Understanding human brain development: from embryos to organoids
Speaker: Paola Arlotta
Institute: Harvard University
Host: Jürgen Knoblich, Florian Raible
Phase transitions in early zebrafish development
Speaker: Carl-Philipp Heisenberg
Institute: IST Austria
Host: Elly Tanaka
Bringing the "PL" to Plants
Speaker: Andrea Mair
Institute: Stanford University
Host: Yasin Dagdas, Markus Teige
Monday Seminar (Internal)
Speaker: VAINORIUS Gintautas (Elling), ALMEIDA Bernardo (Stark), SAVOVA Adriana (Martens)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Dynamic sumoylation and phosphorylation control meiotic chromosome segregation in C. elegans
Speaker: Federico Pelisch
Institute: School of Life Sciences, University of Dundee
Host: Verena Jantsch
Title to be announced
Speaker: Martin Polz
Institute: University of Vienna
Host: Magnus Nordborg
Maintenance of nucleolar homeostasis during development: The role of non-coding RNAs
Speaker: Eliezer Calo
Institute: MIT Department of Biology
Host: DK RNA Biology
Title to be announced
Speaker: Oliver Stork
Institute: Otto-von-Guericke University Magdeburg
Host: Wulf Haubensak
Controlling transposon mobility in a lake
Speaker: Eric Miska
Institute: Gurdon Institute, University of Cambridge
Host: DK RNA Biology
Monday Seminar (Internal)
Speaker: SGROMO Annamaria (Ameres), SCHNABL Jakob (Brennecke), HINTERNDORFER Matthias (Zuber)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Melina Schuh
Institute: MPI for Biophyical Chemistry
Host: Andi Pauli
Small RNA biology in the nematode C. elegans
Speaker: Rene Ketting
Institute: IMB Mainz
Host: DK RNA Biology
Non-conventional RNA processing mechanisms to cope with cellular stress
Speaker: Elif Karagöz
Institute: Max Perutz Labs
Host: DK RNA Biology
Monday Seminar (Internal)
Speaker: TURCO Eleonora (Martens), PHILLIPS Alexander William (Keays), NOGALES MORAL Adrian (Köhler)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
How to make of a photosynthetic animal? - a model systems' approach to coral-algal endosymbiosis
Speaker: Annika Guse
Institute: Centre for Organismal Studies Heidelberg (COS)
Host: Andi Pauli
Monday Seminar (Internal)
Speaker: STEPINAC Emma (Dong), REITER Franziska (Stark), HANDLER Dominik (Brennecke)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
The cerebral cortex: A substrate for computations in high dimensional state space
Speaker: Wolf Singer
Institute: Ernst Struengmann Institute for Neuroscience, Frankfurt/Main
Host: Jürgen Knoblich
Title to be announced
Speaker: Ken Zaret
Institute: University of Pennsylvania
Host: Kikue Tachibana
Monday Seminar (Internal)
Speaker: KIM Jihoon (Koo), SIMS Jason (Schloegelhofer), KLAUS Loni (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Jose Jimenez-Gomez
Institute: INRA
Host: Daniele Filiault
Monday Seminar (Internal)
Speaker: PETRZILEK Jan (Ameres), SALAZAR THULA Oriana Ylida (Zimmer), BENTE Heinrich (Mittelsten Scheid)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Ton Schumacher
Institute: The Netherlands Cancer Institute
Host: Meinrad Busslinger
DK Chromosome Biology PhD Symposium: Chromopalooza - A festival to celebrate chromosome biology
Monday Seminar (Internal)
Speaker: BAUMGARTNER Lisa Christine (Brennecke), MERAI Zsuzsanna (Mittelsten Scheid), DAO Pauline (Tessmar)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Eileen Furlong
Institute: EMBL Heidelberg
Host: Alexander Stark
Title to be announced
Speaker: Harmit Malik
Institute: Fred Hutchinson Cancer Research Center
Host: Andi Pauli
Title to be announced
Speaker: Nicolas Plachta
Institute: Perelman School of Medicine, Philadelphia
Host: Alex Dammermann
Monday Seminar (Internal)
Speaker: KORDIC Darja (Clausen), HOFBAUER Pablo-Andres (Mendjan), DUKIC Dejan (Nordborg)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Dirk Goerlich
Institute: MPI Biophysical Chemistry
Host: Shamba Saha
Monday Seminar (Internal)
