New Christian Doppler Laboratory at the University of Vienna/MFPL
Led by highly qualified scientists, the research groups in Christian Doppler (CD) Laboratories work on application-oriented basic research. They search for innovative answers to current research questions in close coordination with industrial partners. As a consequence, the Christian Doppler Research Association is internationally considered as best practice example. The new laboratory, which is supported by funding from the Federal Ministry of Science, Research and Economy (BMWFW), is concerned with knowledge-based structural biology and biotechnology and will develop foundations that might lead to new therapeutic methods for diseases like Alzheimer’s and cancer.
A successful "Ubiquitin and Friends" symposium at the Josephinum in Vienna
“The early bird catches the worm.” This was the thought on our minds at 9 a.m. on a rainy Saturday on the 13th of May when members of the Vienna BioCenter convened in Vienna’s 9thdistrict to discuss exciting new research in a historical and scientific setting.
€1.1 million worth of FWF grants for three MFPL researchers
The MFPL group leaders Sascha Martens, Gijs Versteeg and Peter Fuchs succeeded in securing a total of 1.1 million euros of funding from the FWF – all three of them during the same board meeting.
“They won’t be back”: Setting the timer for neutrophil termination
Correct timing and balance of the immune response is key for fighting off infections yet preventing extensive damage to our own body. Thus, a constant challenge for our immune system is adjusting offense to achieve defense against pathogens. The lifespan of immune cells plays a central role in the adjustment of the immune response.
A new tool to decipher evolutionary biology
A new bioinformatics tool to compare genome data has been developed by teams from the Max F. Perutz Laboratories, a joint venture of the University of Vienna and the Medical University of Vienna, together with researchers from Australia and Canada. The program called “ModelFinder” uses a fast algorithm and allows previously not attainable new insights into evolution. The results are published in the influential journal Nature Methods.
Start of the new doctoral program "Signaling Mechanisms in Cellular Homeostasis"
The FWF has granted a group of 14 scientists around MFPL group leader Manuela Baccarini the establishment of the new doctoral program “Signaling Mechanisms in Cellular Homeostasis (SMICH)”.
FWF grant awarded to MFPL group leader Gijs Versteeg
Gijs Versteeg, group leader at the MFPL, was awarded an FWF standalone grant to support his project entitled “Inhibition of macrophage activation by TRIM47”. The research efforts of the Versteeg group focus on the immune system and its regulatory mechanisms during infections.
MFPL group leader Sascha Martens awarded prestigious HFSP Program Grant
MFPL group leader Sascha Martens was awarded a Human Frontier Science Program (HFSP) Program Grant. This highly competitive grant is designed to encourage international scientific collaborations across continents and is shared between the Martens group and researchers from Germany, USA and Japan.
Three-dimensional map shows genome structure of stem cells
To fit into the nucleus, the roughly two-meter long DNA needs to fold. This effort can only succeed if the DNA passes multiple packaging stages – from the double helix to whole chromosomes. From this folding process, various three-dimensional structures of the genome arise that interact with each other and thus influence cellular processes. For the first time, scientists from Martin Leeb’s group at the Max F. Perutz Laboratories (MFPL), a joint venture of the University of Vienna and the Medical University of Vienna, and the University of Cambridge succeeded in calculating the 3D structures of mammalian genomes in single cells. The results were published in the renowned journal Nature.
Separating signal from noise during stress in the HOG network
Cellular integrity relies not only on intracellular, but also on extracellular parameters which are often prone to fluctuation. If physico-chemical parameters in a cell’s environment reach extremes, adaptation is crucial for survival.
RAF1, the unexpected moonlighter
Cells have to be able to interpret environmental signals in order to detect what's going on in their surroundings and respond appropriately to cues from both their neighbors and their environment. Within cells, signals are transmitted by specific proteins arranged in hierarchical structures, called signalling cascades. Many of these cascades are extremely well conserved, showing their relevance for a wide range of species.
Seeding Success in Science
Symposium on the occasion of the retirement of Graham Warren, Scientific Director of the Max F. Perutz Laboratories and Dean of the University of Vienna and the Medical University of Vienna