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Physiological processes are driven by the coordinated action of organs, tissues and cells. Coordination of these activities allows organisms to respond appropriately to their changing environment. Within cells themselves, important metabolic processes are often compartmentalised by membranes, which necessitates the flow of information between compartments. How is this information integrated into the appropriate downstream response? We try to understand the basic principles that govern the flow of information in cells with particular emphasis on the role of lipid second messengers. By understanding the mechanisms by which these signals are transduced and propagated, we can better answer why and how things go wrong in disease.
We study how lipids regulate the activity of signaling enzymes, including both protein kinases and phosphatases. We use biochemical and cell biological assays supported by biophysical and structural techniques to deduce how, where, and when the signal is transduced. Our work is underpinned by quantitative biochemistry performed with precisely defined macromolecules. The insights we derive have the potential to rationalize disease pathogenesis at the molecular and atomic levels. For example, in the pro-growth and survival kinase Akt, we have characterized the mechanism by which a mutation associated with cancer and overgrowth disorders leads to kinase activity that is both spatially and temporally de-regulated. Determining how specific mutations drive the development of disease is essential for effective therapeutic intervention.
Thomas studied Biochemistry at the University of Bristol, U.K. before obtaining a PhD in Structural Biology at the MRC Laboratory of Molecular Biology in Cambridge. Thomas moved to the USA in 2005 as an EMBO postdoctoral fellow at the National Institutes of Health in Bethesda, MD and started his own lab as an independent investigator at the Max Perutz Labs in 2012.
Campus Vienna Biocenter 5
1030 Vienna
Room: 1.616
+43-1-4277-52205
Phosphoinositide-dependent kinase 1 (PDK1) is an essential protein kinase that controls cellular and organismal growth. We have elucidated the mechanism by which PDK1 is activated by phosphatidylinositol-3,4,5-trisphosphate (PIP3) at the plasma membrane in response to growth factor-mediated activation of cell surface receptors. Our work reveals previously unknown mechanisms of autoinhibition and trans-autoactivation, with opportunities for the development of novel therapeutics in the treatment of cancer (Levina et al, Nature Communications, 2022).
© Illustration by Dorotea Fracchiolla (Art&Science)
The lipid second messengers PI(3,4,5)P3 and PI(3,4)P2 have long been known to activate Akt by recruiting it to membranes, where it is activated by phosphorylation. We have determined the structure of autoinhibited Akt1, revealing the molecular basis of a disease-causing mutation in the PH domain which gives rise to Proteus Syndrome and some cancers. Phosphorylation is insufficient to fully activate Akt1. Our work implies that Akt signaling is restricted to discrete membrane locations in the cell (Truebestein et al, PNAS, 2021).
Serum- and glucocorticoid-regulated kinase 3 (Sgk3) is activated by the phospholipid phosphatidylinsoitol 3-phosphate (PI3P) in the PI3 kinase pathway. Up-regulation of Sgk3 activity has increasingly been implicated in cancers that exhibit paradoxically low Akt activity. We have discovered that Sgk3 is dependent on PI3P for its activity, which restricts its activity to PI3P-rich endosomes in cells. We have biochemically reconstituted Sgk3 activation downstream of the class III PI 3-kinase Vps34 in vitro (Pokorny et al, Journal of Biological Chemistry, 2021).
Protein Kinase D (PKD) is an essential ser/thr kinase involved in vesicular transport of cargo from the trans-Golgi network to the plasma membrane. We have discovered a novel, ubiquitin-like domain in PKD that mediates its dimerization on diacylglycerol-containing membranes, thereby driving trans-autophosphorylation and activation of its kinase domain (Elsner et al, Journal of Biological Chemistry, 2019).
The protein kinase Akt integrates signals from membrane-embedded lipid second messengers and signals in the form of phosphorylation by upstream protein kinases. We have shown that one without the other is insufficient for Akt activation and that membrane dissociation triggers rapid dephosphorylation and inactivation of Akt (Lučić et al, PNAS, 2018).
We recently demonstrated that the activity of a protein kinase called Akt, which promotes cell growth and proliferation, is strictly governed by the engagement of two specific lipids in cell membranes (Ebner & Lučić et al, Molecular Cell, 2017). Bypassing this requirement leads to uncontrolled growth and cancer.
