Resistance and tolerance: two sides of the same coin
Interleukin 1 alpha (IL-1α) and Interleukin 1 beta (IL-1β) are signaling molecules that regulate inflammation and immunity in response to infection. They bind to the same receptor and were previously thought to be redundant. In a new study published in Science Advances, the lab of Pavel Kovarik has discovered that IL-1α and IL-1β exhibit tissue-specific expression patterns and have distinct functions in the defense against bacterial infections. Whereas IL-1β drives bacterial clearance and hence resistance, IL-1α is essential for host defense by promoting tolerance to infections.
Peter Schlögelhofer promoted to University Professor
Congratulations to group leader Peter Schlögelhofer, who has been promoted to full professor by the University of Vienna. Using the model plant Arabidopsis thaliana, Peter’s lab studies the molecular mechanisms of meiotic recombination, an important process for all sexually reproducing organisms, including humans, plants and animals. In the coming years the lab plans to deepen our mechanistic understanding of meiosis while also branching out into more applied fields of meiosis research.
Keeping meiotic entry in check
The differentiation of germline progenitor cells into meiocytes is crucial for the production of healthy gametes. In C. elegans, this step is governed by three post-transcriptional pathways, one of which relies on specific protein degradation mediated by the SCF PROM-1 ubiquitin ligase. In new work published in Science Advances, the lab of Verena Jantsch has identified the protein phosphatase PPM-1.D as a target of PROM-1 and a novel meiotic regulator. The work is a collaboration with the lab of Sebastian Falk at the Max Perutz Labs as well as the lab of Tim Schedl from Washington University School of Medicine and the lab of Yumi Kim from John Hopkins University.
Aiming for the basket
The nuclear pore basket is a conical, net-like structure that is attached to the main body of the nuclear pore complex. The basket is crucial for the transport of macromolecules between the cell nucleus and the cytoplasm, while it also regulates many aspects of gene expression. The lab of Alwin Köhler has, for the first time, managed to reconstitute key parts of the basket on synthetic membranes. Their study, published in Science Advances, provides new insights into the intricate assembly principles of this important structure, helping to explain how it achieves the flexibility necessary for the transport of large cargo.
ERC grant for Thomas Juffmann
The European Research Council ERC has awarded a Proof of Concept grant to the group of Thomas Juffmann. Following up on an ERC Starting Grant in 2018, the 150.000 EUR funding enables the team to explore applications of fluorescence-lifetime imaging microscopy (FLIM) in medicine and super-resolution microscopy.
Blooming too soon: timing is crucial to error-free cell division
The Bloom (BLM) DNA helicase is an important enzyme in DNA repair and the maintenance of genome stability. Mutations in BLM are associated with Bloom’s Syndrome, a disease characterized by growth defects and increased susceptibility to cancer. In their latest study, published in Science Advances, the lab of Joao Matos and their colleagues at the IRB-Bellinzona and ETH-Zürich (Switzerland) have elucidated the mechanism that regulates the correct timing of BLM activity during mitotic cell division. They show that BLM activity depends on its phosphorylation by two cell cycle kinases and that active BLM promotes the dissolution of potentially dangerous recombination intermediates.
New funding for meiosis research
The Austrian Science Fund (FWF) has awarded a special research programme (SFB) grant to six research groups from the Max Perutz Labs and scientists from the Institute of Molecular Biotechnology (IMBA), the Institute for Science and Technology Austria (IST), and the Johannes Kepler University Linz, Austria (JKU). The program is coordinated by Verena Jantsch and aims to gain novel mechanistic insights into the fundamental biological process of meiosis.
Anete Romanauska wins Science & SciLifeLab Prize
Congratulations to Anete Romanauska who has been awarded the Science & SciLifeLab Prize for Young Scientists in the category “Cell and Molecular Biology”. The international award was created by Science magazine/AAAS and the Swedish research center SciLifeLab with the goal to recognize excellent PhD theses in the life sciences. As part of her prize, Anete has published an essay in Science about her contributions to our understanding of the lipid metabolism of the nuclear envelope.
Faculty promotions at the Max Perutz Labs
Congratulations to Karl Kuchler and Thomas Leonard who have been appointed Professors in the subject field of Molecular Biology by the Medical University of Vienna, and Thomas Juffmann who has been promoted to Associate Professor at the University of Vienna.
‘Network medicine’ directs disease diagnosis
Rare diseases are usually caused by a single genetic defect. Nevertheless, the search for the cause and the assessment of the effects is highly complex and difficult. Jörg Menche’s lab has now developed a multiplex network that maps all genes and their interactions on multiple levels of biological organization. Their study, published in Nature Communications, could help scientists better diagnose the causative genetic defects in disease, as well as understand the underlying mechanisms.
Decoding the role of PHF3 in transcription
Yeast homologue of the PHD finger protein 3 (PHF3) is known to be involved in transcription regulation, but its exact function in mammalian cells has remained unclear. New work from the lab of Dea Slade now shows that PHF3 regulates RNA polymerase II through a specialized domain called SPOC. Their study, published in Nature Communications, identifies PHF3 as a regulator of both transcription and mRNA stability during neuronal differentiation. The work is a collaboration between the Slade Lab, scientists from the Vienna BioCenter, the Institute of Science and Technology (IST, Austria), the Central European Institute of Technology (CEITEC, Czech Republic) and the Max Delbrück Center (Germany).
FWF grants awarded to Max Perutz Labs researchers
The Austrian Science Fund (FWF) has awarded individual project grants to Manuela Baccarini, Boris Görke and Robert Konrat. The funding amounts to a total of 1.3 million Euros and will support research on the ERK signaling pathway, bacterial envelope stress responses, and intrinsically disordered proteins.
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