukaryotic cells. Essential processes such as autophagy, cytokinesis, exo- and endo- cytosis, and cytoskeletal remodeling depend on signal propagation at cellular membranes. Dysregulation of signal transduction at these sites is the cause of a number of hereditary and non-hereditary diseases, including Coffin-Lowry syndrome, spinocerebellar ataxia, myotonic dystrophy, and various cancers. Over 500 kinases and 130 phosphatases regulate signal transduction by phosphorylating or dephosphorylating their target proteins. Given that the chemistry of phosphoryl transfer is conserved, there is a clear need for compartmentalization of what are essentially the same chemical reactions.
One of the most important consequences of the activation of cell surface receptors is the generation of small molecule second messengers. In addition to the freely diffusible second messengers such as cAMP and inositol-1,4,5-triphosphate (IP3), a number of cellular second messengers are lipids. Despite being of fundamental importance to the exquisite spatial and temporal regulation of many cellular processes, the molecular mechanisms of lipid-mediated signal transduction are not well understood. Our goal is to understand how lipid second messengers can turn on signaling pathways at the membrane. To achieve this, we are using a spectrum of biophysical (including X-ray crystallography), biochemical, and cell biological techniques. Recently, we have determined the structure of a novel ubiquitin-like domain in Protein Kinase D (PKD) which mediates its dimerization and activation by trans-autophosphorylation on membranes in response to diacylglycerol production downstream of RTK or GPCR signaling (Elsner et al., Journal of Biological Chemistry 2019). PKD is an essential mammalian kinase involved in trafficking of cargo destined for secretion from the trans-Golgi network to the plasma membrane.
Many of the lipid responsive human protein kinases belong to the AGC family of kinases, of which paradigmatic lipid-activated kinases are Akt and protein kinase C (PKC). In 2017 we demonstrated the allosteric activation of Akt by the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2 for the first time. A mutation in the kinase domain associated with cancer and overgrowth disorders of the brain causes Akt hyperactivation by relieving autoinhibition (Ebner and Lučić et al., Molecular Cell 2017). In our most recent work on Akt, we describe the mechanism of activation in more detail and identify the allosteric coupling between PH domain-mediated autoinhibition and the inactivation of Akt by dephosphorylation (Lučić et al.,PNAS 2018; Leonard [Reply to Letter to Editor], PNAS 2018). Conceptually, Akt can be thought of as an AND gate that integrates multiple signals to drive the biological response.
Fundamentally, we aim to describe signal transduction processes with deep mechanistic insight. By combining structure with quantitative in vitro biochemistry on rigorously validated samples, we can probe the structure-function relationship in absolute terms. We have recently applied these principles to study the Tec and Src family tyrosine kinases, work which has revealed a previously unknown switch in nucleotide binding that drives kinase activation (von Raußendorf et al., Sci Rep 2017).
Protein kinase C (PKC) is regulated by multiple membrane binding domains that respond to calcium, phospholipids, and the lipid second messenger diacylglycerol (DAG). PKC is held in an inactive conformation in resting cells by a complex network of intramolecular interactions that sequester its membrane binding domains and prevent substrate binding by its kinase domain. Using a dual color in vivo membrane translocation assay, we have shown that the ten mammalian PKCs adopt a conserved three-dimensional architecture despite domain rearrangements in their primary sequences (Lučić et al., Journal of Molecular Biology, 2016).
We are also interested in how signal transduction pathways are organized. Scaffolding of signaling proteins in the same pathway enhances specificity, promotes signal amplification by reducing noise, and, ultimately, improves signal propagation through the pathway. Membranes act as the scaffolds for many signaling reactions, including those involved in regulation of the actin cytoskeleton (Truebestein et al., Nature Communications 2016). Our studies are aimed at understanding how diverse signals are integrated, how substrate specificity is encoded not just at the kinase level, and the influence of the membrane environment on multi-component signaling hubs. This is an exciting area of research with frontiers in ageing, cancer, metabolic diseases such as diabetes, and obesity.