We have discovered an allosteric switch in the Src and Tec kinases that converts them into active enzymes by promoting the exchange of ADP for ATP (von Raußendorf et al, Scientific Reports, 2017). The switch depends on recognition of a polyproline motif in the tail of activated receptors at the plasma membrane.
Rho-associated coiled-coil kinase (ROCK) is a key signal transducer in regulating the cytoskeleton. Substrate engagement is controlled by the precise positioning of its kinase domains, which is achieved via a long coiled-coil domain that bridges its membrane binding domains to its kinase domains (Truebestein et al., Nature Communications, 2016).
Membranes are sites of intense signaling activity in eukaryotic cells. Essential processes such as autophagy, cytokinesis, exo- and endo- cytosis, and cytoskeletal remodeling depend on signal propagation at cellular membranes. Dysregulation of signal transduction at these sites is the cause of a number of hereditary and non-hereditary diseases, including Coffin-Lowry syndrome, spinocerebellar ataxia, myotonic dystrophy, and various cancers. Over 500 kinases and 130 phosphatases regulate signal transduction by phosphorylating or dephosphorylating their target proteins. Given that the chemistry of phosphoryl transfer is conserved, there is a clear need for compartmentalization of what are essentially the same chemical reactions.
One of the most important consequences of the activation of cell surface receptors is the generation of small molecule second messengers. In addition to the freely diffusible second messengers such as cAMP and inositol-1,4,5-triphosphate (IP3), a number of cellular second messengers are lipids. Despite being of fundamental importance to the exquisite spatial and temporal regulation of many cellular processes, the molecular mechanisms of lipid-mediated signal transduction are not well understood. Our goal is to understand how lipid second messengers can turn on signaling pathways at the membrane. To achieve this, we are using a spectrum of biophysical (including X-ray crystallography), biochemical, and cell biological techniques. Recently, we have determined the structure of a novel ubiquitin-like domain in Protein Kinase D (PKD) which mediates its dimerization and activation by trans-autophosphorylation on membranes in response to diacylglycerol production downstream of RTK or GPCR signaling (Elsner et al., Journal of Biological Chemistry 2019). PKD is an essential mammalian kinase involved in trafficking of cargo destined for secretion from the trans-Golgi network to the plasma membrane.
Many of the lipid responsive human protein kinases belong to the AGC family of kinases, of which paradigmatic lipid-activated kinases are Akt and protein kinase C (PKC). In 2017 we demonstrated the allosteric activation of Akt by the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2 for the first time. A mutation in the kinase domain associated with cancer and overgrowth disorders of the brain causes Akt hyperactivation by relieving autoinhibition (Ebner and Lučić et al., Molecular Cell 2017). In our most recent work on Akt, we describe the mechanism of activation in more detail and identify the allosteric coupling between PH domain-mediated autoinhibition and the inactivation of Akt by dephosphorylation (Lučić et al.,PNAS 2018; Leonard [Reply to Letter to Editor], PNAS 2018). Conceptually, Akt can be thought of as an AND gate that integrates multiple signals to drive the biological response.
Fundamentally, we aim to describe signal transduction processes with deep mechanistic insight. By combining structure with quantitative in vitro biochemistry on rigorously validated samples, we can probe the structure-function relationship in absolute terms. We have recently applied these principles to study the Tec and Src family tyrosine kinases, work which has revealed a previously unknown switch in nucleotide binding that drives kinase activation (von Raußendorf et al., Sci Rep 2017).
Protein kinase C (PKC) is regulated by multiple membrane binding domains that respond to calcium, phospholipids, and the lipid second messenger diacylglycerol (DAG). PKC is held in an inactive conformation in resting cells by a complex network of intramolecular interactions that sequester its membrane binding domains and prevent substrate binding by its kinase domain. Using a dual color in vivo membrane translocation assay, we have shown that the ten mammalian PKCs adopt a conserved three-dimensional architecture despite domain rearrangements in their primary sequences (Lučić et al., Journal of Molecular Biology, 2016).