Speaker: BRADAMANTE Gabriele (Mittelsten Scheid), ELEWAUT Anais (Obenauf), PACHINGER Claudia (Dammermann)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KNOCH Eva (Becker), EHRMANN Julian Friedrich (Clausen), HOFFMANN David (Penninger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: NAGASAKA Kota (Peters), LIU Grace Jie (Busslinger), SCHÄFER Markus (Zuber)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Genevieve Almouzni
Institute: Institute Curie
Host: Fred Berger
Title to be announced
Speaker: Antia Rodriguez-Villalon
Institute: ETH Zurich
Host: Yasin Dagdas
Monday Seminar (Internal)
Speaker: STEPHANI Madlen (Dagdas), ELLIS Thomas (Nordborg), HOI David Mario (Clausen)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Doug Higgs
Institute: MRC Weatherall Institute of Medicine
Host: Rushad Pavri
Title to be announced
Speaker: Petra Bulankova
Institute: VIB Gent
Host: Ortrun Mittelsten Scheid
Title to be announced
Speaker: Ian Henderson
Institute: University of Cambridge
Host: Magnus Nordborg
Title to be announced
Speaker: Karin De Visser
Institute: NKI
Host: Anna Obenauf
Monday Seminar (Internal)
Speaker: PFLUG Florian (Von Haesseler), GASSLER Johanna (Tachibana), MONTGOMERY Sean (Berger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Richard Henderson
Institute: MRC Laboratory of Molecular Biology
Host: Clemens Plaschka
Title to be announced
Speaker: Karen Oegema
Institute: UCSF
Host: Alex Dammermann
Title to be announced
Speaker: Silvia Ramunda
Institute: UCSF
Host: Yasin Dagdas
Monday Seminar (Internal)
Speaker: TRASSER Marieke (Mari-Ordinez), MITTER Michael (Gerlich), HAAS Lisa (Obenauf)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SERRA Nuria (Becker), DE ALMEIDA Melanie Talata (Zuber), PARYS Katarzyna (Belkhadir)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Paul Neve
Institute: Rothamsted Research, Harpenden
Host: Claude Becker
Monday Seminar (Internal)
Speaker: OSAKABE Akihisa (Berger), CRONIN Shona Mary (Obenauf), WU Szu-Hsien (Koo)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Andrea Schietinger
Institute: Memorial Sloan Kettering Cancer Center
Host: Elly Tanaka
Monday Seminar (Internal)
Speaker: HENDY Oliver James (Stark), PARINOV Anton (Zimmer), MORREALE Francesca (Clausen)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BRIEDIS Krista Rene (Pauli), HISANAGA Tetsuya (Berger), GRÜNBACHER Sarah (Busslinger
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Julia Mahamid
Institute: Shambaditya Saha
Host: European Molecular Biology Laboratory
Title to be announced
Speaker: Ted Farmer
Institute: University of Lausanne
Host: Yasin Dagdas
Monday Seminar (Internal)
Speaker: SHANMUGANATHAN Reshi (Becker), POLIKARPOVA Anastasia (Tanaka), PETROVIC Mina (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LEE Ji-Hyun (Koo), BELACIC Katarina (Haselbach), UMKEHRER Christian (Obenauf)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Alistair Boettiger
Institute: Stanford University
Host: Christa Bücker, Daniel Gerlich
Monday Seminar (Internal)
Speaker: LEESCH Katrin Friederike (Pauli), BYKOV Aleksandr (Cochella), LEE Ho-Seok (Belkhadir)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Valter Longo
Institute: USC Leonard David School of Gerontology
Host: Noelia Urban
Monday Seminar (Internal)
Speaker: NEUMAYR Christoph (Stark), CRESPO ENRIQUEZ Ivan (Urban), MARSONER Theodor (Campbell)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Eva Nogales
Institute: Lawrence Berkeley National Lab
Host: David Haselbach
Title to be announced
Speaker: Rahul Satija
Institute: New York Genome Center
Host: Andi Pauli
Title to be announced
Speaker: John Wherry
Institute: University of Pennsylvania
Host: Johannes Zuber
Monday Seminar (Internal)
Speaker: HOLSTEIN Felix (Obenauf), CUSHION Thomas David (Keays)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Gunnar Rätsch
Institute: ETH Zurich
Host: Alex Stark
Monday Seminar (Internal)