Woong Jae Choi +43-1-4277-52241
Room: 1.222
Thomas Leonard
Group Leader +43-1-4277-52205
Room: 1.616
Aleksandra Levina
PhD Student +43-1-4277-52275
Room: 1.321
Toni Manolova
Diploma/Master Student +43-1-4277-52205
Room: 1.222
Daniel Pokorný
PhD Student +43-1-4277-52241
Room: 1.321.1
Ronja Reinhardt
PhD Student +43-1-4277-52275
Room: 1.321
Katharina Siess
PhD Student +43-1-4277-52241
Room: 1.222
Linda Trübestein
PostDoc +43-1-4277-52241
Room: 1.222
April 15th 2021 - launch of a new Master's course in Molecular Precision Medicine. The program is dedicated to an understanding of human pathogenesis and the treatment of disease at a molecular and mechanistic level. The course brings basic, translational, and clinical scientists together with doctors to educate students in the opportunities, challenges, and future perspectives of precision medicine. Curriculum Director: Thomas Leonard.
Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is activated by the phospholipid phosphatidylinsoitol 3-phosphate (PI3P) in the PI3 kinase pathway. Up-regulation of Sgk3 activity has increasingly been implicated in cancers that exhibit paradoxically low Akt activity. We have discovered that Sgk3 is dependent on PI3P for full activity, independent of its phosphorylation state. Consequently, Sgk3 activity is likely to be restricted to PI3P-rich endosomes in cells. Our work opens up potential therapeutic avenues for targeting Sgk3 in cancer.
The PI is perfectly normal - honestly. 2 years after his students bought him a bungee jump for becoming a tenured Professor at the Max Perutz Labs, Thomas thanked them all and stepped off Jauntalbrücke in Carinthia, Austria for a 96 m plunge towards the river below. Sadly, none of his students could be convinced to jump with him. Check out the video to see what students can do for their PI!
Protein kinase D (PKD) senses the lipid second messenger diacylglycerol (DAG) and transduces the signal into downstream protein phosphorylation. A novel ubiquitin-like domain (ULD) is required for PKD dimerization and activation on membranes in the cell. In this review article we discuss the structural and biochemical basis of PKD activation by DAG.
Congratulations Kathi on the cover of Biochemical Society Transactions! In this mini-review, we discuss the mechanisms by which Akt is activated and inactivated with a particular focus on the roles of the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2. We also examine how redistribution of these lipids within the endomembrane system has the potential to both spatially and temporally control Akt activity at cellular compartments distal to the plasma membrane.
Congratulations Kathi on being awarded an Austrian Academy of Sciences DOC Fellowship! Kathi's proposal focuses on the role of the membrane-associated PH domain leucine rich repeat-containing protein phosphatase (PHLPP) in Akt signaling.
A ubiquitin-like domain controls Protein Kinase D dimerization and activation by trans-autophosphorylation.
Elsner, Daniel J; Siess, Katharina M; Gossenreiter, Thomas; Hartl, Markus; Leonard, Thomas A
Conformational sampling of membranes by Akt controls its activation and inactivation.
Lučić, Iva; Rathinaswamy, Manoj K; Truebestein, Linda; Hamelin, David J; Burke, John E; Leonard, Thomas A
A switch in nucleotide affinity governs activation of the Src and Tec family kinases
von Raußendorf, Freia; de Ruiter, Anita; Leonard, Thomas A.
PI(3,4,5)P3 Engagement Restricts Akt Activity toCellular Membranes
Michael Ebner, Iva Lučić, Thomas A. Leonard, and Ivan Yudushkin
A molecular ruler regulates cytoskeletal remodelling by the Rho kinases.
Truebestein, Linda; Elsner, Daniel J; Fuchs, Elisabeth; Leonard, Thomas A
Project title: 'PI3K signaling - navigating upstream and downstream of Akt' (P 33066)
Dr. Linda Trübestein is a recipient of a Hertha Firnberg Postdoctoral Fellowship (FWF).