We are also interested in how signal transduction pathways are organized. Scaffolding of signaling proteins in the same pathway enhances specificity, promotes signal amplification by reducing noise, and, ultimately, improves signal propagation through the pathway. Membranes act as the scaffolds for many signaling reactions, including those involved in regulation of the actin cytoskeleton (Truebestein et al., Nature Communications 2016). Our studies are aimed at understanding how diverse signals are integrated, how substrate specificity is encoded not just at the kinase level, and the influence of the membrane environment on multi-component signaling hubs. This is an exciting area of research with frontiers in ageing, cancer, metabolic diseases such as diabetes, and obesity.
Sumire Antonioli
PhD Student +43-1-4277-52241
Room: 1.222
Julia Gobl
+43-1-4277-52275
Room: 1.321.1
Thomas Leonard
Group Leader +43-1-4277-52205
Room: 1.616
Aleksandra Levina
PhD Student +43-1-4277-52275
Room: 1.321
Lucas Piech
PhD Student +43-1-4277-52241
Room: 1.222
Ronja Reinhardt
PhD Student +43-1-4277-52275
Room: 1.321
Thomas will present at the upcoming EMBO Workshop 'Cancer cell signaling: Linking molecular knowledge to cancer therapy', which is being held in Cavtat, Croatia. He will discuss our recent work on the 'master' kinase PDK1, the implications of the work for cellular signaling downstream of PDK1, and therapeutic opportunities in cancer treatment.
In recent years, Akt has emerged as a clinical target in the treatment of various cancers and overgrowth disorders. Two types of inhibitors have been developed to specifically target Akt: ATP-competitive inhibitors and allosteric inhibitors, which recognize a unique interface between its regulatory, PIP3-binding PH domain, and its kinase domain. In our recent collaboration with John Burke's lab at the University of British Columbia, we have revealed the conformational changes induced by inhibitor binding, the results of which may inform the future development of Akt-targed therapeutics.
The regulation of protein kinase activity by activation loop phosphorylation is a well-characterized mechanism. Protein kinases that auto-phosphorylate usually do so in trans: dimerization results in reciprocal phosphorylation of the activation loop by the other protomer. However, we have discovered that Protein Kinase D (PKD) has evolved the inverse solution to the same problem. PKD is an inactive dimer that is activated by kinase domain dissociation followed by cis-autophosphorylation.
The myotonic dystrophy kinases of the DMPK family are conserved regulators of actomyosin contractility. The four prototypical DMPK members are obligate homodimers with a conserved architecture of N-terminal kinase domains, a central coiled-coil, and C-terminal membrane binding domains. Remarkably, the length of the coiled-coil domain of each family member varies between 10 and 145 nm, but is astonishingly well conserved. We present a model in which the activity of these kinases is regulated by their spatial positioning with respect to the membrane.
Congratulations, Linda and Harald, whose work has been featured in the ESRF Highlights 2021 magazine. To read about their work on Akt activation by PIP3, click on the link below to download the magazine.
Congratulations, Dr. Pokorny! Good luck in your next career step and thanks for everything you have contributed to the lab over the last 4 years. It has been a pleasure having you in the lab and we will for sure miss you. Daniel starts work in January at DIANA Biotechnologies, a biotech spin-off of the Institute of Organic Chemistry and Biochemistry, Prague. We wish him all the best in his new career!
April 15th 2021 - launch of a new Master's course in Molecular Precision Medicine. The program is dedicated to an understanding of human pathogenesis and the treatment of disease at a molecular and mechanistic level. The course brings basic, translational, and clinical scientists together with doctors to educate students in the opportunities, challenges, and future perspectives of precision medicine. Curriculum Director: Thomas Leonard.
The PI is perfectly normal - honestly. 2 years after his students bought him a bungee jump for becoming a tenured Professor at the Max Perutz Labs, Thomas thanked them all and stepped off Jauntalbrücke in Carinthia, Austria for a 96 m plunge towards the river below. Sadly, none of his students could be convinced to jump with him. Check out the video to see what students can do for their PI!
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation.
Levina, Aleksandra; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation.
Truebestein, Linda; Hornegger, Harald; Anrather, Dorothea; Hartl, Markus; Fleming, Kaelin D; Stariha, Jordan T B; Pardon, Els; Steyaert, Jan; Burke, John E; Leonard, Thomas A
In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.