Speaker: JAEGLE Benjamin (Nordborg), RIESER Sarah Christine (Zuber), KOLESNIKOVA Sofia (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HAJDUSITS Bence (Clausen), HOHMANN Urlich (Brennecke/Plaschka), JAMGE Bhagyshree (Berger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ROMANAUSKA Anete (Koehler), VOGT Vivien (Zuber), TREPTE Philipp (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SEREBRENI Leonid (Stark), GARBRECHT Joachim (Dammermann), VALLEBUENO Miguel (Swarts)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LEODOLTER Julia (Clausen), JELENIC Stela (Saha), SCHMUECKER Anne (Berger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ZHAO Jierui (Dagdas), KOBAYASHI Wataru (Tachibana), TARDIVO Pietro (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Jef Boeke
Institute: NYU Langone Health
Host: Luisa Cochella
Monday Seminar (Internal)
Speaker: ROSS James Julian (Brennecke), GUTIERREZ PEREZ Paula (Cochella), VALLOT Antoine (Tachibana)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Joanna Wysocka
Institute: Stanford University
Host: Christa Bücker, Kikue Tachibana
Monday Seminar (Internal)
Speaker: LUST Katharina (Tanaka), NAGUMO WONG Sakurako (Knoblich), CLAVEL Marion (Dagdas)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: MEREITER Stefan (Penninger), TIKANOVA Polina (Burga), CTORTECKA Claudia (Mendjan)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Eran Segal
Institute: Weizmann Institute
Host: Ortrun Mittelsten Scheid
Monday Seminar (Internal)
Speaker: BOSONE Camilla (Knoblich), BLAHA Andreas (Pauli)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Richard Youle
Institute: NIH
Host: Sascha Martens
Title to be announced
Speaker: Stefanie Sprunck
Institute: Regensburg University
Host: Andi Pauli/Ortrun Mittelsten Scheid
Monday Seminar (Internal)
Speaker: BENNABI Isma (Gerlich), DIMITROVA Mariya (Peters), MASSELINK Wouter (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: FALCON CHAVEZ Francisco Javier (Tanaka), CALDERON DOMINGUEZ Lesly (Busslinger), ANDREEV Veselin Ivanov (Brennecke)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: ASANOVIC Igor (Martinez), TAVERNINI Katherina (Urban), GUTIERREZ PEREZ Irene (Peters)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Andrew Dillin
Institute: University of California, Berkeley
Host: Yasin Dagdas
Title to be announced
Speaker: Fay-Wie Li
Institute: Cornell University
Host: Fred Berger
Monday Seminar (Internal)
Speaker: REY Ulises (Zimmer), UIJTTEWAAL Esther (Elling), SCHNEIDER Maximilian (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Jennifer Lippincott-Schwartz
Institute: Janelia Farm
Host: Kristina Djinovic Carugo
Monday Seminar (Internal)
Speaker: STOCK Jessica (Pauli), PICCHIANTI Lorenzo (Dagdas), SIDHAYE Jaydeep (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: GABARRO SOLANAS Rut (Urban), KAGAWA Harunobu (Rivron), BECERRIL PEREZ Fernando (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: HOFBAUER Lorena (Stark), DEYETT Alison Ann (Mendjan), VUNJAK Milica (Versteeg)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Steve Jackson
Institute: Gurdon Research Institute
Host: Rushad Pavri
Monday Seminar (Internal)
Speaker: SCHENK Robyn (Busslinger), LEE Joonsun (Elling), RODRIGUES VIANA Angela Maria (Ameres)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Valentina Greco
Institute: Yale University School of Medicine
Host: Noelia Urban
Monday Seminar (Internal)
Speaker: MILJKOVIC Frane (Köhler), STOCKINGER Alexander (Raible), SUGIURA Takuji (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Naama Barkai
Institute: Weizmann Institute of Science
Host: Luisa Cochella
Monday Seminar (Internal)
Speaker: DA CUNHA E SILVA MARTINS COSTA Catarina (Knoblich), VAN DER LELIJ Petra (Peters), FAHRENBERGER Martin (Von Haeseler)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: John Marioni
Institute: EMBL-EBI
Host: Arndt von Haeseler