Project title: 'Bridging the Gap - Regulation of the Cytoskeleton by the DMPK kinases' (T 915)
Project title: 'Structure, Function, and Regulation of Protein Kinase D' (P 30584)
Project title: 'Regulation of the membrane-associated tumor suppressor phosphatase PHLPP'
Project title: 'Lipid-activated kinases in cell shape and motility' (P 28135)
The Leonard Group is a member of the special doctoral program 'Signaling Mechanisms in Cellular Homeostasis (W1261)', reviewed and funded by the Austrian Science Fund (start 2017).
15th Microsymposium on Small RNAs
Apr 22 - Apr 23This year, the Microsymposium is a two-day international conference that brings together young scientists, junior and senior group leaders from all over the world to present and discuss their latest findings in the exciting field of small RNAs and other RNA biology related topics. The Microsymposium was founded in 2005 and has established itself as the major small RNA meeting in Europe. It is organized by the four research institutions GMI, IMBA, IMP, and Max Perutz Labs, as well as by the RNA community of the Vienna BioCenter.
The Microsymposium is a registration-free meeting for all its participants!
Acquired resistance to targeted inhibitors of the MAPK pathway confers cross‐resistance to immunotherapy
14:00 - 15:00
ZoomSpeaker: Lisa Haas
Institute: IMP - Obenauf Lab
Monday Seminar (Internal)
12:30 - 13:30 ZoomSpeaker: LIU Haijun (Nordborg), GEHRE Maja (Brennecke), NEMCKO Filip (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Working on research in rare diseases for a patient organization
14:00 - 15:00 ZoomSpeaker: Gaston Sendin
Institute: DEBRA Austria
Host: Post Doc Reps
Investigating the clonal evolution of resistance to targeted therapy and its cross-resistance to immunotherapy
14:00 - 15:00 ZoomSpeaker: Christian Umkehrer
Institute: IMP - Obenauf Lab
GoldenBac: a simple, highly efficient, and widely applicable system for construction of multi-gene expression vectors for use with the baculovirus expression vector system
14:00 - 15:00 ZoomSpeaker: Jana Neuhold
Institute: VBCF
Host: Arthur Sedivy
Visualising the Building Blocks of Life Inside of Cells
11:00 - 12:00 ZoomSpeaker: Martin Beck
Institute: MPI of Biophysics
Host: Clemens Plaschka, Shotaro Otsuka
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: NAVALAYEU Tsimafei (Ameres), ZMAJKOVIC Jakub (Zuber), JONSSON Gustav (Penninger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Allyship and gender intelligence: practical steps towards gender parity
15:00 - 16:00 ZoomSpeaker: Roshni Mooneeram
Institute: EMBL
Host: VBC Equality and Diversity Group
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HINTERNDORFER Matthias (Zuber), CHUGUNOVA Anastasia (Pauli), REUMANN Daniel (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: NOGALES MORAL Adrian (Köhler), NAJM Ramsey K. (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
14:00 - 15:00 ZoomSpeaker: Qian Wu
Institute: University of Leeds
Host: Clemens Plaschka
Title to be announced
14:00 - 15:00 ZoomSpeaker: Grayson Camp
Institute: University of Basel
Host: SFB Neuro Stem Modulation
Regulation of Replication Timing and Chromosome Architecture
16:00 - 17:00 IMBA/GMI Lecture HallSpeaker: David Gilbert
Institute: Florida State University
Host: Rushad Pavri
Eminent domains: PI(4,5)P2 distribution and homeostasis in the plasma membrane
14:00 - 15:00 ZoomSpeaker: Gerry Hammond
Institute: University of Pittsburgh School of Medicine
Host: Ivan Yudushkin
Eminent domains: PI(4,5)P2 distribution and homeostasis in the plasma membrane
14:00 - 15:00 ZoomSpeaker: Gerry Hammond
Institute: University of Pittsburgh School of Medicine
Host: Ivan Yudushkin
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KORESHOVA Alevtina (Burga), REITER Franziska (Stark), SGROMO Annamaria (Ameres)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PHILLIPS Alexander William (Keays), WIDEN Sonya Angeline (Burga), VOICHEK Yoav (Nordborg)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Structural studies for chromatin as a regulator of the genome function