Pokorny, Daniel; Truebestein, Linda; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A
A ubiquitin-like domain controls Protein Kinase D dimerization and activation by trans-autophosphorylation.
Elsner, Daniel J; Siess, Katharina M; Gossenreiter, Thomas; Hartl, Markus; Leonard, Thomas A
Conformational sampling of membranes by Akt controls its activation and inactivation.
Lučić, Iva; Rathinaswamy, Manoj K; Truebestein, Linda; Hamelin, David J; Burke, John E; Leonard, Thomas A
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
Michael Ebner, Iva Lučić, Thomas A. Leonard, and Ivan Yudushkin
A molecular ruler regulates cytoskeletal remodelling by the Rho kinases
Truebestein, L., Elsner, D.J., Fuchs, E., Leonard, T.A.
Project title: 'PI3K signaling - navigating upstream and downstream of Akt' (P 33066)
Dr. Linda Trübestein is a recipient of a Hertha Firnberg Postdoctoral Fellowship (FWF).
Project title: 'Bridging the Gap - Regulation of the Cytoskeleton by the DMPK kinases' (T 915)
Project title: 'Structure, Function, and Regulation of Protein Kinase D' (P 30584)
Project title: 'Regulation of the membrane-associated tumor suppressor phosphatase PHLPP'
Project title: 'Lipid-activated kinases in cell shape and motility' (P 28135)
The Leonard Group is a member of the special doctoral program 'Signaling Mechanisms in Cellular Homeostasis (W1261)', reviewed and funded by the Austrian Science Fund (start 2017).
Mucociliary WNT signaling promotes cilia biogenesis and beating
15:00 - 16:00
IMP Lecture HallSpeaker: Carina SeidlInstitute: German Cancer Research CenterHost: Elly Tanaka
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: POPOVA Mariia (Peters), RITSCHKA Birgit (Tanaka), DOMBEY Rodolphe (Mari-Ordonez)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Functional proteomics by induced proximity
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Mikko TaipaleInstitute: University of TorontoHost: Alex Stark, Uli Elling
A non-coding gene approach to animal systematics
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Bastian FrommInstitute: Uni TromsoHost: Oleg Simakov
Structural insights into tail-anchored membrane protein biogenesis by the GET insertase complex
14:00 - 15:00 VBC5 Lecture Hall A+B/ZoomSpeaker: Melanie McDowellInstitute: MPI for BiophysicsHost: Sebastian Falk
A journey through seed physiology, biophysics, ecology, and evolution to discover the molecular function of the putative water sensor FLOE1
16:00 - 17:00 ZoomSpeaker: Sue RheeInstitute: Carnegie Institution for Science, StanfordHost: Yasin Dagdas
Monday Seminar (Internal)
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Looking through a tree darkly at the history of life using phylogenies
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Liam RevellInstitute: UMass BostonHost: Oleg Simakov
Crystallography and Cryo-EM: At odds or best friends? A case study in targeted protein degradation
14:00 - 15:00 IMP Lecture Hall/ZoomSpeaker: Gabriel LanderInstitute: Scripps Research InstituteHost: David Haselbach
How understanding meristem growth in Arabidopsis can help us to modify barley shoot architecture
11:30 - 12:30 GMI Orange Seminar RoomSpeaker: Rüdiger SimonInstitute: Heinrich-Heine UniversityHost: Yasin Dagdas
The generation of neural diversity
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Claude DesplanInstitute: NYU and NYU Abu DhabiHost: Jürgen Knoblich
Co-evolution of the Ess1-CTD axis in polar fungi suggests distinct roles for protein folding and phase separation in cold tolerance
15:00 - 16:00 IMP Lecture HallSpeaker: Steven D. HanesInstitute: SUNY-Upstate Medical UniversityHost: Dea Slade
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: TELONI Federico (Gerlich), NGUYEN Vu (Mittelsten Scheid), PUSHPA BOSE Greeshma (Urban)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Macronucleus, speciation and sex in ciliates
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Alexey PotekhinInstitute: LFUI, MondseeHost: Oleg Simakov
A chromatin-modifying activity links haem catabolism, chloroplast development and cellular differentiation in Arabidopsis
11:30 - 12:30 GMI Orange Seminar RoomSpeaker: Enrique Lopez-JuezInstitute: Royal Holloway University of LondonHost: Silvia Ramundo
Monday Seminar (Internal)
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The evolution of bilaterian life cycles
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Chema MartinInstitute: Queen Mary University of LondonHost: Oleg Simakov
Title to be announced