Monday Seminar (Internal)
Speaker: DUXBURY Zane (Becker), VOLKOVA Ksenia (Köhler), RAUSCHMEIER Rene (Busslinger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Christopher Vakoc
Institute: Cold Spring Harbor Laboratory
Host: Johannes Zuber
Monday Seminar (Internal)
Speaker: ANISIMOVA Aleksandra (Karagöz), LIN Tzi-Yang (Tanaka), ANDREATTA Gabriele (Raible)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KHANDEKAR Ameya (Martinez), LOUBIERE Vincent (Stark), NGUYEN Vu (Mittelsten Scheid)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LANDLER Lukas (Keays), REUMANN Daniel (Knoblich), CLARKE Amy (Zagrovic)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: Clifford Brangwynne
Institute: Princeton University
Host: Daniel Gelrich
Monday Seminar (Internal)
Speaker: HAENDELER Simon (Von Haeseler), KRAMMER Teresa (Tanaka), DENEKE Victoria (Pauli)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LEITNER Marie-Christin (Mendjan), YU Changwei (Brennecke), MANDLBAUER Ariane (Cochella)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LORENZO ORTS Laura (Pauli), HORN Sabrina (Peters), SEONG Jinwoo (Rivron)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: SAAD RODRIGUES Carolina (Schloegelhofer), OTSUKI Leo (Tanaka), SCHMIDT Clara (Mendjan)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LÖFKE Christian (Dagdas), SANTILLAN Emilio Manuel (Cochella), TAKACS Zsuzsanna (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BATTY Paul Daniel (Gerlich), JACOBS Jelle (Stark), BAUMANN Verena (Martens)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: RITSCHKA Birgit (Tanaka), LEIENDECKER Lukas (Obenauf), PISUPATI Rahul Bharadwaj (Nordborg)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: VOGEL Antonia (Clausen), INCARBONE Marco (Mittelsten Scheid), TELONI Federico (Gerlich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: AYALA MUNOZ Farja Isabel (Plaschka), PETROVA Olga (Clausen), STALTNER Moritz (Ameres)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: BASSAT Elad (Tanaka), RUANGROENGKULRITH Siwat (Tachibana), DOMBEY Rodolphe (Mari-Ordonez)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: FEDL Anna (Busslinger), TERIYAPIROM Isaree (Koo), LI Chong (Knoblich)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: LIU Haijun (Nordborg), GEHRE Maja (Brennecke), NEMCKO Filip (Stark)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: NAVALAYEU Tsimafei (Ameres), ZMAJKOVIC Jakub (Zuber), JONSSON Gustav (Penninger)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Monday Seminar (Internal)
Speaker: KORESHOVA Alevtina (Burga), VOLKNER Manuela (Tanaka)
Institute: Open only to IMP/IMBA/GMI/Max Perutz Labs
Title to be announced
Speaker: David Sabatini
Institute: MIT, Whitehead Institute
Host: Yasin Dagdas
+43 1 4277 240 01
Today: 9am - 5pm
Vienna Biocenter (VBC)
Dr. Bohr-Gasse 9, 1030 Vienna
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Until recently proteins were considered as nature’s robots performing both unique chemical transformations or specifically interacting with their cognate binding partners under environmental conditions suitable for living organisms. Common understanding is that these functionalities rely on the existence of stably folded protein scaffolds. This structure-function paradigm, however, has been put in question: it is now acknowledged that an increasing number of proteins are lacking stably folded tertiary structures and that this intrinsic flexibility contributes to their biological functionality. The emerging picture is that proteins have evolved to substantially increase the diversity of their conformational ensembles and that even in seemingly random-coil-like disordered proteins there is a hidden structural simplicity that needs to be addressed by appropriate experimental techniques and theoretical concepts which grasp the essential properties of the underlying structural components.