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Hitoshi Kurumizaka
Institute: University of Tokyo
Host: Kikue Tachibana
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Jan Boettcher
Institute: TU Munich
Host: Anna Obenauf
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RODIRUGEZ TERRONES Diego (Tanaka), KORDIC Darja (Clausen), CRESPO ENRIQUEZ Ivan (Urban)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
16:00 - 17:00 ZoomSpeaker: Miguel Moreno Mateos
Institute: Andalusian Center of Developmental Biology
Host: SFB Neuro Stem Modulation
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Gioacchino Natoli
Institute: Humanitas University
Host: Meinrad Busslinger
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: GARCIA LEON Marta (Dagdas), KLAUS Loni (Stark), JAVALI Alok (Rivron)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VOICHEK Maya Shinan (Brennecke), PETRZILEK Jan (Ameres), KALIS Robert (Zuber)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Dana Peer
Institute: Memorial Sloan Kettering Cancer Center
Host: Anna Obenauf
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ELEWAUT Anais (Obenauf), ANDRIONE Mara (Zimmer), DAO Pauline (Tessmar)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Valter Longo
Institute: USC Leonard David School of Gerontology
Host: Noelia Urban
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SALAZAR THULA Oriana Ylida (Zimmer), DUKIC Dejan (Nordborg), HANDLER Dominik (Brennecke)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Stefano Di Talia
Institute: Duke University Medical Center
Host: Andi Pauli
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LEE Du-Hwa (Belkhadir), PACHINGER Claudia (Dammermann lab), BAUMGARTNER Lisa (Brennecke)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Fanni Gergely
Institute: Cancer Research UK, Cambridge Institute
Host: Alex Dammermann
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: TRASSER Marieke (Mari-Ordonez), BRADAMANTE Gabriele (Mittelsten Scheid), GERT Krista (Pauli)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HOI David (Clausen), HENDY Oliver (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DE ALMEIDA Melanie (Zuber), VEEDIN RAJAN Vinoth Babu (Tessmar)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HARVEY Zachary (Berger), PACHECO FIALLOS Francis Belen (Plaschka), WU Szu-Hsien (Koo)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SESTINI Giovanni (Rivron), MORREALE Francesca (Clausen), PASAJILIC Djurdja (Martinez)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Taekjip Ha
Institute: Johns Hopkins University
Host: Clemens Plaschka
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: CORSI Flavia (Golobordko), BRUNNER Hanna (Haselbach), CRONIN Shona (Obenauf)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Holger Puchta
Institute: Karlsruhe Institute of Technology (KIT)
Host: Ortrun Mittelsten Scheid
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LEHMANN Christian (Knoblich), MURPHY Paul (Clausen), HISANAGA Tetsuya (Berger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
16:00 - 17:00 ZoomSpeaker: Madeline Lancaster
Institute: MRC Laboratory of Molecular Biology
Host: SFB Neuro Stem Modulation
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Didier Stainier
Institute: MPI for Heart and Lung Research
Host: Elly Tanaka
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SPICER Maximilian (Gerlich), GRÜNBACHER Sarah (Busslinger), BUENDIA Daniel (Mari-Ordonez)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Richard Youle
Institute: NIH
Host: Sascha Martens
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VERTESY Abel (Knoblich), POLIKARPOVA Anastasia (Tanaka), LEESCH Katrin Friederike (Pauli)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Andrew Dillin
Institute: University of California, Berkeley
Host: Yasin Dagdas