14:00 - 15:00 VBC5 Lecture Hall A+B/ZoomSpeaker: Michele VendruscoloInstitute: University of CambridgeHost: Oliviero Carugo
Regulation of protein biogenesis in health and disease
10:00 - 11:00 IMP Lecture HallSpeaker: Danny NedialkovaInstitute: MPI of BiochemistryHost: Clemens Plaschka
Monday Seminar (Internal)
12:00 - 13:00 IMP Lecture HallSpeaker: CHUGUNOVA Anastasia (Pauli), RÖTZER Johannes (Dolan), JONSSON Gustav (Penninger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ANTONIOLI Sumire (Leonard), BENEDUM Johannes (Slade), LITTLEBOY Jamie (Knoblich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
The smallest vertebrate brain knows how to sing
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Benjamin JudkewitzInstitute: Charite BerlinHost: Oleg Simakov
Neuro-immune interactions in the gut
11:00 - 12:00 ZoomSpeaker: Daniel MucidaInstitute: Rockefeller UniversityHost: Meinrad Busslinger
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SANDRU Ana Maria (Baccarini), LI Chong (Knoblich), PABST Gabriel (Zuber)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Ancient Pathogen Phylogenomics: Detection, Reconstruction and Analysis
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Meriam GuellilInstitute: University of ViennaHost: Oleg Simakov
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Lacra BintuInstitute: Stanford UniversityHost: Alex Stark
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DIEZMA Laura (Nordborg/Mari-Ordonez), GHOSH Dipannita (Grade), PATEL Rajvi (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Mechanisms of chromosome compaction
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Anton GoloborodkoInstitute: IMBAHost: Oleg Simakov
Title to be annouced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Adele MarstonInstitute: Wellcome Centre Cell Biology, University of EdinburghHost: Daniel Gerlich, Joao Matos
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KORDIC Darja (Clausen), DEIBER Sebastian (Dolan), GEHRE Maja (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Madhav JagannathanInstitute: ETH ZurichHost: Julius Brennecke
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ZMAJKOVIC Jakub (Zuber), MAURER Eric (Peters), NOGALES MORAL Adrian (Köhler)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HUETTER Christiane (Menche), BASSAT Elad (Tanaka), PETRZILEK Jan (Ameres)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
The evolution of structural variants in humans and nonhumans
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Marie SaitouInstitute: NMBU NorwayHost: Oleg Simakov
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KALIS Robert (Zuber), NAJM Ramsey (Knoblich), GEROCZ Emoke (Gerlich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: AUGUSTO Pedro (Zimmer), POLISSENI Claudio (Tanaka), SILVA Raquel (Foisner)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Complex brain development in octopus
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Eve SeuntjensInstitute: KU LeuvenHost: Oleg Simakov
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: GUO Pin (Dolan), ELEWAUT Anais (Obenauf), Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Total RNA-RNA interactome capture in bacteria
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Gaurav DugarInstitute: Uni AmsterdamHost: Oleg Simakov
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: STUART Hannah (Tanaka), KORESHOVA Alevtina (Burga), ZHAN Ni (Dagdas)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Cell type evolution in spiralian animals
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Tim WollesenInstitute: University of ViennaHost: Oleg Simakov
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Jean-Christophe MarineInstitute: VIB-KU Leuven Center for Cancer BiologyHost: Johannes Zuber
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: CRONIN Shona (Obenauf), KANNO Tatsuo (Berger), PACHINGER Claudia (Dammermann)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Early evolution of animal genome regulation
13:15 - 14:15 HS2 (Hörsaal 2) in the UBB (ground floor)Speaker: Arnau Sebe-PedrosInstitute: CRG BarcelonaHost: Oleg Simakov
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Laurent NguyenInstitute: University of LiegeHost: Noelia Urban
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SHUKLA Vikas (Berger), RODRIGUEZ TERRONES Diego (Tanaka), WIDEN Sonya (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Stein AertsInstitute: VIB Center for Brain and Disease ResearchHost: Alex Stark