A hallmark of our research is the integrative application of a novel computational biology concept (meta-structure concept) and information-rich NMR spectroscopy directed towards a better understanding of the underlying mechanisms of important biological problems. Finally, as much of protein function is predicated on dynamics, we are developing novel methodological approaches which combine biochemistry, bioorganic chemistry and NMR spectroscopy to unravel the microscopic details of functionally important protein plasticity with potential applications also in drug development programs.
Robert Konrat studied Chemistry in Graz, Austria, and did postdoctoral research at the Université de Lausanne and University of Toronto. He held faculty positions at the University of Innsbruck and visiting professorships at the École Normale Supérieur, Paris, France, University of Barcelona, Spain and the University of California, San Diego, USA.
Correlated structural fluctuations in IDPs are probed by a novel NMR technique developed in our laboratory employing cross-correlated paramagnetic spin relaxation. An application to the Osteopontin-Heparin complex revealed unprecedented details of structural adaptations upon polysaccharide binding.
A novel technique was developed to probe protein-receptor binding in living cells. By combining advanced cell biology and sophisticated NMR techniques unique information about receptor-binding sites can be obtained that allows the determination of IDP-receptor complexes in native environments.
A central theme of the laboratory is to overcome the dichotomy of globular proteins and IDPs. To this end, we have developed computational and NMR techniques that unravel hidden structural compaction in IDPs. The IDP-region of CFTR partly exists in a compact state that facilitates binding to the structured nucleotide-binding domain.
We have developed a versatile prediction method of identifying protein targets and the identification of novel chemical scaffolds for protein targets exclusively based on primary sequence information of the protein (meta-structure) or a 2D representation of the small molecule (Shannon-Entropy Descriptor, SHED).
Our integrated methods platform offers exciting possibilities in biomedical research: identification of novel drugs and their targets, drug repurposing, pathway and mode of action analysis of drugs. Finally, preliminary big data analysis of existing drugs has revealed a surprising hidden relationship among different disease areas.
Toward Rational Fragment-Based Lead Design without 3D Structures.
Henen, Morkos A; Coudevylle, Nicolas; Geist, Leonhard; Konrat, Robert
Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core.
Brüschweiler, Sven; Konrat, Robert; Tollinger, Martin
Compensatory adaptations of structural dynamics in an intrinsically disordered protein complex.
Kurzbach, Dennis; Schwarz, Thomas C; Platzer, Gerald; Höfler, Simone; Hinderberger, Dariush; Konrat, Robert
Project title: "NMR investigations of the hyperphosphorylated IDP Osteopontin" (P28359)
Project title: “Structural Dynamics of IDPs probed by Cross-Correlated NMR Spin Relaxation" (P 28359)
LS17-008, Structure Zoom (as Co-PI with Christian Becker)
ITN: FLUOR21 participant
2016-2019: The Group Konrat participates in the special Doctoral Program "Integrative Structural Biology" reviewed and funded by the Austrian Science Fund FWF.
Novartis, Boehringer-Ingelheim, UCB, Alkahest, IDPharma, Everpharma, Neuropore
Project-leader: Kristina Djinović-Carugo and Robert Konrat
Business partner: Boehringer Ingelheim RCV GmbH & Co KG and Biomin Holding GmbH
Duration: 01.02.2017 - 31.01.2024
CD Laboratory for knowledge-based structural biology and biotechnology
Christian Doppler Research Association
University of Vienna
Description: The scientists will primarily investigate protein structure, which is crucial for the development of new therapeutic methods for a great variety of diseases ranging from Alzheimer’s and infectious diseases to cancer. This renders it a most valuable tool in biomedical research. In order to gain new insights into protein structure, function and interactions that could potentially be translated into new therapies, the researchers will employ a combination of bioinformatics, protein production and high-end biophysical and structural biology techniques. The collected information will ultimately be combined in an information pipeline for both research and biotechnology.