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PANAROTTO-PERICLES Melanie (Peters), LEE Ho-Soek (Belkhadir), CHAKRABORTY Oisorjo (Grade)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LEE Ji-Hyun (Koo), PETROVIC Mina (Gerlich), BELACIC Katarina (Haselbach)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Nevan Krogan
Institute: UCSF - Gladstone Institute
Host: Manuela Baccarini
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture Hall Speaker: SHIRZADIAN YAZD Mehrta (Balzarotti), KOLESNIKOVA Sofia (Gerlich), BAUCELLS Julia Garcia (Dammermann)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: John Diffley
Institute: The Francis Crick Institute
Host: Rushad Pavri, Jan-Michael Peters
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Azim Surani
Institute: Gurdon Institute, University of Cambridge
Host: Andi Pauli
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HOLSTEIN Felix (Obenauf), KHALDIEH Nina (Ameres), HOHMANN Ulrich (Brennecke/Plaschka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Michael Lichten
Institute: NIH
Host: Peter Schlögelhofer
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: NAVA GARCIA Marintia Mayola (Köhler), TARDIVO Pietro (Tanaka), GEISMANN Maximilian (Balzarotti)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
14:00 - 15:00 ZoomSpeaker: Magdalena Goetz
Institute: LMU Department of Physiological Genomics
Host: SFB Neuro Stem Modulation
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Julia Mahamid
Institute: EMBL
Host: Shamba Saha
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SCHMUECKER Anna (Berger), VOGT Vivien (Zuber), HEIDARI KHOEI Heidar (Rivron)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Alejandro Sanchez Alvarado
Institute: Stowers Inst. for Medical Research
Host: Elly Tanaka
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ELLIS Thomas (Nordborg), JELENIC Stela (Saha)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Patrick Cramer
Institute: MPI for Biophysical Chemistry
Host: Alexander Stark, Clemens Plaschka
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Steve Jackson
Institute: Gurdon Research Institute
Host: Rushad Pavri
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: TREPTE Philipp (Knoblich), ABDRAKHMANOV Alibek (Dagdas), EHRMANN Julian (Clausen)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
16:00 - 17:00 ZoomSpeaker: Josh Huang
Institute: Duke University School of Medicine
Host: SFB Neuro Stem Modulation
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Adele Marston
Institute: Wellcome Centre Cell Biology, University of Edinburgh
Host: Daniel Gerlich, Joao Matos
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ROSS James (Brennecke), ISBANER Sebastian (Balzarotti), STREUBEL Susanna (Dolan)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Kai Johnsson
Institute: MPI for Medical Research
Host: Daniel Gerlich
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: JUNKER Sabryna (Clausen), ZHAO Jierui (Dagdas), ISHIHARA Keisuke (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Xin Chen
Institute: Johns Hopkins University
Host: Fred Berger
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VALLEBUENO Miguel (Swarts), SAJTOS Bettina (Zuber), NAGUMO WONG Sakurako (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LUST Katharina (Tanaka), CLAVEL Marion (Dagdas), TIKANOVA Polina (Burga)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: CTORTECKA Claudia (Mendjan), MULVEY Hugh (Dolan), LORBEER Franziska (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SCHELLHAAS Ulla (Plaschka), MEREITER Stefan (Penninger), RADHAKRISHNA PILLAI Balashankar (Saha)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: COLOZZA Gabriele (Koo), BLAHA Andreas (Pauli), PÜHRINGER Florian (Burga)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: JUNG Pauline (Obenauf), LICHT-MAYER Simon (Penninger), CAYGILL Samuel (Dolan)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: FALCON CHAVEZ Francisco Javier (Tanaka), KOK Jian Yi (Berger), VORLÄNDER Matthias (Plaschka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SODERHOLM