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VOICHEK Yoav (Norborg), SESTINI Giovanni (Rivron), PETROULAKI Vasiliki (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BRUNNER Hanna (Haselbach), FRIDRICH Arie (Berger), AKULOVA Vasilina (Swarts)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Wouter de LaatInstitute: Hubrecht InstituteHost: Christa Bücker
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DE SANTIS Martina (Rivron), BUENDIA Daniel (Mari-Ordonez), ENGL Magdalena (Slade)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Ron DrorInstitute: Stanford UniversityHost: David Haselbach
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VOJTEK Matus (Stark), LEHMANN Christian (Knoblich), LEE Du-Hwa (Belkhadir)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Petra SchwilleInstitute: MPI of BiochemistryHost: Alwin Köhler
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Alejandro Sweet-CorderoInstitute: University of California San FranciscoHost: Anna Obenauf
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SPICER Maximilian (Gerlich), ESTIVILL I CAPAAROS Guillem (Obenauf), MURPHY Paul (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Imaging processes of cell division across scales
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Jan EllenbergInstitute: EMBL HeidelbergHost: Shotaro Otsuka
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: JÄGER Christina (Van der Veeken), PRADHAN Saurabh (Rivron), RAFANEL Baptiste (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BELACIC Katarina (Haselbach), HARVEY Zachary (Berger), MILOJKOVIC Lidija (Urban)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: GOMEZ SEGALAS Alba (Balzarotti), KOLESNIKOVA Sofia (Gerlich), HANDLER Dominik (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Dirk InzeInstitute: VIBHost: Andreas Bachmair
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Ian HicksonInstitute: University of CopenhagenHost: Joao Matos
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: BAUCELLS Julia (Dammermann), PANAROTTO-PERICLES Melanie (Peters), VOICHEK Maya Shinan (Brennecke)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Maria LlorensInstitute: CBMHost: Noelia Urban
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DMITRIEV Vladimir (Goloborodko), HISANAGA Tetsuya (Berger), KHALDIEH Nina (Ameres)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Kathrin LangInstitute: ETH ZurichHost: Tim Clausen
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SOMMER Theresa (Rivron), SHIRZADIAN YAZD Mehrta (Balzarotti), VERTESY Abel (Knoblich)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Joanna WysockaInstitute: Stanford School of MedicineHost: Christa Bücker
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: POLIKARPOVA Anastasia (Tanaka), CHAKRABORTY Oisorjo (Grade), CORSI Flavia (Goloborodko)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: FESSELET Jeanne (Kovarik), KHAURATOVIC Uladzislava (Matos/Golobordko), SHEN Jingyi (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMP Lecture HallSpeaker: Andre NussenzweigInstitute: NIHHost: Jan-Michael Peters
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Roger GeigerInstitute: Institute for Research in Biomedicine, BellinzonaHost: Joris Van der Veeken
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: PERNEBRINK Mattias (Tanaka), HOHMANN Ulrich (Brennecke/Plaschka), MANOLOVA Toni (Falk)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: WU Shuangyang (Dolan), SCARAMUZZA Federico (Tessmar), KROGULL Daniel (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HEIDARI KHOEI Heidar (Rivron), BELL Caelan (Gerlich), GALUSKA Philipp (Djinovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Daniele CanzioInstitute: UCSFHost: Anton Goloborodko
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ABDRAKHMANOV Alibek (Dagdas), WILLIAMS Thomas (Clausen), GEISMANN Maximilian (Balzarotti)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: JELENIC Stela (Saha), PACHECO FIALLOS Franics Belen (Plaschka), FONTES OLIVEIRA Tiago Manuel (Penninger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: NAGUMO WONG Sakurako (Knoblich), LORENZO ORTS Laura (Pauli), ROSS James (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Samer HattarInstitute: NIHHost: Kristin Tessmar
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RAFFL Gerald (Ameres), SAJTOS Bettina (Zuber), ISHIHARA Keisuke (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Anshul KundajeInstitute: Stanford UniversityHost: Alex Stark