Adrian (Versteeg), NEUDOLT Andrea (Obenauf), ANDREEV Veselin (Brennecke)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HUMER Theresa (Pauli), CECI GINISTRELLI Lavinia (Mendjan), SANCHEZ DE MEDINA HERNANDEZ Victor (Dagdas)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: CORIC Aida (Tessmar), GOGOVA Rebeca (Clausen), LEE Heetak (Koo)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: TAVERNINI Katherina (Urban), CASEY Chloe (Dolan), DOLESCHALL Balint (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PORTELL I DE MONTSERRAT Julia (Brennecke), ATTRILL Sarah (Dolan), CALDERON DOMINGUEZ Lesly (Busslinger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: REY Ulises (Zimmer), BOURGUET Pierre (Berger), UIJTTEWAAL Esther (Elling)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BECERRIL PEREZ Fernando (Tanaka), KETTEL Paulina (Karagöz), PUSHPA BOSE Greeshma (Urban)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DEYETT Alison Ann (Mendjan), FIESLER Charlie (Zimmer), PICCHIANTI Lorenzo (Dagdas)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VÖLKL Isabella (Bücker), TSAREV Aleksandr (Ameres), GABARRO SOLANAS Rut (Urban)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Joan Massague
Institute: Memorial Sloan Kettering Cancer Center
Host: Anna Obenauf
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: AULER Markus (Baccarini), MADHUSUDHANAN Jalaja (Zimmer), SCHENK Robyn (Busslinger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DA CUNHA E SILVA MARTINS COSTA Catarina (Knoblich), SHULKINA Alexandra (Versteeg), STOCKINGER Alexander (Raible)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Ulrich Hartl
Institute: Max Planck Institute of Biochemistry
Host: Tim Clausen
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LEE Joonsun (Elling), MILJKOVIC Frane (Köhler), HOFBAUER Lorena (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: FAHRENBERGER Martin (Von Haeseler), RAUSCHMEIER Rene (Busslinger), GUPTA Ankit (Golobordko)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SCHMÖLLERL Johannes (Zuber), FAAS Victoria (Clausen), ANISIMOVA Aleksandra (Karagöz)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BRAGULAT TEIXIDOR Helena (Otsuka), SALEWSKIJ Kirill (Penninger), KAGAWA Harunobu (Rivron)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: CASEY Alexandra (Dolan), CERRON ALVAN Luis Miguel (Leeb), SIDHAYE Jaydeep (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SCHOLZ Julia (Otsuka), NGUYEN Vu (Mittelsten Scheid), STANKUNAS Edvinas (Köhler)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LEYVA GONZALEZ Marco (Tanaka), KOLLER Manuela (Campbell), PINTER Theresa (Busslinger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KHANDEKAR Ameya (Martinez), LOUBIERE Vincent (Stark), BAUER Bernd (Martens)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PASSERA Alessandro (Balzarotti), MILIVOJEV Nadja (Raible), HOLCIK Laurenz (Von Haeseler)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: IGOLKINA Anna (Nordborg), KRAMMER Teresa (Tanaka), AMANN Sascha Josef (Haselbach)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SCHMIDT Clara (Mendjan), GRABARCZYK Daniel (Clausen), SAAD RODRIGUES Carolina (Schlögelhofer)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: YU Changwei (Brennecke), HAENDELER Simon (Von Haeseler), ALMEIDA Bernardo (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LEITNER Marie-Christin (Mendjan), BATISTA ROCHA Andreia Sofia (Knoblich), DENEKE Victoria (Pauli)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KELLNER Max Josef (Penninger), SEONG Jinwoo (Rivron), HORN Sabrina (Peters)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: OTSUKI Leo (Tanaka), LEV Itamar (Zimmer), HODAKOVA Zuzana (Haselbach)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Richard Flavell
Institute: Yale University School of Medicine
Host: Meinrad Busslinger
+43 1 4277 240 01
Today: 9am - 5pm
Vienna Biocenter (VBC)
Dr.-Bohr-Gasse 9, 1030 Vienna