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: STEINACKER Thomas (Gerlich), EDER Stephanie (Zimmer), TIKANOVA Polina (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SCHELLHAAS Ulla (Plaschka/Ameres), RUSCH Emma (Goloborodko), CLAVEL Marion (Dagdas)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RADHAKRISHNA PILLAI Balashankar (Saha), ADELMANN Leonie (Raible), BLAHA Andreas (Pauli)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: VULIN Milica (Obenauf), MEREITER Stefan (Penninger), BINDL Michael (Leeb)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LORBEER Franziska (Stark), MULVEY Hugh (Dolan), PÜHRINGER Florian (Burga)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HOLZER Elisabeth (Martens), COLOZZA Gabriele (Koo), FALCON CHAVEZ Francisco (Tanaka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RÖHSNER Josef (Pauli), OKUN Anastasia (Karagöz), JUNG Pauline (Obenauf)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Sir Philip CohenInstitute: University of DundeeHost: Egon Ogris
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LICHT-MAYER Simon (Penninger), CAYGILL Samuel (Dolan), MIGOTTI Mario (Konrat)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Feng ShaoInstitute: National Institute of Biological Sciences, BeijingHost: Pavel Kovarik
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SHUNMUGAM Dhanlakshmi (Baccarini), CECI GINISTRELLI Lavinia (Mendjan), VORLÄNDER Matthias (Plaschka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Lydia FinleyInstitute: Memorial Sloan Kettering Cancer CenterHost: Johannes Zuber
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KOK Jian Yi (Berger), HUMER Theresa (Pauli), SODERHOLM Adrian (Versteeg)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Stephan GruberInstitute: University of LausanneHost: Franz Klein
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: STRAVS Ana (Knoblich), SANCHEZ DE MEDINA HERNANDEZ Victor (Dagdas), KRUMWIEDE Luisa (Gaidt)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: TAVERINI Katherina (Urban), SHETTY Kavya Krishna (Stark), CORIC Aida (Tessmar)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Nancy KlecknerInstitute: Harvard UniversityHost: Franz Klein
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: GRABARCZYK Daniel (Clausen), PROTELL I DE MONTSERRAT Julia (Brennecke/Plaschka), MANCHENO JUNCOSA Estela (Mendjan)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Edward LemkeInstitute: IMB MainzHost: David Haselbach
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: ATTRILL Sarah (Dolan), UIJTTEWAAL Esther (Elling), SCIBISZ Grzegorz (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: DOLESCHALL Balint (Knoblich), FENG Sonjie (Bücker), BOURGUET Pierre (Berger)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Rotem SorekInstitute: Weizmann Institute of Science, RehovotHost: Julius Brennecke
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: HORENKAMP Simone (Tanaka), CASEY Chloe (Dolan), KAPRAL Thomas (Zagrovic)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KOBAKHIDZE George (Dong), ANGELOPOULOU Eleni (Ellis), PACHANO Tomas (Stark)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: RAMIREZ America (Köhler), VÖLKL Isabella (Bücker), HOANG Oi Pui (Technau)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
11:00 - 12:00 IMBA/GMI Lecture HallSpeaker: Mounia LaghaInstitute: Institut de Genetique Moleculaire de MontpellierHost: Andrea Pauli
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: LEITNER Moritz (Martinez), VOGEL Alexander (Yudushkin), KETTEL Paulina (Karagöz)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: TSAREV Aleksandr (Ameres), FIESELER Charlie (Zimmer), ABESAMIS Kim Ivan (Dong)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: STREUBEL Susanna (Dolan), KLEIFELD Justus (Urban), ORLIC Lucija (Matos)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SHULKINA Alexandra (Versteeg), GEETHA Sowmya (Jantsch), MADHUSUDHANAN Jalaja (Zimmer)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: KOLLER Manuela (Campbell), GUPTA Ankit (Goloborodko), SCHMÖLLERL Johannes (Zuber)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: MARCHIORI Elisa (Van der Veeken), ACHLEITNER Anja (Martens), FAAS Victoria (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: SALEWSKIJ Kirill (Penninger), KIRCHGATTERER Paul (Gaidt), REN Kaike (Otsuka)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
12:30 - 13:30 IMP Lecture HallSpeaker: MIHAILOVIC Milica (Karagöz), BELL Lillie (Clausen)Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
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Today: 9am - 5pm
Vienna Biocenter (VBC)
Dr.-Bohr-Gasse 9, 1030 Vienna